Acta Biomaterialia
·
2016
·
IF 6.008
Tao Xiang,Ting Lu,Yi Xie,Wei-Feng Zhao,Shu-Dong Sun,Chang-Sheng Zhao
The chemical compositions are very important for designing blood-contacting membranes with good antifouling property and blood compatibility. In this study, we propose a method combining ATRP and click chemistry to introduce zwitterionic polymer of poly(sulfobetaine methacrylate) (PSBMA), negatively charged polymers of poly(sodium methacrylate) (PNaMAA) and/or poly(sodium p-styrene sulfonate) (PNaSS), to improve the antifouling property and blood compatibility of polysulfone (PSf) membranes. Attenuated total reflectance-Fourier transform infrared spectra, X-ray photoelectron spectroscopy and water contact angle results confirmed the successful grafting of the functional polymers. The antifouling property and blood compatibility of the modified membranes were systematically investigated. The zwitterionic polymer (PSBMA) grafted membranes showed good resistance to protein adsorption and bacterial adhesion; the negatively charged polymer (PNaSS or PNaMAA) grafted membranes showed improved blood compatibility, especially the anticoagulant property. Moreover, the PSBMA/PNaMAA modified membrane showed both antifouling property and anticoagulant property, and exhibited a synergistic effect in inhibiting blood coagulation. The functionalization of membrane surfaces by a combination of ATRP and click chemistry is demonstrated as an effective route to improve the antifouling property and blood compatibility of membranes in blood-contact.
研究领域:
材料科学
·
生物医学工程
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DOI
PubMed
高影响因子
Polymers
·
2021
·Vol. 13
·期 2
·182
·
IF 4.329
Shuo Zeng,Jinwei Shi,Anchao Feng,Zhao Wang
This study aimed to modify an electrospun regenerated cellulose (RC) nanofiber membrane by surface grafting 2-(dimethylamino) ethyl methacrylate (DMAEMA) as a monomer via atom transfer radical polymerization (ATRP), as well as investigate the effects of ATRP conditions (i.e., initiation and polymerization) on enzyme immobilization. Various characterizations including XPS, FTIR spectra, and SEM images of nanofiber membranes before and after monomer grafting verified that poly (DMAEMA) chains/brushes were successfully grafted onto the RC nanofiber membrane. The effect of different ATRP conditions on laccase immobilization was investigated, and the results indicated that the optimal initiation and monomer grafting times were 1 and 2 h, respectively. The highest immobilization amount was obtained from the RC-Br-1h-poly (DMAEMA)-2h membrane (95.04 ± 4.35 mg), which increased by approximately 3.3 times compared to the initial RC membrane (28.57 ± 3.95 mg). All the results suggested that the optimization of initiation and polymerization conditions is a key factor that affects the enzyme immobilization amount, and the surface modification of the RC membrane by ATRP is a promising approach to develop an advanced enzyme carrier with a high enzyme loading capacity.Keywords:electrospinning;atom transfer radical polymerization;nanofiber membrane;enzyme immobilization
研究领域:
生物材料学
·
酶工程
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DOI
PubMed
高影响因子
JOURNAL OF BIOMATERIALS SCIENCE-POLYMER EDITION
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2017
·
IF 1.9
Yu Wei,Jingxun Zhang,Xiantao Feng,Dongyin Liu
Zwitterionic copolymers keep good resistance to platelet adhesion and nonspecific protein adsorption. In this study, A block copolymer brushes consisting of carboxybetaine methacrylate (CBMA) and glycidyl methacrylate (GMA) were grafted from silicon wafers via surface-initiated atom transfer radical polymerization, and then the Arg-Glu-Asp-Val (REDV) peptide was attached to the polymer brush via an reactive epoxy group of the P(GMA) unit to improve endothelial cells (ECs) selectivity. These modified surfaces were evaluated with scanning electron microscopy, atomic force microscopy, attenuated total reflectance-Fourier transform infrared spectra, X-ray photoelectron spectroscopy, and static water contact angle measurement. The results showed that REDV-modified zwitterionic brushes were successfully constructed on silicon wafers. The biocompatibility of the membrane was determined by plasma recalcification time assay and platelet adhesion test. The results showed that the modified substrate exhibited good blood compatibility. Moreover, the proliferation of ECs and smooth muscle cells onto the REDV-modified copolymer brushes were examined to demonstrate the synergistic effect of CBMA with antifouling property and REDV peptide with ECs selectivity. All assays showed that the silicon wafers displayed excellent EC selectivity after modification. In summary, REDV-modified zwitterionic brushes had great potential for cardiovascular stent implantation.
