Food Bioscience
·
2025
·
IF 5.9
Zi-Xuan Ding,Yue-Hua Chen,Jia-Nuo Zhang,Wen-Yu Wang,Xin-Ru Zhang,Rui-Bo Sun,Hui Zhang,Ming Xie,Hui-Peng Song
Processed Buddha's hand fruit (PBHF) is a widely consumed food, but its flavor profile and functional mechanisms remain understudied. In this study, human sensory evaluation (n = 120), E-tongue, E-nose, microbiomics, and metabolomics were integrated to comprehensively analyze PBHF's flavor characteristics and elucidate its dietary improvement mechanisms. Human sensory evaluation identified PBHF as predominantly sweet and sour with a soft texture, accompanied by subtle notes of saltiness, pomelo peel, liquorice, refreshment, hawthorn, fragrant aroma, and cinnamon. These findings were corroborated by E-tongue analysis, which confirmed sweetness and sourness as the primary tastes. E-nose detection revealed 36 aroma components, including limonene as the key contributor to the pomelo peel flavor. In animal studies, PBHF regulated dietary patterns in mice, significantly reducing weight gain and enhancing gastrointestinal motility. Importantly, it showed no adverse effects on organ indices (spleen, kidney, liver, or thymus). Microbiomics analysis indicated that PBHF increased the abundance of digestive bacteria such as Limosilactobacillus reuteri , Lacticaseibacillus johnsonii , and Ligilactobacillus murinus . Metabolomics profiling further demonstrated that PBHF mitigated weight gain by upregulating metabolic pathways such as lipolysis in adipocytes, fatty acid degradation, and glycerolipid metabolism. By synergizing large-scale human sensory evaluation, electronic sensory evaluation, microbiomics, and metabolomics, this study systematically deciphered PBHF's flavor attributes and mechanistic roles in promoting digestion and metabolic health. These findings provide robust scientific evidence for PBHF's potential applications in functional food development.
研究领域:
食品科学
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风味化学
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营养科学
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感官分析
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生物传感器（电子舌/电子鼻）
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微生物组学
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代谢组学
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功能食品
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胃肠生理学
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肥胖研究
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DOI
高影响因子
JOURNAL OF FOOD SCIENCE
·
2025
·Vol. 90
·期 12
·e70753
·
IF 3.4
Yu-Mei Zhai,Yongcheng Liao,Hong Li,Hui-dan Xiang,Weiwei Wu,Xiao-Juan Tang,Min Gong,Yun-Guo Liu
Honeysuckle samples from various plots in Pingyi County, Linyi City were selected and analyzed by integrating electronic tongue (E-tongue), electronic nose (E-nose), HS-SPME-GC-MS, and GC-IMS technologies with multivariate statistical analysis methods, a systematic analysis of the flavor characteristics and plot differentiation patterns of volatile organic compounds (VOCs) was conducted in the study. The results indicated that the E-tongue provided distinct sensor response patterns that correlated with taste attributes such as sweetness and bitterness, effectively discriminating samples from different plots. E-nose analysis further showed that aroma-related response intensities exhibited significant plot-based variation. Through HS-SPME-GC-MS and GC-IMS techniques, a total of 203 volatile components were identified. Based on HS-SPME-GC-MS data, using VIP > 1 and OAV ≥ 1 as screening criteria, seven key volatile markers were determined. From the GC-IMS data, 24 characteristic compounds were screened out using the criterion of VIP > 1, with aldehydes comprising the highest proportion. Furthermore, the random forest (RF) algorithm was employed to integrate these two sets of data. Monte Carlo cross-validation showed that the model accuracy reached 1.0, successfully identifying 15 key volatile compounds. This study provided a theoretical foundation and data support for optimizing the quality evaluation system of honeysuckle and innovating origin traceability technology through multi-dimensional flavor analysis and key marker screening.
