JOURNAL OF CHEMICAL AND ENGINEERING DATA
·
2024
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IF 2
Jie Li,Huan Zhou,Jie Yang,Cunbing Xu,Sifan Wang,Yifan Li,Jiangbo Chen
The solid–liquid phase equilibria of the Li+, Na+, Ca2+//Cl––H2O quaternary system at 298.15 and 323.15 K are studied via the isothermal solubility phase equilibrium method. The solubility data and liquid properties of density and pH are obtained. The phase diagrams of the quaternary systems, including the water free diagram, the water diagram, and the dry salt diagram, are plotted to show the phase regions, water content, and salting-in effect. NaCl occupies the largest phase region at both 298.15 and 323.15 K. One double salt LiCl·CaCl2·5H2O occurs at 298.15 K and builds up two invariant points; one incommensurate invariant point saturated by (NaCl, LiCl·H2O, LiCl·CaCl2·5H2O) and one commensurate invariant point saturated by (NaCl, CaCl2·4H2O, LiCl·CaCl2·5H2O), but at 323.15 K, no double salt forms. The salting-in effect that happened in ternary systems still occurs in the quaternary Li+, Na+, Ca2+// Cl––H2O system at both temperatures. NaCl saturated concentration increases with LiCl and CaCl2 contents and results in a very high total salt content at commensurate invariant points, e.g., they are 56.92 and 60.62% at 298.15 and 323.15 K, respectively.
研究领域:
化学
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物理化学
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DOI
高影响因子
FOOD CONTROL
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2025
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IF 6.3
Junping Liu,Yuhao Huang,Xing Lu,Wenzhi Yu,Kaibo Yu,Shengfeng Peng,Lei Zhou,Wei Liu
Pot-stewed duck neck (PSDN) is a popular leisure food in China. However, PSDN is rich in nutrients and has high water activity, which can easily cause the oxidation of fat and protein, and microbial growth, resulting in a short shelf life. As a potential preservative, plant essential oils have restricted application due to their poor water solubility, effumability, and easy oxidizability. In this study, the porous starch that had absorbed cinnamon and zanthoxylum essential oils (EOs) was encapsulated by electrostatic adsorption between chitosan and sodium alginate, and solid preservative (SP) was further formed by crosslinking of Ca 2+ with sodium alginate. Results showed that SP exhibited good encapsulation property and sustained-release effect on EOs. Cinnamon EO showed antibacterial properties and the main component was cinnamaldehyde. Antioxidant property was observed in zanthoxylum EO and the main components were linalool and D-limonene. Subsequently, SP was used to preserve PSDN and stored in modified atmosphere packaging (MAP). Results showed that the SP-MAP treatment provided at least double-time extension of the PSDN shelf life for 3 and 11 days at 25 and 4 ○ C, respectively. The lower values of volatile base nitrogen and thiobarbituric acid indicated that the lipid oxidation of PSDN was delayed. Besides, microbial growth of PSDN with SP-MAP was inhibited with the lowest total viable and fungal counts, and the results of incubation and enumeration of pathogenic bacteria in PSDN samples indicated that Escherichia coli , Bacillus subtilis and Staphylococcus aureus were effectively inhibited during the storage time. Therefore, solidifying essential oils combined with MAP was a promising method to preserve pot-stewed meat products.
研究领域:
食品科学
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生物技术
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DOI
高影响因子
Physiological Reports
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2026
·Vol. 14
·期 11
·e70975
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IF 2.1
Yunxian Wang,Fenglan Chu,Yanhua Gong,Ruihong Guo,Hui Dong
Despite the ubiquitous use of monosodium glutamate (MSG) as a food additive, its specific effects on intestinal health and disease remain largely unclear. Here we found mucosal application of MSG induced an upward intestinal short-circuit current ( I sc ) in the murine ileum, which was significantly reduced by extracellular Cl − , Na + , and Ca 2+ removal. Mechanistically, MSG-induced I sc was significantly attenuated by pharmacological inhibition of key transporters (NCX, SGLT1, NKA) and secretory channels (CaCC, CFTR, IK Ca ). Furthermore, disrupting intracellular Ca 2+ homeostasis via endoplasmic reticulum (ER) chelation or blockade of IP 3 R, RyR, SOCE/CRAC, and VGCC significantly suppressed both the ileal I sc and MSG-stimulated Ca 2+ signaling in IECs. Importantly, MSG triggered a simultaneous elevation in intracellular Ca 2+ and a reduction in Na + , which were abolished by the blockers of NCX and SGLT1. In vivo, MSG-induced Ca 2+ -dependent ion transports were significantly reduced in irritable bowel syndrome with diarrhea (IBS-D) mice. Our findings indicate that MSG drives Ca 2+ -dependent intestinal ion transports through a complex network orchestrated by SGLT1 and NCX under healthy state, which is markedly attenuated in IBS-D. This study provides novel insights into the gastrointestinal impact of dietary MSG in both health and bowel disease.
