CLAYS AND CLAY MINERALS
·
2024
·Vol. 66
·期 5
·415-425
·
IF 2
Honghai Wu,Zhenhao Song,Meixiang Lv,Dan Zhao,Guangping He
Many types of oxidative pollutants are dangerous chemicals and may pose a health risk, but an inexpensive and effective method for mitigating those risks would offer significant advantages. The objective of this study was, therefore, to investigate the potential for Fe-pillared montmorillonite to fill that gap. Surface mediated reduction reactions by ferrous species often play an important role in governing the transport, transformation, and fate of hazardous oxidative contaminants. Compared to the untreated montmorillonite (Mnt), the synthetic polyhydroxyl-Fe pillared montmorillonite (Fe-Mnt) was found to be somewhat similar to goethite in promoting the ability of specifically adsorbed Fe(II) to reductively transform 2-nitrophenol (2-NP). The 2-NP was efficiently removed within 30 min from solutions at the optimum neutral pH in a mixed reduction system of Fe(II)/Fe-Mnt under an anoxic atmosphere. This demonstrated that the specifically adsorbed Fe(II) of Fe-Mnt can enhance 2-NP reduction. The highly enhanced 2-NP reduction by Fe(II) through Fe-Mnt surface catalysis can, therefore, be ascribed to clearly increased amounts of an adsorbed Fe(II) species surface complex, which gave rise to enhanced Fe(II) reductive activity that enabled the rapid reduction of 2-NP. The reduction processes produced a faster transformation of 2-NP in a Fe-Mnt suspension than in a Mnt suspension. The transformation kinetics were described using pseudo-first-order rate equations. Moreover, in addition to the effects of mineral surface properties, the interactions were affected by the aqueous chemistry, and the removal rates of 2-NP were increased at pHs of 6.0–7.3. In the present study, the structure and surface reactivity of Fe-Mnt was characterized in depth. The polyhydroxyl-Fe added to Mnt and the pH were determined to be the two key controlling factors to mediate the reductive transformation of 2-NP in the presence of Fe-Mnt in comparison to goethite and Mnt. Finally, the catalysis mechanism responsible for the enhanced 2-NP reduction by Fe(II) was elucidated using cyclic voltammetry.
研究领域:
环境化学
·
催化科学
·
污染治理
·
材料化学
·
表面反应动力学
✓ 已验证
DOI
高影响因子
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
·
2020
·
IF 4.872
Ruifen Kang,Aneela Perveen,Chunmei Li
T-2 toxin is a kind of group A trichothecenes mycotoxins , frequently detected in various foods and feeds, having high toxic effects on both humans and animals. The present study aims to investigate the toxic effects of T-2 toxin exposure to ICR mice during pregnancy and lactation on liver glycolipid metabolism of young mice. The pregnant mice were given 0, 0.005 and 0.05 mg of T-2 toxin/kg bw daily through oral gavage from late gestation (GD 14) to the lactation (LD 21). Liver and serum samples of the young mice were collected on postnatal day 21 (PND 21), PND 28 and PND 56. The results showed that T-2 toxin increased the contents of triglycerides (TG), total cholesterol (T-CHO) and glucose in serum of young mice on PND 21 and PND 28. In addition, obvious lipid droplets of liver in T-2 toxin treatment groups were observed, especially in 0.05 mg group of PND 21and PND 28. Compared with the control group, T-2 treatment also increased the expressions of genes associated with liver glycolipid metabolism, such as PEPCK , Glut2 , Fas , Acox1 , Hmgcr , PPARα , Srebp1 and CD36 . These results demonstrated T-2 toxin exposure to pregnant mice could cause liver glycolipid metabolism disruption in the young mice and the toxic effects weakened on PND 56.