研究领域:
食品化学
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分析化学
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植物科学
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感官分析
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化学计量学
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产地溯源
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DOI
PubMed
高影响因子
FOOD CONTROL
·
2021
·
IF 5.548
Weibin Ma,Eric T. Johnson
Strategies for preventing the growth of mycotoxigenic fungi in agricultural commodities need to be identified. In this study, sorbaldehyde and ( E , E )-2,4-heptadienal, two natural aldehydes as derivatives of the common food preservative sorbic acid, were investigated for their antifungal efficacy as fumigants against Aspergillus flavus in stored peanut seeds. In vitro assays demonstrated that both sorbaldehyde and ( E , E )-2,4-heptadienal exhibited stronger inhibitory effects on A. flavus than sorbic acid. Moreover, the vapor phase of these two aldehydes were much more effective than direct contact on A. flavus growth. ( E , E )-2,4-Heptadienal showed higher fumigant activity than sorbaldehyde, with 50% effective concentration (EC 50 ) values of 1.5 and 2.6 mg/l air, and minimum inhibitory concentration (MIC) values of 16 and 8 mg/l air, respectively. Furthermore, fumigation with sorbaldehyde or ( E , E )-2,4-heptadienal could significantly reduce and delay A. flavus growth in stored peanut seeds, and the infection was completely inhibited by 100 mg/l air sorbaldehyde or 75 mg/l air ( E , E )-2,4-heptadienal. These results revealed that ( E , E )-2,4-heptadienal, a natural food flavour with better safety than sorbaldehyde, has high potential as an antifungal fumigant for protecting peanut seeds from contamination of A. flavus during storage.
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DOI
高影响因子
CARBOHYDRATE POLYMERS
·
2025
·
IF 12.5
Chen Xu,Xiang Shi,Huifang Sun,Lijuan Yu,Liang Zhang,Di Lan,Xiaolu Wu,Mengran Chen,Nanqi Cheng,Ying Pan,Jiayi He,Ronghua Yin,Lutan Zhou,Na Gao,Jinhua Zhao
Fucosylated glycosaminoglycan (FG) from Holothuroidea exhibits notable structural diversity and multiple biological activities. This study investigated the HfFG isolated from the sea cucumber Holothuria floridana , focusing on its chemical structure and biological activities. Structural analysis of eleven oligosaccharides (a-k) and a depolymerized product (dHfFG-II) using NMR identified the HfFG backbone as chondroitin sulfate E (CS-E), with various branches, including L-Fuc 2S4S , L-Fuc 3S4S , L-Fuc 4S , and the unique disaccharide D-GalNAc 4S -α1,2-L-Fuc 3S4S , attached at C-3 of GlcA. A high L-Fuc 2S4S (40 %) and disaccharide branch (35 %) content allowed their contiguous distribution within the CS-E chain, as evidenced by the predominant hexasaccharides (i, j) in size-homogeneous Fr4 and the novel nonasaccharide k in Fr5. Notably, previously unreported branches and sequences in HfFG were confirmed, offering new understanding of the natural HfFG structure. HfFG showed potent inhibitory activities on the intrinsic tenase complex (iXase), heparanase, and P-selectin binding to PSGL-1. Depolymerization selectively modulated these activities, preserving anti-iXase potency while attenuating heparanase and P-selectin inhibition. These activities were dependent on oligosaccharide chain length and sequence. Comparing the activities of FG and its oligosaccharides highlights their potential for the rational design of targeted inhibitors of heparanase or P-selectin binding to PSGL-1, with significant implications for therapeutic applications.
