PROGRESS IN ORGANIC COATINGS
·
2023
·
IF 6.6
Qiuhua Xie,Zhihua Zhang,Na Li,Li Cui,Ping Wang,Yuanyuan Yu,Qiang Wang
In this study, transglutaminase-mediated alkylation modification of zein with octadecylamine (OA) was carried out to enhance the hydrophobicity of zein and the potential application of modified zein in the functionalization of textiles was evaluated. The reaction between OA and zein was demonstrated from the results of sodium dodecyl sulfate polyacrylamide gel electrophoresis (SDS-PAGE), Fourier transform infrared (FTIR) and 1 H nuclear magnetic resonance ( 1 H MIR). The hydrophobicity of zein significantly increased and the secondary structure of zein slightly changed after alkylation modification. The alkylated zein imparted excellent hydrophobic function to cotton textiles with a water contact angle (WCA) value of 131.7° and the hydrophobicity was long-lasting. Scanning electron microscope (SEM) showed a coarse surface formed on cotton fabric due to the participation of OA. The hydrophobic functionalization of the cotton fabric with alkylated zein did not cause negative impact on the mechanical properties and air permeability of the fabric.
研究领域:
材料科学
·
纺织工程
·
化学
✓ 已验证
产品关联
DOI
高影响因子
JOURNAL OF PHARMACY AND PHARMACOLOGY
·
2024
·
IF 2.8
Lou Yutao,Zou Xiaozhou,Pan Zongfu,Huang Zhongjie,Zheng Shuilian,Zheng Xiaowei,Yang Xiuli,Bao Meihua,Zhang Yuan,Gu Jinping,Zhang Yiwen
ObjectivesThis study aimed to reveal the anti-fibrotic effects of Botrychium ternatum (Thunb.) Sw. (BT) against idiopathic pulmonary fibrosis (IPF) and to preliminarily analyze its potential mechanism on bleomycin-induced IPF rats.MethodsThe inhibition of fibrosis progression in vivo was assessed by histopathology combined with biochemical indicators. In addition, the metabolic regulatory mechanism was investigated using 1H-nuclear magnetic resonance-based metabolomics combined with multivariate statistical analysis.Key findingsFirstly, biochemical analysis revealed that BT notably suppressed the expression of hydroxyproline and transforming growth factor-β1 in the pulmonary tissue. Secondly, Masson’s trichrome staining and hematoxylin and eosin showed that BT substantially improved the structure of the damaged lung and significantly inhibited the proliferation of collagen fibers and the deposition of extracellular matrix. Finally, serum metabolomic analysis suggested that BT may exert anti-fibrotic effects by synergistically regulating tyrosine metabolism; phenylalanine, tyrosine and tryptophan biosynthesis; and synthesis and degradation of ketone bodies.ConclusionsOur study not only clarifies the potential anti-fibrotic mechanism of BT against IPF at the metabolic level but also provides a theoretical basis for developing BT as an effective anti-fibrotic agent.
研究领域:
药理学
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代谢组学
·
呼吸病学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
CHEMICAL RESEARCH IN CHINESE UNIVERSITIES
·
2019
·Vol. 35
·期 3
·403-409
·
IF 1.071
Zhou Jie,Wu Shaojie,Zhang Wenhui,Liu Qing,Yang Bin,Ren Yinghui,Ma Haixia,Zhao Fengqi,Hu Rongzu
Three energetic ion salts of 3,6-bis[(1 H -1,2,3,4-tetrazol-5-yl)-amino]-1,2,4,5-tetrazine(BTATz), namely, methylamine salt(compound 1 ), ethylenediamine salt(compound 2 ), and diethylamine salt(compound 3 ), were synthesized and characterized by elemental analysis, Fourier transform infrared spectrometry, 1 H NMR spectroscopy, and 13 C NMR spectroscopy. The crystal structure of compound 1 was determined by single-crystal X-ray crystallography, and structural analysis revealed that it belonged to the monoclinic system with P 2 1 /c space group. In addition, the thermal behavior of the three compounds was studied by differential scanning calorimetry and thermogravimetry techniques. The thermal decomposition peak temperatures of the compounds were 574.89, 545.60, and 606.72 K, indicating that the three ion salts exhibited good thermal stability. The kinetic mechanism equations of the main decomposition process and the entropy of activation(Δ S ≠ ), enthalpy of activation(Δ H ≠ ), and Gibbs free energy of activation(Δ G ≠ ) of the three compounds were also obtained. Moreover, the thermal safety of the compounds was evaluated by the values of the self-accelerated decomposition temperature( T SADT ), thermal ignition temperature( T TIT ), and critical temperature of thermal explosion( T b ). The results showed that all the compounds demonstrated good thermal safety, and the thermal safety of compound 3 was better than that of the others.
