PEST MANAGEMENT SCIENCE
·
2026
·
IF 4.2
Jia Lin,Wensha Ding,Yuling Liang,Guoqing Yue,Jun Chen,Yunbo Song,Ying Li,Qinge Ji,Yongyue Lu
BACKGROUND Beta-cypermethrin (BC) and thiamethoxam (TH) are widely applied insecticides in cover spray programs targeting tephritid pests, yet their sublethal effects on Fopius arisanus , a major fruit fly parasitoid, remain largely unexplored. Therefore, we evaluated the impacts of BC and TH on the demographics, detoxifying enzymes, nutrients, and transcriptome of F. arisanus . RESULTS Our results demonstrated that both insecticides exerted profound adverse impacts on the fecundity, longevity, and oviposition period of F. arisanus adults. In the F 1 generation, exposure to LC 30 BC and TH significantly prolonged preadult duration, impaired preadult survival, and decreased fecundity, lifespan, APOP, R 0 , λ, and r. Nutritional analyses revealed a time-dependent depletion across all treatments, with all nutrients significantly diminished at 5 days post-exposure compared with the control. Concurrently, glutathione S-transferase (GST) and cytochrome P450 O -deethylation activities were markedly elevated under LC 30 treatment relative to the control throughout 1–3 days post-exposure. Carboxylesterase (CarE) activity was significantly increased following LC 30 BC exposure across all observation periods. In addition, lipid and carbohydrate levels were negatively correlated with CarE and GST activities at specific time points, indicating that the maintenance of detoxification occurred at the expense of nutrients. Regarding the transcriptome, 562 and 190 DEGs were identified in the BC versus control and TH versus control comparisons, respectively, with KEGG enrichment highlighting shared pathways in xenobiotic metabolism, including P450 and other enzymes. CONCLUSION These results demonstrate that sublethal BC and TH compromises the fitness and ecological function of F. arisanus , underscoring the need for environmentally compatible pest management strategies. © 2026 Society of Chemical Industry.
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高影响因子
BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY
·
2020
·Vol. 84
·期 12
·2491-2498
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IF 1.516
Liang Haohui,Pan Yanna,Teng Yilong,Yuan Shilin,Wu Xiao,Yang Hongjie,Zhou Ping
The pancreatic β-cell death or dysfunction induced by oxidative stress plays an important effect on the development and progression of diabetes mellitus. Based on our previous findings, a natural proteoglycan extracted from Ganoderma Lucidum, named FYGL, could treat T2DM in vivo. In this study, we investigated the effects of FYGL on STZ‐induced apoptosis of INS-1 cells and its underlying mechanisms. The results showed that FYGL significantly improved the cell viability and alleviated the apoptosis in STZ‐treated INS‐1 cells. Moreover, FYGL markedly decreased the intracellular ROS accumulation and NO release, and deactivated NF-κB, JNK, and p38 MAPK signaling pathways in STZ-induced INS-1 cells. Furthermore, FYGL improved the insulin secretion through inhibiting the activation of JNK and improving the expression of Pdx-1 in INS-1 cells damaged by STZ. These results indicated that FYGL could protect pancreatic β-cells against apoptosis and dysfunction, and be used as a promising pharmacological medicine for diabetes management.Abbreviations: T2DM: type 2 diabetes mellitus; FYGL: Fudan-Yueyang G. lucidum; ROS: reactive oxygen species; NO: reactive oxygen species; NF-κB: nuclear factor kappa beta; JNK: c-jun N-terminal kinase; MAPK: mitogen-activated protein kinase; Pdx-1: Pancreatic duodenal homeobox 1
研究领域:
药理学
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糖尿病
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细胞生物学
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分子生物学
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高影响因子
POWDER TECHNOLOGY
·
2020
·
IF 4.142
Yu Zhang,Qian Shao,Chunyu Chen,Heyun Jiang,Fengmei Su,Qian Hu,Zhanhu Guo
Facile microwave-hydrothermal method was successfully used to synthesize Beta-bismuth (III) oxide (β-Bi 2 O 3 ) nanopowders under the low calcination temperature (350 °C) with a demonstrated diameter of about 40–200 nm. UV–vis diffuse reflection spectroscopy revealed that the resulting β-Bi 2 O 3 nanopowders exhibited a broad absorption with a low band gap of about 2.64–2.85 eV. When the reaction temperature of microwave-hydrothermal process was 180 °C (the sample is named as 180 MH), an optimal methyl orange (MO) degradation efficiency of 95.0% was achieved after visible light irradiation of 120 min. β-Bi 2 O 3 nanopowders also had a strong degradation effect on the tetracycline (TC). Kinetic studies indicated that the photocatalytic degradation process of MO and TC could be well fitted to the pseudo-first-order kinetics. The mechanisms for the enhanced photocatalytic degradation were disclosed as well, and the h + and O 2 •- were dominating radicals for MO degradation. This paper provides a way to synthesize nanostructural materials for wide applications.
