MOLECULES
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2023
·Vol. 28
·期 3
·1479
·
IF 4.6
Shuai Liu,Keming Zheng,Yilin Jiang,Susu Gai,Bohan Li,Dehai Li,Shuang Yang,Zhihua Lv
Penindolone (PND) is a novel broad-spectrum anti-Influenza A Virus (IAV) agent blocking hemagglutinin-mediated adsorption and membrane fusion. The goal of this work was to reveal the metabolic route of PND in rats. Ultra-high-performance liquid chromatography tandem high-resolution mass spectrometry (UHPLC–HRMS) was used for metabolite identification in rat bile, feces and urine after administration of PND. A total of 25 metabolites, including 9 phase I metabolites and 16 phase II metabolites, were characterized. The metabolic pathways were proposed, and metabolites were visualized via Global Natural Product Social Molecular Networking (GNPS). It was found that 65.24–80.44% of the PND presented in the formation of glucuronide conjugate products in bile, and more than 51% of prototype was excreted through feces. In in vitro metabolism of PND by rat, mouse and human liver microsomes (LMs) system, PND was discovered to be eliminated in LMs to different extents with significant species differences. The effects of chemical inhibitors of isozymes on the metabolism of PND in vitro indicated that CYP2E1/2C9/3A4 and UGT1A1/1A6/1A9 were the metabolic enzymes responsible for PND metabolism. PND metabolism in vivo could be blocked by UGTs inhibitor (ibrutinib) to a certain extent. These findings provided a basis for further research and development of PND.Keywords:penindolone;biotransformation;metabolite;liquid chromatography–mass spectrometry
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SENSORS AND ACTUATORS A-PHYSICAL
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2023
·
IF 4.6
Yaxuan Xiao,Jinhua Zhang,Xiong Zhao,Bin Fang,Li Ma,Nanjing Hao
Chlamydomonas, a microorganism with significant potential for various biotechnological and industrial applications. However, bioorganisms are always vulnerable and contingent, while artificial microrobots with robust and stable mechanical properties, making them highly desirable for expanding applications. Herein, we propose an artificial Chlamydomonas-like acoustics-actuated microrobot. Through the numerical simulation, we investigated the impact of tail tip angle and tail spacing on acoustic streaming intensity. Our findings reveal that smaller tip angles and wider tail spacing result in stronger acoustic streaming intensity. Based on optimization, we propose a microrobot structure with a tail tip angle of 5° and a tail spacing of 100 µm. Ultraviolet (UV) polymerization is employed to fabricate the microrobot. The effect of exposure time on manufacturing precision is examined. The acoustic propulsion of the bioinspired microrobot is verified by experiments, and the velocity of the microrobot can reach as fast as approximately 200 µm/s. Meanwhile, the vibration amplitude of the microrobot tail can be easily adjusted by the applied voltage . These findings not only provide important guidelines for the rational design of microrobots, but also offer novel insights into the applications of acoustic-driven techniques.
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JOURNAL OF ALLOYS AND COMPOUNDS
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2023
·
IF 6.2
Hao Zhong,Kang Chen,Chenglei Qin,Chengguang Lang,Jiangwen Liu,Hui Wang,Junrui Zhang,Liuzhang Ouyang
Onsite hydrogen generation by sodium borohydride hydrolysis resolves hydrogen energy supply system challenges. However, the spent-NaBH 4 regeneration is still a problem in the closed loop of this irreversible reaction. As the by-product is the key to the problem, NaB(OH) 4 is regarded as not the boron source but the hydrogen source of NaBH 4 regeneration. Therefore, in this study, inexpensive Al metal and NaB(OH) 4 are ball milled under argon to regenerate NaBH 4 without additional hydrogen input. However, the ball-milling reaction is hindered by the flexible Al and impact oxide layer, and the NaBH 4 yield is only approximately 22 %. Therefore, a brittle intermetallic compound Mg 2 Al 3 is reacted with NaB(OH) 4 by ball milling, achieving a NaBH 4 yield of over 42 %. The mechanism study shows that the brittleness of the raw material plays an important role in promoting the ball-milling reaction. This study achieves NaBH 4 regeneration using only Al as the reducing agent and provides a promising method to promote the mechanochemical regeneration of NaBH 4 .
