ACS Nano
·
2025
·
IF 16
Yan Deng,Hao Cheng,Ji Zhu,Yue Jiang,Hongwu Sun,Guocheng Li,Jing Wei,Ruoyi Xue,Rang Feng,Jingwen Cao,Wenkang Yu,Yalan Wang,Mingqi Xu,Quanming Zou,Haibo Li
Parenteral subunit vaccines typically elicit systemic humoral immune responses but often struggle to induce mucosal immunity. Herein, we developed a promising adjuvant system, TB/P2C-NE, a tamibarotene-loaded nanoemulsion incorporating the TLR2/6 agonist Pam2CSK4. Upon intramuscular vaccination, TB/P2C-NE promoted antigen-specific mucosal immune responses in the gastrointestinal tract, accompanied by systemic humoral and cellular response. Mechanistically, tamibarotene upregulated the intestinal homing molecule CCR9 on lymphocytes through dendritic cell modulation, while Pam2CSK4 increased IL-6 secretion at the injection sites, further amplifying CCR9 expression and lymphocyte activation and leading to enhanced lymphocyte homing to the intestinal mucosa and a subsequent boost in mucosal immunity. Notably, TB/P2C-NE induced long-term gastrointestinal mucosal responses, maintaining elevated sIgA levels for up to three months post-immunization, and also induced gastrointestinal mucosal immunity in combination with a polysaccharide conjugate antigen. Immunization with recombinant intimin using TB/P2C-NE as the adjuvant resulted in a robust protective effect against the EHEC O157:H7 challenge. In summary, TB/P2C-NE offers an adjuvant strategy potentially accelerating the development of vaccines targeting gastrointestinal infections.
研究领域:
免疫学
·
疫苗学
·
药剂学
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产品关联
DOI
PubMed
高影响因子
SEPARATION AND PURIFICATION TECHNOLOGY
·
2025
·
IF 9
Yiming Li,Liyuan Zhang,Yanyan Chen,Lei Fang,Wei Bao,Kuanjun Fang
Nanofiber filters often face the challenge of achieving both high filtration efficiency and low pressure drop simultaneously. To address this issue and strike a balance between these two critical parameters, a novel three-dimensional (3D) nanofiber filter with high porosity, integrated with large microspheres, was developed. A microsphere suspension was prepared for one-step spinning, utilizing polycaprolactam-6 (PA-6) and polystyrene (PS) microspheres with large particle sizes to design an innovative PS microsphere/PA-6 nanofiber membrane structure. This membrane was specifically engineered for the filtration of ultrafine particulate matter (PM) with diameters ≤ 1 μm. Through gas jet spinning, PS microspheres were successfully embedded into PA-6 nanofibers, resulting in a “bead chain”-shaped PS microsphere/PA-6 nanofiber membrane with a fluffy, three-dimensional structure. By adjusting the ratio of PS microspheres, the stacking configuration of the nanofiber membrane was optimized. The optimal filtration performance was achieved when the microspheres were incorporated at 1.5 % w/w. Under these conditions, the membrane demonstrated exceptional filtration efficiency of 99.58 ± 0.09 % at a high flow rate, while maintaining a low pressure drop of 105 ± 2 Pa. This combination of high-efficiency filtration and low resistance highlights the superior performance of membrane, making it a promising solution for advanced filtration applications.
研究领域:
材料科学
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环境工程
·
纳米技术
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产品关联
DOI
高影响因子
POLYMER ENGINEERING AND SCIENCE
·
2021
·Vol. 61
·期 5
·1415-1426
·
IF 2.428
Fangjuan Wu,Anlin Chen,Hanlu Pan,Denghui Li,Lingjie Zhang,Hui Fang,Xiangfang Peng,Elena Bekyarova
Three-dimensional boron nitride/graphene nanoplatelets (3D-BN-GNP) scaffolds were fabricated using an ice-templating method and polyamide 6 (PA6)-based composites were prepared by vacuum impregnation of caprolactam monomers into the scaffolds, followed by polymerization. The BN sheets in the PA6/3D-BN and PA6/3D-BN-GNP composites display a predominant parallel alignment along the ice-crystal formation constructing thermally conductive paths. The addition of few GNPs assists the dispersion of BN sheets in the PA6/3D-BN-GNP composites and repair the broken thermal paths caused by local agglomeration of the BN sheets. Consequently, GNPs play a morphology-promoted synergistic role in the enhancement of the thermal conductivity of the PA6/3D-BN-GNP composites. The PA6/3D-BN-GNP composite prepared with 23.40 wt% BN sheets and 2.60 wt% GNPs exhibits the highest thermal conductivity of 2.80 W m −1 K −1 , which is 833% and 33% higher than the values recorded for the pure PA6 and the PA6/3D-BN composite at BN loading of 26.18 wt%, respectively. Infrared imaging analysis revealed that the surface of the PA6/3D-BN-GNP composite has a fast response to heating and cooling, suggesting the potential of the composites in thermal management applications.