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DOI
PubMed
高影响因子
Journal of Advanced Research
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2026
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IF 17.1
Yi Wang,Laiming Zhang,Jiaxiong Wu,Ziyang Deng,Yunxuan Li,Xingqian Ye,Haibo Pan,Shiguo Chen
Introduction Phenolic compounds are regarded as promising α-glucosidase inhibitors for regulating postprandial blood glucose, but their α-glucosidase inhibitory activity in vivo is much lower than that in vitro . The small intestinal mucus layer serves as a barrier that impedes the binding of phenolic compounds to α-glucosidase, thereby attenuating their activity in vivo , yet the solution to this bottleneck remains unclear. Objectives Selecting prodelphinidin B digallate (proDB DG) as a representative phenolic compound, this study aimed to enhance its in vivo α-glucosidase inhibitory activity by screening the compound that can pre-regulate the barrier properties of the mucus layer. Methods The Caco-2/HT29-MTX-E12 co-culture model was used to screen the compound that can enhance the α-glucosidase inhibitory activity of proDB DG in vivo . This enhanced mechanism was analyzed using ultraviolet–visible light spectroscopy, zeta potential, rheological behavior, transmission electron microscopy, molecular dynamics simulation and Transwell mucus diffusion model. The improved α-glucosidase inhibitory activity and its biosafety were further confirmed by animal experiments. Moreover, the screened compound and proDB DG based tablets were developed. Results Ca 2+ improved the activity of proDB DG in lowering postprandial hyperglycemia in vivo . This enhancement of activity is attributed to its pre-regulation on the barrier properties of the mucus layer. Specifically, Ca 2+ -derived mucin aggregation increased the porosity and diffusivity of the mucus layer, thereby improving the permeability of proDB DG and facilitating its binding to α‑glucosidase. Ca 2+ also competitively bound with the mucus layer, and weakened the interaction between proDB DG and mucins. Furthermore, Ca 2+ –proDB DG based tablets possessed significant hypoglycemic effect and biosafety in vivo . Conclusion Ca 2+ regulates the barrier properties of the mucus layer, thereby promoting proDB DG to reach the mucosa quickly and then interact with α-glucosidase effectively, which may break the application limitations of proDB DG and even phenolic compounds as α-glucosidase inhibitors clinically.
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DOI
PubMed
高影响因子
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
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2025
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IF 8.5
Lingyu Han,Nuo Dong,Jixin Yang,Bing Hu
The present study investigated the impact of Ca 2+ regulated sodium alginate gelation on buckwheat noodle digestion, as well as its physiological and biochemical effects on rat. An endogenous method was employed for noodle preparation, and the rate of starch hydrolysis was evaluated. Buckwheat noodles prepared using this approach exhibited significantly reduced rates of starch digestion compared to conventional methods. Increased concentrations of sodium alginate and Ca 2+ led to the formation of dense gel networks that promoted weight gain in diabetic rats while simultaneously lowering postprandial blood glucose levels and improving glucose intolerance and abnormal insulin tolerance. Moreover, these gel networks enhanced liver glycogen synthesis by increasing SOD and CAT activities while reducing the levels of ALT and MDA, thereby mitigating morphological damage in the liver. Buckwheat noodles prepared using this endogenous method were found to potentially exhibit hypoglycemic effects and mitigate complications associated with type 2 diabetes.