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JOURNAL OF MATERIALS SCIENCE
·
2023
·Vol. 58
·期 42
·16322-16335
·
IF 4.5
Yang Lechen,Li Yong,Huan Dajun,Yang Yifan,Wang Jingxin,Zhu Chunling
Aircraft icing is a fairly common phenomenon, which may occur during take-off, landing and flight of the aircraft. In order to ensure flight safety, it is necessary to carry out research on aircraft anti-icing technology. Here, we demonstrate a facile method to prepare icephobic coatings that can be applied to aircraft anti-icing systems by epoxy-silicone composite resin and polytetrafluoroethylene particles. Studies have shown that this icephobic coating not only has good superhydrophobicity, abrasion resistance and aging resistance, but also has excellent anti-icing function. Supercooled droplet impact and delayed icing test results show that the icephobic surface can completely repel supercooled (− 2 °C) water droplets at − 10 °C (rebound within ~ 12 ms), while delaying the freezing process for ~ 718 s. After 10 times of mechanical deicing, the coating still maintained a low ice adhesion strength (~ 112.4 kPa) and consistent wettability. In addition, the icing state of the developed coating was evaluated by used the icing wind tunnel to simulate the icing environment of the aircraft during natural flight, and the results showed that it can significantly reduce the thickness of ice accumulation. The above properties of this icephobic surface provide a new idea for aircraft anti-icing technology. Graphical abstract
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MICROPOROUS AND MESOPOROUS MATERIALS
·
2021
·
IF 5.455
Jiayuan Wang,Mingquan Li,Yajie Fu,Cederick Cyril Amoo,Yujia Jiang,Ruiqin Yang,Xu Sun,Chuang Xing,Elton Maturura
Zeolites are vital industrial materials applied widely in the field of heterogeneous catalysis . Porous zeolites are essentially synthesized in the presence of soft or hard templates in processes such as hydrothermal, solvothermal, and ionothermal synthesis. Herein, we demonstrated a facile ambient pressure technique to synthesize NaY zeolite using a glass tube as a reactor and a fluid sealant to create a physical barrier between the reactor contents and the atmosphere. The synthesized zeolite Y was characterized by XRD , SEM, TEM , UV-Raman, N 2 sorption , MAS NMR, and XRF spectroscopy . In comparison to the traditional hydrothermal synthesis routes, the avoidance of high-pressure synthesis apparatus not only reduces safety risks but also significantly improves the yield of zeolite products with a crystallinity of 52% and Si/Al = 3.51. Furthermore, the process is leaner, efficient, and reduces costs. Optimum conditions realized for the synthesis of highly crystalline zeolite Y were 90 °C and 18 h crystallization temperature and period respectively, using 1-dodecanol as a sealant. Subsequently, PEG6000 emerged the best among organic templates investigated to improve porosity while maintaining high crystallinity of the zeolite.
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Biomaterials Science
·
2021
·Vol. 9
·期 24
·8323-8334
·
IF 6.843
Caixia Sun,Wenqian Wang,Xiaolian Sun,Weihua Chu,Jun Yang,Jianjun Dai,Yanmin Ju
Bacterial infections with a high mortality rate have become serious health issues for human beings. As natural enzymes play an important role in the survival and proliferation of bacteria, effective inhibition of bacterial natural enzyme activities is important for antimicrobial therapy. Herein, a novel enzymatic antibacterial strategy, of enhancing nanozyme activity but reducing bacterial natural enzyme activity, is developed based on yolk–shell Fe2C@Fe3O4-PEG thermogenic nanozymes with highly magnetothermal properties and thermal-enhanced peroxidase-like activities. When applying an alternating magnetic field, the special yolk–shell Fe2C@Fe3O4-PEG nanozymes show a better magnetothermal effect than Fe2C (yolk) and Fe3O4 (shell) due to the increased value of their magnetic energy product, and the peroxidase-like activity of the nanozymes is further improved. Meanwhile, remarkably restrained by the enhanced magnetothermal effect from the nanozymes, typical natural enzyme activities of bacteria are detected with an inhibition rate of nearly 80%. Both in vitro and in vivo experiments exhibit superior synergistic antibacterial efficacy. The antimicrobial mechanisms are explained as the reduction of natural enzyme activities and the disruption of cell walls and membranes induced by the self-magnetothermal effect of nanozymes along with the production of abundant ˙OH radicals derived from the thermal-enhanced peroxidase-like activity of nanozymes. Overall, this work focuses on an intrinsically thermogenic nanozyme, which provides a potential platform for future synergistic antibacterial application.