研究领域:
材料科学
·
热传导工程
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DOI
高影响因子
JOURNAL OF MICROBIOLOGY AND BIOTECHNOLOGY
·
2025
·
IF 3.1
Jiahui Sun,Luyao Shi,Fan Xu,Hanyan Sun,Yitong Liu,Jiangyun Sun,Qingxin Zhou
Colorectal cancer (CRC) is a worldwide health issue. It causes illness and death in millions of people each year. A positive correlation has been observed between the intake of dietary fat and the development of CRC. The composition of gut microbiota exhibits a significant correlation with pathophysiologic processes in intestine. Clinical treatment remains inadequate due to the complex pathogenic mechanisms of CRC triggered by a high-fat diet (HFD). Naringenin, a flavonoid from grapefruit, has anti-cancer activity. Our findings suggest that naringenin enhances gut microbiota diversity by increasing the abundance of beneficial bacterial species while reducing opportunistic pathogenic bacteria. The fecal microbiota transplantation assay (FMT) demonstrated that the anti-HFD-CRC activity of naringenin depended on the gut microbiota. Furthermore, naringenin antagonized the IL-6/STAT3 pathway. These results suggest that naringenin may be a potential treatment for HFD-CRC.
研究领域:
肿瘤学
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营养学
·
微生物学
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产品关联
DOI
PubMed
高影响因子
ENVIRONMENTAL POLLUTION
·
2025
·
IF 7.3
Qiuhui Qian,Ji Wu,Cuizhen Wang,Zheng Yang,Ying Cheng,Yuansi Zheng,Xuedong Wang,Huili Wang
As a synthetic rubber antioxidant, the environmental monitoring concentrations of N-(1,3-Dimethylbutyl)-N′-phenyl-p-phenylenediamine (6-PPD) have exceeded the risk threshold, attracting widespread attention. Although investigations into the harmful effects on zebrafish have commenced, a comprehensive exploration of its toxicological impacts and underlying molecular mechanisms remains to be conducted. By using zebrafish as a model, this study systematically evaluated 6-PPD-induced lipid metabolism disorders and inflammation response following environmental exposure. Bioinformatics analysis revealed that 6-PPD target genes enriched in the hepatitis B pathway, indicating potential hepatic toxicity via inflammatory pathways. Therefore, we hypothesize that 6-PPD could trigger hepatotoxicity through the crosstalk between lipid metabolism and inflammation. Further experiments substantiated this hypothesis by showing lipid accumulation in the liver following 6-PPD exposure, along with elevated triglyceride (TG) and total cholesterol (TC) levels, and imbalanced expression of lipid metabolism-related marker genes. Additionally, 6-PPD exposure induced the accumulation of reactive oxygen species (ROS) and inhibited the differentiation and maturation of immune cells, resulting in immune evasion. Most of these abnormalities were exacerbated in a dose-dependent manner with increasing concentrations of 6-PPD. The addition of the PPARγ pathway agonist puerarin (PUE) or NF-κB pathway inhibitor quinazoline (QNZ) to 6-PPD exposure group mitigated these toxic effects, validating our conjecture that lipid metabolism disorder and inflammatory responses may result from the regulation of the PPARγ/NF-κB pathway.
研究领域:
环境毒理学
·
分子生物学
·
发育生物学
·
免疫学
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DOI
PubMed
高影响因子
JOURNAL OF RADIOANALYTICAL AND NUCLEAR CHEMISTRY
·
2015
·Vol. 308
·期 1
·287-295
·
IF 1.034
Jing P. F.,Liu H. J.,Zhang Q.,Hu S. Y.,Hu C.,Peng L.,Lei L. L.
The adsorption of thorium(IV) [Th(IV)] was studied using a novel 6-o-monotosyl-deoxy-β-cyclodextrin inclusion complex of dibenzoyl (inclusion complex), which was acquired by the reaction of dibenzoyl and 6-OTs-β-CD with the mole ratio of 1:2. The adsorption of Th(IV) onto inclusion complex were investigated as a function of pH value, contact time, temperature, interfering ions and Th(IV) concentration using batch adsorption technique. The maximum adsorption of Th(IV) and the equilibrium adsorption capacity were found to be 89 ± 1 % and 17.83 mg g −1 respectively at pH 3.0, equilibrium time 20 min and initial Th(IV) concentration 20 mg L −1 . Adsorption kinetics, adsorption isotherm and thermodynamics were carried out.
