IMMUNITY
·
2024
·
IF 25.5
Rui Ding,Xiaoyan Yu,Zhilin Hu,Yu Dong,Haiyan Huang,Yuerong Zhang,Qiaoqiao Han,Zhi-Yu Ni,Ren Zhao,Youqiong Ye,Qiang Zou
RNA splicing is involved in cancer initiation and progression, but how it influences host antitumor immunity in the metabolically abnormal tumor microenvironment (TME) remains unclear. Here, we demonstrate that lactate modulates Foxp3-dependent RNA splicing to maintain the phenotypic and functional status of tumor-infiltrating regulatory T (Treg) cells via CTLA-4. RNA splicing in Treg cells was correlated with the Treg cell signatures in the TME. Ubiquitin-specific peptidase 39 (USP39), a component of the RNA splicing machinery, maintained RNA-splicing-mediated CTLA-4 expression to control Treg cell function. Mechanistically, lactate promoted USP39-mediated RNA splicing to facilitate CTLA-4 expression in a Foxp3-dependent manner. Moreover, the efficiency of CTLA-4 RNA splicing was increased in tumor-infiltrating Treg cells from patients with colorectal cancer. These findings highlight the immunological relevance of RNA splicing in Treg cells and provide important insights into the environmental mechanism governing CTLA-4 expression in Treg cells.
研究领域:
免疫学
·
肿瘤学
·
分子生物学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Heliyon
·
2024
·
IF 3.4
Chenhan Lv,Haixiang Cheng,Rui Fan,Jingyu Sun,Xinghai Liu,Yinghui Ji
Organic fluorine compounds are acute carcinogenic and mutagenic to humans. Photoelectrocatalysis (PEC) treatment is an innovative technology in the field of the removal of fluorine compounds, and thus current research focused on improving stability and catalytic ability of photoanode. In this study, it has been synthesized a rGO/BiOI photocathode for the efficient degradation of 4-Fluoroaniline (4-FA). The physical characterization and photoelectrochemical properties of the photocathode was determined. The results indicate that the PEC treatment with the rGO/BiOI photocathode was more efficient compared with individual processes. During the optimization experiments, the PEC treatment achieved 99.58 % and 72.12 % of 4-FA degradation and defluorination within 1 h. Cyclic stability experiments show that rGO/BiOI photocathode was efficient and stable, which reached 96.91 % and 67.64 % of 4-FA degradation and defluorination after five cycles. Mechanism analysis indicates that the PEC process was based on an electrochemical reaction and photo-induced processes. The degradation product of 4-FA was mainly 2,4-di-t-butylphenol, and trapping experiments indicates that h + is the primary oxidizing species. Therefore, PEC treatment with rGO/BiOI photocathode is a competitive green approach to remove fluorine compounds pollutants and brings new insights into development of PEC treatment.
研究领域:
环境科学
·
材料科学
✓ 已验证
DOI
PubMed
高影响因子
APPLIED CATALYSIS A-GENERAL
·
2015
·
IF 3.942
Jun Chen,Shuanghong Tian,Jiang Lu,Ya Xiong
This study aims to provide a direction to tailor catalytic activity of catalyst by selectively exposing a crystal facet. Herein three sheet-like MgO materials with the primarily exposed crystal facet of (1 1 1), (1 1 0), (2 0 0) were prepared, respectively. Results show that the catalytic ozonation on each MgO substantially enhanced the removal of 4-chlorophenol and total organic carbon when compared with ozonation alone or that on traditional MgO. The pseudo first-order reaction constant of 4-chlorophenol removal in ozonation catalyzed by MgO(1 1 1), MgO(1 1 0), MgO(2 0 0) is 4.8, 2.5, 3.1 times higher than that in the single ozonation, respectively. When different dosage but the same surface area of MgO was applied, their catalytic activities changed as MgO(1 1 1) > MgO(1 1 0) > MgO(2 0 0). It indicates that the catalytic activity significantly depends on the crystal facet besides the surface area. That is because the drawbacks, such as edges, steps, and kinks, on each facet decreased in the order of (1 1 1) > (1 1 0) > (2 0 0). CO 2 -TPD and zeta potential measurement show that the drawbacks caused more and stronger surface basic groups in the form of hydroxyl and isolated oxygen due to the availability of more unsaturated coordination sites. These active basic centers make the easy formation of basic microenvironment near MgO particles and thus favor the ozonation. Finally, the catalytic mechanism was explored and compared by evaluating the ozone decomposition, qualitatively and quantitatively identifying hydroxyl radicals, and determining the ozone utilization efficiency. It reveals that MgO with more surface basic groups can enhance the transformation rate of ozone to hydroxyl radicals more efficiently. All these results show that MgO is a very potential ozonation catalyst and the catalytic activity can be tailored by exposing crystal facet with more drawbacks.
