Aggregate
·
2023
·
IF 18.8
Xinyue Lao,Yuan Liu,Lihua Li,Menglin Song,Yingjin Ma,Mo Yang,Guanying Chen,Jianhua Hao
Outbreaks of infectious viruses offer a formidable challenge to public healthcare systems and early detection of viruses is essential for preventing virus propagation. In this work, an ultrasensitive plasmon-enhanced fluorescence resonance energy transfer (FRET) biosensor based on core-shell upconversion nanoparticle (csUCNP) and gold nanoparticle (AuNP) for accurate detection of SARS-CoV-2 viral RNA is presented. In this biodetection assay, the Tm 3+ /Er 3+ co-doped csUCNP NaGdF 4 :Yb/Tm@NaYF 4 :Yb/Er acts as an energy donor and AuNP serves as an energy acceptor. The upconversion emission of Tm 3+ and the design of the core-shell structure led to a simultaneous surface plasmon effect of AuNP. The localized surface plasmon resonance (LSPR) arising from collective oscillations of free electrons significantly enhanced FRET efficiency between Er 3+ and AuNP. The as-prepared biosensor obtained a limit of detection (LOD) as low as 750 a m , indicating that the integration of FRET and surface plasmon into one biodetection assay significantly boosted the sensitivity of the biosensor. In addition, samples extracted from clinical samples are also utilized to validate the effectiveness of the biosensor. Therefore, this innovative plasmon-enhanced FRET biosensor based on Tm 3+ /Er 3+ co-doped csUCNP may pave the way for rapid and accurate biodetection applications.
研究领域:
生物医学工程
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纳米技术
·
病毒学
✓ 已验证
产品关联
DOI
高影响因子
JOURNAL OF MATERIALS SCIENCE-MATERIALS IN ELECTRONICS
·
2018
·Vol. 29
·期 9
·7692-7700
·
IF 2.324
Hu Zhen,Guo Haiyong,Zhao Li,Wu Yadan,Wang Shimin,Wan Li
A double-layer composite film (DLCF) that consists of upconversion composite La(OH) 3 :Er 3+ /Yb 3+ +P25 (UC + P25) as underlayer and large TiO 2 spheres (LS-TiO 2 ) as overlayer is designed as the photoelectrode of dye-sensitized solar cells (DSSCs). The upconversion luminescent material La(OH) 3 :Er 3+ /Yb 3+ can convert near-infrared region to visible light to improve the light absorption, and LS-TiO 2 has been used as light-scattering layer to increase the optical length in the film and enhance light harvesting. The DLCF with lower absorbed dye achieved the highest conversion efficiency due to the synergistic effect of the upconversion luminescent layer and the light-scattering layer, and with an optimum mixing ratio, a conversion efficiency of 9.24% is attained, which is a significant improvement of 68.3% compared with the pure P25 film photoelectrode.
研究领域:
材料科学
·
能源研究
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产品关联
DOI
高影响因子
JOURNAL OF LUMINESCENCE
·
2022
·
IF 4.171
Yunkang Bu,Yu Chen,Xingyue Chen,Yichun Zhang,Degang Deng,Yuyu Shen,Liuyan Zhou,Chenwei Xu
Up conversion luminescent materials Sr 2 YTaO 6 : Er 3+ , Yb 3+ phosphors were prepared by high temperature calcination . In view of the formation, temperature characteristics , and photoluminescence features of the sample, X-ray diffraction and photoluminescence were used. Under the excitation at 980 nm, the series of samples is significantly stimulated by Er 3+ up-conversion luminescence and Yb 3+ sensitization at 524, 550 and 659 nm. According to the diversity of temperature sensing performance from these three highest peaks, a dual-mode temperature sensor on account of fluorescence intensity ratio (thermally coupled level between 2 H 11/2 and 4 S 3/2 , and nonthermally coupled energy levels between 2 H 11/2 and 4 F 9/2 ) is achieved by using a single luminescent center. Moreover, the phosphor has strong thermal stability, which is helpful to improve the accuracy of temperature measurement. Under the temperature measurement of a dual-mode temperature sensor, it is calculated that the optimal absolute sensitivity S a of thermally coupled energy level is 0.78 × 10 −3 K −1 (473 K) and relative sensitivity S r is 1.32 %K −1 (293 K), and the maximum optimal absolute sensitivity S a of non-thermally coupled energy level is 1.02 × 10 −4 K −1 (473 K) and relative sensitivity S r is 0.58 %K −1 (293 K). All results imply that Sr 2 YTaO 6 : Er 3+ , Yb 3+ phosphors are promising materials for self-referenced optical temperature measurement.