研究领域:
毒理学
·
营养学
✓ 已验证
DOI
PubMed
高影响因子
Food Bioscience
·
2020
·
IF 3.067
Liang Gao,Xinyi Cheng,Xuwei Yu,Xiaosan Wang,Qingzhe Jin,Xingguo Wang
1-Oleoyl-2-palmitoyl-3-linoleoylglycerol (OPL) is a critical structured lipid in human milk fat and it plays an important role in infants' health. The development of an efficient method for such compound preparation is necessary. In this study, one- and two-step methods for OPL production by enzymatic acidolysis of fractionated palm stearin with mixed acids were compared in solvent-free and solvent systems. The results demonstrated that in the solvent system, the OPL contents by the one- and two-step methods were 45.8% and 56.7%, respectively. In the solvent-free system, the one- and two-step methods resulted in the formation of 43.7% and 54.8% OPL, respectively. Subsequently, acidolysis conditions of the two-step method were optimized. Under the optimum conditions, the content of OPL was 57.7%, and 83.2% of palmitic acid was at the sn-2 position . The prepared OPL has potential to be applied in infant formulas.
研究领域:
食品科学
·
生物化学
✓ 已验证
DOI
高影响因子
DALTON TRANSACTIONS
·
2015
·Vol. 44
·期 41
·18012-18018
·
IF 4.197
Yongfeng Liu,Yaxiong Yang,Xin Zhang,You Li,Mingxia Gao,Hongge Pan
The thermal dehydrogenation process of the KOH-containing Mg(NH2)2–2LiH system was systematically investigated by identifying changes in the structure and composition of its components by XRD and FTIR. During ball milling, the added KOH reacts with Mg(NH2)2 and LiH to produce MgO, KH and Li2K(NH2)3. During the initial heating process (<120 °C), the newly formed KH and Li2K(NH2)3 react with Mg(NH2)2 and LiH to yield MgNH, LiNH2 and Li3K(NH2)4 along with hydrogen release. Raising the temperature to 185 °C results in a reaction between Mg(NH2)2, MgNH and LiH that gives Li2Mg2N3H3 as the product and further releases hydrogen. As the temperature is increased to 220 °C, Li2Mg2N3H3 reacts with LiNH2 and LiH to produce Li2MgN2H2 and H2. Meanwhile, two parallel reactions between Li2Mg2N3H3, Li3K(NH2)4 and LiH also generate additional hydrogen. Specifically, the KH and Li2K(NH2)3, formed in situ during ball milling, serve as reactants in the dehydrogenation reaction of the Mg(NH2)2–2LiH system, which is responsible for the significantly improved thermodynamics and kinetics of hydrogen storage.
研究领域:
材料科学
·
化学工程
✓ 已验证
DOI
高影响因子
COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
·
2018
·
IF 2.829
Jingqin Qin,Guangyi Liu,Hongli Fan,Wen Tan
In this paper, the flotation separation of hemimorphite from quartz was investigated by using di(2-ethylhexyl) phosphoric acid (DEHPA) as a collector. The results elucidated that DEHPA exhibited better flotation performances to hemimorphite than dibutyl phosphoric acid (DBP), tributyl phosphate (TBP), octanoic acid (OA) and palmitic acid (PA). And DEHPA also possessed good selectivity against quartz flotation and could realize the effective flotation separation of hemimorphite from quartz under pH 6.0–10.0. The adsorption and contact angle findings clearly indicated that DEHPA selectively adsorbed on hemimorphite, hardly on quartz. After DEHPA treatment, the hydrophobicity of hemimorphite was dramatically improved. Zeta potential suggested that DEHPA anion anchored on hemimorphite surfaces mainly through chemical bonds. FTIR inferred that DEHPA chemisorbed on to hemimorphite surfaces by formation of the Zn O bonds between the O atoms of the P( O)(OH) group and the surface zinc atoms, simultaneously with splitting the O H bonds of the P O H group. XPS gave clear evidences that the adsorbed DEHPA combined with Zn(II) species on hemimorphite surfaces to generate the Zn(II)-DEHPA surface complexes.
