COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
·
2023
·
IF 5.2
Luping Chen,Shixiang Liu,Fengyuan Gao,Hailin Cong,Bing Yu,Youqing Shen
Transcatheter arterial chemoembolization (TACE) is one of the common methods of treating tumors and usually requires an accompanying injection of an exogenous contrast agent, but the exogenous contrast agent is highly susceptible to removal by blood flow , which greatly reduces the efficiency of the operation. Here, we developed a uniformly sized Ag 2 S/BaSO 4 /DOX@PEGDAMS that integrates embolization, drug loading, and visualization with a microfluidic device . The microspheres can be imaged stably under NIR-II/X-ray for a long time, and the luminescence of NIR-II is better than that of X-ray. This breaks the limitations of conventional X-ray-only imaging of embolic microspheres . The microscope images and scanning electron microscope EDS results showed that the microspheres were regularly spherical with uniform particle size, and the signature elements such as Ag, S, and Ba were uniformly distributed in the microspheres. In vitro cytotoxicity assays and apoptosis assays have demonstrated that the microspheres have good biocompatibility and can effectively inhibit tumor cell growth due to the presence of DOX. The ability of microspheres to aggregate in blood vessels and block blood flow was verified by modeling and embolizing in rabbit ear tumors. In conclusion, Ag 2 S/BaSO 4 /DOX@PEGDAMS shows excellent embolization, drug loading, and imaging capabilities, and has the potential to be used for TACE and other diseases requiring interventional embolization therapy.
研究领域:
生物医学工程
·
药学
·
癌症治疗
·
材料科学
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产品关联
DOI
高影响因子
CHEMICAL ENGINEERING JOURNAL
·
2021
·
IF 13.273
Xiao-Shuai Zhang,Kai Cheng,Jian-Shuang Wei,Zhuo-Yao Huang,Xiao-Lin Hou,Yong-Guo Hu,Xiao-Quan Yang,Fang Zhang,Xing Sun,Wei Chen,Bo Liu,Yuan-Di Zhao
In this paper, a mixture of lecithin, polyethylene glycol monostearate, and polyethylene glycol phospholipid (DSPE-PEG 2000 ) is used to wrap hydrophobic nano silver sulfide (Ag 2 S) and 3 ∼ 5 nm ultra-small gold nanoparticle (mAu) to form ∼ 150 nm hydrophilic nanocomposite probe Ag 2 S/ [email protected] 2000 (ASAuDP) with good stability and dispersion. The probe combines the functions of Ag 2 S and mAu, while mAu can significantly inhibit the fluorescence (FL) of Ag 2 S, thereby reducing the phototoxicity of probe when circulating in the body. When the ASAuDP probe is phagocytosed by tumor cell, Ag 2 S and mAu are separated due to the rupture of probe, thereby restoring the ability of FL imaging and ROS production. MTT test, blood analysis and organ pathology test prove that ASAuDP is a safe probe. In vitro and in vivo imaging experiments prove that the ASAuDP probe presents good FL, CT and photoacoustic imaging capabilities. In vitro and in vivo treatments prove that the ASAuDP probe has both photothermal and sonodynamic therapy abilities, and the synergy between them has the best therapeutic effect. Therefore, ASAuDP probe is a kind of integrated diagnostic and therapeutic probe with good safety, and it has a good application prospect in the treatment of tumor.
