Science Advances
·
2024
·Vol. 10
·期 15
·
IF 11.7
Kerong Chen,Anwei Zhou,Xinyuan Zhou,Jielei He,Yurui Xu,Xinghai Ning
Disruptions in metal balance can trigger a synergistic interplay of cuproptosis and ferroptosis, offering promising solutions to enduring challenges in oncology. Here, we have engineered a Cellular Trojan Horse, named MetaCell, which uses live neutrophils to stably internalize thermosensitive liposomal bimetallic Fe-Cu MOFs (Lip@Fe-Cu-MOFs). MetaCell can instigate cuproptosis and ferroptosis, thereby enhancing treatment efficacy. Mirroring the characteristics of neutrophils, MetaCell can evade the immune system and not only infiltrate tumors but also respond to inflammation by releasing therapeutic components, thereby surmounting traditional treatment barriers. Notably, Lip@Fe-Cu-MOFs demonstrate notable photothermal effects, inciting a targeted release of Fe-Cu-MOFs within cancer cells and amplifying the synergistic action of cuproptosis and ferroptosis. MetaCell has demonstrated promising treatment outcomes in tumor-bearing mice, effectively eliminating solid tumors and forestalling recurrence, leading to extended survival. This research provides great insights into the complex interplay between copper and iron homeostasis in malignancies, potentially paving the way for innovative approaches in cancer treatment.
研究领域:
肿瘤学
·
纳米技术
·
治疗学
·
生物医学工程
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DOI
PubMed
高影响因子
JOURNAL OF COLLOID AND INTERFACE SCIENCE
·
2022
·
IF 9.965
Xiaofeng Wang,Chengcheng Zhang,Zuyi Zhang,Yaoming Gai,Qingbo Li
The interface site between metal and support possess unique electronic and morphological structure, providing distinct active centers for favorable reaction in catalytic conversion of biomass derivatives to valuable chemicals. In this study, a series of Cu-Co/CeO x catalysts were prepared for hydrogenolysis of 5-hydroxymethylfurfural (HMF) to 2,5-dimethylfuran (DMF) via reduction of the corresponding layered double hydroxide precursors. The characterizations indicated the formation of CoCe-Vö interface (Vö denotes oxygen vacancy) and the effect of hydrogen spillover from Cu species to CoCe-Vö interface. Furthermore, the experiments and theoretical calculations verified that CoCe-Vö interface could activate the C O bond. The optimized catalyst showed a DMF yield of > 90% at 180 °C and 1.5 MPa H 2 with no deactivation in the cycling tests. This study reveals the interfacial effects of the nanocatalysts, including the oxygen vacancies and hydrogen spillover, on hydrogenolysis of HMF, which provided a simple and efficient approach for synthesis of high-performance non-noble metal nanocatalysts applied to the hydrogenolysis of various biomass derivatives.
研究领域:
催化化学
·
生物质转化
·
纳米材料科学
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DOI
高影响因子
JOURNAL OF MATERIALS SCIENCE-MATERIALS IN ELECTRONICS
·
2024
·Vol. 35
·期 17
·1-12
·
IF 2.8
Liu Yang,Yang Jingdong,Wen Jiaxin,Ye Junliu,Liu Huan,Lu Liwei
Recently, rechargeable magnesium-ion batteries (MIBs) and rechargeable magnesium/lithium hybrid-ion batteries (MLHBs) have gained recognition as promising energy storage devices. However, the conventional CuS cathodes exhibit sluggish kinetics and poor cycle stability, thereby impeding the advancement and application of CuS. In this work, we have developed an economical and simple in-situ approach for synthesizing CuS@Cu foam (CSC) and evaluated its potential as a cathode material for both MIBs and MLHIBs. In both MIBs and MLHIBs, the CSC cathode demonstrates competitive performance. In MIBs, at a current density of 100 mA g −1 , the initial discharge specific capacity of the CSC is 150.94 mAh g −1 , which is higher than that of commercial CuS (3.99 mAh g −1 ). In MLHIBs, the CSC exhibits a discharge specific capacity of 502.95 mAh g −1 after 70 cycles at a current density of 100 mA g −1 , which significantly surpasses the discharge specific capacity of commercial CuS (229.52 mAh g −1 ). This performance improvement is attributed to the presence of Li + ions, which expedite the reaction kinetics, obviate the need for an activation process, and effectively facilitate the conversion reaction. In conclusion, by in-situ synthesis of CSC, the active material CuS firmly adheres to the Cu foam current collector. This approach is not only economical and simple but also significantly enhances the reactivity of the electrode material, thereby improving the electrochemical performance. This work provides valuable insights for the design, synthesis, and performance optimization of cathode materials of magnesium metal-based batteries.