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DOI
高影响因子
Materials Science & Engineering C-Materials for Biological Applications
·
2019
·
IF 4.959
Xinyan Jiang,Mengzhen Xi,Liangjiu Bai,Wenxiang Wang,Lixia Yang,Hou Chen,Yuzhong Niu,Yuming Cui,Huawei Yang,Donglei Wei
A green strategy by integrating surface-initiated metal-free photoinduced electron transfer-atom transfer radical polymerization (PET-ATRP) with mussel-inspired polydopamine (PDA) chemistry, was used to fabricate multi-walled carbon nanotubes (MWCNTs)/poly(4-vinylpyridine) (P4VP) nanocomposites. Self-healing nanocomposite hydrogels were facilely designed with these nanocomposites through dynamic supramolecular interactions. Using mussel-inspired PDA chemistry from MWCNTs, nanocomposites (MWCNTs@PDA-P4VP) were successfully prepared by metal-free PET-ATRP with MWCNTs@PDA-Br as an initiator, rhodamine B as photocatalyst, 4-vinylpyridine (4VP) as monomer, respectively. Importantly, the obtained nanocomposite hydrogels had high mechanical strength (2.9 MPa), prior fracture strain (633.8%) and excellent self-healing property (90.6%). These methodologies will provide opportunities for the design of eco-functional materials or flexible biosensors.
研究领域:
材料科学
·
化学工程
·
生物医学工程
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产品关联
DOI
PubMed
高影响因子
APPLIED SURFACE SCIENCE
·
2019
·
IF 5.155
Jingjing Wang,Wenhui Zhang,Yuxia Zheng,Nan Zhang,Changsen Zhang
Multi-functionalized magnetic graphene was prepared by surface-initiated initiators for continuous activator regeneration atom transfer radical polymerization (ICAR ATRP) mediated by polydopamine chemistry . The obtained multi-functionalized magnetic graphene was used as an adsorbent for application in adsorption and speciation of arsenic. Adsorption kinetics and isotherms of arsenic were investigated by batch adsorption experiments. The adsorbent displayed simultaneous or selective removal ability for As(III) and As(V) within different pH ranges. The adsorption of both As(III) and As(V) agreed well with the Freundlich isotherm model, and they were effectively adsorbed through chelation and electrostatic interaction, respectively. Moreover, the functionalized magnetic graphene was examined as a column packing material for speciation analysis of arsenic using solid phase extraction technique. As(III) and As(V) could be effectively separated through a sequential elution strategy. An alkaline solution was firstly employed to selectively elute As(V), and then an acidic solution was utilized to elute As(III). The developed adsorbent in the present study was successfully applied to the determination of As(III) and As(V) in natural and environmental water samples with satisfactory results.
研究领域:
材料科学
·
环境科学
✓ 已验证
产品关联
DOI
高影响因子
HOLZFORSCHUNG
·
2020
·Vol. 74
·期 8
·799-809
·
IF 1.826
Yu Wang,Zuwu Tang,Shengchang Lu,Min Zhang,Kai Liu,He Xiao,Liulian Huang,Lihui Chen,Hui Wu,Yonghao Ni
Wood is a natural, abundant, renewable resource, which is easily processed, has beautiful texture and good mechanical strength, and is widely used for furniture, flooring, decor and building construction. However, wood is vulnerable to moisture and microorganisms, resulting in deformation, cracks, mold and degradation, which causes aesthetic problems and/or shortens the service life of wood products. In this paper, superhydrophobic wood (wood-F) was fabricated by grafting poly(2-(perfluorooctyl)ethyl methacrylate) (PFOEMA) onto wood by atom transfer radical polymerization (ATRP). Fourier transform infrared spectroscopy (FTIR), X-ray photoelectron spectroscopy (XPS) and scanning electron microscopy (SEM) with an energy-dispersive X-ray spectroscopy (EDS) showed that PFOEMA was successfully grafted onto wood. The resultant wood-F exhibited excellent water resistance with a contact angle (CA) of 156° and hysteresis of 4°. The modified wood also showed abrasion resistance, self-cleaning ability and anti-mold properties, all of which are desirable for various wood products.