研究领域:
材料科学
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环境科学
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高影响因子
RSC Advances
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2020
·Vol. 10
·期 39
·22966-22971
·
IF 3.119
Ling Xiao,Dehui Chi,Guiju Sheng,Wenjuan Li,Penghui Lin,Sicheng Liang,Liangliang Zhu,Peipei Dong
UDP-glucuronosyltransferases (UGTs) and β-glucuronidase (GUS) catalyze entirely distinct metabolism reactions. UGTs are responsible for the glucuronidation of a variety of drugs, endogenous and environmental chemicals, whereas GUS hydrolyzes glucuronides and liberates the parent substrates. Information on the overlap of ligand selectivity between UGT and GUS is essential for exploring the pharmacological or toxicological effects of the inhibitors of these two metabolic enzymes. This study is conducted to test whether UGTs and GUS share common ligands, by investigating the inhibitory effects towards E. coli GUS by a series of UGT typical substrates and inhibitors. Results showed that three typical ligands of UGTs, including two specific substrates (estradiol and trifluoperazine, E2 and TFP) and one selective inhibitor (magnolol, Mag), can inhibit the activity of GUS. Kinetic assays indicated that all the three UGT specific chemicals displayed competitive inhibition, with Ki values of 31.4 (E2), 56.9 (TFP), and 16.6 μM (Mag). Docking studies further revealed that the three chemicals can enter the active sites of GUS by forming contacts with residues Glu-413, Trp-549, Asp-163, Tyr-472, Arg-562, or bound water. Our study indicates that ligand selectivity overlaps between UGTs and GUS, and some chemicals can act as co-inhibitors of these two metabolic enzymes. The pharmacological or toxicological effects of those co-inhibitors require further investigations.
研究领域:
药理学
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生物化学
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毒理学
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高影响因子
COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
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2019
·
IF 3.131
Lanxiang Ma,Dongwen Pang,Chunlin Deng
The competitive and cooperative adsorptions of proteins on the surface of implanted materials can affect the biocompatibility and osteogenesis of the material. The adsorption processes are related to the properties of the materials, as well as to the nature of the proteins. Competitive adsorption of bovine serum albumin (BSA) and lysozyme (LSZ), both sequentially, and from a mixture, was investigated on a beta-tricalcium phosphate (β-TCP) nanocoating using quartz crystal microbalance with dissipation technique. In experiments with individual proteins, the BSA adlayer showed higher adsorption quality and viscoelasticity than the LSZ on the β-TCP surface. In the sequential adsorption of LSZ + BSA, protein exchange was observed but not in the BSA + LSZ sequence, because of the larger molecular and higher surface affinity of BSA relative to LSZ. The substitution rate increased as the increasing concentration of the BSA solution. With a BSA&LSZ mixture, the total amount of protein adsorbed was greater than that for individual or sequential adsorption, owing to the formation of BSA and LSZ agglomerates. The electrostatic force and affinity were dominant factors governing the adsorption behavior between BSZ and LSZ on the β-TCP surface. This work will be beneficial to understand the protein adsorption mechanism on β-TCP surface and provide information to design better osteogenic materials.
研究领域:
生物材料学
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分子生物学
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高影响因子
Scientific Reports
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2015
·Vol. 5
·期 1
·1-10
·
IF 5.578
Tong Mingquan,Zhang Daliang,Fan Weibin,Xu Jun,Zhu Liangkui,Guo Wen,Yan Wenfu,Yu Jihong,Qiu Shilun,Wang Jianguo,Deng Feng,Xu Ruren
Chiral zeolitic materials with intrinsically chiral frameworks are highly desired because they can combine both shape selectivity and enantioselectivity. In the field of zeolite, the synthesis of chiral polymorph A of zeolite Beta or chiral polymorph A-enriched zeolite Beta is one of the biggest challenges. We demonstrate here a generalized extremely concentrated fluoride route for the synthesis of chiral polymorph A-enriched zeolite Beta in the presence of five achiral organic structure-directing agents. The polymorph A-enriched Ti-Beta shows a higher enantioselectivity for the asymmetric epoxidation of alkenes than the normal Ti-Beta.