研究领域:
食品科学
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营养学
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生物化学
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DOI
PubMed
高影响因子
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
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2025
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IF 8.5
Cheng Wang,Hao Yu,QiHang Bu,ZiHan Wang,Ning Jiang,JiaoYang Chen,RongXue Sun,QianYuan Liu,JianHua Xu,JiaJun Fu
Given the environmental challenges caused by petroleum-based plastics, this study developed a novel green carboxymethyl chitosan (CMCS)-based active packaging composite film (CP) through a synergistic strategy of precise Ca 2+ coordination cross-linking and small-molecule plasticizing. Based on this strategy, the CP-4.5 film (CaCl 2 : 7 wt%, DL-3-phenyllactic acid (3-PLA): 4.5 wt%) exhibited exceptional mechanical properties, including high flexibility (Young's modulus: 0.747 GPa; elongation at break: 65.2 %) and high toughness (18.4 MJ m −3 ). The incorporation of CaCl 2 not only occupied voids within the CP film but also increased the physical cross-linking strength and density of the polymer network. This structural reorganization impeded the diffusion of O 2 and H 2 O molecules, reducing oxygen permeability by 85.9 % and water vapor permeability by 57.6 %. Additionally, 3-PLA, functioning as a broad-spectrum antibacterial agent, imparted the CP film with superior antibacterial activity. The CP film exhibited recyclability and repairability, and underwent complete biodegradation within 56 days. Overall, the synergistic effect of CaCl 2 and 3-PLA endowed the CP film with superior mechanical properties, barrier properties, antimicrobial activity, and environmental sustainability, effectively mitigating the quality deterioration of refrigerated grass carp fillets during storage, demonstrating the promising potential of the CP film for food packaging applications.
研究领域:
材料科学
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食品科学
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环境科学
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DOI
PubMed
高影响因子
Acta Pharmaceutica Sinica B
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2025
·
IF 14.6
Qian Jing,Mengnan Zhao,Yan Tang,Tao Chen,Mingyan Sun,Dandan Mi,Lan Zou,Rujing Wang,Jun Lu,Sanjun Shi
Interference with calcium homeostasis provokes tumor cell death and immune response, providing a novel direction for tumor immunotherapy as a promising cancer treatment strategy. Nevertheless, most reported Ca 2+ -overloaded nanoinducers encounter challenges such as intricate preparation procedures, safety concerns arising from inorganic material input, and limited anti-tumor efficiency. Herein, we synthesized a biocompatible and pH-sensitive Ca-doped cyclodextrin metal-organic framework (Ca/K-MOF) as a carrier, which was then loaded with photosensitizer hypericin (HY) via a simple one-pot synthesis to form HY@Ca/K-MOF. To enhance the stability both in vitro and in vivo , we coated HY@Ca/K-MOF with a hydrophilic layer of PEG ( PEG HY@Ca/K-MOF). When exposed to 590 nm photoirradiation, PEG HY@Ca/K-MOF, with its pH-responsive dissociation, the Ca 2+ and HY mediators released at the tumor site share the responsibility of triggering intracellular Ca 2+ disturbances, which amplified the production of reactive oxygen species (ROS) and led to mitochondrial calcium overload through modulating mitochondrial MICU1 function. Under photocontrol, this interplay between ROS generation and mitochondrial calcium overload created a bidirectional amplification effect, where each process reinforced the other, subsequently eliciting a pyroptosis-evoked immune response. Significantly, this newly constructed delivery platform effectively suppressed both primary and distant tumors without the need for additional immunological interventions. In summary, this Ca 2+ -doped MOF-based nanomaterial provides a promising approach for efficient tumor photo-controlled mitochondrial Ca 2+ overload-pyroptosis immunotherapy.
