DESALINATION
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2025
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IF 9.8
Tunga Kuhana Arsene,Zihao Zhai,Junyong Zhu,Miaomiao Tian,Yatao Zhang
Nanofiltration membranes' performance hinges on their ion sieving and water permeability, which are affected by the crosslinking degree, uniformity, thickness, and microstructure of the active layer. Additive control offers a promising approach for optimizing membrane properties. This study presents a novel approach to improve water permeance of nanofiltration membranes by introducing organophosphorus end-capping reagents ((2-aminoethyl) triphenyphosphonium bromide (ATPB), (3-aminopropyl) triphenylphosphonium bromide (ATPPB), and 2-(diphenyphosphino) ethylamine (DPPE)) as co -reactive additives in the aqueous phase during interfacial polymerization. These reagents influenced the amine monomer's diffusion behavior, leading to a more homogeneous and potentially thinner polyamide (PA) layer, as demonstrated by molecular dynamics (MD) simulations. By regulating this process, we effectively modified pore characteristics, charge density distribution, and structural properties of the PA layer, all through a straightforward one-step method. The ATPB-0.015 membrane emerged as the optimal choice due to its excellent performance, characterized by a nodular buried structure, a water permeance of 16.3 L m −2 h −1 bar −1 , and a high Na 2 SO 4 rejection (98.5 %). In addition, the amide and phosphorus units on the ATPB-0.015 membrane surface facilitated the removal of 97.48 % of Escherichia coli through hydrogen bonding and electrostatic interaction, enhancing its anti-bacterial property. Anti-fouling tests employing bovine serum albumin (BSA) and humic acid (HA) as foulants revealed that the ATPB-0.015 membrane demonstrated a faster recovery ratio than the control membrane, primarily attributed to its enhanced surface hydrophilicity. This study demonstrates a facile method for designing nanofiltration membranes with controlled structure and functional performance characteristics.
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COLLOIDS AND SURFACES B-BIOINTERFACES
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2024
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IF 5.4
Lin Wang,Yu Pang,Meihua Xin,Mingchun Li,Lulu Shi,Yangfan Mao
Chitosan exhibits good biocompatibility and some antibacterial activity , making it a popular choice in biomedicine, personal care products, and food packaging. Despite its advantages, the limited antibacterial effectiveness of chitosan hinders its widespread use. Introducing a six-membered heterocyclic structure through chemical modification can significantly enhance its antimicrobial properties and broaden its potential applications. In order to explore the effect of six-membered heterocyclic structure on the antibacterial and antibiofilm activities of chitosan. In this study, seven chitosan derivatives containing six-membered heterocyclics were prepared. They were characterized using Fourier transform infrared (FT-IR) spectroscopy, nuclear magnetic resonance (NMR) spectroscopy, and elemental analysis . Cell viability assay showed that they were non-toxic. The antibacterial and antibiofilm activities against Escherichia coli ( E. coli ) and Staphylococcus aureus ( S. aureus ) were evaluated. Our research findings demonstrate that increasing the hydrophobicity , alkalinity and charge density of the substitute groups improved the antibacterial and antibiofilm activities of chitosan. This study also offers valuable insights into the quantitative structure-activity relationships of chitosan derivatives in terms of antibacterial and antibiofilm activities.
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Progress in Natural Science-Materials International
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2025
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IF 7.1
Jianqiang Xin,Xinger Liu,Chong He,Wenbin Li,Yuheng Zhang,Ze Wu,Anran Guo
Porous aluminum borate ceramics are ideal candidates for high-temperature thermal insulation applications. In this work, lightweight, high strength and thermal insulating aluminum borate whisker-based porous ceramics with hierarchical pore structure were fabricated by the combination of freeze-gel casting and in situ reaction. The effects of B/Al ratio on the morphology of aluminum borate whiskers and the addition amount of agar on the pore structure and properties of aluminum borate whisker-based porous ceramics were investigated. The aluminum borate whisker-based porous ceramics exhibited a typical hierarchical pore structure, including macro pores formed by the growth of ice crystal in the freeze casting process and micro pores in pore walls formed by the overlapped aluminum borate whiskers generated from the in situ reaction of B 4 C and Al 2 O 3 . Results shows when the B/Al molar ratio was 6:9 and the addition amount of agar was 0.4 g, the resultant aluminum borate whisker-based porous ceramics shows a low density (0.20 g/cm 3 ), high porosity (93.5 %), high compressive strength (4.09 MPa) and low thermal conductivity (0.072 W/(m·K)), which can be regarded as a promising high temperature thermal insulation structural material.