研究领域:
材料科学
·
木材科学
·
高分子化学
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产品关联
DOI
高影响因子
CHINESE JOURNAL OF POLYMER SCIENCE
·
2015
·Vol. 33
·期 11
·1491-1502
·
IF 1.835
Fang Li-feng,Wang Na-chuan,Zhou Ming-yong,Zhu Bao-ku,Zhu Li-ping,John Angelin Ebanezar
To functionalize poly(vinyl chloride) (PVC) for various applications, monomers containing tertiary amine group are incorporated into PVC via atom transfer radical polymerization (ATRP) initiated by the labile chlorines in their backbones. The kinetics of synthesis was carefully investigated, and it is proven that the grafting polymerization process can be effectively controlled by regulating the reaction time. The membranes are fabricated using PVC and copolymers by non-solvent induced phase separation (NIPS) process. The hydrophilicity and pore structure of copolymer membranes were enhanced as well, these membranes are endowed with positive charge. When PDMA% ( i.e. , the PDMA weight percentage in copolymer) is 31.1%, the flux and Victoria blue B rejection are 26.0 L·m -2 ·h -1 (0.5 MPa) and 91.2%, respectively. Thus, the newly synthesized polymer is proven to be a promising material for dye separation with positive charges.
研究领域:
高分子化学
·
材料科学
·
膜技术
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产品关联
DOI
高影响因子
JOURNAL OF SUPERCRITICAL FLUIDS
·
2017
·
IF 2.991
Lei Bao,Shuyi Fang,Dongdong Hu,Yuan Zong,Ling Zhao,Weikang Yuan,Tao Liu
Several amphiphilic nonfluorinated polymers, poly(vinyl acetate)-block-poly(dimethylaminoethyl methacrylate) (PVAc -b- PDMAEMA) and poly(vinyl acetate- alt -diethyl maleate) (PVDBM) -b- PDMAEMA with different ratios of CO 2 -philic and hydrophilic groups, were synthesized using RAFT/MADIX polymerization and ATRP. Stability measurements revealed that PVDBM 8 -b- PDMAEMA 22 could emulsify 80% CO 2 in H 2 O, with stable CO 2 -in-water (C/W) emulsions observed for more than 48 h under 20.0 MPa at 25 °C, which was 20 times longer than PVAc -b- PDMAEMA did. The optimal degree of polymerization (DP) for CO 2 -philic groups in PVDBM- b -PDMAEMA was 8, because increasing the DP of PVDBM increased the CO 2 -philicity, whereas increased molecular weight limited the miscibility in water. Molecular dynamics simulations were applied to determine the hydrophilic/CO 2 -philic balance (HCB). It was found that enhanced CO 2 -philic tails widened the HCB range, and the optimal range of the HCB was varied with CO 2 -philic tail types. Both experimental and simulation results demonstrated that enhancing the CO 2 -philicty of surfactant tails can improve the stability of C/W emulsions.
研究领域:
材料科学
·
化学工程
·
高分子化学
✓ 已验证
DOI
高影响因子
Analytical Methods
·
2020
·Vol. 12
·期 36
·4438-4446
·
IF 2.596
Na Wang,Chan Wang,Hou Chen,Liangjiu Bai,Wenxiang Wang,Huawei Yang,Donglei Wei,Lixia Yang
As robust functional polymers, polymer brush-based hybrid nanomaterials have potential application in the highly sensitive determination of tumor markers (TMs). Currently, there are plentiful reports on the polymerization methods of functional polymer brushes. Low ppm ATRP (activators (re)generated by electron transfer for atom transfer radical polymerization (A(R)GET ATRP), initiators for continuous activator regeneration atom transfer radical polymerization (ICAR ATRP) and electrochemically mediated atom transfer radical polymerization (eATRP)) is a facile and robust methodology with the advantages of simplicity, eco-friendliness and wide applicability to prepare well-defined polymeric materials. In this work, a controlled polymer brush-type functional nanoprobe is successfully fabricated by functional AGET ATRP and used as a sandwich-type electrochemical immunosensor for precise detection of TMs (alpha-fetoprotein, AFP). Using graphene oxide (GO) as an excellent conductive matrix, a GO-based poly-heterozygosis pyridine nanomaterial (GO@PHPY) is obtained by surface-initiated AGET ATRP and photocatalytic modification. The nanoprobe is assembled using GO@PHPY and a detection antibody (Ab2) to detect AFP, in which Cu(II) serves as a signal label to coordinate with the pyridyl group. Under optimized conditions, the electrochemical sensor exhibits a good detection effect on AFP, with a detection range of 0.1 pg mL−1 to 100 ng mL−1 and a low detection limit of 0.08 pg mL−1. It is worth noting that the detection platform can be applied to the detection of real human serum samples. Thus, it is a desirable platform for AFP detection in clinical diagnosis and practical applications. Meanwhile, this work proves that designing and constructing functional polymer brushes is one of the most effective methods for developing new materials for analytical scientific applications.