研究领域:
纳米医学
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癌症免疫治疗
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生物无机化学
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光动力治疗
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分子生物学
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药物递送系统
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DOI
PubMed
高影响因子
ACS Applied Materials & Interfaces
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2025
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IF 8.2
Benyan Zheng,Hongjie Zhang,Gaoyuan Yu,Rui Geng,Yanxiang Sang,Guimin Huang,Xuechun Wang,Jing Wang,Yuan Hu,Xiaopeng Ma
Nanozyme-mediated nanocatalytic therapy, by mimicking the activity of redox enzymes, generates highly toxic reactive oxygen species (ROS) within tumor cells, thereby opening a pathway for tumor-specific therapy. However, achieving satisfactory therapeutic outcomes with nanozymes remains challenging due to the inherent complexity of the tumor microenvironment (TME). In this context, we designed a two-dimensional layered double hydroxide (LDH) nanozyme loaded with Au nanoparticles, while incorporating bioactive Ca2+ and Fe3+ ions (denoted as MgCaFe-LDH@Au NSs) to target the specific needs of the TME. The designed nanozyme mimics glucose oxidase to facilitate self-sufficient H2O2 production and simulates catalase and glutathione peroxidase to overcome the adverse conditions of hypoxia and elevated GSH levels in the TME. Subsequently, the nanozyme emulates peroxidase activity to generate ROS, amplifying oxidative stress and causing redox imbalance, ultimately inducing ferroptosis in tumor cells. Moreover, MgCaFe-LDH@Au NSs also function as an inorganic semiconductor sonosensitizer with a tunable band structure, enabling the generation of abundant ROS under ultrasound irradiation to achieve synergistic sonodynamic and catalytic therapy. Notably, the high levels of ROS induced by the nanozyme, along with the interference in tumor ATP synthesis, enhanced the calcium overload in the TME caused by the release of Ca2+ from the nanozyme. In summary, this two-dimensional nanomaterial, through nanozyme and ultrasound-catalyzed synergistic disruption of tumor energy supply and redox balance, exhibited significant therapeutic efficacy in a 4T1 tumor-bearing mouse model. This study also highlights the immense potential of multimetal LDHs as inducers of calcium overload and ferroptosis in tumor therapy.
研究领域:
生物医学工程
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肿瘤学
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纳米医学
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DOI
PubMed
高影响因子
Small Science
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2025
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IF 8.3
Jingyan Huang,Dongheng Lu,Cairong Xiao,Jiezhong Guan,Xiaoshuang Wang,Changhao Li,Peng Yu,Yan Wang
Increasing studies have emphasized the role of implant surface modifications in enhancing osseointegration through the synergistic regulation of osteogenesis and angiogenesis. While both topography and electrical cues have been shown to promote these processes, the interplay between these biophysical characteristics and their combined effects remain unclear. This study employs polarized BaTiO 3 nanorod arrays (NBTP) on titanium surfaces as model substrates to engineer a mechanobiological and piezoelectric microenvironment. Nanotopography improves hydrophilicity, piezoelectric properties, and surface potential due to sharp reduction in Young's modulus. In vitro experiments reveal that topography-mediated mechanobiological remodeling primarily enhances osteogenesis in mesenchymal stem cells (MSCs) and angiogenesis in endothelial cells (ECs) via Piezo2/Piezo1/Ca 2+ signaling. The augmented electric field further amplifies this mechanical stress-driven osteogenic/angiogenic response by activating Ca v1.2 and potentiating Piezo2/Piezo1 signaling. Microarray analysis and blocking experiments identify the PI3K/AKT/mTOR/GSK3β pathway as a key mediator. Together, topography and the built-in electric field activate paracrine crosstalk between MSCs and ECs, indirectly enhancing osteogenesis and angiogenesis. In vivo studies confirm that nanorod topography significantly improves vascularized osseointegration, while the built-in electric field accelerates bone healing by remodeling the peri-implant microenvironment. These findings advance the design of high-performance bone implants by elucidating the mechanobiological–piezoelectric coupling mechanism underlying vascularized osteogenesis.
研究领域:
生物材料
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生物医学工程
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细胞生物学
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力学生物学
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组织工程
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信号转导
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纳米技术
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产品关联
DOI
PubMed
高影响因子
JOURNAL OF APPLIED POLYMER SCIENCE
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2025
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IF 2.8
Weihang Zhang,Shiyun Lin,Youlu Hua,Yanfa Mao,Qihang Xv,Jian Zhou,Deqiang You,Sheng Cao,Xiaojian Wang
Conventional ureteral stents frequently cause mucosal damage during placement due to surface hydrophobicity and elevated friction coefficients. Additionally, post-insertion complications such as bacterial adhesion and calculus deposition pose significant clinical risks. To address these challenges, we developed a polyacrylamide/sodium alginate-Ca 2+ (PAAm/SA-Ca 2+ ) dual-network hydrogel as a functional coating for ureteral stents. By modulating calcium chloride (CaCl 2 ) concentration, we optimized the PAAm/SA-Ca 2+ dual-network hydrogel's cross-linking density, resulting in enhanced hydrophilicity, reduced swelling ratio (from 48.5% to 17.3%), and a lower coefficient of friction (COF) (from 0.19 to 0.06). The hydrogel coating exhibited excellent stability and sustained lubricity with a uniform thickness of approximately 16 μm. Notably, the coating reduced calculus deposition by 74% over a 7-day period and demonstrated exceptional antibacterial efficacy, achieving 97% inhibition against Escherichia coli ( E. coli ) and 98% against Staphylococcus aureus ( S. aureus ). Furthermore, the coating displayed favorable hemocompatibility. These findings highlight the potential of PAAm/SA-Ca 2+ dual-network hydrogel coatings for improving ureteral stent performance.