研究领域:
纳米技术
·
癌症研究
·
生物医学工程
·
材料科学
·
诊疗学
✓ 已验证
产品关联
DOI
高影响因子
Journal of Materials Chemistry B
·
2023
·Vol. 11
·期 6
·1279-1287
·
IF 7
Haoyu Chen,Zifu Cai,Jialing Gui,Ying Tang,Peng Yin,Xiaohua Zhu,Youyu Zhang,Haitao Li,Meiling Liu,Shouzhuo Yao
In this work, a ratiometric fluorescent nanoplatform for the detection of ascorbic acid (AA) was constructed based on the Ag2S quantum dots (QDs) and multifunctional hydroxyl cobalt oxide nanoflakes (CoOOH NFs). Ag2S QDs can be assembled on the surface of CoOOH NFs by electrostatic adsorption, resulting in the quenching of the NIR fluorescence emission of Ag2S QDs at 680 nm effectively through the inner filter effect (IFE). o-Phenylenediamine (OPD), a common substrate of oxidase-like (OXD) mimic, is rapidly oxidized into the fluorescent product of 2,3-diaminophenazine (DAP) with the appearance of an emission peak at 575 nm under the catalysis of CoOOH NFs. After AA was added, the fluorescence emission of DAP declined because of the decline in the OXD-like activity of CoOOH NFs due to the transformation of Co2+. Simultaneously, Ag2S QDs were released, accompanied by the recovery of red fluorescence. These two fluorescent signals can be excited at the same excitation wavelength, simplifying the detection procedure. Using F575/F680 as the readout, the quantification of AA can be realized with the linear range and detection limit of 0.2 μM–20 mM and 0.014 μM, respectively. The ratiometric fluorescence sensor can be effectively used to determine the content of AA in real samples such as juice and serum. This work integrates the in-situ formation of the fluorescent species via the catalysis of the nanozyme and the redox reaction to destroy the CoOOH NFs nanozyme as well as the two dimensional nanoflake induced turn-off-on strategy for Ag2S QDs, which provides a specific strategy for the selective detection of AA and may offer a reliable approach for the construction of other biosensing platforms.
研究领域:
分析化学
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生物传感
·
纳米材料科学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
·
2023
·
IF 4.4
Xiufeng Wang,Yao Jin,Wenhui Ai,Siqi Wang,Zhiqing Zhang,Ting Zhou,Fang Wang,Guodong Zhang
Near infrared (NIR) emission Ag 2 S quantum dots (QDs) are of great value for biochemical sensing with strong anti-interference and low toxicity. Herein, NIR fluorescence Ag 2 S QDs were synthesized successfully. Combined with the excellent oxidase-like characteristics of manganese dioxide (MnO 2 ) nanosheets, a fluorescence and colorimetric dual-mode sensor for sulfide anion was developed. MnO 2 nanosheets could effectively catalyze the oxidation of TMB to produce blue TMB oxide (ox TMB), at the same time, the fluorescence of Ag 2 S QDs could be effectively quenched by fluorescence internal filtration effect (IFE) and dynamic quenching effect. The enzyme-like activity was weakened and the NIR fluorescence of Ag 2 S QDs was restored when sulfide anion (S 2− ) was added, due to the reduction of MnO 2 to Mn 2+ .The linear ranges for fluorescence and colorimetric analysis of S 2− were 2–250 μM and 0.3–50 μM, with detection limits of 0.6 and 0.215 μM, correspondingly. The dual-mode sensor had a wider detection range, higher sensitivity and shorter reaction time, which could be used for highly selective detection of S 2− in different concentration ranges. In addition, it had been successfully applied to the determination of sulfide in water samples with satisfactory accuracy and sensitivity.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
MICROCHIMICA ACTA
·
2019
·Vol. 186
·期 7
·1-9
·
IF 5.479
Qin Xiaofei,Geng Liping,Wang Qianqian,Wang Yan
A photoelectrochemical (PEC) method is described for aptamer-based detection of ofloxacin (OFL). It is making use of a TiO 2 nanotube array (NTA) that is sensitized with a structure composed of polydopamine and silver sulfide nanoparticles. The NTA were prepared by a two-step synthetic method. First, the TiO 2 nanotube electrode was covered with Ag 2 S nanoparticles via successive ionic layer adsorption and reaction strategy. Next, they were coated with a thin film of polydopamine (PDA) by in-situ polymerization. The inorganic/organic nanocomposites exhibit distinctly enhanced visible-light PEC activity. This was exploited to fabricate a PEC aptasensor. The PDA film serves as both the sensitizer for charge separation and as a support to bind the aptamer against OFL. The aptasensor undergoes a decrease in photocurrent due to the formation of the aptamer-OFL complex. Under the optimized conditions and at a typical working potential of 0 V (vs. Hg/Hg 2 Cl 2 ), the NTA has a linear response in the 5.0 pM to 100 nM OFL concentration range and a 0.75 pM detection limit (at S/ N = 3). The aptasensor was successfully applied to the determination of OFL in spiked milk samples.
Schematic illustration for the preparation and mechanism of the photoelectrochemical aptasensor for ofloxacin. TiO 2 NTs: TiO 2 nanotube arrays; PDA: polydopamine; MCH: 6-mercapto-1-hexanol; OFL: ofloxacin; PEC: photoelectrochemistry; CB: conduction band; VB: valence band; LUMO: the lowest unoccupied molecular orbital; HOMO: the highest occupied molecular orbital; AA: ascorbic acid.