研究领域:
材料科学
·
电化学
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DOI
高影响因子
WASTE MANAGEMENT
·
2021
·
IF 7.145
Chengrui Guo,Xia Qin,Rui Guo,Yue Lv,Mingran Li,Ziyuan Wang,Tinghui Li
The heterogeneous Fenton-like process with bimetallic chelated magnetic chitosan aerogel (Cu-Fe@CTS) as catalyst was applied to treat pre-coagulated leachate nanofiltration concentrate. The process conditions were optimized by Box-Behnken Design (BBD) and the maximum UV 254 removal reached 96.06% under the conditions of temperature 87.62 °C, oxidant dosage 0.2395 mol/L and catalyst dosage 1 g/L. The TOC concentration was reduced from 847.5 to 99.7 mg/L and COD concentration was reduced from 1625 to 464 mg/L. The three-dimensional (3D) fluorescence analysis showed that most of Fulvic acid-like (FA-like) was removed. The adsorption experiment showed that the catalyst reached the adsorption balanced after 60 min and the corresponding FA adsorption removal reached 14.1%. The addition of Tert-butanol (TBA) reduced the FA removal by 59.4%, indicating that the hydroxyl radicals ( OH) was the main active species. Experiments of the OH capture at different pH showed that the Fenton-like system produced more OH at pH of 4, at which the maximum FA removal was 96.61%, while the FA removal still reached 94.26% at pH of 7. The OH capture at different temperature showed that the Fenton-like system produced more OH at 90 °C. KI and TBA shielding experiments showed that OH was produced on the catalyst surface rather than being produced by catalysis of free metal ions in the solution.
研究领域:
环境科学
·
催化化学
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DOI
高影响因子
INTERNATIONAL JOURNAL OF HYDROGEN ENERGY
·
2016
·Vol. 41
·期 22
·9611-9618
·
IF 3.205
Jinhua Xiao,Wenying Zhang,Chunyan Xiong,Bo Chi,Jian Pu,Li Jian
Spinel oxides with the general formula of MnCu x Co 2−x O 4 (x = 0.1, 0.3, 0.5, 0.7 respectively) are used as coating materials on the metallic interconnect SUS 430 alloy to reduce the cathodic performance degradation by Cr poisoning and the interfacial resistance to improve the surface stability. The effect of Cu doping at the B position of spinel on the electrical conductivity and coefficient of temperature expansion (CTE) is investigated to determine the oxidation behavior and effectiveness as a protective layer. The result confirms that MnCu 0.5 Co 1.5 O 4 spinel shows highest electrical conductivity of 105.46 S cm −1 at 750 °C in air and an average CTE value of 12.27 × 10 −6 K −1 at temperature range of 20–960 °C. MnCu 0.5 Co 1.5 O 4 coating is stable enough after 2000 h cyclic oxidation at 750 °C. The growth of Cr 2 O 3 and formation of MnCr 2 O 4 in the scale layer are effectively suppressed by the presence of MnCu 0.5 Co 1.5 O 4 coating. The oxidation kinetics obeys the parabolic law with a rate constant as low as 2.76 × 10 −15 g 2 cm −4 ·s −1 and the ASR contributed by the oxide scale is 8.04 mΩ cm 2 at 750 °C. The research indicates that MnCu 0.5 Co 1.5 O 4 is a promising coating material for metallic interconnects of the intermediate temperature solid oxide fuel cells .