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CHEMICAL ENGINEERING JOURNAL
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2024
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IF 13.3
Yanling Lin,Xiaojun He,Tian Huang,Jing Zhao,Liyue Liu,Jiaqi He,Jianliang Shen,Qizhi Ren
The emergence of multidrug-resistant (MDR) bacteria represented by MRSA poses a great challenge to current anti-infection treatment. The traditional antibacterial agents containing Ag + have been receiving intense attention due to their broad-spectrum activity. Compared with the Ag + , the high-valent silver ions including Ag 2+ and Ag 3+ have superior antibacterial ability. However, their extreme instability has severely limited their development as antimicrobials, and so far, no high-valent silver antimicrobials have been reported. Herein an unusual and water-soluble high-valent silver (II + III)-porphyrin complex (AgTMPyP) which can stably exist in an aqueous medium for at least 200 days, its corresponding composite AgTMPyP@GO was also successfully prepared. AgTMPyP@GO shows an excellent photothermal conversion rate (32.17 %) under excitation by an 808 nm near-infrared laser along with dual enzyme-like (peroxidase-like and oxidase-like) activities. When used for photothermal therapy, AgTMPyP@GO can effectively destroy biofilms and kill methicillin-resistant Staphylococcus aureus (MRSA) in vitro . The composite efficiently eradicates MRSA from wounds and rapidly promote wound healing in vivo . Moreover, hemolysis, blood routine, and blood biochemistry tests all demonstrate that AgTMPyP@GO has good biocompatibility. This work reveals that AgTMPyP@GO provides a synergistic antibacterial platform with effective antibacterial performance both in vivo and in vitro .
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Theranostics
·
2025
·Vol. 15
·期 9
·3995
·
IF 13.3
Min Lin,Xiumei Liu,Jing Li,Hong Zou,Jie Wang,Zi Yan,Ying Liu,Yaqi Lyu,Nianping Feng
Rationale: Retinoblastoma is one of the most aggressive paediatric cancers originating from retina and finally invades vitreous humour or other tissues if treated improperly. Current interventions often fail due to the complexities of tumour progression and drug resistance driven by frequent intravitreal injection and epithelial-mesenchymal transition (EMT). Consequently, there is an unmet need for more effective, less invasive treatments. Methods: A near-infrared (NIR)-responsive liposome/hydrogel platform that incorporates quercetin (QUE) and doxorubicin (DOX) co-loaded liposomes (QD Lipo), and indocyanine green (ICG) in a low-gelling temperature agarose hydrogel (LAgel) was developed to improve efficacy through localized, on-demand delivery of chemo-photothermal therapy directly at the site of tumour. The initial phase of the study examined the injectability, reversibility and stability of QD Lipo/ICG/LAgel under NIR using cryo -SEM technique and rheological measurement. Following this, photothermal conversion capability and controlled release of QD Lipo, alongside the mobility and penetration of QD Lipo was investigated using infrared thermal imaging, nanoparticle tracking analysis and fluorescence microscope. Moreover, retinoblastoma orthotopic model was established to corroborate the anti-tumour effectiveness in vivo . Flow cytometry, H&E, immunohistochemical staining, animal imaging and western blotting were performed to identify the underling mechanism of QD Lipo/ICG/LAgel to improve the treatment. Results: The thermosensitivity and photothermal conversion capabilities of QD Lipo/ICG/LAgel enable precise, on-demand drug delivery in vitreous, significantly reducing the need for frequent intravitreal injections. In vitro and in vivo evaluation demonstrated that with facilitation of QUE, our platform effectively targets the rapid tumour progression and overcome therapeutic resistance of mild photothermal therapy (PTT), by modulating EMT process and inhibiting heat shock protein (HSP) level. Conclusions: This innovative approach not only mitigates the current challenges of repeated invasive medication, but also sets new strategies for treating complex ocular diseases.
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ACS Applied Nano Materials
·
2025
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IF 5.5
Zhenzhen Li,Yu Su,Jiayin Fang,Ye Lu,Xia Xiao,Biwen Yang,Haolin Chen,Binggang Ye,Zhouyi Guo,Zhiming Liu
We report a groundbreaking textile modification strategy utilizing fluorescent whitening carbon dots (FW-CDs) to simultaneously achieve multifunctional performance while maintaining fabric comfort. Through controlled hydrothermal synthesis of traditional VBL precursor, bright blue-emitting FW-CDs with extremely high brightness and nanoscale uniformity were successfully fabricated. The FW-CDs, forming hydrogen bonds with cotton, exhibit a superior binding affinity, enhancing the whitening performance significantly with a whiteness index of 94.3, compared to 92.6 for VBL controls. Moreover, they endow the fabric with remarkable durability, ensuring 95.25% whiteness retention after 5 accelerated laundering cycles, and excellent UV stability, maintaining 97.61% of the initial whiteness after 96 h of UV exposure. The engineered textile system also exhibited remarkable multifunctionality: FW-CDs also have excellent antibacterial, antioxidant, and UV-shielding properties. At a concentration of 0.5% (o.w.f), the antibacterial rate against Escherichia coli and Staphylococcus aureus exceeds 99%. The DPPH radical scavenging rate is 58.6%, and the UV-protection factor (UPF) increases from 4.1 to 7.6. Moreover, the modification barely affects cotton’s original properties. This first demonstration of CDs integrating four functionalities (whitening/antibacterial/antioxidant/UV-blocking) with durability positions this technology as an industrially feasible nanomaterial solution within the textile industry.