研究领域:
生物医学工程
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材料科学
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泌尿外科学
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生物材料
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表面工程
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DOI
高影响因子
CHEMICAL ENGINEERING JOURNAL
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2026
·
IF 13.2
Haiyan Yang,Wenbo Han,Chun Shi,Dongtian Miao,Dawei Wang,Zhengjun Shi,Jing Yang,Jingjie Shen
Conventional conductive hydrogels face persistent sustainability challenges including energy-intensive fabrication processes, poor subzero temperature tolerance, and rapid dehydration under ambient conditions, contributing to electronic waste accumulation. To address these limitations, we developed an eco-friendly CaTPD hydrogel through rapid room-temperature polymerization initiated by a tannic acid-Ca 2+ complex, eliminating external energy requirements. The synthesis incorporates renewable biomass resources - dialdehyde cellulose derived from sustainable cellulose sources and plant-derived tannic acid - aligning with green chemistry principles. Structural characterization confirmed the formation of a porous network with coordinated complexes, yielding exceptional mechanical properties including 153 kPa tensile strength, 1423.1% fracture elongation, and 988.9 kJ/m 3 toughness. The incorporated calcium chloride imparted remarkable environmental stability, maintaining complete flexibility at −80 °C and preserving 81.5% of initial mass after 15 days at ambient conditions. The hydrogel demonstrated repeatable adhesion to diverse substrates (up to 32.3 kPa to wood) through multiple interfacial interactions. As a strain sensor, it achieved broad detection range (0–400% strain) with tunable sensitivity (gauge factor 1.63–16.87) and maintained signal stability over 3000 cycles. Practical applications were demonstrated through reliable monitoring of human motions ranging from large-scale joint movements to subtle swallowing actions. This work establishes a sustainable paradigm for flexible electronics by integrating biomass-derived materials with energy-efficient manufacturing, offering a viable solution to reduce energy consumption and electronic waste in sensor production while maintaining high performance under extreme conditions, ultimately contributing to cleaner production in the electronics industry.
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高影响因子
ACS Applied Engineering Materials
·
2023
·
IF 0
Yu-cheng Zhang,Ya-qi Xue,Takayo Ogawa,Satoshi Wada,Jin-Ye Wang
Manufacturing biocompatible materials with higher-order structure has great significance because they can mimic the extracellular medium of the human organism and are a novel strategy for tissue regeneration. In this study, a device with stiffness-gradient characteristics based on two biocompatible materials, alginate with presolidification and photocurable acrylamide-containing supporting bath, was designed and constructed by the 3D printing technique. The presolidification can avoid rapid diffusion of alginate in aqueous solutions, improve mechanical properties without the introduction of heterogeneous gel precursor, and endow gradient stiffness by the controlled diffusion of calcium ions. Besides, a photocurable supporting bath was combined to manufacture a device with a dual-gradient structure by a 4-step procedure, including 3D printing, removal of the inner hydrogel, solidification of alginate, and curing of the supporting bath. A cylinder-like container was manufactured as the template, and the wall of the resultant container with two types of gradient structures showed parabola-like stiffness changes (open upward), resulting from calcium ion diffusion-controlled gradient solidification and alginate diffusion-controlled gradient photocuring. Moreover, the resultant device exhibited lower cytotoxicity to both adherent and suspension cells than containers manufactured with alginate. Because of the high water uptake of the photocured supporting bath, the removal of toxic metabolic products together with cell culture medium from the container leads to better cell compatibility. This diffusion-controlled device is also applicable to other additive manufacturers with biomedical significance.
研究领域:
生物材料
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组织工程
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增材制造
·
细胞培养
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DOI
危险品化学品经营许可证（带存储）