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BIOMATERIALS
·
2021
·
IF 12.479
Kuo Zhang,Hui Zhang,Xiao-Ran Zou,Ying Hu,Da-Yong Hou,Jia-Qi Fan,Chao Yang,Zi-Ming Chen,Shi-Fang Wen,Hui Cao,Pei-Pei Yang,Lei Wang
Different from chemical (small molecular inhibitor) and biological (monoclonal antibody) drugs, herein, based on angiogenesis-related neuropilin-1 (NRP-1), we develop a biomimetic superstructure drug, i.e. an antibody-like peptidic network (ALPN) to achieve the high-efficient treatment of choroidal neovascularization (CNV). The ALPN in nanoparticulated formulation (ALPN-NP S ) can bind NRP-1 through targeting unit and form fibrous peptidic networks trapping NRP-1 on the surface of endothelial cells (ECs), leading to anti-angiogenesis. The ALPN shows high-efficacy against angiogenesis in CNV rat model ascribed to the superstructure-enhanced binding and blockage of NRP-1. The very low dose of ALPN (0.263 μg/Kg) exhibits similar anti-angiogenesis effect comparing with monoclonal antibody bevacizumab (23.5 μg/Kg), which shows potential advantages over traditional monoclonal antibodies.
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SEMICONDUCTOR SCIENCE AND TECHNOLOGY
·
2020
·Vol. 35
·期 10
·104001
·
IF 2.361
Jiangdong Gong,Haiyang Yu,Huanhuan Wei,Yongshen Zheng,Chunqing Yuan,Mingxue Ma,Hong Han,Kexin Guo,Jialiang Xu,Wentao Xu
Organometal halide perovskites (OHPs) exhibit extraordinary properties in the emulation of synaptic plasticity in artificial synaptic electronic devices. However, the instability of OHPs has hindered their further application. Here, a novel two-terminal artificial synapse based on two-dimensional perovskite (R-MPEA)1.5PbBr3.5(DMSO)0.5 was developed to address this challenge. Essential biological functions including excitatory post-synaptic current, paired-pulse facilitation, spike-number dependent plasticity, spike-voltage dependent plasticity, spike-duration dependent plasticity, and spike-rate dependent plasticity, have been demonstrated in OHP-based synaptic devices. More importantly, this is the first demonstration of an air-stable OHP-based artificial synapse. The OHP-based synaptic device achieved extremely low energy consumption (∼21 fJ per event) in short-term memory and exhibited good stability at ambient atmosphere over 300 h. These results may open a new avenue for next-generation synaptic electronics and neuromorphic computing.
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Journal of Materials Chemistry B
·
2020
·Vol. 9
·期 4
·1082-1088
·
IF 5.344
Lingshu Kong,Zijian Gao,Xinyao Li,Guanghui Gao
Self-adhesiveness is highly desirable for conformal and seamless wearable electronics. Here, a starch-tackifying method is proposed to obtain adhesive and robust hydrogel conductors with the assistance of amylopectin (Amy). The conductive hydrogels are composed of Amy/poly(acrylamide–acrylic acid) polymer networks, which can be assembled into wearable sensors. The hydrogels rely on physical interactions such as hydrogen bonding that can be generated on the surface of the material, including skin, to exhibit robust and repeatable self-adhesive behaviors. Besides, the construction of a covalent and dynamic dual cross-linking network endows the hydrogel with good mechanical properties to bear repeated stretching and flexible deformation. In particular, the hydrogel is assembled into a wearable stretchable and compressible sensor and exhibits a repeatable and stable resistance signal variation for detecting both large and tiny scale human activities and physiological signals, such as bending of joints, speaking, walking, and jumping. Accordingly, the amylopectin-enabled skin-mounted hydrogel sensor can be considered as an ideal choice for human movement monitoring and personal health diagnosis.