研究领域:
材料科学
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光学工程
·
无机化学
·
功能材料
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生物医学传感
✓ 已验证
DOI
高影响因子
Laser & Photonics Reviews
·
2025
·Vol. 19
·期 14
·2402225
·
IF 10
Qian Zhu,Yongsheng Sun,Yuzhen Wang,Zhiguo Xia
Flexible temperature sensors are crucial for monitoring physiological parameters in smart human wearable devices, however, there is a challenge to realize reproducible, sensitive, real-time, and in-situ temperature sensing simultaneously. Herein, Er 3+ /Yb 3+ co-doped Li 2 HfO 3 phosphor thermometries have been designed and prepared, which demonstrate bright upconversion luminescence and precise temperature sensing capabilities. The temperature sensing characteristics of thermally coupled energy states in Li 2 HfO 3 :Er 3+ , Yb 3+ are explored based on the fluorescence intensity ratio technique, with a maximum relative sensitivity of 0.875% K −1 and a temperature uncertainty of 0.017 K at 300 K. In addition, flexible composite fluorescent optical fiber temperature sensors have been fabricated, and the fiber with a double-cladding structure is employed to monitor human body temperature and airflow heat with satisfying performances. This work not only provides a promising rare earth phosphor thermometry but also opens a new avenue for the development of flexible optical fiber temperature sensors for health management.
研究领域:
生物医学工程
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光学传感
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体温调节
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可穿戴设备
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分子诊断
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产品关联
DOI
高影响因子
JOURNAL OF MOLECULAR STRUCTURE
·
2025
·
IF 4.7
Tongxuan Mi,Yuhong Zhang,Luo Su,Jingyi Zhang,Jingliang Zhang,AoTian Zhang,Hang Liu
In this paper, a series of Sm 3+ single-doped and Sm 3+ /Er 3+ co-doped lead-free double perovskite cesium sodium bismuthate hexachloride(Cs 2 NaBiCl 6 ) fluorescent materials are successfully synthesized by solvothermal method, and their multimode luminescence properties and temperature sensing properties are systematically studied. The yellow, orange and green tunable luminescence of Cs 2 NaBiCl 6 :Sm 3+ /Er 3+ phosphor are achieved by adjusting the excitation wavelength(380, 410, 980 nm). The material exhibits multi-color luminescence characteristics under different excitation. Moreover, the anti-counterfeit design exhibits robust security and resistance to duplication. Based on the luminescence intensity ratio(LIR) technology, the relative sensitivity(S R ) of Cs 2 NaBiCl 6 :15 %Sm 3+ /20 %Er 3+ reaches 3.06 %K −1 (313 K) under 410 nm excitation. The study provides a new idea for the development of multi-functional lead-free perovskite materials in the field of optical anti-counterfeiting and precision temperature measurement.
