JOURNAL OF CONTROLLED RELEASE
·
2024
·
IF 10.5
Lianxin Li,Yu Xiong,Yuewen Zhang,Yujiao Yan,Ruixin Zhao,Fengmei Yang,Meng Xie
Alzheimer's disease (AD) is one of the most common neurodegenerative diseases characterized by cognitive and memory impairment. Metal ion imbalance and Mitochondrial dysfunction, leading to abnormal aggregation of β-amyloid protein (Aβ), are key factors in the pathogenesis of AD. Therefore, we designed a composite nanometer system of red blood cell (RBC) membranes-encapsulated Prussian blue nanoparticles (PB/RBC). Prussian blue nanoparticles (PBNPs) can chelate Cu 2+ and reduce reactive oxygen species (ROS). The RBC membranes are a kind of natural long-lasting circulating carrier. At the same time, through NIR irradiation, the excellent photothermal ability of PBNPs can also temporarily open the blood-brain barrier (BBB), enhance the transmission efficiency of PB/RBC across the BBB, and depolymerize the formed Aβ deposits, thereby achieving the optimal therapeutic effect. In vitro and in vivo studies demonstrated that PB/RBC could inhibit Cu 2+ -induced Aβ monomers aggregation, eliminate the deposition of Aβ plaques, improve the quality of mitochondria, restore the phagocytic function of microglia, alleviate neuroinflammation in APP/PS1 mice, and repair memory damage. In conclusion, our biofilm-camouflaged nano-delivery system provides significant neuroprotection by inhibiting Cu 2+ -induced Aβ monomers aggregation, photothermally depolymerizing Aβ fibrils and reducing the level of ROS, thus effectively ameliorating and treating AD.
研究领域:
神经科学
·
纳米技术
·
药学
·
生物医学工程
✓ 已验证
产品关联
DOI
PubMed
高影响因子
COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
·
2024
·
IF 4.9
Fangxin Deng,Shoushu Wei,Xiangwei Zhang,Yanping Zhu,Qingze Chen,Zhiyi Deng,Runliang Zhu
A novel single-atom-like Co/Fe catalyst (i.e., Co/Fe-N-C) was synthesized by pyrolysis of a Zn/Co/Fe zeolitic imidazolate framework, and applied in peroxydisulfate (PDS) activation for removal of organic contaminants from wastewater. The isolated diatomic metal-nitrogen sites were detected by X-ray adsorption fine-structure. The degradation of four contaminants (i.e., phenol, bisphenol A, 2,4-dichlorophenol, and N-methyl-2-pyrrolidone) with a concentration of 100 mg/L could be degraded separately within 20 min by the Co/Fe-N-C system with 10 mmol/L of PDS, 0.5 g/L of catalyst dosage, and initial pH of 3. Besides, 79.2 % of phenol could be mineralized in 120 min, and the turn-over frequency value of the catalyst was calculated to be 27.17 min −1 , which was higher than the commonly reported homogeneous PS-AOPs. Moreover, the Co/Fe-N-C exhibited high stability (mineralization rate over 70 % after 5 cycles), a wide initial pH range (3−9), and high catalytic performance at 5–20 mmol/L of PDS concentrations. Based on the analysis of radical scavenging experiments and electron spin resonance spectra, the radical and non-radical pathways for PDS activation were proved in the system, and the contribution of phenol degradation by each pathway was clarified.
研究领域:
环境科学
·
催化化学
✓ 已验证
产品关联
DOI
高影响因子
Food Bioscience
·
2025
·
IF 5.9
Gengli Huang,Shuo Qi,Xiaodong Lu,Zehua Zhang,Kaiqing Wu,Zhouping Wang
Kanamycin (KAN) residues in environment and food sources pose a considerable threat to human health, creating a strong demand for developing facile yet highly sensitive analytical methods. Herein, a highly sensitive aptasensor based on a bimetallic organic framework nanozyme was constructed for dual-modal KAN detection, employing both colorimetric and photothermal signals regulated by aptamer-controlled nanozyme activity. The synthesized Zr-Fe-MOF, exhibiting peroxidase-like activity, catalyzed the oxidization of colorless 3, 3′, 5, 5′-tetramethylbenzidine (TMB), resulting in the formation of a blue-colored oxidized TMB, which could generate detectable colorimetric and photothermal signals. Once bound to aptamer, its catalytic activity was significantly enhanced due to the formation of nanozyme-aptamer conjugates with increased negative charge. However, this activity was restored through the highly sensitive recognition of the target by the aptamer, leading to a decrease in colorimetric and photothermal signals. Thus, this aptamer-modulated Zr-Fe-MOF enable effective dual-modal detection of KAN, achieving detection limits of 0.17 μM and 0.47 μM for KAN in colorimetric and photothermal modes, respectively. Recoveries of 98.34%–108.8% and 91.67%–106.80% were respectively obtained by colorimetric and photothermal methods. The proposed dual-modal aptasensor demonstrates exceptional performance, paving the way for further exploiting antibiotic residues sensing platform.