研究领域:
环境科学
·
材料科学
✓ 已验证
DOI
高影响因子
JOURNAL OF ORGANIC CHEMISTRY
·
2024
·
IF 3.3
Yan-Ling Liu,Xian-Chen He,Jie Gao,Ke-Rong Li,Kai Chen,Hao-Yue Xiang,Hua Yang
Herein, visible light-induced, nickel-catalyzed direct functionalization of the Hantzsch esters (HEs) with readily accessible alkyl bromides has been successfully achieved by taking advantage of HE as the reductant and substrate through an aromatization-dearomatization process. In this strategy, the single electron reduction of alkyl bromides by reactive Ni(I) species is essential for the success of this late-stage transformation. A wide range of 4-alkyl-1,4-dihydropyridines were rapidly assembled in moderate to good yields under mild conditions, rendering this photoinduced approach attractive for synthetic and medicinal chemistry.
研究领域:
有机化学
·
光化学
·
催化
·
合成方法学
·
药物化学
✓ 已验证
DOI
高影响因子
ENVIRONMENTAL POLLUTION
·
2019
·
IF 5.714
Zhao Yang,Xu Zhang,Siji Pu,Renxiang Ni,Ying Lin,Yong Liu
A novel heterogeneous Fenton-like system (Mg/Fe-O 2 ) which could directly convert oxygen (O 2 ) to hydrogen peroxide/hydroxyl radicals (H 2 O 2 / • OH) was developed and used to degrade 4-chlorophenol. The Mg/Fe bimetallic particles were prepared by chemical displacement process and characterized by XRD, SEM and TEM. The in situ continuous production of H 2 O 2 / • OH and the effect of the mole ratio of Mg to Fe in the Mg/Fe bimetallic particles and the operating parameters on the degradation 4-chlorophenol in Mg/Fe-O 2 system were investigated in detail. It was found that the Mg/Fe bimetallic particles with the mole ratio of Mg to Fe of 32:1 had the best performance for the 4-chlorophenol degradation and the maximum cumulative concentration of H 2 O 2 , the degradation efficiency of 4-chlorophenol and the removal efficiency of TOC in Mg/Fe-O 2 system were 34.5 mg/L, 100% and 91.8%, respectively, at pH 3, O 2 flow rate 400 mL/min, dosage of Mg/Fe bimetallic particles 2 g/L, 4-chlorophenol initial concentration 50 mg/L and reaction time 60 min. It was revealed by radical scavenging experiments that • OH, particularly the surface-bound • OH, were the predominant reactive oxygen species in Mg/Fe-O 2 system for the degradation of 4-chlorophenol. The main intermediates of 4-chlorophenol degradation were detected by high-resolution liquid chromatography equipped with time-of-flight mass spectrometry (HRLC–ToF-MS) and ion chromatography (IC). Based the results of control experiments and the electrochemical tests, the possible pathway and mechanism of 4-chlorophenol degradation in Mg/Fe-O 2 system were tentatively proposed.
研究领域:
环境科学
·
化学工程
✓ 已验证
DOI
PubMed
高影响因子
Journal of Water Process Engineering
·
2022
·
IF 7.34
Xiying Zhu,Lijia Liu,Yudan Wang,Fuqiu Ma,Yao Tian,Hongxing Dong,Chunhong Zhang
Seawater contains abundant uranium, which could provide a long–term supply for developing the nuclear power industry. Developing an efficient uranium–selective adsorbent is therefore an urgent requirement. In this work, we used a simple Friedel–Crafts alkylation reaction and a subsequent phosphorylation reaction to prepare porous phosphorylated hyper-crosslinked calix[4]arene (C4HP) for potential use in the recovery of uranium from seawater. The effect of the initial pH, adsorbent composition, sorbent dose and contact time on the sorption of uranyl ions was investigated. Because of the introduction of the phosphate groups , C4HP shows an excellent adsorption capacity of 336.4 mg·g −1 for uranium, which is much higher than that of hyper-crosslinked calix[4]arene (C4H) without phosphorylation. Meanwhile, C4HP functioned as a promising adsorbent for uranyl extraction with fast capture kinetics (the adsorption equilibrium can be reached in 150 min). After 6 cycles, C4HP maintained its original adsorption capacity of 76.2 % (255.4 mg·g −1 ). Furthermore, C4HP possesses excellent adsorption selectivity for uranium in artificial seawater, with a K d U of ~4.1 × 10 4 mL·g −1 , much higher than that of other metals. This makes it useful for broad applications and capturing uranium from natural seawater. The effective extraction of uranyl was primarily attributed to the chelation of uranyl ions with phosphate groups .