研究领域:
海洋生物学
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生物化学
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药理学
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DOI
PubMed
高影响因子
FOOD CHEMISTRY
·
2026
·
IF 9.8
Yawen He,Chengxun Lin,Bin Zhang,Zixuan Wang,Jiangui Li,Zhenfan Yu
Fuji apples from the Aksu production region are highly favored by consumers. In contrast, those from the Yili region exhibit marked differences in flavor profiles, the mechanisms of which remain unclear. This study investigated the flavor variations in Fuji apples from these two producing regions by integrating analyses of both volatile and non-volatile metabolites. The results from the electronic nose and electronic tongue indicated that the sensors for W1W, W2W, W5S, and sourness exhibited the most pronounced responses in Fuji apples from the Aksu region. 16 key aroma-active compounds and 143 non-volatile differential compounds were identified. The aroma of Fuji apples was predominantly characterized by esters and terpenoids, with representative compounds including hexyl 2-methylbutanoate, 3-Methylbutyl acetate, 2-Methylbutyl acetate, and citronellol. These compounds collectively impart fruity, sweet, and floral notes. Furthermore, the peel of the ‘Yanfu 6’ cultivar from Aksu exhibited distinctive rosy and woody notes, while its pulp possessed a pineapple-like aroma. KEGG pathway enrichment analysis demonstrated that amino acid metabolism, fatty acid metabolism, and phenylalanine metabolism are interconnected. This study provides valuable insights for systematically understanding the formation of characteristic aromas in Fuji apples from the Xinjiang region
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DOI
PubMed
高影响因子
APPLIED SURFACE SCIENCE
·
2024
·
IF 6.3
Kaiting Chen,Xinyu Han,Qian Wang,Kaijie Liu,Xiangguang Yang,Yibo Zhang
The selective catalytic reduction of NO by CO (CO-SCR) presents an economical and promising approach to mitigate emissions of NO x and CO from motor vehicles. A bimetallic Rh-Mn supported catalyst Rh-Mn/CoAlO was synthesized through the reduction of citric acid and ethylene glycol, and subsequently employed in the CO-SCR reaction. Tests assessing its catalytic performance revealed that the Rh-Mn/CoAlO catalyst displayed superior CO-SCR activity, maintaining high efficiency (≥90 % at 230 °C) and stability while simultaneously reducing the usage of noble metals. Various characterization techniques, including H 2 -TPR, NO-TPD, CO-pulse, and XPS, indicated that the Rh-Mn/CoAlO catalyst possessed enhanced dispersion of noble metals. This increased dispersion ensured optimal contact between Rh and Mn, as well as the support, fostering a synergistic interaction that facilitated electron transfer. Consequently, the catalyst’s adsorption and activation capabilities for NO were significantly improved. In situ DRIFTs studies further elucidated that the catalyst primarily followed the E-R mechanism, wherein NO is adsorbed onto the catalyst surface, and subsequently, the N and O atoms generated from pyrolysis react with CO in the gas phase. The findings of this study are anticipated to offer an effective strategy for designing catalysts with exceptional low-temperature activity and high dispersibility for the reduction of NO using CO.
研究领域:
环境科学
·
催化化学
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DOI
高影响因子
COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
·
2021
·
IF 4.539
Han Jia,Daofan Wang,Fengbin Lv,Qiang Wang,Li Lv,Xin Wei,Lin Song,Haidong Jia,Kaihe Lv,Dexin Liu
Both negatively charged SiO 2 nanoparticle and positively charged AlOOH nanoparticle have been widely used in various fields, including enhanced oil recovery (EOR). In this study, the mixed binary AlOOH/SiO 2 nanoparticle (MBN) systems are constructed and firstly employed in EOR. The measurements of zeta potential and Z-average diameter indicate that the stable MBN aqueous dispersion could be obtained by controlling AlOOH/SiO 2 mass ratios, which is quantificationally confirmed via the e-DLVO theory. Then the ternary TX-100-AlOOH-SiO 2 (TX-A-S) system exhibits the great ability to stabilize the emulsion at the much low nanoparticle concentration (0.15 wt% in total). The emulsion stability is further evaluated in the harsh conditions (high shear, temperature and electrolyte concentration). Moreover, core flooding and microscopic visualization experiments reflect the TX-A-S stabilized emulsion can dramatically enhance tertiary oil recovery (~23% of initial oil in place), which should be attributed to the high improvement of both displacement and sweep efficiency.