研究领域:
材料科学
·
能源材料
·
固体氧化物燃料电池
·
表面工程
·
电化学
·
高温腐蚀
·
功能涂层
✓ 已验证
DOI
高影响因子
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
·
2021
·
IF 6.953
Ping Sun,Wei Zhang,Binze Zou,Lincheng Zhou,Zhengfang Ye,Quanlin Zhao
Attapulgite (ATP) has a unique porous layered chain structure and is an excellent environment-friendly decolorizer. However, its high viscosity makes it difficult to separate. First, it was combined with magnetic Fe 3 O 4 nanoparticles to obtain Fe 3 O 4 -ATP that is easy to recycle and reuse. Then, Fe 3 O 4 -ATP nanoparticles were embedded in chitosan (CS) gel beads, and glutaraldehyde was used for cross-linking and curing. Lastly, ethylenediaminetetraacetic acid (EDTA) was successfully connected to Fe 3 O 4 -ATP/CS gel beads through amidation reaction, which further increased the capability of the adsorbent to adsorb heavy metal ions. The prepared magnetic composite adsorbent is a sphere with a rough surface and porous structure. The maximum adsorption capacity of the prepared Fe 3 O 4 -ATP/EDTA/CS adsorbent for Pb(II), Cu(II), and Ni(II) is 368.32, 267.94, and 220.31 mg g −1 , respectively. After 5 times of repeated use, Fe 3 O 4 -ATP/EDTA/CS still showed good adsorption capacity for Cu(II), Pb(II), and Ni(II). Fe 3 O 4 -ATP/EDTA/CS has a large adsorption capacity for heavy metal ions, a wide pH applicability, good reuse, and rapid magnetic separation. In addition, Cu(II) loaded Fe 3 O 4 -ATP/EDTA/CS also showed good catalytic degradation performance for bisphenol A. This study prepared a new type of adsorbent with good adsorption performance and provided a promising method for the treatment of wastewater.
研究领域:
环境科学
·
材料科学
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DOI
高影响因子
IONICS
·
2021
·Vol. 27
·期 10
·4439-4448
·
IF 2.817
Huang Xiangjin,Li Jianwen,Xie Chunsheng,Zhang Huasheng,Wei Shoulian,Lai Wenfeng,Xian Shaoling,Huang Sicong
Herein, a nanocomposite comprising polyvinyl pyrrolidone (PVP) and cobalt(II) hydroxide (Co(OH) 2 ) nanoparticles (PVP–Co(OH) 2 ) was synthesized via a hydrothermal method and used for detection of Cu(II) ions. Using PVP grafted nanosized Co(OH) 2 as a surfactant could decrease the aggregation and reduce the particle size. The conducted morphology investigations showed that PVP–Co(OH) 2 nanocomposite was composed of small spherical particles with a diameter of 40–80 nm that could accelerate mass diffusion and favor the deposition-stripping process of Cu(II) ions. High catalytic activity of Co(OH) 2 and good affinity of PVP to Cu(II) ions synergistically enhances sensing performance of the PVP–Co(OH) 2 nanocomposite-modified electrode than Co(OH) 2 - and PVP-modified electrodes. A linear response was obtained for Cu(II) ion concentration over a range of 1.0–90.0 μg/L, with a detection limit of 0.26 μg/L (S/N = 3). The proposed electrode exhibited good performance in terms of selectivity, stability, and reproducibility. It was also employed to detect Cu(II) ions in water and food samples, and the results were in good agreement with those obtained by graphite furnace atomic absorption spectrometry.