研究领域:
分析化学
·
生物传感技术
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Journal of Materials Chemistry C
·
2019
·Vol. 7
·期 5
·1307-1315
·
IF 6.641
Bin Zeng,Fei Chen,Zhenyang Liu,Zhongyuan Guan,Xu Li,Feng Teng,Aiwei Tang
Herein, we demonstrated a seed-mediated growth method for the synthesis of ternary AgInS2 (AIS) and quaternary Ag–In–Zn–S (AIZS) nanocrystals (NCs) by means of a partial cation exchange with In3+ and Zn2+ ions. Binary Ag2S NCs with different sizes were synthesized first, which then acted as the seeds to prepare different-sized AIS NCs through the incorporation of In3+. The formation mechanism of AIS NCs was studied in terms of the temporal evolution of the morphology and crystal structure, and the heterostructured Ag2S-AIS NCs were formed as intermediates during the growth process of AIS NCs. Variation in the Ag/In feeding ratios from 1 : 1 to 1 : 3 led to a broad tuning of the optical band gap and photoluminescence (PL) maximum of AIS NCs, in which very small-sized AIS NCs with a tetragonal phase were obtained. Subsequently, the incorporation of Zn2+ into AIS NCs resulted in the widening of the optical band gap and the shift of the PL maximum to higher energy with the enhancement of the absolute PL quantum yields (PLQYs). When the reaction temperature was increased, the PL emission maximum could be tuned from 2.04 to 2.33 eV and the absolute PLQYs could be tuned from 16% to 58%. Time-resolved PL spectroscopy was used to study the PL decay dynamics of the AIS and AIZS NCs, and the PL emission was related to the recombination of the surface-related states, intrinsic defects and donor–acceptor (D–A) pairs. The ternary and quaternary Ag-based semiconductor NCs have long-lived excitons, which may have promising applications in the field of energy conversion.
研究领域:
材料科学
·
纳米技术
·
光学
✓ 已验证
产品关联
DOI
高影响因子
ACS Applied Materials & Interfaces
·
2016
·
IF 7.145
Jiangluqi Song,Chao Ma,Wenzhe Zhang,Xiaodong Li,Wenting Zhang,Rongbo Wu,Xiangcan Cheng,Asad Ali,Mingya Yang,Lixin Zhu,Ruixiang Xia,Xiaoliang Xu
Attention on semiconductor nanocrystals have been largely focused because of their unique optical and electrical properties, which can be applied as light absorber and luminophore. However, the band gap and structure engineering of nanomaterials is not so easy because of their finite size. Here we demonstrate an approach for preparing ternary AgInS2 (AIS), quaternary AgZnInS (AZIS), AgInS2/ZnS and AgZnInS/ZnS nanocompounds based on cation exchange. First, pristine Ag2S quantum dots (QDs) with different sizes were synthesized in one-pot, followed by the partial cation exchange between In3+ and Ag+. Changing the initial ratio of In3+ to Ag+, reaction time and temperature can control the components of the obtained AIS QDs. Under the optimized conditions, AIS QDs were obtained for the first time with a cation disordered cubic phase and high photoluminescence (PL) quantum yield (QY) up to 32% in aqueous solution, demonstrating the great potential of cation exchange in the synthesis for nanocrystals with excellent optical properties. Sequentially, Zn2+ ions were incorporated in situ through a second exchange of Zn2+ to Ag+/In3+, leading to distinct results under different reaction temperature. Addition of Zn2+ precursor at room temperature produced AIS/ZnS core/shell NCs with successively enhancement of QY, while subsequent heating could obtain AZIS homogeneous alloy QDs with a successively blue-shift of PL emission. This allow us to tune the PL emission of the products from 483 to 675 nm and fabricate the chemically stable QDs core/ZnS shell structure. Based on the above results, a mechanism about the cation exchange for the ternary nanocrystals of different structures was proposed that the balance between cation exchange and diffusion is the key factor of controlling the band gap and structure of the final products. Furthermore, photostability and in vitro experiment demonstrated quite low cytotoxicity and remarkably promising applications in the field of clinical diagnosis.