研究领域:
分析化学
·
生物医学工程
·
环境科学
✓ 已验证
产品关联
DOI
高影响因子
SENSORS AND ACTUATORS B-CHEMICAL
·
2024
·
IF 8
Yang Xuan,Yating Gao,Yinan Zhao,Wenliang Zhang,Xinyu Bian,Mingfan Zhang,Ruoyun Zhang,Shubiao Zhang
Nanomaterials with intrinsic enzyme activity (nanozymes) have been widely used as artificial enzymes in biomedicine, especially in tumor diagnosis and treatment. Herein, a kind of water-soluble silver nanozyme (Ag@GQD) was developed with a simple method, which showed two enzymatic activities (peroxidase and oxidase-like activity). Based on the excellent catalytic performance of oxidase-like activity, a simple and highly sensitive colorimetric detection strategy for glutathione (GSH) was established. What’s more, after absorbing DOX, Ag/DOX@GQD could realize the combined treatment of reactive oxygen species and chemotherapy. In conclusion, this study provided evidences that Ag@GQD is effective in tumor diagnosis and treatment, which provided new ideas for exploring nanozymes based on the integration of diagnosis and treatment.
研究领域:
生物医学
·
纳米医学
·
肿瘤学
✓ 已验证
产品关联
DOI
高影响因子
SENSORS AND ACTUATORS B-CHEMICAL
·
2024
·
IF 8
Xin-He Duan,Hong-Wei Li,Yi Li,Zhijiu Huang,Sha Liu,Yuqing Wu
Acetaldehyde (AH) is defined as a carcinogen, the widely existence in alcoholic beverages has led its determination an essential aspect related to human health. Fluorine doped carbon dots (dF-CDs) is developed, which process light-activated oxidase-mimic property and high stability at acidic condition. Under the UV irradiation, dF-CDs generate reactive oxygen species (ROS) to oxidize o -phenylenediamine (OPD) into 2,3-diaminophenazine (DAP), showing absorption peak at 450 nm and strong emission at 577 nm, meanwhile, the produced DAP quenches the original emission of dF-CDs at 455 nm via an inner filter effect (IFE). However, the introduction of AH inhibits such processes efficiently, thereby establishing a colorimetry and ratiometric fluorescence method for AH determination. Of note, this dual-responsive method has been used for the accurate AH determination in Chinese Baijiu . Therefore, the developed method not only provide a dual-sensing platform to determine AH, but also extends the applications of CDs in food analysis.
研究领域:
分析化学
·
食品安全
·
生物医学
✓ 已验证
产品关联
DOI
高影响因子
ChemSusChem
·
2024
·
IF 7.5
Yun Liu,Guijiang Liu,Lichuan Chen,Song Hong
Graphical Nitrogen-doped iron-based nanoparticles (Fe NPs-N@C), characterized by the presence of Fe8−N2 active sites, are synthesized to exhibit oxidase-like activity, facilitating the oxidation of 3,3′,5,5′-tetramethylbenzidine (TMB) to yield the blue product, oxTMB. Designing metal nanoparticles with oxidase-mimicking capabilities has garnered significant attention due to their promising attributes. However, understanding the intricate catalytic mechanisms underlying these nanoparticles poses a formidable challenge. In this study, a straightforward pyrolysis procedure was employed to synthesize nitrogen-doped iron-based nanoparticles (Fe NPs-N@C) with Fe8−N2 serving as active sites. The confirmation of these sites was thoroughly confirmed through density functional theory (DFT) calculations complemented by experimental validation. The resulting Fe NPs-N@C nanoparticles, averaging 5.45 nm in size, exhibited excellent oxidase-mimicking activity, with v max =1.11×10 −7 M s −1 and k m =1.67 mM, employing 3,3′,5,5′-tetramethylbenzidine as a substrate. The oxidation pathway and catalytic mechanism of Fe NPs-N@C involved 1O 2 ⋅ radicals, validated through electron paramagnetic resonance analysis and DFT calculations. Furthermore, Fe NPs-N@C/TMB system was devised for ascorbic acid and nitrite quantitative detection. This method demonstrated the capability to detect ascorbic acid within concentrations ranging from 1 to 55 μM, with a limit of detection (LOD) of 0.81 μM, and nitrite within concentrations from 1 to 160 μM, with a LOD value of 0.45 μM. These findings offer a comprehensive understanding of the catalytic mechanisms of Fe NPs-N@C nanoparticles at the atomic level, along with its potential for colorimetric sensor in future.