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Advanced Science
·
2024
·Vol. 11
·期 30
·2401711
·
IF 14.3
Chuan Cao,Fangzhi Mou,Manyi Yang,Shuming Zhang,Di Zhang,Luolin Li,Tong Lan,Dunyi Xiao,Wei Luo,Huiru Ma,Jianguo Guan
Individual differences in size, experience, and task specialization in natural swarms often result in heterogeneity and hierarchy, facilitating efficient and coordinated task accomplishment. Drawing inspiration from this phenomenon, a general strategy is proposed for organizing magnetic micro/nanorobots (MNRs) with apparent differences in size, shape, and properties into cohesive microswarms with tunable heterogeneity, controlled spatial hierarchy, and collaborative tasking capability. In this strategy, disparate magnetic MNRs can be manipulated to show reversible transitions between synchronization and desynchronization by elaborately regulating parameter sets of the rotating magnetic field. Utilizing these transitions, alongside local robust hydrodynamic interactions, diverse heterospecific pairings of disparate magnetic MNRs can be organized into heterogeneous microswarms, and their spatial organization can be dynamically adjusted from egalitarian to leader-follower-like hierarchies on the fly, both in open space and complex microchannels. Furthermore, when specializing the disparate MNRs with distinct functions (“division of labor”) such as sensing and drug carrying, they can execute precise drug delivery targeting unknown sites in a collaborative sensing-navigating-cargo dropping sequence, demonstrating significant potential for precise tumor treatment. These findings highlight the critical roles of attribute differences and hierarchical organization in designing efficient swarming micro/nanorobots for biomedical applications.
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INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
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2024
·
IF 7.7
Haoyuan Chen,Qiqi Wang,Yupei Deng,Jingchun Zhang,Ying Wang,Huimin Zhao,Yu Zhu,Yilin Zhang,Maroosha Javed,Linghua Zhuang,Guowei Wang
Chitosan-gelatin-flavonoid functional composite films were prepared with chitosan, gelatin, and three flavonoids (Naringenin, Apigenin, and Luteolin). The effect of three flavonoids on physical, antioxidant, and antibacterial properties of functional composite film was investigated from experimental and Density functional theory (DFT) simulations. The tensile strength, thermal stability, water solubility, water vapor permeability, antioxidant activity, and antibacterial activity of chitosan-gelatin-flavonoid functional composite films were improved with flavonoid (Naringenin, Apigenin, and Luteolin) incorporation. The release behavior of Apigenin from functional composite film was much lower than that of Naringenin or Luteolin. ABTS + radical scavenging ability values of functional composite films followed: Luteolin (69.53 %) > Naringenin (41.39 %) > Apigenin (36.13 %). The antibacterial activities of functional composite films against Staphylococcus aureus followed: Luteolin (52.03 mm) > Apigenin (49.34 mm) > Naringenin (43.15 mm). The total number, location of hydroxyl groups on ring-B, and the unsaturation degree on pyrone ring of flavonoids influenced antioxidant and antibacterial activities of functional composite films. The minimum bond dissociation enthalpy values of flavonoids followed: Luteolin < Apigenin < Naringenin. The interaction energy of Apigenin-chitobiose was stronger than that of Naringenin or Luteolin. These results will shed light on flavonoid selection for functional composite films of food packaging.
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ADVANCED FUNCTIONAL MATERIALS
·
2024
·
IF 18.5
Yuxuan He,Yihang Zhang,Bocheng Xiang,Changhui Fu,Huayang Zhang,Danyan Zhan,Zhiguang Guo
Hygroscopic salt hydrogel photothermal composites and related technology are a promising pathway for water harvesting. However, due to the overly cumbersome preparation process, the distribution of the surface photothermal layer is difficult to control and the photothermal efficiency is low. In this paper, a method is proposed to greatly simplify the preparation process of photothermal layer hydrogels and improve their atmospheric water harvesting performance by constructing temperature-sensitive interpenetrating networks. Due to the decomposition of some reversible hydrated structures in the network during heating and warming, carbon nanotubes move autonomously to form a layered structure with a photothermal effect on the upper surface, which can return to its original state after cooling and remain stable at room temperature or under solar illumination. Compared with hydrogels with general layered structure or overall distribution of photothermal materials, agar/GG/PAM/CNT hydrogel has faster moisture adsorption efficiency and higher desorption efficiency, and during the 24 h continuous sorption–desorption cycle is capable of achieving high water yield of 2.57 L water kg sorbents −1 day −1 , superior to most recent hydrogel adsorbents. Simplifying the preparation process while maintaining high efficiency, while greatly improving photothermal performance, paves the way for cost-effective mass production applications for a wide range of hygroscopic salt-hydrogel photothermal composites.