研究领域:
材料科学
·
生物医学工程
·
化学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
TALANTA
·
2021
·
IF 6.057
Huan Gao,Junfang Zhang,Xuan Wei,Qinshu Zhu,Tianxiang Wei
Developing efficient and sensitive cytosensing method has great significance for the detection of low abundant circulating tumor cells (CTCs). Electrochemiluminescence (ECL) biosensor, as an attractive analytical tool, has shown a great potential in sensitive cell counting. Its detection efficiency is strongly dependent on the electrochemiluminescent materials, whose property is related to its morphology and surface vacancies. Herein, the ultrathin Lu 2 O 3 –S nanosheets contain abundant oxygen vacancies were newly synthesized. Its special two-dimensional (2D) structure morphology and surface vacancy endowed it intensified and stable ECL emission. The possible mechanism was deduced from experiments and discussed. Then, through integrating with a DNA device cycle-amplification system plus signal conversion pretreatment, we constructed a crossed enhanced ECL cytosensing platform. In this system, the target cells were transformed into programmable sequences, which could be next coupled with DNA device cycle-amplification on the modified electrode surface. Using Ag 2 S quantum dots as the energy acceptor toward Lu 2 O 3 –S donor, and CCRF-CEM cells (CEM) as the model CTCs, an enhanced ECL cytosensing platform was proposed, displaying good analytical performance for acute lymphoblastic leukemia cancer cell detection. The ECL signal responded proportionately on the CEM cells concentration in a wide range of 5 × 10 to 1 × 10 6 cells/mL, and a low detection limit of 10 cells/mL was obtained. This work provided an alternative way to design high-performance ECL luminophores, and also would be an effective solution for CTCs counting.
研究领域:
生物传感器
·
纳米技术
·
癌症诊断
·
分析化学
·
生物化学
✓ 已验证
DOI
PubMed
高影响因子
ACS Nano
·
2022
·
IF 18.027
Yihan Fu,Fei Ye,Xuwu Zhang,Yuchu He,Xiaoyu Li,Yongfu Tang,Jing Wang,Dawei Gao
Currently, one of the main reasons for the ineffectiveness of tumor treatment is that the abnormally high tumor interstitial pressure (TIP) hinders the delivery of drugs to the tumor center and promotes intratumoral cell survival and metastasis. Herein, we designed a “nanomotor” by in situ growth of Ag2S nanoparticles on the surface of ultrathin WS2 to fabricate Z-scheme photocatalytic drug AWS@M, which could rapidly enter tumors by splitting water in interstitial liquid to reduce TIP, along with O2 generation. Moreover, the O2 would be further converted to reactive oxygen species (ROS), accompanied by increased local temperature of tumors, and the combination of ROS with thermotherapy could eliminate the deep tumor cells. Therefore, the “nanomotor’’ could effectively reduce the TIP levels of cervical cancer and pancreatic cancer (degradation rates of 40.2% and 36.1%, respectively) under 660 nm laser irradiation, further enhance intratumor drug delivery, and inhibit tumor growth (inhibition ratio 95.83% and 87.61%, respectively), and the related mechanism in vivo was explored. This work achieves efficiently photocatalytic water-splitting in tumor interstitial fluid to reduce TIP by the nanomotor, which addresses the bottleneck problem of blocking of intratumor drug delivery, and provides a general strategy for effectively inhibiting tumor growth.
研究领域:
纳米技术
·
癌症治疗
·
光催化
·
生物医学工程
✓ 已验证
产品关联
DOI
PubMed
高影响因子
ADVANCED FUNCTIONAL MATERIALS
·
2021
·Vol. 32
·期 7
·2109469
·
IF 18.808
Xiong Zhou,Ziyou Wang,Yau Kei Chan,Yingming Yang,Zheng Jiao,Limei Li,Jiyao Li,Kunneng Liang,Yi Deng
Pathogenic infection inevitably provokes chronic inflammation and stalls the normal orchestrated course of wound-healing cascades. However, current antibacterial therapies focus on the inherent bactericidal functions of biomaterials. To take full advantage of infection microenvironment (IME) peculiarities, an IME-activated nanocatalytic membrane consisting of electrospun poly (lactic-co-glycolic acid) (PLGA) scaffolds, MXene/Ag 2 S bio-heterojunctions (MX/AS bio-HJs), and lactate oxidase (LOx) for chronic cutaneous regeneration is devised and developed. In this “intelligent” system, PLGA membranes gradually degrade to lactate, and LOx consumes lactate to yield abundant hydrogen peroxide (H 2 O 2 ) in a microenvironment-responsive manner. In addition, MX/AS bio-HJs in membranes not only exert benign photothermal effects and generate reactive oxygen species upon NIR light, but also catalyze the produced H 2 O 2 to overwhelming hydroxyl radicals (·OH) through Fenton-like reactions, which all result in rapid synergistic sterilization. Furthermore, in vivo assays demonstrate that the nanocatalytic membranes reshape the stalled chronic wound into a regenerative wound by massacring bacteria, stopping bleeding, boosting epithelialization/collagen deposition of the wound beds, and promoting angiogenesis. As envisaged, the proposed tactic opens up a promising opportunity for arming membranes with IME-responsive nanocatalytic activity to remedy bacteria-invaded stalled full-thickness wounds.