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ACS Applied Energy Materials
·
2019
·
IF 0
Li-Ping Yang,Jian-Li Mi,Jia-Hao Liang,Zhao-Yang Zu,Peng Zhang
A simple and efficient method was developed to prepare a copper–carbon (Cu–C) catalyst with high oxygen reduction reaction (ORR) activity via direct pyrolysis of a mixture of metal salts (Cu(NO3)2·3H2O and Zn(CH3COO)2) and 1,3,5-benzenetricarbocylic acid at 1010 °C under a N2 stream. It is found that the Cu–C catalyst exhibits superior catalytic activity toward ORR with a half-wave potential of 0.81 V and a four-electron transfer pathway in 0.1 M KOH electrolyte. Generally, it is known that N plays an important role for the high ORR catalytic activities of nonprecious metal-doped carbon materials. Herein, we demonstrate that N is not required for the superior catalytic activity of Cu–C materials. Both the Cu particles and the embedded Cu atoms in the carbon substrate are suggested to provide the ORR active sites. In addition, despite the fact that the Zn is removed during the pyrolysis, the adding of Zn salt in the precursor is important for the enhanced catalytic activity. The evaporation of Zn during the pyrolysis results in the large surface area of the catalyst, which is beneficial to the mass transfer during the catalytic process. Moreover, a large number of carbon defects can be created via the removal of Zn atoms that facilitated the ORR.
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CHEMOSPHERE
·
2019
·
IF 5.108
Xiaodan Ma,Mengyuan Qi,Zhiling Li,Youkang Zhao,Peisheng Yan,Bin Liang,Aijie Wang
Obtaining efficient antibiotic-mineralizing consortium or pure cultures is a central issue for the deep elimination of antibiotic-contaminated environments. However, the antibiotic chloramphenicol (CAP) mineralizing consortium has not yet been reported. In this study, an efficient CAP-mineralizing consortium was successfully obtained with municipal activated sludge as the initial inoculum. This consortium is capable of aerobically subsisting on CAP as the sole carbon, nitrogen and energy sources and completely degrading 50 mg L −1 CAP within 24 h. After 5 d, 71.50 ± 2.63% of CAP was mineralized and Cl − recovery efficiency was 90.80 ± 7.34%. Interestingly, the CAP degradation efficiency obviously decreased to 18.22 ± 3.52% within 12 h with co-metabolic carbon source glucose. p -nitrobenzoic acid ( p- NBA) was identified as an intermediate product during CAP biodegradation. The consortium is also able to utilize p- NBA as the sole carbon and nitrogen sources and almost completely degrade 25 mg L −1 p- NBA within 24 h. Microbial community analysis indicated that the dominant genera in the CAP-mineralizing consortium all belong to Proteobacteria (especially Sphingobium with the relative abundance over 63%), and most bacteria could degrade aromatics including p- NBA, suggesting these genera involved in the upstream and downstream pathway of CAP degradation. Although the acclimated consortium has been successively passaged 152 times, the microbial community structure and core genera were not obviously changed, which was consistent with the stable CAP degradation efficiency observed under different generations. This is the first report that the acclimated consortium is able to mineralize CAP through an oxidative pathway with p -NBA as an intermediate product.
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JOURNAL OF MEDICINAL CHEMISTRY
·
2019
·
IF 6.054
Ran Zhang,Xue-Qing Song,Rui-Ping Liu,Zhong-Ying Ma,Jing-Yuan Xu
As FDA-approved chemotherapeutic agents, cisplatin, oxaliplatin, and 5-fluorouracil are widely used in clinic but limited by severe side-effects. To ameliorate their respective defects, a series of “dual-prodrug” by linking oxoplatin and 5-FU were designed and synthesized. The assembled compounds 10–17, named Fuplatin, exhibited much higher cytotoxicity against the tested cancer cells while lower cytotoxicity toward the human normal lung cells than free drugs or their combinations. Among them, 14 enhanced cellular accumulation with 62- and 825-fold amount of oxaliplatin and 8 at 9 h, respectively, significantly induced DNA damage and cell apoptosis, and inhibited migration and invasion in HCT-116 cells. Compound 14 arrested the cell cycle at S and G2 phases and up-regulated thymidylate synthase and p53, consistent with the results of the combination, suggesting 14 adopted a collaborative mode of 5-FU and oxaliplatin to kill cancer cells. In vivo, compound 14 showed high antitumor effect and no observable toxicity in NOD/SCID mice bearing HCT-116 tumors.
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