研究领域:
材料科学
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催化化学
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PubMed
高影响因子
BIOCONTROL
·
2021
·Vol. 67
·期 1
·1-13
·
IF 3.571
Zhang Hao,Wang Jin-Yan,Chen Yi-Juan,Siemann Evan,Ji Xiang-Yun,Jiang Jie-Xian,Wan Nian-Feng
The effects of plant volatiles on parasitoids are important with regards to the tri-trophic interactions among host plants, insect herbivores, and their natural enemies. However, the effects of plant volatiles on the important parasitoid ( Microplitis pallidipes Szépligeti; Hymenoptera: Braconidae) of noctuids have not been determined at the molecular, laboratory, and outdoor scales with complementary approaches. The odorant binding protein 8 of M. pallidipes (MpOBP8) with an open reading frame of 459 bp was cloned and successfully expressed in Escherichia coli (Eubacteriales: Enterobacteriaceae). The purified protein MpOBP8 had a relatively high binding capacity to the plant volatile β- ionone (Ki value was 28.86 μM) in the fluorescence competitive binding assay. Meanwhile, Y-tube olfactometer experiments indicated that β- ionone selectively attracts the parasitic wasp as the ratio of M. pallidipes selecting β- ionone vs. control was 2:1. Likewise, field screenhouse experiments verified the above results as the ratio of M. pallidipes selecting β- ionone vs. control was close to 2:1. This study suggested that β- ionone is a plant volatile that attracts the parasitoid M. pallidipes , and MpOBP8 may play a key role in the discrimination of M. pallidipes in searching for hosts via β- ionone. In general our results suggest that β- ionone has the potential to enhance the biocontrol effect of parasitoids on insect herbivores.
研究领域:
昆虫学
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分子生物学
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生态学
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农业科学
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高影响因子
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
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2023
·
IF 4.4
Jiaxin Liu,Keke Ning,Yao Fu,Yujie Sun,Jiangong Liang
N-acetyl-beta-D-glucosaminidase (NAG) is an important biomarker for early clinical diagnosis of renal disease, suggesting the necessity to develop a fast and sensitive method for its detection. In this paper, we developed a fluorescent sensor based on polyethylene glycol (4 0 0) (PEG-400)-modified and H 2 O 2 -assisted etched sulfur quantum dots (SQDs). According to the fluorescence inner filter effect (IFE), the fluorescence of SQDs can be quenched by the p-nitrophenol (PNP) generated by NAG-catalyzed hydrolysis of p-Nitrophenyl-N-acetyl-β-D-glucosaminide (PNP-NAG). We successfully used the SQDs as a nano-fluorescent probe to detect the NAG activity from 0.4 to 7.5 U·L −1 , with a detection limit of 0.1 U·L −1 . Furthermore, the method is highly selective and was successfully used in the detection of NAG activity in bovine serum samples, suggesting its great application prospect in clinical detection.
研究领域:
生物化学
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医学检测
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纳米技术
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高影响因子
MICROPOROUS AND MESOPOROUS MATERIALS
·
2025
·
IF 4.7
Zhiping Wang,Rui Zhu,Jiejie Ling,Han Jiang,Lei Liu,Yan Gao,Hailang Liu,Le Xu
Zeolite Beta, discovered in 1967, features a unique three-dimensional (3D) 12-ring channel system and a highly tunable Si/Al ratio (SAR), granting exceptional stability and acidity crucial for catalysis. While conventional hydrothermal synthesis normally yields zeolite Beta with the SAR range of 10–30 using tetraethylammonium hydroxide (TEAOH) as the organic structure-directing agent (OSDA), the discovery of Al-rich natural mineral (Tschernichite) with the ∗BEA topology (SAR∼3.3) spurred efforts to synthesize low-SAR Beta zeolite for enhanced acid site density, hydrophilicity and ion-exchange capacity, enabling applications like dehydration, separation and shape-selective catalysis. However, achieving low SARs for the hydrothermal crystallization of zeolite Beta is still challenging, requiring excess Na + which promotes impurity phases (e.g., GIS , ANA , MOR ), prolongs crystallization period and reduces yield. Inspired by our recent work on the kinetic-control synthesis of high-silica NaY zeolite using aluminophosphate as the aluminum carrier, this study presents an accelerated, impurity-free synthetic route to achieve Al-rich zeolite Beta. Using the pre-synthesized aluminophosphate (e.g., AlPO-5) as a partial Al source favors the formation of a silica-rich Beta zeolite nucleus, thus effectively suppresses impurities (eliminating GIS phase in Na + -containing system) and amorphous phase (in Na + -free system), ultimately accelerating crystallization process. Based on this synthetic control, this study successfully synthesized the phase-pure Beta zeolite at SAR of 7.55 (Na + -free) and 6.58 (Na + -containing), while this strategy was extended to the Beta zeolite synthesis with other aluminophosphate, including SSZ-51 ( SFO) and AlPO-18 ( AEI) .