研究领域:
化学
·
材料科学
·
物理化学
✓ 已验证
DOI
高影响因子
RARE METALS
·
2020
·Vol. 39
·期 12
·1473-1482
·
IF 2.161
Feng Shao-Ping,Huang Kun
Abstract Separation of palladium (Pd) and platinum (Pt) by solvent extraction is difficult because of their extremely similar physicochemical properties. Development of new extractants with a high extraction efficiency and excellent separation selectivity is the primary focus for enhancing the separation of Pd and Pt by solvent extraction. In this study, a new extractant, 2-((2-methoxyethyl)thio)-1H-benzimidazole (MOBI), which contains N, S, and O atoms, was synthesized and used to separate Pd(II) and Pt(IV) from a hydrochloric acid aqueous solution. The experimental results revealed that Pd(II) and Pt(IV) were effectively separated under the optimal conditions: MOBI concentration of 0.005 mol·L −1 , HCl concentration of 0.2 mol·L −1 , organic/aqueous (O/A) phase ratio of 1.0, and contact time of 15 min. The separation coefficient between Pd(II) and Pt(IV) was 1246.40, which indicates that MOBI has a higher selectivity for Pd(II) than Pt(IV). In addition, the mechanism of coordination between Pd(II) and MOBI was demonstrated through the slope method, Fourier transform infrared spectroscopy (FTIR), hydrogen-1 nuclear magnetic resonance spectroscopy ( 1 H NMR), and carbon-13 nuclear magnetic resonance spectroscopy ( 13 C NMR). The results revealed that MOBI could coordinate with Pd(II) via the N atom in the benzimidazole ring of MOBI molecules to form [Pd(MOBI) 2 Cl 2 ] (O) . Graphic abstract
研究领域:
化学
·
材料科学
✓ 已验证
DOI
高影响因子
Nanoscale Research Letters
·
2019
·Vol. 14
·期 1
·1-15
·
IF 3.159
Protsak Iryna S.,Morozov Yevhenii M.,Dong Wen,Le Zichun,Zhang Dong,Henderson Ian M.