研究领域:
材料科学
·
光学安全
·
温度传感
·
固体物理
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无机化学
✓ 已验证
产品关联
DOI
高影响因子
OPTICAL MATERIALS
·
2023
·
IF 3.9
Chunyang Kang,Xianwei Zuo,Lei Zhao,Cuiling Ren,Yan Wang,Yidan Liu,Xin He,Xin Li,Genliang Han
The red emission of upconversion nanoparticles (UCNPs) is located in an “optical window” range of the biological tissue, which has a promising prospect in biology application. In this work, novel red-emitting NaYF 4 :Yb 3+ /Er 3+ UCNPs with CH 3 COO − modifications were synthesized by single-mode focused microwave method. The morphology, structure, and luminescence properties of as-prepared UCNPs were characterized. The results showed that single-mode focused microwave method was an effective approach to prepare hydrophilic and strongly red emission UCNPs within a drastically reduced reaction time (only 10 min) compared to the traditional methods. Importantly, we also demonstrated that the CH 3 COO − modified NaYF 4 :Yb 3+ /Er 3+ UCNPs could be successfully applied for in vitro imaging of HeLa cells. This work not only provides a rapidly synthetic methodology for the preparation of red-emitting UCNPs but also offers an effective material for cancer cell imaging .
研究领域:
材料科学
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纳米技术
·
生物医学工程
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细胞生物学
✓ 已验证
产品关联
DOI
高影响因子
JOURNAL OF RARE EARTHS
·
2025
·
IF 7.2
Yuhong Zhang,Xuezhong Yang,Hongqun Zhu,Chunhui Sun,Haoran Wang,Haozhou Tian,Hang Liu
Here, a new type of Sb 3+ ions alloying with RE 3+ (RE = Er, Ho) ions heavy concentration doped Cs 2 NaBiCl 6 double perovskites (DPs) was successfully synthesized by solvothermal method. The structure and morphology of all samples were characterized with X-ray diffraction, energy dispersive spectroscopy and X-ray photoelectron spectroscopy. The excitation and emission spectra for all samples are investigated in detailed. Under 354 nm excitation, a strong broad blue emission band from 400 to 500 nm is obtained in Cs 2 NaBiCl 6 :15 mol%Sb 3+ DPs. Compared with the Cs 2 NaBiCl 6 :RE 3+ sample, the emission intensities of Er 3+ and Ho 3+ ions for Cs 2 NaBiCl 6 :Sb 3+ /RE 3+ DPs are enhanced by 38 and 29 times due to alloying Sb 3+ ions, respectively. And the self-trapped exciton (STE) emission intensity is also dramatically increased. The energy transfer process from free exciton (FE) to STE and excited state level of RE 3+ contribute to increased luminescence intensity. In addition, the temperature-dependent luminescence spectra of Cs 2 NaBiCl 6 :Sb 3+ /RE 3+ samples were measured from 83 to 423 K. The luminescence thermal enhancement phenomenon is obtained at lower temperature range. At last, the anti-counterfeiting application of Cs 2 NaBiCl 6 :Sb 3+ /RE 3+ samples is elaborated due to their bright multi-color emission under different excitation and temperatures.