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INDUSTRIAL & ENGINEERING CHEMISTRY RESEARCH
·
2019
·
IF 3.375
Xue Wang,Jing Zeng,Xingmei Lu,Jiayu Xin,Suojiang Zhang
Butene plays an essential role in the area of petrochemical industry. The production of butene from the biomass-derived platform molecule γ-valerolactone (GVL) is of great interest. GVL decarboxylation reaction occurred under high temperature because the catalytic activity of the catalysts used before was not efficient for this reaction. In this work, beta zeolite with Si:Al = 5 was synthesized and used for GVL decarboxylation. It exhibited a higher catalytic performance than other commercial zeolites due to a large number of Lewis acid sites and relatively large micropore size. At 300 °C, 99.5% GVL conversion and 98% butene yield were obtained after condition optimizing. For further research, the influence of the Brønsted/Lewis acid ratio was investigated, and it turned out that Lewis acid was more active than Brønsted acid in crystalline material on GVL decarboxylation for the first time.
研究领域:
石油化工
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催化
·
绿色化学
·
可再生能源
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高影响因子
LUMINESCENCE
·
2015
·Vol. 30
·期 7
·1071-1076
·
IF 1.518
Lining Sun,Yannan Qiu,Tao Liu,Jing Feng,Wei Deng,Liyi Shi
We used the synthesized dinaphthylmethane (Hdnm) ligand whose absorption extends to the visible-light wavelength, to prepare a family of ternary lanthanide complexes, named as [Ln(dnm) 3 phen] (Ln = Sm, Nd, Yb, Er, Tm, Pr). The properties of these complexes were investigated by Fourier transform infrared (FT-IR) spectroscopy, diffuse reflectance (DR) spectroscopy, thermogravimetric analyses, and excitation and emission spectroscopy. Generally, excitation with visible light is much more advantageous than UV excitation. Importantly, upon excitation with visible light (401–460 nm), the complexes show characteristic visible (Sm 3+ ) as well as near-infrared (Sm 3+ , Nd 3+ , Yb 3+ , Er 3+ , Tm 3+ , Pr 3+ ) luminescence of the corresponding lanthanide ions, attributed to the energy transfer from the ligands to the lanthanide ions, an antenna effect. Now, using these near-infrared luminescent lanthanide complexes, the luminescent spectral region from 800 to 1650 nm, can be covered completely, which is of particular interest for biomedical imaging applications, laser systems, and optical amplification applications. Copyright © 2015 John Wiley & Sons, Ltd.
研究领域:
材料科学
·
无机化学
·
光物理
·
光学材料
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生物医学成像
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激光技术
·
光放大
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高影响因子
MEDICAL SCIENCE MONITOR
·
2018
·
IF 1.894
Zeng Li,Xiao-chang Liu,Rui Li,Jun Chang
Background Beta-secretase 1 (BACE1) is a rate-limiting enzyme in the generation of amyloid beta peptides, which are associated with Alzheimer’s disease (AD). It has been reported that Schisandrin B could improve cognitive functions in animal models of AD, but the underlying mechanisms are not completely understood. Material/Methods In this research, in order to investigate the effects of Schisandrin B on amyloid-β (Aβ) metabolism and its mechanisms, amyloid precursor protein (APP) and its proteolytic products were determined by enzyme-linked immunosorbent assay (ELISA), western blotting, and RT-PCR after incubation of N2a/Swe cells with Schisandrin B. Results The results indicated that Schisandrin B can significantly reduce the level of secretion of Aβ 40 and Aβ 42 secreted in N2a/Swe cells. Additionally, there was nonsignificant change in APP level after Schisandrin B treatment. Treatment of Schisandrin B dramatically reduced the mRNA and protein expression levels of BACE1. Moreover, Schisandrin B treatment resulted in a reduction of protein level of sAPPβ, an APP fragment cleavage by BACE1. Conclusions These results suggest that Schisandrin B inhibits the transcription and translation of BACE1, suppresses the activity of BACE1, and ultimately attenuates Aβ generation, which provides a novel mechanism for the regulation of Aβ metabolism by Schisandrin B.
研究领域:
神经生物学
·
分子药理学
·
神经退行性疾病研究
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药物代谢
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生物化学
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PubMed
高影响因子
危险品化学品经营许可证（带存储）