研究领域:
分析化学
·
环境科学
·
材料科学
✓ 已验证
DOI
高影响因子
Royal Society Open Science
·
2018
·Vol. 5
·期 4
·
IF 2.504
Donglin He,Huiping Zhang,Ying Yan
Cu-ZSM-5 catalysts were prepared by chemical vapour deposition for catalytic wet peroxide oxidation (CWPO) of phenol in a fixed bed reactor. Firstly, Cu-ZSM-5 catalysts with Cu loading of 0.5, 2, and 6 wt% were prepared and characterized by X-ray diffraction (XRD), N2 adsorption–desorption and X-ray photoelectron spectra (XPS). The characterization results demonstrated that CuO was uniformly dispersed on ZSM-5 with slight effect on the structure properties of the support. Then, several variables, such as the copper loading, reaction temperature, catalyst bed height and feed flow rate were investigated in the CWPO of phenol in aqueous solution at high concentration (1000 ppm). Compared with the catalyst prepared by the impregnation method, the Cu-ZSM-5 prepared by chemical vapour deposition has a better capacity of further oxidizing the intermediate organic products into carbon dioxide and water with less metal loading. Based on the Cu-ZSM-5 catalyst with Cu loading of 6 wt%, complete removal of phenol and a high TOC reduction (around 70%) have been achieved at the temperature of 80°C feed flow rate of 2 ml min−1 and catalyst bed height of 3 cm. Moreover, this catalyst maintained high catalytic activity after three runs with high phenol conversion (94%) under this optimum operating condition. Finally, the reaction mechanism was studied based on the intermediates detected by high-performance liquid chromatography (HPLC).
研究领域:
环境科学
·
催化化学
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DOI
高影响因子
FOOD CHEMISTRY
·
2022
·
IF 9.231
Xin Tang,Yu Zhang,Jiaying Wu,Zhiyuan He,Yun Xing,Jie Yang,Zhirong Zou,Ke Huang,Huimin Yu,Xiaoli Xiong
In this work, a 3D ultra-thin NiCo-LDH nanosheet array coated Cu nanoparticles on carbon cloth (NiCo-LDH@Cu NSA/CC) was ultrafast synthesized by plasma magnetron sputtering for the first time. This method has low toxicity and is easy to operate. As a durable and efficient 3D heteronanoarray electrocatalyst for glucose detection, NiCo-LDH@Cu NSA/CC has higher stable conductivity and faster electron transport rate than NiCo-LDH NSA/CC and Cu nanoparticles, which work through synergistic effect to form a high-performance sensing platform. The NiCo-LDH@Cu NSA/CC heteronanosheet structure has good electrocatalytic performance for glucose oxidation, with the sensitivity of the two linear ranges (0.001–1 mmol L −1 and 1–6 mmol L −1 ) being 9710 μA L mmol −1 cm −2 and 4870 μA L mmol −1 cm −2 , respectively, and the detection limit (LOD) is 157 nmol L −1 (S/N = 3). The sensor has been successfully applied to detect glucose in beverages and serum.
研究领域:
材料科学
·
生物传感
·
化学
✓ 已验证
DOI
PubMed
高影响因子
Materials Today Communications
·
2025
·
IF 4.5
Kang Li,Guoge Zhang,Wenfang Li,Shuoxun Jin,Ken Chen,Aihua Yi,Zhongmiao Liao,Wen Zhu,Yi Huang,Zhisheng Zhu,Min Wang,Jiajing Yang,Rujian Liang
The as-deposit (AD) and heat-treated (HT) Al-Cu alloy obtained via wire arc additive manufacturing (WAAM) technology was coated by plasma electrolytic oxidation (PEO), respectively. The reticular big Al 2 Cu grains in the AD Al alloy substrate evolved into numerous small particles and nano precipitates after the heat treatment. The thickness and surface roughness of the PEO coatings on both substrates were increased gradually with the increase of oxidation time. The coating on the HT Al alloy was deposited faster with a rougher surface structure. Although most Al 2 Cu grains were dissolved in the electrolyte at the earlier oxidation stage, some Cu-containing compounds and metallic Cu were gradually deposited in the coatings at the discharge spark oxidation period. The coatings were mainly composed of γ-Al 2 O 3 and α-Al 2 O 3 , and the ratio of α-Al 2 O 3 was increased obviously with the oxidation time. Besides, the coating on the HT sample consisted of a higher ratio of α-Al 2 O 3 than that on the AD alloy, especially at the end of PEO processing. The PEO coatings were made up of two sub-layers, a thin compact inner layer and a porous outer layer. In comparison, the coating on the HT alloy was a bit denser and more uniform. The substrates displayed a adhesion wear trait while the coated samples shew a slight abrasive wear manner over the abrasion test, with a still ball as the friction pair . and the coated HT alloy had a better wear resistance than the coated AD alloy did.