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ACS Applied Polymer Materials
·
2025
·
IF 4.7
Li Tang,Fang Liu,Yue Xu,Dan Xiao,Zidan Zhang,Haoyu Jiang,Liang Gong,Jianxin Tang
Bilayer hydrogel actuators, with their anisotropic structure akin to biological tissues, are poised to revolutionize the fields of soft robotics and tissue engineering. Despite their promise, achieving a harmonious balance between high bulk toughness, robust interface toughness, and actuating property has been a formidable challenge, significantly hindering their broader application. By employing a dual-strategy approach, we successfully developed a poly(N-isopropylacrylamide-co-acrylamide)-agar/poly(acrylamide-co-acrylic acid) [p(NIPAM-co-AAM)-agar/p(AAM-co-AAC)] (NM–AMC) LCST- and UCST-type double-layer hydrogel actuator. First, the double-network strategy enhanced the mechanical properties of the hydrogel. Second, the synchronous UV polymerization method effectively improved the toughness of the interface between the two layers of hydrogels. The NM–AMC double-layer hydrogel actuator integrates the low-temperature response characteristics of NM (lower critical solution temperature-type) and the high-temperature response characteristics of AMC (upper critical solution temperature-type). This design confers a unique dual-thermal response behavior on the actuator, enabling it to achieve reversible bending angle changes from +361.33 to −417.33° over a temperature range of 5–85 °C. More importantly, after 5 cycles, the NM–AMC bilayer hydrogel actuator did not have obvious delamination, indicating that the NM–AMC bilayer hydrogel shows an excellent interface toughness between the two layers of hydrogels. Inspired by the adaptive mechanisms of plants in nature, a series of NM–AMC biomimetic hydrogel actuators were designed to emulate the morphology of flowers and leaves. This innovation not only substantially expands the actuating range of hydrogel actuators but also offers new insights into the intelligent design and manufacture of responsive hydrogel systems, thereby advancing the development of biomimetic hydrogel technology.
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MOLECULAR ECOLOGY
·
2024
·
IF 4.5
Juliane P. C. Monteiro,Heike Pröhl,Mariana L. Lyra,Andrés E. Brunetti,Eli C. de Nardin,Thais H. Condez,Célio F. B. Haddad,Ariel Rodríguez
Colour signals play pivotal roles in different communication systems, and the evolution of these characters has been associated with behavioural ecology, integumentary production processes and perceptual mechanisms of the species involved. Here, we present the first insight into the molecular and histological basis of skin colour polymorphism within a miniaturized species of pumpkin toadlet, potentially representing the lowest size threshold for colour polytypism in tetrapods. Brachycephalus actaeus exhibits a coloration ranging from cryptic green to conspicuous orange skin, and our findings suggest that colour morphs differ in their capability to be detected by potential predators. We also found that the distribution and abundance of chromatophores are variable in the different colour morphs. The expression pattern of coloration related genes was predominantly associated with melanin synthesis (including dct , edn1 , mlana , oca2 , pmel , slc24a5 , tyrp1 and wnt9a ). Up-regulation of melanin genes in grey, green and brown skin was associated with higher melanophore abundance than in orange skin, where xanthophores predominate. Our findings provide a significant foundation for comparing and understanding the diverse pathways that contribute to the evolution of pigment production in the skin of amphibians.
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APPLIED CATALYSIS A-GENERAL
·
2024
·
IF 4.7
Na Xu,Shiji Liu,Qidi Xu,Pingchuan Yuan,Ping Zhang,Shujuan Zhuo,Changqing Zhu,Jinyan Du
In this work, novel porous g-C 3 N 4 nanosheets modulated by up-conversion carbon quantum dots (CQDs/CNS) were successfully fabricated. Using the photocatalytic inactivation of Escherichia coli (E. coli) and Staphylococcus aureus (S. aureus) as the model reaction, the visible light-triggered antibacterial activity was evaluated. It was found that the photocatalytic performance towards bacterial inactivation is significantly improved, with the minimum inhibitory concentration (MIC) in CQDs/CNS against E. coli and S. aureus only being 12.5 and 40 ppm, respectively. The enhancement in antibacterial behavior can be attributed to the introduction of up-conversion CQDs. On the one hand, it extends absorption region to the visible light which promotes the generation of e - - h + pairs. On the other hand, it narrows the energy band gap which accelerates the separation of carriers and transferance of charges at the interface. This study provides a new insight for developing a CQDs-based g-C 3 N 4 system for effective bacterial disinfection.
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