研究领域:
生物医学工程
·
材料科学
·
伤口愈合
·
纳米技术
·
生物材料
✓ 已验证
产品关联
DOI
高影响因子
ADVANCED FUNCTIONAL MATERIALS
·
2024
·
IF 18.5
Jiasheng Bao,Ruiqi Liu,Zhouyu Yu,Zhen Cheng,Baisong Chang
Despite multifunctional theranostics hold vast potential in deep tissue bioimaging and tumor therapy, activatable nanomedicine with integration of precise diagnosis and effective treatment is usually achieved at the cost of complicated synthesis chemistries. Here, a facile way to design bioresponsive Ag 2 S-Ag Janus probes coated by polyethylene glycol (PEG) (denoted as AAP) is showed, active in the second near-infrared window (NIR-II, 1000–1700 nm). In tumor microenvironment, Ag part can yield hydroxyl radicals (·OH) by consuming H 2 O 2 for high-efficiency chemodynamic therapy (CDT), while Ag 2 S part has impressive photothermal therapy (PTT). The synergistic benefits from Ag and Ag 2 S parts further boosted CDT effect of AAP Janus probes with high photothermal conversion efficiency up to 56.8%. Moreover, multiple lines of evidence supported that extremely faint fluorescence of AAP Janus probes can be significantly activated by overexpressed levels of H 2 O 2 , showing bright NIR-II emission at ≈1270 nm with over 5.6 × 10 3 -fold increase in signal intensity. AAP Janus probes are easily activatable for NIR-II imaging for tumor-specific identification, and effectively ablate tumor tissues with tumor inhibition rate of 96.2%. This study expects that AAP Janus probe will open up a new route to achieve precise tumor diagnosis and treatment in the NIR-II window.
研究领域:
生物医学工程
·
纳米技术
·
癌症治疗
·
生物成像
✓ 已验证
产品关联
DOI
高影响因子
Translational Oncology
·
2023
·
IF 5
Jiale Cai,Guiping Hu,Lihua Hu,Junge Chen,Dan Chen,Dan Liu,Xiaolei Wang,Boxian Hu,Cheng Li
Introduction Sonodynamic therapy (SDT) has potential clinical applications for cancer therapy, and is yet restricted by complex tumor microenvironmental (TME) factors. Thus, the research problem of TME modulation as well as efficient tumor treatment still needs to be clarified. Method In this study, a calcium carbonate (CaCO 3 ) nanoplatform was designed for ultrasound (US) and TME response-triggered, which encapsulated Ag 2 S and loaded with l -Arg, and further wrapped with RBC/Platelet membrane, named as QD@Ca/M L-Arg . Results Non-invasive US-triggered SDT by Ag 2 S and acidic environment-responsive drug release were achieved. In vitro experiments validated the efficacy of SDT, Ca-ion interference and nitric oxide (NO) gas therapy as combined therapy for cancer treatment. By means of RNA sequencing, the cancer therapeutic mechanism of SDT in redox-related pathways was elucidated. The immunosuppressive TME was simulated with a M2-macrophage/cancer cell co-culture system to confirm the immune activating effect of immunogenic cell death (ICD). Conclusion Accordingly, the potential of QD@Ca/M L- Arg- was demonstrated for in vitro TME modulation, cancer therapeutic efficacy and clinical translation.
研究领域:
癌症治疗
·
纳米技术
·
生物医学工程
·
分子生物学
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免疫学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
危险品化学品经营许可证（带存储）