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产品关联
DOI
高影响因子
TALANTA
·
2025
·
IF 6.1
Jiahui Huang,Siyi Wei,Maopu Tu,Weiqi Deng,Le Zhong,Fan Jiang,Zhixin Li,Ray P.S. Han,Xiaoyu Deng,Shaohua Xu,Yingzhou Tao
The measurement of total antioxidant capacity (TAC) is vital for evaluating the nutrient content of foods and beverages. The development of novel mimetic enzyme materials with high catalytic activity has led to the creation of highly sensitive methods for TAC assessment. In this study, we introduce a simple and efficient approach for preparing uniformly distributed Cu 2 O/Cu nanoparticles supported on graphite-phase carbon (g-C@Cu 2 O/Cu NPs). These g-C@Cu 2 O/Cu NPs demonstrate excellent peroxidase-like (POD-like) enzymatic activity and exhibit a strong binding affinity for TMB, with a K m value of 0.24 mM. A colorimetric analytical platform for TAC assessment was developed, utilizing g-C@Cu 2 O/Cu NPs, TMB, and H 2 O 2 as the chromogenic system. The method achieved a limit of detection for ascorbic acid as low as 0.15 μM, with a linear range from 0.5 to 100 μM. Furthermore, this method was successfully applied to evaluate TAC in real samples, highlighting its significant potential for food nutritional analysis.
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产品关联
DOI
PubMed
高影响因子
Nanoscience and Nanotechnology Letters
·
2019
·Vol. 11
·期 10
·1366-1374
·
IF 0
Ding Zhexu,Yang Haiyu,Du Min,Ruan Xiaofang,Luo Jun,Chen Sha,Li Ding
Nowadays, extensive use of copper in electric industries has severely contaminated aquatic environments. To address this issue, combining fungal biomass with nanomaterials is considered as an efficient way for adsorbing heavy metals from wastewater. In this work, a novel composite material
"Fungal mycelium coupled with Carbon nanotubes" (FM-CNTs) was synthesized and used for adsorption of Cu(II) ions in aqueous solution. To begin with, potassium permanganate and concentrated nitric acid were used as strong oxidants to modify the surface of CNTs, creating additional carboxyl
groups for coupling with amine groups from the surface of FM. Next, various characterization approaches such as SEM-EDX, FT-IR, XPS and TGA, were used to investigate the interaction between FM-CNTs and Cu(II) ions. Characterization results showed that the surface of FM-CNTs were significantly
changed after absorbing Cu(II) ions. Further, the effect of pH on adsorption capacity of FM-CNTs for Cu(II) was explored, showing that FM-CNTs had the best adsorption performance at pH of 5. Finally, Langmuir-Freundlich isothermal models were performed to analyze the adsorption behavior of
FM-CNTs for Cu(II). The experimental data from the adsorption of Cu(II) by FM-CNTs were best fitted to the Langmuir model, and the maximum adsorption amount of the FMCNTs for Cu(II) was found to be 342.22 mg/g. More importantly, FM-CNTs showed better adsorption capacity than fungal mycelium
alone. Overall, FM-CNTs exhibited excellent performance for adsorption of Cu(II) ions, thus greatly broadening its application prospects in copper-contaminated wastewater treatment.
研究领域:
环境科学
·
材料科学
·
化学工程
✓ 已验证
DOI
危险品化学品经营许可证（带存储）