研究领域:
胶体化学
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石油工程
·
界面科学
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DOI
高影响因子
JOURNAL OF FOOD SCIENCE
·
2020
·Vol. 85
·期 5
·1489-1499
·
IF 2.479
Shiye Zhu,Jiaxing Li,Yating Liu,Liang Chen
Eucommia ulmoides Oliver seed oil ( E.u oil) as a functional oil is rich in many natural active components such as α-linolenic acid (56% to 63%), vitamin E, aucubin, and so on. In this study, water-in-oil (W/O) microemulsions composed of Eucommia ulmoides Oliver seed oil, distilled water, a blend of Sorbitan monooleate 80 (Span 80) and Polysorbate (20) sorbitan monooleate (Tween 80), and propylene glycol were prepared for improving the compatibility of Eucommia ulmoides Oliver seed oil. Pseudoternary phase diagrams were built to illustrate the phase behavior of the microemulsions, based on hydrophilic–lipophilic balance values, cosurfactant type, the proportion of cosurfactant, and the changing environmental stress. Dynamic light scattering, transmission electron microscopy, and electrical conductivity measurements were performed to characterize the microstructural aspects. The optimum process conditions at which the Eucommia ulmoides Oliver seed oil-loaded microemulsion had good tolerance to pH and salinity were: Propylene glycol served as cosurfactant, water–Propylene glycol, and Span 80-Tween 80 ratios separately kept constant at 1:1 and 6:4. These microemulsions with narrow size distribution, nanoscale particle size (below 60 nm), transparent appearance had a wide range of oil phase content and free-radical scavenging capacity toward DPPH and ABTS radicals with half-maximal inhibitory concentration (IC 50 ) values of 49.20 and 33.43 mg/mL, respectively. Practical Application This nanostructure, environmental stability, and antioxidant activity of microemulsions containing Eucommia ulmoides Oliver seed oil is a potential delivery system as an alternative to α -linolenic acid and can be used for the delivery of peptides, proteins, antioxidants, and water-soluble nutrients.
研究领域:
食品科学
·
植物化学
·
药物传递系统
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DOI
高影响因子
GREEN CHEMISTRY
·
2015
·Vol. 18
·期 5
·1240-1248
·
IF 8.02
Yifeng Tao,Ruijuan Dong,Ioannis V. Pavlidis,Biqiang Chen,Tianwei Tan
Vitamin E (VE) has significant biological activities and thus its acylation to increase its stability is of extreme interest. We developed an efficient and sustainable approach using imidazolium-based ionic liquids as dual solvent-catalysts for the esterification between α-tocopherol (the most active form of VE) and succinic anhydride. Although in literature it is reported that lipase can catalyze this reaction, hereby we demonstrate that the reaction observed in DMSO and DMF is catalyzed by the histidyl residues of the protein. Histidine and its analogue containing an imidazole ring were tested as organocatalysts for the production of α-tocopherol succinate. In light of the imidazole organocatalysis, commercially-available 3-alkyl-1-methyl imidazolium ILs [CnC1Im][X−] were investigated as dual solvent-catalysts for the esterification of α-tocopherol with succinic anhydride, and provided satisfactory yields and reaction rates. [C5C1Im][NO3−] can be recycled by water extraction, instead of organic solvent extraction to separate α-tocopherol succinate from [C5C1Im][NO3−], with an average yield of 94.1% for 4 subsequent batches, while the catalytic activity of the recycled ILs showed almost no loss after 4 batches. The developed protocol for the synthesis of α-tocopherol esters and IL recycling bears industrial potential due to the ease of use and the efficient recycling.