研究领域:
矿物加工工程
·
表面化学
✓ 已验证
DOI
高影响因子
JOURNAL OF MATERIALS RESEARCH
·
2014
·Vol. 29
·期 24
·2934-2941
·
IF 1.815
Hongxu Guo,Di Guo,Zishan Zheng,Weng Wen,Jianhua Chen
Zn3(VO4)2 nanorods with visible light-driven photocatalytic activity were prepared by hydrothermal reaction and characterized by x-ray diffraction, Fourier transform infrared, scanning electron microscopy, x-ray photoelectron spectroscopy, UV–vis diffuse reflectance spectra, and Brunauer–Emmett–Teller surface area and pore size analyzer. The Zn3(VO4)2 nanorods consisted of rods with a thickness of approximately 30 nm, length in the range 400–600 nm, and width in the range 150–250 nm. The photocatalytic degradation activities for methylene blue (MB) and 4-nitrophenol (4-NP) over the Zn3(VO4)2 nanorods were studied in detail. The photocatalytic activity of the as-prepared photocatalyst for MB and 4-NP in visible light under the same conditions was about 3.5 times and 2.5 times higher than that of N–TiO2, respectively. The main active species in the photodegradation come from •OH, and the photogenerated electrons also partly involved in the photocatalytic degradation process, in which the •OH radicals formed were in proportional to the light illumination time obeying zero-order reaction rate kinetics.
研究领域:
材料科学
·
环境科学
✓ 已验证
产品关联
DOI
高影响因子
JOURNAL OF HETEROCYCLIC CHEMISTRY
·
2024
·
IF 2
Guofang Jiang,Can Zhang,Xiaohong Xing,Jinbo Ouyang,Hong Yang,Zongbo Xie,Zhanggao Le
A novel and highly efficient method for the synthesis of 1-(4-hydroxybutyl)-2-benzoyl indoles from 2-pyrrolidine benzaldehyde and α -bromoacetophenone in a choline chloride (ChCl)/ZnCl 2 eutectic mixture was developed. This method, which does not require any catalyst, additive, or alkali, is useful for realizing tandem cyclization reactions. Several indoles were produced after cyclization and ring opening processes. Not all the compounds obtained are reported in the literature. This synthetic strategy proves that deep eutectic solvents can replace catalysts and organic solvents. Consequently, this is an environmentally friendly strategy that has significant potential in the development of green and sustainable chemistry.
研究领域:
有机化学
·
绿色化学
✓ 已验证
DOI
高影响因子
ACTA PHARMACOLOGICA SINICA
·
2024
·
IF 6.9
Xia Rui-xue,Zou Pei-chen,Xie Jun-ting,Tang Ya-bin,Gong Miao-miao,Fan Fu,Aihemaiti Ayinazhaer,Liu Yu-qing,Shen Ying,Zhou Bin-bing S.,Zhu Liang,Lei Hui-min
RAS is the most frequently mutated oncoprotein for cancer driving. Understanding of RAS biology and discovery of druggable lynchpins in RAS pathway is a prerequisite for targeted therapy of RAS-mutant cancers. The recent identification of KRAS G12C inhibitor breaks the “undruggable” curse on RAS and has changed the therapy paradigm of KRAS-mutant cancers. However, KRAS mutations, let alone KRAS G12C mutation, account for only part of RAS-mutated cancers. Targeted therapies for cancers harboring other RAS mutations remain the urgent need. In this study we explored the pivotal regulatory molecules that allow for broad inhibition of RAS mutants. By comparing the expression levels of nucleotide pyrophosphatase (NPPS) in a panel of cell lines and the functional consequence of increased NPPS expression in RAS-mutant cells, we demonstrated that cancer cells with various kinds of RAS mutations depended on NPPS for growth and survival, and that this dependence conferred a vulnerability of RAS-mutant cancer to treatment of NPPS inhibition. RAS-mutant cells, compared with RAS-wildtype cells, bored and required an upregulation of NPPS. Transcriptomics and metabolomics analyses revealed a NPPS-dependent hyperglycolysis in RAS-mutant cells. We demonstrated that NPPS promoted glucose-derived glycolytic intermediates in RAS-mutant cells by enhancing its interaction with hexokinase 1 (HK1), the enzyme catalyzing the first committed step of glycolysis. Pharmacological inhibition of NPPS-HK1 axis using NPPS inhibitor Enpp-1-IN-1 or HK1 inhibitor 2-deoxyglucose (2-DG), or genetic interfere with NPPS suppressed RAS-mutant cancers in vitro and in vivo. In conclusion, this study reveals an unrecognized mechanism and druggable lynchpin for modulation of pan-mutant-RAS pathway, proposing a new potential therapeutic approach for treating RAS-mutant cancers.