Abstract Three poly(organosiloxanes) (hydromethyl-, dimethyl-, and epoxymethylsiloxane) of different chain lengths and pendant groups and their mixtures of dimethyl (DMC) or diethyl carbonates (DEC) were applied in the modification of fumed silica nanoparticles (FSNs). The resulting modified silicas were studied in depth using 29 Si, 1 H, and 13 C solid-state NMR spectroscopy, elemental analysis, and nitrogen adsorption-desorption (BET) analysis. The obtained results reveal that the type of grafting, grafting density, and structure of the grafted species at the silica surface depend strongly on the length of organosiloxane polymer and on the nature of the “green” additive, DMC or DEC. The spectral changes observed by solid-state NMR spectroscopy suggest that the major products of the reaction of various organosiloxanes and their DMC or DEC mixtures with the surface are D (RR’Si(O 0.5 ) 2 ) and T (RSi(O 0.5 ) 3 ) organosiloxane units. It was found that shorter methylhydro (PMHS) and dimethylsiloxane (PDMS) and their mixtures with DMC or DEC form a denser coverage at the silica surface since S BET diminution is larger and grafting density is higher than the longest epoxymethylsiloxane (CPDMS) used for FSNs modification. Additionally, for FSNs modified with short organosiloxane PMHS/DEC and also medium organosiloxane PDMS/DMC, the dense coverage formation is accompanied by a greater reduction of isolated silanols, as shown by solid-state 29 Si NMR spectroscopy, in contrast to reactions with neat organosiloxanes. The surface coverage at FSNs with the longest siloxane (CPDMS) greatly improves with the addition of DMC or DEC. The data on grafting density suggest that molecules in the attached layers of FSNs modified with short PMHS and its mixture of DMC or DEC and medium PDMS and its mixture of DMC form a “vertical” orientation of the grafted methylhydrosiloxane and dimethylsiloxane chains, in contrast to the reaction with PDMS/DEC and epoxide methylsiloxane in the presence of DMC or DEC, which indicates a “horizontal” chain orientation of the grafted methyl and epoxysiloxane molecules. This study highlights the major role of solid-state NMR spectroscopy for comprehensive characterization of solid surfaces. Graphical abstract
研究领域:
材料科学
·
分析化学
✓ 已验证
DOI
PubMed
高影响因子
Revista Brasileira de Farmacognosia-Brazilian Journal of Pharmacognosy
·
2022
·Vol. 32
·期 5
·812-818
·
IF 2.464
Zhou Meichen,Yin Shining,Yu Mingming,Wu Aiying,Wang Cong,Lu Jingguang
“Fufang huangliansu” prescription, as a Chinese patent herbal medicine, is widely applied in clinical practice, and its main physiologically active components are berberine hydrochloride and total glucosides of paeony. In this study, a rapid, simple, and accurate quantitative 1 H NMR method was developed and validated to determine the two main components of “fufang huangliansu” prescription, berberine hydrochloride and total glucosides of paeony. Dimethyl terephthalate was selected as an internal standard, and the signals for berberine hydrochloride at δ 8.94 ppm (H-13) and total glucosides of paeony at δ 7.55 ppm (H-3″, 5″) were selected for the construction of calibration curves. Method validation was performed in terms of specificity, precision, accuracy, repeatability, stability, and linearity. The results indicated that the assay was precise and in line with the China Food and Drug Administration guidance. The assay has been successfully applied to determine the content of berberine hydrochloride and total glucosides of paeony in “fufang huangliansu” obtained from two pharmaceutical companies. This finding indicates that this 1 H NMR method has the potential as a reliable method for quality control of Chinese patent medicines containing berberine. Graphical abstract
研究领域:
药学
·
分析化学
·
中医药
✓ 已验证
DOI
高影响因子
ELECTROCHIMICA ACTA
·
2026
·
IF 5.8
Yinghang Kou,Zilong Liu,Zhenyu Wang,You Fu,Mingjie Jia,Yaxin Li,Yinggang Jia,Hong-bin Sun
A 5-Ph-Tet protective layer is engineered on Zn for dendrite-free aqueous zinc-ion batteries. • Strong Zn-tetrazole coordination lowers the desolvation barrier and guides preferential Zn (002) deposition. • The layer suppresses byproduct formation by modulating the interfacial chemical environment. • It enables 3400 h of cycling in a symmetric cell and 5000 cycles in a Zn@5-Ph-Tet||NVO full cell. Constructing an artificial interfacial protective coating on the zinc surface represents a facile yet effective strategy to suppress dendrite growth and parasitic reactions in aqueous zinc-ion batteries. In this work, a protective coating containing 5-phenyl-1H-tetrazole (5-Ph-Tet) was applied onto the zinc anode surface. Owing to its electrochemical properties and a pKa of approximately 4.3, 5-Ph-Tet can buffer local pH variations at the zinc anode interface during the inevitable hydrogen evolution reaction (HER). Furthermore, the abundant zincophilic nitrogen atoms on 5-Ph-Tet coordinate with Zn 2+ , thereby facilitating uniform Zn deposition. Electrochemical evaluations validated the effectiveness of the 5-Ph-Tet protective layer: the symmetric cell exhibited a cycling life of 3400 h under the testing conditions of 1 mA cm −2 and 1 mAh cm −2 (versus only 105 h for Bare Zn), while the Zn||NVO full cell demonstrated excellent cycling stability at 1 A g −1 , remaining free from short-circuiting even after 5000 cycles. This work offers a new strategy for future investigations into anode protection in aqueous zinc-ion batteries.