研究领域:
化学
·
环境科学
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产品关联
DOI
高影响因子
ACS Applied Materials & Interfaces
·
2024
·
IF 8.3
Yong Li,Lidan Liu,Can Zheng,Ang Gao,Yinjing He,Zhike Liu,Dapeng Wang,Shengzhong Frank Liu
For organic–inorganic hybrid perovskite solar cells (PSCs), the volatilization of organic components and the presence of undercoordinated Pb2+ ions are the primary causes of device stability imbalance. These factors also serve as significant determinants that restrict the commercialization scale of PSCs. Here, 6-trifluoromethylnicotinamide (TNA) molecules, featuring amide and trifluoromethyl groups at both ends, were introduced as Lewis additives into the precursor solution of perovskite to anchor all cation defect sites and optimize the crystallization process of perovskite. Theoretical calculations confirmed that the −NH2 and C═O groups within the amide group on one side of the TNA molecule synergistically passivated the undercoordinated Pb2+ ions, whereas the trifluoromethyl group on the other side formed hydrogen bonds with the organic components of perovskite. The scorpion-like bilateral all-cation anchoring ability of TNA molecules was further substantiated through experimental characterization. Upon optimization of the TNA treatment concentration, a perovskite film characterized by large grains and a reduced defect density of states was achieved. The photovoltaic performance of PSCs incorporating TNA exhibited significant enhancement with an increase in efficiency from 22.42% (Control) to 24.15%. Under a harsh high-humidity environment, the comprehensive cation passivation effect of TNA significantly hindered the decomposition and phase transition of perovskite films, thereby ensuring excellent humidity stability for the PSCs.
研究领域:
材料科学
·
能源技术
·
化学工程
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产品关联
DOI
PubMed
高影响因子
JOURNAL OF THE SCIENCE OF FOOD AND AGRICULTURE
·
2024
·
IF 3.3
Jun-qi Zhan,Jun-xin Wu,Jing-jing Fu,Gao-shang Li,Fang Wu,Yue-wen Chen
BACKGROUND Giant salamander protein peptide is a peptide with rich functional properties. Giant salamander protein peptide KGEYNK (KK-6) is a peptide with both antioxidant and anti-inflammatory properties. The antioxidant and anti-inflammatory mechanisms of KK-6 are still unclear. When we studied the functional mechanism of KK-6, we found that the antioxidant property of KK-6 has a synergistic and promoting effect on anti-inflammatory properties. RESULTS KK-6 enhances cellular resistance to LPS via the MAPK/NF-κB signaling pathway, leading to increased levels of inflammatory factors: interleukin-1β (764.81 ng mL −1 ), interleukin-6 (1.06 ng mL −1 ) and tumor necrosis factor-α (4440.45 ng mL −1 ). KK-6 demonstrates potent antioxidant properties by activating the Nrf2 signaling pathway, resulting in elevated levels of antioxidant enzymes (glutathione peroxidase: 0.03 μg mL −1 ; superoxide dismutase: 0.589 μg mL −1 ) and a reduction in the concentration of the oxidative product malondialdehyde (967.05 μg mL −1 ). CONCLUSION Our findings highlight the great potential of KK-6, a peptide extracted from giant salamander protein, as a remedy for intestinal inflammation. Through its dual role as an antioxidant and anti-inflammatory agent, KK-6 offers a promising avenue for alleviating inflammation-related damage and oxidative stress. This study lays the foundation for further exploration of giant salamander products and highlights their importance in health and novel food development. © 2024 Society of Chemical Industry.
研究领域:
生物化学
·
免疫学
·
营养学
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产品关联
DOI
PubMed
高影响因子
CHEMISTRY-A EUROPEAN JOURNAL
·
2017
·Vol. 24
·期 9
·2242-2248
·
IF 5.317
Dandan Jiang,Xiqian Li,Qiong Jia
Graphical A facile synthetic strategy based on host–guest interactions was developed to prepare multilayer cucurbit[6]uril-based magnetic nanoparticles, MNPs-(HA-DAH 5 /HA-CB[6] 5 ). The compound was employed as a blood purification material for the removal of LDL from plasma because it had good blood compatibilitiy and could be easily separated with an external magnet. Efficient removal of low density lipoprotein (LDL) is a key challenge due to its high level in plasma as a primary risk factor in the pathogenesis of atherosclerotic cardiovascular disease. In this work, a facile synthesis strategy based on host–guest interactions was developed to prepare multilayer cucurbit[6]uril-based magnetic nanoparticles, MNPs-(HA-DAH 5 /HA-CB[6] 5 ). The compound was employed as a blood purification material for the removal of LDL from plasma because it had good blood compatibility and could be easily separated with an external magnet. The efficient removal of LDL was attributed to the electrostatic interactions between the positive charged apoB-100 domain of LDL and the negative charged adsorbent. Moreover, the prepared material exhibited high recyclability and could release LDL in physiological saline for recyclable use. MNPs-(HA-DAH 5 /HA-CB[6] 5 ) offered promising perspectives and broad applications in extracorporeal treatment for the removal of LDL.