研究领域:
材料科学
·
环境科学
·
核能技术
✓ 已验证
产品关联
DOI
高影响因子
International Journal of Electrochemical Science
·
2023
·
IF 1.5
Chengyi Zhu,Jianxiong Liu,Xiaohua Yu,Yingjie Zhang,Xiaodong Jiang,Peng Dong,Yannan Zhang
4-Bromoanisole (4BA) is recommended for LiNi0.6Co0.2Mn0.2O2 (NCM 622) cathode materials as a safety electrolyte additive. The effect of anti-overcharge on NCM 622 cathodes are analyzed by cyclic voltammetry, constant current charge and discharge, AC impedance and scanning electron microscopy (SEM) measurement. The overcharge test results show that 4BA can be effectively electropolymerized at 4.45 V (vs. Li/Li + ), which can consume the overcharge current and protect the working electrode from voltage runaway. The time for the voltage rising to the overcharge state is availably delayed from about 16 hours to about 37 hours. The strategy can block off further oxidation of the active material and electrolyte, and finally promote the overcharge tolerance of the Li-ion batteries. Moreover, it is also found that the use of 4BA as a safety electrolyte additive does not obviously effect the electrochemical performance of NCM 622 and can effectively improve its cycle stability at high cut-off voltage (4.7 V).
研究领域:
材料科学
·
电化学
✓ 已验证
产品关联
DOI
高影响因子
Journal of Energetic Materials
·
2023
·
IF 2.1
Jin-Qiang Zhou,Yi-Ming Wang,Hua Fang,Peng Deng,Jian-Xin Nie,Xue-Yong Guo,Rui Liu
The design and preparation of new high-energy composite DAP-4/Al is very important for the study of composite solid propellants. In this work, the combustion properties and reaction mechanism of DAP-4/Al composites doped with WO3 nanoparticles were studied. DAP-4/Al composites were prepared by different mass ratios. The combustion state, combustion time, pressure, pressurization rate and flame temperature of DAP-4/Al/WO3 with different mass ratios were monitored. The results show that the combustion performance of DAP-4/Al can be significantly improved under the catalysis of WO3. Compared with DAP-4/Al-5, the average combustion time of DAP-4/Al/W-4 is significantly reduced by ~ 70 ms, the average combustion pressure is increased by 654 KPa, and the average pressurization rate is increased by 0.22 MPa·s−1. Under the catalysis of WO3, the activated substances can react rapidly with H2dabco2+ and NH+ to produce CO2, CO, N2 and H2O. When the mass ratio is 20:80:2, the average maximum combustion heat of DAP-4/Al/W-4 is 8474 J/g, which is higher than 493 J/g of DAP-4/Al-5. The reaction mechanism of WO3 catalyzed DAP-4/Al system was further analyzed by TG-MS and XPS. This work provides a new idea for the future application of DAP-4/Al composites in solid propellants.
研究领域:
材料科学
·
燃烧与推进
✓ 已验证
产品关联
DOI
高影响因子
OPTICAL MATERIALS
·
2024
·
IF 3.8
Jie Yang,Huimin Du,Yue Deng,Meifang Liu,Xingzuo Liu,Jun Yang,Shanshan Hu
Quantitative detection of permanganate ( MnO 4 ‐ ) and 4-nitrophenol (4-NP) is essential for environmental safety. Fluorescence detection technology is one of the most widely used detection technologies, which can be used for the detection of various anions and organic pollutants. In this paper, Ba 4 Lu 3 F 17 :Tb 3+ phosphors were successfully obtained by hydrothermal method. The morphology transition of Ba 4 Lu 3 F 17 crystal from nanoparticles through octahedron to hexagonal prism was realized in the pH range of 3–11. The best luminescent samples were obtained by changing the type of additives and the doping concentration of Tb 3+ ions. The obtained Ba 4 Lu 3 F 17 :Tb 3+ has high selectivity and anti-interference for MnO 4 ‐ and 4-NP detection, with the detection limits being 0.79 μM and 1.28 μM, respectively.