研究领域:
材料科学
·
生物化学
·
催化化学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
APPLIED CATALYSIS B-ENVIRONMENTAL
·
2025
·
IF 21.1
Tao Xu,Meihui Jiang,Xuhui Mao,Falak Sher,Tianlin Ren,Kun Xin,Irshad Hussain,Helin Hua,Xu Wang
This study investigated the important role of hydroxyl groups for the preparation of γ-Al 2 O 3 sphere supported metal catalysts. γ-Al 2 O 3 spheres were calcinated at varied temperatures for the analysis of surface hydroxyl group, and they were subsequently loaded with iron to evaluate the metal dispersion and the performance for catalytic ozonation. The results showed that the critical site for metal anchoring was hydroxyl group, thus a higher hydroxyl group content favored the metal dispersion on γ-Al 2 O 3 spheres; meanwhile, the iron-loaded catalysts prepared by the γ-Al 2 O 3 support calcinated at 300 °C achieved the highest catalytic efficiency for p -nitrophenol degradation (74.6 %). The favorable performance of the catalyst was attributed to the excellent dispersion of iron oxide particles, and the abundant oxygen vacancy sites that facilitated the formation of ozone-activating sites, Fe-centered hydroxyl groups ([Fe-OH]). This study provides an important theoretical guidance for the design and application of ozone catalysts.
研究领域:
环境科学
·
催化化学
✓ 已验证
产品关联
DOI
高影响因子
CHEMICAL ENGINEERING JOURNAL
·
2024
·
IF 13.3
Binrong Li,Na Li,Zhiwei Guo,Chen Wang,Xuedong Wang,Zhi Zhu,Xu Tang,Pengwei Huo
Polymeric carbon nitride (PCN) is an environmentally friendly photocatalyst for solar-driven H 2 O 2 production, but the activity of original PCN is still not satisfactory. The main limitation is the sluggish exciton dissociation leading to slow generation and conversion of superoxide radical (•O 2 − ) intermediate. Herein, the PCN with dual defect sites and compact interlayer is rationally designed for H 2 O 2 photosynthesis with an ultrahigh rate of 3930.9 μmol g −1 h −1 and rapid •O 2 − yield rate of 1.92 min −1 . The enhanced activity is attributed to effective exciton dissociation during interlayer and intralayer process. Moreover, nitrogen vacancies change the oxygen adsorption configuration (formation of C − O − O − C bridge mode), thus promoting O 2 adsorption and activation. A well-matched linear relationship was established between the concentration of nitrogen vacancies and •O 2 − /H 2 O 2 production. This work not only provides in-depth insights for the photocatalytic H 2 O 2 generation mechanism, but also offers a new paradigm for designing efficient PCN-based photocatalysts for energy conversion.
研究领域:
材料科学
·
光催化
·
能源转换
✓ 已验证
产品关联
DOI
高影响因子
ANALYTICAL AND BIOANALYTICAL CHEMISTRY
·
2024
·
IF 3.8
Wang Shulong,Huang Wenfang,Lin Qingyan,Feng Yinyin,Wei Qingmin,Xu Jiayao,Wang Rong,Luo Zhihui
Nanocatalytic medicine, which aims to accurately target and effectively treat tumors through intratumoral in situ catalytic reactions triggered by tumor-specific environments or markers, is an emerging technology. However, the relative lack of catalytic activity of nanoenzymes in the tumor microenvironment (TME) has hampered their use in biomedical applications. Therefore, it is crucial to develop a highly sensitive probe that specifically responds to the TME or disease markers in the TME for precision diagnosis and treatment of diseases. In this work, a chiral photoacoustic (PA) nanoprobe (D/L-Ce@MoO 3 ) based on the H 2 O 2 -catalyzed TME activation reaction was constructed in a one-step method using d -cysteine (D-Cys) or l -cysteine (L-Cys), polymolybdate, and cerium nitrate as raw materials. The designed and synthesized D/L-Ce@MoO 3 chiral nanoprobe can perform in situ, non-invasive, and precise imaging of pharmacological acute liver injury. In vivo and in vitro experiments have shown that the D/L-Ce@MoO 3 probe had chiral properties, the CD signal decreased upon reaction with H 2 O 2 , and the absorption and PA signals increased with increasing H 2 O 2 concentration. This is because of the catalytic reaction between Ce ions doped in the nanoenzyme and the high expression of H 2 O 2 caused by drug-induced liver injury to produce ·OH, which has a strong oxidizing property to kill tumor cells and destroy the Mo-S bond in the probe, thus converting the chiral probe into an achiral polyoxometalate (POM) with PA signal.