研究领域:
肿瘤学
·
分子生物学
·
癌症治疗
✓ 已验证
DOI
高影响因子
BIOORGANIC CHEMISTRY
·
2021
·
IF 5.275
Le-Yun Sun,Cheng Chen,Jianpeng Su,Jia-Qi Li,Zhihui Jiang,Han Gao,Jia-Zhu Chigan,Huan-Huan Ding,Le Zhai,Ke-Wu Yang
The emerging COVID-19 pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has raised a global catastrophe. To date, there is no specific antiviral drug available to combat this virus, except the vaccine. In this study, the main protease (M pro ) required for SARS-CoV-2 viral replication was expressed and purified. Thirty-six compounds were tested as inhibitors of SARS-CoV-2 M pro by fluorescence resonance energy transfer (FRET) technique. The half-maximal inhibitory concentration (IC 50 ) values of Ebselen and Ebsulfur analogs were obtained to be in the range of 0.074–0.91 μM. Notably, the molecules containing furane substituent displayed higher inhibition against M pro , followed by Ebselen 1i (IC 50 = 0.074 μM) and Ebsulfur 2k (IC 50 = 0.11 μM). The action mechanism of 1i and 2k were characterized by enzyme kinetics, pre-incubation and jump dilution assays, as well as fluorescent labeling experiments, which suggested that both compounds covalently and irreversibly bind to M pro , while molecular docking suggested that 2k formed an S S bond with the Cys145 at the enzymatic active site. This study provides two very potent scaffolds Ebsulfur and Ebselen for the development of covalent inhibitors of M pro to combat COVID-19.
研究领域:
生物化学
·
药理学
·
病毒学
✓ 已验证
DOI
PubMed
高影响因子
JOURNAL OF MOLECULAR LIQUIDS
·
2024
·
IF 5.3
Wen-bo Zhao,Wen-shuo Zhang,Jun Shen,Yu-gao Wang,Yan-xia Niu
The high-temperature coal tar wash oil contains two valuable components, namely, quinoline and 2-methylnaphthalene. These two components are challenging to separate during the deep processing. To address this issue, the COSMO-RS (Conductor-like Screening Mode for Real Solvent) model was utilized to identify them as a potential deep eutectic solvents (DESs) extractant. Based on the calculated infinite dilution activity coefficient, the performance indexes of DESs , including selectivity, solubility, and performance index were determined and utilized to identify high-performance extractants for the quinoline/2-methylnaphthalene system. Finally five DESs were selected based on these indexes, they are DES1 formed by Choline chloride: propionic acid with the molar ratio of 1:1, similarly, DES2 is Choline chloride:oxalic acid of 1:1, DES3 Tetraethylammonium chloride:propionic acid of 1:1, DES4 Tetraethylammonium bromide:itaconic acid of 1:2 and DES5 Tetraethylammonium bromide:propionic acid of 1:2. The liquid–liquid phase equilibrium experiments of the aforementioned five DESs at different temperatures (30 ℃, 40 ℃, and 50 ℃) under atmospheric pressure were conducted. The results showed that five kinds of DESs had good extraction effect on quinoline. The DESs formed by choline chloride and anhydrous oxalic acid had the best extraction effect. The quantum chemical single-molecule optimization of different HBDs and HBAs in DESs, intermolecular interaction energy analysis and independent gradient modeling shows that it is mainly induced by the formation of shared electron pairs by providing empty orbitals from DESs and lone pair of electrons from the quinoline molecule, and the main force is the weak hydrogen bonding force.