研究领域:
环境科学
·
材料科学
✓ 已验证
产品关联
DOI
高影响因子
APPLIED CATALYSIS B-ENVIRONMENTAL
·
2024
·
IF 20.2
Taotao Zhao,Yuchi Liu,Chenyang Shen,Gui Liu,Jun Yao,Xiaofeng Qian,Qiang He,Feifei Mei,Deming Meng,Xuefeng Guo,Luming Peng,Nianhua Xue,Yan Zhu,Yuming Zhou,Weiping Ding
Here, we report a high-performance catalyst MoS x @HSSZ-39 for conversion of CO x to C 2–4 hydrocarbons, in which MoS x clusters for CO x hydrogenation at the first to intermediate methanol and then the zeolitic acid sites surrounding for further conversion of methanol to hydrocarbons. For CO 2 hydrogenation, C 2–4 hydrocarbons of ∼90% selectivity in organic products at 32.7% of CO 2 conversion and excellent stability of 1000 h on stream are obtained. For CO hydrogenation, 95% of C 2–4 hydrocarbons, 83% of LPG or 74% of propane selectivities at > 22% CO conversion and stable more than 200 h on stream are obtained. The cooperation among the MoS x clusters and the zeolitic acid sites constitutes the catalyst of intimate bifunction, which is the key to the high catalytic performance for CO x hydrogenation.
研究领域:
催化化学
·
能源化学
✓ 已验证
产品关联
DOI
高影响因子
CELLULOSE
·
2021
·Vol. 28
·期 10
·6481-6498
·
IF 5.044
Lang Daning,Shi Ming,Xu Xia,He Shixue,Yang Chao,Wang Lu,Wu Ronglan,Wang Wei,Wang Jide
Abstract 4-Nitrophenol is a highly toxic environmental pollutant. It is a challenge to selectively remove it from a mixture of various pollutants. Herein, we report a study on the selective adsorption of 4-nitrophenol by using molecularly imprinted polymers (MIPs). The imprinted polymer was synthesized using cellulose as a framework, onto which, the complex of the imprinting molecule (i.e., 4-nitrophenol) and a candidate material [namely, 2-(dimethylamino)ethyl methacrylate. DMAEMA] was grafted. The obtained MIP showed an excellent adsorption capacity with good selectivity. Also, the adsorption of 4-nitrophenol by the obtained MIP was fast and the adsorbent exhibited good recyclability. The thermodynamics and kinetics of the adsorption process of 4-nitrophenol by MIP was thoroughly studied, where an otherwise-equivalent non-imprinted polymer was used as a control in the experiments. The selectivity of the MIP adsorbent for 4-niteophenol was evaluated by two types of experiments: (1) adsorption experiments in single-component adsorbate systems (containing 4-nitrophenol, 3-nitrophenol, catechol, or hydroquinone), and (2) competitive adsorption experiments in binary adsorbate systems (containing 4-nitrophenol plus either 3-nitrophenol, catechol or hydroquinone). The selectivity coefficient for 4-nitrophenols was twice of those of other phenols (that were all around 2), indicative of the extent of the affinity of MIPs to these phenolic compounds. The recyclability of the adsorbent was evaluated for 5 adsorption–desorption cycles, where the adsorption capacity of the last cycle remained over 90.2% of that of the first cycle. Graphic Abstract
研究领域:
环境科学
·
材料科学
✓ 已验证
产品关联
DOI
高影响因子
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
·
2020
·
IF 3.232
Na Li,Xing Hu,Junhui Pan,Ying Zhang,Deming Gong,Guowen Zhang
4–Octylphenol is an endocrine disruptor , belonging to environmental estrogens. It can be enriched in the human body through the food chain and may harm human health. Herein, we used a variety of spectroscopic techniques, molecular docking, and gel electrophoresis to study the interaction of 4–octylphenol and ctDNA . It was found that the mechanism of ctDNA quenching the endogenous fluorescence of 4–octylphenol was static quenching, and formed a complex. The negative enthalpy change (Δ H °), entropy change (Δ S °) and Gibbs free energy (Δ G °) have shown that 4–octylphenol and ctDNA spontaneously bind together under the action of hydrogen bonds and van der Waal's force . Viscosity, melting temperature and iodide quenching experiments showed that 4–octylphenol acted on the groove of ctDNA. Insignificant change in circular dichromism spectra further confirmed this binding mode. The binding sites and groups for 4–octylphenol and ctDNA interaction were identified by molecular docking. Gel electrophoresis found that 4–octylphenol at high concentrations caused DNA cleavage. Above findings may lay a theoretical foundation for understanding the toxicity mechanism of 4–octylphenol.
研究领域:
生物化学
·
毒理学
·
环境科学
✓ 已验证
DOI
PubMed
高影响因子
危险品化学品经营许可证（带存储）