研究领域:
有机化学
·
生物化学
·
绿色化学
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DOI
高影响因子
NEW JOURNAL OF CHEMISTRY
·
2016
·Vol. 40
·期 7
·6332-6339
·
IF 3.277
Ren Liu,Huiwen Ge,Xue Wang,Jing Luo,Zhiquan Li,Xiaoya Liu
In this paper, a facile, economical and environmentally friendly synthetic method was developed to fabricate a Ag nanoparticle (NP) decorated graphene (GR/TA/Ag) composite with tannic acid (TA) as a reducing agent and stabilizing agent. The GR/TA/Ag composite was fully characterized using Fourier transform infrared spectroscopy (FTIR), ultraviolet-visible absorption spectroscopy (UV-vis), Raman spectroscopy, and X-ray photoelectron spectroscopy (XPS). Scanning electron microscopy (SEM) and transmission electron microscopy (TEM) demonstrated that Ag NPs with diameters of up to 6 nm were homogeneously and uniformly deposited on graphene sheets. With an increasing concentration of AgNO3 used for immersion, the amount of Ag NPs loaded kept increasing without aggregation or deformation. The antibacterial properties of the GR/TA/Ag composite were studied using Gram-negative E. coli ATCC 25922 and Gram-positive S. aureus ATCC 6538 via both the disk diffusion method and the shaking flask method. The disk diffusion method results showed that the synthesized GR/TA/Ag composite had great release antibacterial properties owing to the loading of Ag NPs. In addition, the presence of TA gave the composite good non-release antibacterial properties, based on the results of the shaking flask method. The ingenious combination of the release-killing capabilities of Ag NPs and the contact-killing capabilities of TA bestow two-level antibacterial activity on the GR/TA/Ag composite, promoting the GR/TA/Ag composite as part of a new generation of powerful antibacterial agents with promising applications.
研究领域:
材料科学
·
微生物学
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DOI
高影响因子
npj Flexible Electronics
·
2023
·Vol. 7
·期 1
·1-9
·
IF 14.6
Shang Chao,Xu Qunhui,Liang Nengmin,Zhang Jianpeng,Li Lu,Peng Zhengchun
Tactile sensing has been a key challenge in robotic haptics. Inspired by how human skin sense the stress field with layered structure and distributed mechanoreceptors, we herein propose a design for modular multi-parameter perception electronic skin. With the stress field sensing concept, complex tactile signals can be transformed into field information. By analyzing the stress field, the real-time three-dimensional forces can be resolved with 1.8° polar angle resolution and 3.5° azimuthal angle resolution (achieved up to 71 folds of improvement in spatial resolution), we can also detect the hardness of object in contact with the electronic skin. Moreover, we demonstrate random assembly of the sensing arrays and integration of our electronic skin onto differently curved surfaces do not lead to any measurement variation of the stress field. This result reveals that the sensing elements in our electronic skin system can be modularly made and exchanged for specific applications.
研究领域:
机器人学
·
生物医学工程
·
材料科学
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DOI
高影响因子
Cell Metabolism
·
2025
·
IF 30.9
Yu-Zhang Wang,Wei-Hai Chen,Zi-Yi Han,Shi-Man Zhang,Ping Ji,Cheng Zhang,Jun-Long Liang,Xian-Zheng Zhang
Bacteria-based metabolic therapy has been acknowledged as a promising strategy for tumor treatment. However, the insufficient efficiency of wild-type bacteria severely restricts their therapeutic efficacy. Here, we elaborately develop an ʟ-cyst(e)ine-addicted bacteria-nanodrug biohybrid for metabolic therapy through a dual-selection directed evolution strategy. Our evolved strain exhibits a 36-fold increase in ʟ-cystine uptake and a 23-fold improvement in total activity of cysteine desulfhydrases compared with the wild-type strain. By conjugating with DMXAA-loaded liposomes, the engineered bacteria-nanodrug biohybrid not only prevents the influx of nutrients into the tumor by blocking neovasculature but also achieves efficient and durable CySS catabolism locally. The unavailable of Cys species disrupts redox homeostasis and strikingly increases intracellular ROS level, achieving favorable therapeutic outcomes in multiple tumor models. Our study not only highlights the promise of directed evolution strategy in enhancing the stability and efficiency of bacteria-based living biocatalyst but also provides new opportunities for antitumor metabolic therapy.
研究领域:
生物医学工程
·
肿瘤学
·
合成生物学
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产品关联
DOI
PubMed
高影响因子
危险品化学品经营许可证（带存储）