✓ 已验证
DOI
高影响因子
ELECTROCHIMICA ACTA
·
2014
·
IF 4.086
Shuaiyuan Han,Baohua Yue,Liuming Yan
The poly(vinylphosphonic acid) (PVPA), poly(4-(α-methyl)vinyl-1 H -1,2,3-triazole) (PMVTri), and poly(VPA- co -MVTri) were synthesized, and proton exchange membranes were prepared based on the acid-base polymeric composite of PVPA and PMVTri, and acid-base amphoteric copolymer of poly(VPA- co -MVTri). The overall performances of PVPA, proton conductivity, thermal and oxidative stability, and water resistance, are greatly improved by compositing of PMVTri or copolymerization with 4-(α-methyl)vinyl-1 H -1,2,3-triazole (MVTri). About four or eight folds improvement in maximum proton conductivity was observed in the polymeric composite of PVPA/PMVTri or acid-base amphoteric copolymer poly(VPA- co -MVTri) because of the redistribution of ions in the heterostructures of PVPA and PMVTri, respectively, compared with the pristine PVPA. At the same time, the oxidative stability and the water resistance of PVPA were also greatly improved attributing to the absent of α-H in the main chain of PMVTri and the acid-base interaction between the phosphonic acid groups and the triazolyl groups, respectively.
研究领域:
材料科学
·
高分子化学
·
电化学
·
膜技术
✓ 已验证
DOI
高影响因子
GREEN CHEMISTRY
·
2015
·Vol. 18
·期 6
·1738-1750
·
IF 8.02
Jiliang Ma,Linxin Zhong,Xinwen Peng,Runcang Sun
A simple and effective synthesis of 3,4-dihydropyrimidin-2(1H)-ones/thiones and their derivatives from aldehydes, β-dicarbonyl compounds and urea or thiourea using D-xylonic acid both as a green solvent and an effective catalyst is described. Taking the environment and economy into account, the work presented here has the merits of environmental friendliness, easy operation, simple work-up, excellent yields and the avoidance of organic solvents and inexpensive catalysts. In addition, the good properties of D-xylonic acid have also been validated by the synthesis of 5-phenyl-1(4-methoxyphenyl)-3[(4-methoxyphenyl)-amino]-1H-pyrrol-2(5H)-one and 12-phenyl-9,9-dimethyl-8,9,10,12-tetrahydrobenzo[a]xanthen-11-one. The synthesized compounds were characterized by FT-IR, 1H NMR, 13C NMR and melting point.
研究领域:
有机化学
·
绿色化学
·
催化
·
合成
✓ 已验证
产品关联
DOI
高影响因子
CATALYSIS TODAY
·
2021
·
IF 6.766
Jiyuan Fan,Saumitra Saxena,Chengkun Xiao,Jinlin Mei,Gang Wang,Aiping Chen,Wen Zhang,Haidong Li,Aijun Duan,William L. Roberts
Oxidative desulfurization of model oil and heavy fuel oil (HFO) was investigated under mild conditions using H 2 O 2 as an oxidant and acetonitrile as an extractant. The influence factors in the oxidation and extraction processes were evaluated and optimized. The molecular characteristics of the raw feedstock and the desulfurized oils, and the corresponding extraction phases were systematically analyzed by APPI FT-ICR MS, 1 H NMR, etc. The results showed that the desulfurization rate of dibenzothiophene reached 97.7% after 10 min reaction, while the sulfur removal efficiency of HFO was 30.7% under optimized conditions. The structures of sulfur compounds were described in heteroatom type, carbon number distribution vs unsaturation degree. The detected main sulfur-containing compounds are S 1 , S 2 , S 3 , NS, OS, O 2 S, O 2 S 2 , and O 4 S 2 . Based on the APPI FT-ICR MS results, it can be found that almost all the S 1 species have been transformed into sulfone after the oxidation process. Furthermore, the sulfone of O 2 S 1 and O 4 S 2 species in extraction phases were in double bond equivalent (DBE) range from 9 to 25 and carbon number with ≤ 40. 1 H NMR results showed that the α to aromatic CH 3 combined naphthenic CH-CH 2 group accounted for 73.2% in the extraction phase.