研究领域:
材料科学
·
分析化学
·
生物医学工程
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产品关联
DOI
PubMed
高影响因子
Polymer Chemistry
·
2021
·Vol. 12
·期 18
·2722-2730
·
IF 5.582
Tianai Tang,Kai Tu,Xiang Xu,Jian Xie,Duo Zhang,Zexin Zhang,Lifen Zhang,Zhenping Cheng
The design and fabrication of micron-size Janus particles (JPs) with new structures and properties are still great challenges although various methods have been used to synthesize nano-size JPs. Therefore, it is of great significance to develop a high-efficiency preparation and facile functionalization technology for micron-size JPs. Herein, we developed a facile one-pot suspension polymerization to synthesize micron-size JPs which can be easily further functionalized for the first time. The key of this method is to use an amphiphilic block copolymer prepared by atom transfer radical polymerization (ATRP) as the macromolecular surfactant (MS). On the one hand, within a certain hydrophile–lipophile balance (HLB) range, the reversed micelles in the oil phase were used to absorb water and expand, then aggregate and fuse, and finally phase separate from the oil phase to form JPs. On the other hand, the MS prepared by ATRP has an initiating group at the MS chain end, which is exposed on one side on the surface of the JPs, so that the facile functionalization of the JPs can be further realized by the ATRP strategy.
研究领域:
材料科学
·
高分子化学
·
纳米技术
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产品关联
DOI
高影响因子
JOURNAL OF THE SCIENCE OF FOOD AND AGRICULTURE
·
2025
·
IF 3.5
Bingchen Wang,Yifan Wang,Lin Chen,Xiuyuan Zhang,Kuo He
BACKGROUND To address the severe health risks posed by aflatoxin B 1 (AFB 1 ) in grain, this study employed polydopamine-based atom transfer radical polymerization (p-ATRP) and cytochrome C-catalyzed atom transfer radical polymerization (c-ATRP) as cytocompatible modification techniques to coat the surface of living Lactobacillus plantarum (LAB) cells with the temperature-sensitive polymer poly( N -isopropylacrylamide) (PNIPAAm). RESULTS Two novel bioadsorbents were synthesized. The incorporation of PNIPAAm as an ‘AFB 1 vacuum cleaner’ layer significantly enhances LAB's adsorption efficiency and enables temperature-controlled desorption. Compared with p-ATRP, c-ATRP uses cytochrome C (from LAB's membrane protein) as a biocatalyst to replace the necessary copper catalyst in p-ATRP, eliminating the risk of copper toxicity and pollution. The exceptional AFB 1 adsorption capabilities of LAB@PNIPAAm can be precisely modeled using the Lagergren pseudo-second-order and Freundlich frameworks, with an adsorption capacity attaining 74.88 ng mL −1 . Furthermore, LAB@PNIPAAm displays unique temperature-responsive properties, achieving an adsorption efficiency of 78% at 22 °C and a temperature-controlled desorption rate of 69% upon temperature elevation to 37 °C. It is noteworthy that the c-ATRP technology also enhances the stress resistance of LAB. CONCLUSION These findings offer novel insights into the surface engineering of viable bacterial cells and the efficient bioremediation of multiple pollutants in complex environments. © 2025 Society of Chemical Industry.
研究领域:
食品科学
·
微生物学
·
环境科学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
ACS SYMPOSIUM SERIES
·
2012
·
IF 0
Pingwei Liu,Weiqiang Lu,Wen-Jun Wang,Bo-Geng Li,Zhibin Ye,Shiping Zhu
Amphiphilic diblock copolymers consisting of linear or hyperbranched polyethylene (PE) and poly[oligo (ethylene glycol) methyl ether methacrylate] (POEGMA) were synthesized via atom transfer radical polymerization (ATRP) initiated by PE macroinitiators (MIs). The MIs contained an end-capping 2-bromoisobutyryl group per chain. Their linear and hyperbranched structures were first synthesized through a ‘‘living’’ polymerization of ethylene under pressure of 27.6 and 1 atm, respectively, using Pd–diimine catalyst, [(ArN=C(Me)–(Me)C=NAr)Pd(CH2)3C(O)O(CH2)2OC(O)C(CH3)2Br]+ SbF6− (Ar = 2,6-(iPr)2C6H3) (1). In the ATRP of OEGMA, the effect of solvent, ligand, and MI concentration on the block copolymer formation were studied. The macroinitiator and block copolymer samples were characterized by GPC, 1H NMR, and DSC measurements. All samples possessed well-defined topologies/structures with narrow molecular weight distributions and controlled lengths of PE and POEGMA blocks. The block structures were verified by an intrinsic viscosity study. Micelle formation and its temperature sensitivity were also analyzed by dynamic light scattering.
研究领域:
高分子化学
·
材料科学
✓ 已验证
DOI
危险品化学品经营许可证（带存储）