研究领域:
纳米技术
·
生物医学工程
·
癌症研究
·
药学
·
成像科学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
CHEMICAL ENGINEERING JOURNAL
·
2024
·
IF 13.3
Zhujun Luo,Lizhu Yuan,Jonathan W.C. Wong,Minghan Zhu,Yuanyuan Yu,Kai Wang,Hua Yin,Shaoyu Tang,Junfeng Niu
The ubiquity and ecotoxicity of tri (1,3-dichloro-2-propyl) phosphate (TDCPP) in aquatic environments make it essential to develop efficient related treatment techniques. The present research aims to systematically explore the mechanisms and toxicity changes of TDCPP degradation through UV-driven hydrogen peroxide process (UV/H 2 O 2 ). The results revealed degradation efficiency of TDCPP attained 95 % with 0.5 mM H 2 O 2 , corresponding to a reaction rate constant ( k ) of 0.04919 min −1 . Furthermore, three typical chlorinated OPEs (Cl-OPEs) were simultaneously degraded by the UV/H 2 O 2 process, with different degradation efficiencies, according to the following order: TCEP
研究领域:
环境科学
·
毒理学
·
微生物学
✓ 已验证
产品关联
DOI
高影响因子
JOURNAL OF ENVIRONMENTAL MANAGEMENT
·
2024
·
IF 8
Zhimin Xu,Zhanpeng Liu,Shunling Li,Fangfang Li,Peng Gao,Siyao Wang,Youcheng Lin,Guomei Xiong,Zhiqun Li,Hongbo Peng
Peroxydisulfate (PDS) and peroxymonosulfate (PMS) could be efficiently activated by heat to generate reactive oxygen species (ROS) for the degradation of organic contaminants . However, defects including the inefficiency treatment and pH dependence of monooxidant process are prominent. In this study, synergy of heat and the PDS-PMS binary oxidant was studied for efficient triclosan (TCS) degradation and apply in rubber wastewater. Under different pH values, the degradation of TCS followed pseudo-first-order kinetics, the reaction rate constant ( k obs ) value of TCS in heat/PDS/PMS system increased from 1.8 to 4.4 fold and 6.8–49.1 fold when compared to heat/PDS system and heat/PMS system, respectively. Hydroxyl radicals (·OH), sulfate radicals (SO 4 · - ) and singlet oxygen ( 1 O 2 ) were the major ROS for the degradation of TCS in heat/PDS/PMS system. In addition, the steady-state concentrations of ·OH/ 1 O 2 and SO 4 · - /·OH/ 1 O 2 increased under acidic conditions and alkaline conditions, respectively. It was concluded that the pH regulated the ROS for degradation of TCS in heat/PDS/PMS system significantly. Based on the analysis of degradation byproducts, it was inferred that the dechlorination , hydroxylation and ether bond breaking reactions occurred during the degradation of TCS. Moreover, the biological toxicity of the ten byproducts was lower than that of TCS was determined. Furthermore, the heat/PDS/PMS system is resistant to the influence of water substrates and can effectively improve the water quality of rubber wastewater. This study provides a novel perspective for efficient degradation of TCS independent of pH in the heat/PDS/PMS system and its application of rubber wastewater.
研究领域:
环境科学
·
化学工程
✓ 已验证
产品关联
DOI
PubMed
高影响因子
ENVIRONMENTAL RESEARCH
·
2024
·
IF 7.7
Min Zhang,Jin Wang,Xinyuan Zhan,Wusong Xu,Maolin He,Ding Ma,Zhengbo Yue
Thiocyanate (SCN − ), a non-volatile inorganic pollutant, is commonly found in various types of industrial wastewater, which is resistant to hydrolysis and has the potential to be toxic to organisms. Premagnetized iron-copper-carbon ternary micro-electrolytic filler (pre-Fe/Cu/C) was prepared to degrade SCN − . Pre-Fe/Cu/C exhibited the most significant enhancement effect on SCN − removal when magnetized for 5 min with an intensity of 100 mT, and the SCN − removal rate was the highest at an initial pH of 3.0 and an aeration rate of 1.6 L/min. The electrochemical corrosion and electron transfer in the pre-Fe/Cu/C system were confirmed through SEM, XPS , FTIR , XRD , and electrochemical tests. This resulted in the formation of more corrosion products and multiple cycles of Fe 2+ /Fe 3+ and Cu 0 /Cu + /Cu 2+ . Additionally, density functional theory (DFT) calculations and electron paramagnetic resonance (EPR) were utilized to illustrate the oxygen adsorption properties of the materials and the participation of reactive oxygen species ( 1 O 2 , ·O 2 − , and ·OH) in SCN − removal. The degradation products of SCN − were identified as SO 4 2− , HCO 3 − , NH 4 + , and N 2 . This study introduced the use of permanent magnets for the first time to enhance Fe/Cu/C ternary micro-electrolytic fillers, offering a cost-effective, versatile, and stable approach that effectively effectively enhanced the degradation of SCN − .
研究领域:
环境科学
·
化学工程
✓ 已验证
产品关联
DOI
PubMed
高影响因子
危险品化学品经营许可证（带存储）