研究领域:
化学工程
·
分析化学
·
环境科学
✓ 已验证
DOI
高影响因子
JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY
·
2026
·
IF 5.3
Zhu Guo,Yujing Zhang,Ping Zou,Caiyun Sun,Liya Cui,Gang Wang,Chao Wang
A novel class of 6-aryl-1-(3,4,5-trimethoxyphenyl)-1H-pyrazolo[3,4-b]pyrazine derivatives was designed and synthesized as tubulin polymerization disruptors. Among them, compound 10t emerged as the most potent agent, exhibiting IC₅。 values of 0.13-0.18 µM against HeLa, SGC‑7901, and MCF‑7 cancer cell lines. Functional studies revealed that 10t effectively inhibits tubulin assembly in vitro, destabilizes cellular microtubule networks, induces G₂/M cell‑cycle arrest, and triggers apoptosis. Molecular docking indicated that 10t binds to the colchicine site on tubulin, forming a unique hydrogen bond with β‑Asn349 that is not observed with the reference compound CA‑4. Importantly, 10t showed significantly lower cytotoxicity toward normal HUVECs than CA‑4, suggesting an improved safety profile. Collectively, these findings establish the pyrazolo[3,4‑b]pyrazine scaffold as a promising platform for microtubule‑targeting anticancer agents and identify 10t as a compelling lead for further development.
✓ 已验证
DOI
高影响因子
ACS Nano
·
2024
·
IF 15.8
Jingtang Wang,Ting Ou,Lu Gao,Lei Zeng,Heyuan Sun,Yong Hu,Xiaopeng Pei,Ying Tan
Lithium metal batteries (LMBs) employing high-voltage nickel-rich cathodes represent a promising strategy to enable higher energy density storage systems. However, instability at the electrolyte–electrode interfaces (EEIs) currently impedes the translation of these advanced systems into practical applications. Herein, 1,3-dimethyl-1H-imidazol-2(3H)-one (DMIO), integrating structural features of vinylene carbonate (VC) while substituting oxygen with electron-donating nitrogen, has been synthesized and validated as a multifunctional electrolyte additive for high-voltage LMBs. Theoretical calculations and experimental results demonstrate that the potent electron-donating nitrogen in DMIO enables preferential DMIO oxidation at the cathode while preserving its carbon–carbon double bond for a concomitant reduction on the anode. Thereby, robust DMIO-derived EEIs are generated, reinforcing cycling in the full cells. Additionally, DMIO leverages Lewis acid-based interactions to coordinate and sequester protons from acidic LiPF6 decomposition byproducts, concurrently retarding LiPF6 hydrolysis while attenuating parasitic consumption of EEIs by acidic species. Consequently, incorporating DMIO into conventional carbonate electrolytes enables an improved capacity retention of Li||NCM622 cells to 81% versus 26% in the baseline electrolyte after 600 cycles. Similarly, DMIO improves Li anode cycling performance, displaying extended life spans over 200 h in Li||Li symmetric cells and enhancing Coulombic efficiency from 76% to 88% in Li||Cu cells. The synergistic effects of DMIO on both the cathode and anode lead to substantially improved cell lifetime. This rationally designed, multifunctional electrolyte additive paradigm provides vital insights that can be translatable to further electrolyte molecular engineering strategies.
研究领域:
材料科学
·
电化学
✓ 已验证
DOI
PubMed
高影响因子
危险品化学品经营许可证（带存储）