研究领域:
生物医学工程
·
材料科学
·
心血管疾病研究
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产品关联
DOI
PubMed
高影响因子
POLYMER DEGRADATION AND STABILITY
·
2020
·
IF 4.032
Shuo Fan,Chenchen Zhu,Dequn Wu,Xueli Wang,Jianyong Yu,Faxue Li
An inherent flame-retardant PA6 (FR-PA6) containing polydiphenylsiloxane (PDPS) was synthesized under the action of ethylene glycol (EG) via a facile “2-step” bulk polymerization. Inspiringly, EG acted not only as a ‘chain-linker’ to connect PA6 oligomer with PDPS moiety but also as a charring agent to increase the charring capacity of FR-PA6 after combustion. The prepared FR-PA6 reached 28.3% of limiting oxygen index (LOI), and passed the V-0 level of UL94 test with suppressed melt-dripping. After investigating the char residues and pyrolysis volatiles of FR-PA6 after combustion, the formation of silicon-rich protective layer was proved to be the essential factor to increase the flame retardancy of FR-PA6 via reducing the diffusion of pyrolysis volatiles, restricting the heat transfer and mass loss as well as preventing polymer melts from dripping. This work thus makes a worthwhile contribution to the development of FR-PA6 by offering a novel route that is easily accessible to industrial fabrication.
研究领域:
材料科学
·
高分子化学
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产品关联
DOI
高影响因子
POLYMER TESTING
·
2022
·
IF 4.931
Wen-Jie Jin,Xian-Wei Cheng,Wei-Lin He,Wei Chen,Jin-Ping Guan,Qin-Fang Qian,Jin-Long Xu
Developing durable and sustainable flame retardant (FR) polyamide 6 (PA6) fabric is of great interest. Herein, an eco-friendly Maillard reaction product (MRP) was developed by carbonyl-amino condensation between glucose and thiourea. Then, the functional PA6 fabric was developed through an exhaustion process. We further explored the anti-dripping ability, flame retardancy and washing durability, FR mechanism and physical properties of MRP-modified PA6 fabric. The modified PA6 fabric possessed a high LOI of 31.6% and a low damaged length of 11.3 cm without dripping action. The smoke emission was also reduced by 38.2% after MRP modification, although the Caramel skeleton exerted a scaffold effect with PA6. The MRP macromolecule inhibited PA6 flammability through gas-phase FR mechanism. In addition, the MRP macromolecule could firmly adsorb on PA6 fabric, corresponding to superior washing durability, and the V-0 rate was also reached after 40 washings. The modified PA6 fabric also had a yellowish-brown color and improved tensile strength.
研究领域:
材料科学
·
纺织工程
·
可持续发展
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DOI
高影响因子
NEW JOURNAL OF CHEMISTRY
·
2015
·Vol. 39
·期 10
·7971-7978
·
IF 3.086
Huan Liu,Kai Tao,Peipei Zhang,Wei Xu,Shenghu Zhou
Ordered tungsten and aluminum co-doped mesoporous KIT-6 catalysts (W-Al-KIT-6) with different Si/Al molar ratios were successfully synthesized by a one-pot synthesis method. The obtained W-Al-KIT-6 catalysts were tested for catalytic conversion of 1-butene and ethene to propene via isomerization of 1-butene to 2-butene and subsequent cross metathesis of 2-butene and ethene. Various characterization techniques, such as ICP-OES, XRD, BET, TEM, Raman, XPS and NH3-TPD, were used to characterize the catalysts. The introduction of Al did not change the mesoporous structure of KIT-6 when the nominal Si/Al was 10, 20 or 30. Moreover, the sample demonstrated a larger amount of acidic sites. The W-Al-KIT-6 catalysts with suitable Si/Al ratios illustrated a superior catalytic performance to W-KIT-6 catalyst. The origin of catalytic performance enhancement over W-Al-KIT-6 catalysts is preliminarily discussed and ascribed to the highly disperse W species and a large amount of acidic sites. The acidic sites were formed by the introduction of a suitable amount of Al in the W-KIT-6 framework, which accelerated the isomerization of 1-butene to 2-butene and promoted the cross metathesis of 2-butene and ethene to propene.
研究领域:
材料科学
·
催化化学
✓ 已验证
产品关联
DOI
高影响因子
危险品化学品经营许可证（带存储）