研究领域:
化学工程
·
材料科学
✓ 已验证
产品关联
DOI
高影响因子
MATERIALS SCIENCE IN SEMICONDUCTOR PROCESSING
·
2024
·
IF 4.2
Yi Chen,Zhu Ma,Tangjie Yu,Zhuowei Du,Wei You,Junbo Yang,Shanyue Hou,Yanlin Li,Qianyu Liu,Wenwen Li,Qian Zhang,Hao Du,Yixian Li,Fuchun Gou,Qiang Yang,Guoming Li,Yuelong Huang,Kuan Sun,Yaohua Mai,Wei Long
Interface defect is one of the main factors that lead to non-radiative recombination of carriers at the interface and the decomposition of perovskites . This ultimately results in low efficiency and poor stability of perovskite solar cells (PSCs). Here, a passivated molecule called 2-Aminopyridine (2-APy) was proposed to reduce the defects of the interface between the perovskite and the hole transport layer. The results showed that the amino group in 2-aminopyridine can interact with the vacancy and free iodide ions on the surface of perovskite, thus passivating the defects at the interface and enhancing the hole transport capacity. As a result, 2-APy-modified PSCs exhibited inhibited non-radiative recombination, and the efficiency of PSCs increased to 21.46 %. The increase in the efficiency of PSCs is primarily seen in the rise of the open circuit voltage (V OC , from 1.12 to 1.15 V) and short circuit current (J SC , from 22.86 to 23.77 mA/cm 2 ). This work demonstrates that pyridine is an effective group for passivating the defects between the perovskite layer and the hole transport layer.
研究领域:
材料科学
·
能源科学
·
化学工程
✓ 已验证
产品关联
DOI
高影响因子
Materials Today Communications
·
2024
·
IF 3.7
Doudou Ma,Chuanhui Zhang,Yilong Wei,Li Ma,Xiaoliang Zhao,Weijie Zhang
Type 2 diabetes (T2D) is a chronic metabolic disorder characterised by hyperglycaemia, insulin resistance, and relative insulin deficiency. Insulin resistance results in patients requiring increased insulin injections and its limited bioavailability. The present subject matter aims to use Pueraria lobata polysaccharides, which can alleviate insulin resistance and have hypoglycaemic potency, as a medicinal excipient to prepare a hydrogel with excellent slow-release properties, which can be used to load insulin for injection or as a diabetic wound dressing material. Pueraria lobata polysaccharides (PLR) were extracted by hydroalcohol precipitation, and oxidised Pueraria lobata polysaccharides (O-PLR) were successfully prepared by sodium periodate oxidation and verified by structural characterisation. Subsequently, double crosslinked hydrogels were prepared using oxidised Pueraria lobata polysaccharides, chitosan and cellulose acetoacetate, and several of their properties were investigated in detail. The experimental results showed that the O-PLR double-crosslinked hydrogels possessed good rheological properties and injectability, as well as excellent self-healing and antimicrobial activities; moreover, the O-PLR hydrogels exhibited significant hypoglycemic activity, which is expected to be an important material for the treatment of Type 2 diabetes mellitus. Overall, this study provides a reliable theoretical and experimental basis for the development of hydrogels with hypoglycaemic, pro-healing and antibacterial functions.
研究领域:
药学
·
生物材料学
·
糖尿病研究
✓ 已验证
产品关联
DOI
高影响因子
危险品化学品经营许可证（带存储）