研究领域:
材料科学
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光学材料
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发光与光子学
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稀土掺杂
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防伪技术
✓ 已验证
产品关联
DOI
高影响因子
JOURNAL OF ALLOYS AND COMPOUNDS
·
2021
·
IF 5.316
Zhurong Mo,Shaoshan Su,Yanping Huo,Hongli Wen,Andrzej Suchocki,Deshmukh Abdul Hakeem
Fundamental understanding of the Stokes and anti-Stokes emissions in luminescence materials and their mechanism is very important for different technological applications. In this article, we report the dual mode, down/upconversion (DC/UC), luminescence in a LiAlSi 2 O 6 (β-spodumene) single host along with its mechanistic investigations. A series of emission tunable Li 1- x AlSi 2 O 6 : x Er 3+ (LAS: x Er 3+ ; 0 ≤ x ≤ 0.07) and Li 0.99- y AlSi 2 O 6 :0.01Er 3+ , y Yb 3+ (LAS:0.01Er 3+ ,yYb 3+ ; 0.001 ≤ y ≤ 0.007) phosphor powders were prepared by solid state reaction method at 1300 °C. The formation of single-phase phosphors is verified by XRD technique and other structural properties are investigated by FT-IR, UV-Vis-NIR spectra. The phosphors produced NIR DC emission at 1535 nm (under 380 and 980 nm excitation) and an intense red UC emission at 655 nm (under both 980 and 808 nm excitations). The dual mode emission intensity of the LAS:0.01Er 3+ is further improved by co-doping Yb 3+ ions via energy transfer from Yb 3+ to Er 3+ . The red UC emission intensity of LAS:0.01Er 3+ ,0.005Yb 3+ phosphor under 980 nm excitation is ~10 times stronger than the singly doped LAS:0.01Er 3+ phosphor. In addition, the phosphors can also be efficiently excited by 808 nm laser and hence can be used for biological application since 808 nm NIR irradiation exhibits higher light penetration depth without inducing overheating. The mechanism of energy transfer from Yb 3+ to Er 3+ by considering different emission pathways viz: ground state absorption (GSA), excited state absorption (ESA), energy transfer upconversion (ETU), back energy transfer (BET) and cross relaxation (CR) are discussed in detail. Based on the dual mode emissions, the LAS: x Er 3+ and LAS: x Er 3+ , y Yb 3+ ( x = 0.1 and 0.001 ≤ y ≤ 0.007) phosphors could be a potential candidate not only for the biological application as bio-probe but also as energy convertors for solid-state lighting, displays, and solar cell applications.
研究领域:
材料科学
·
光学
·
光子学
·
生物技术
✓ 已验证
DOI
高影响因子
JOURNAL OF PHYSICS AND CHEMISTRY OF SOLIDS
·
2021
·
IF 3.995
Xiangyan Yun,Jun Zhou,Yaohui Zhu,Xiong Li,Shan Liu,Chen Fang,Mingxia Lv,Denghui Xu
Up-conversion fluorescent materials serve a significant function as the detection materials of temperature sensors . In this study, a series of green-emitting LiLuW 2 O 8 :Yb 3+ , Er 3+ phosphors applied in optical temperature sensing detection were successfully synthesized via the solid-state process in air. The crystal structure, luminescence properties, luminescence mechanism, and optical temperature sensing properties of samples were investigated. LiLuW 2 O 8 :Yb 3+ , Er 3+ phosphor with excitation at 980 nm emits pronounced green emissions owing to the 2 H 11/2 → 4 I 15/2 and 4 S 3/2 → 4 I 15/2 transitions of Er 3+ ions. The whole emission processes of LiLu 0.72 W 2 O 8 :0.24 Yb 3+ , 0.04Er 3+ sample are all two-photon processes. Moreover, we apply thermal coupling levels ( 2 H 11/2 , 4 S 3/2 ) for temperature sensing and the value of sensing sensitivity can reach the maximum of about 1.41% K −1 . All the experimental results imply that LiLuW 2 O 8 :Yb 3+ , Er 3+ phosphors show good potential in temperature sensing.
研究领域:
材料科学
·
光学
·
温度传感
✓ 已验证
产品关联
DOI
高影响因子
Journal of Materials Chemistry B
·
2023
·Vol. 11
·期 24
·5565-5573
·
IF 7
Xuran Zhang,Jianfei Ding,Liang Zou,Huihui Tian,Ying Fang,Jinfen Wang
Near-infrared optogenetics based on up-conversion materials provides a promising tool for the dissection of neural circuit functions in deep brain regions. However, it remains a challenge to combine near-infrared up-conversion optogenetic stimulation with high-density electrophysiological recording in a minimally invasive manner. Here, we develop a flexible device for simultaneous electrophysiological recording and near-infrared optogenetics. The flexible device is constructed by integrating polymer-based flexible recording microelectrodes with electrodeposited NaYF4:Yb3+, Er3+ up-conversion films that can convert deep-tissue-penetrating near-infrared light into visible light for optogenetic activation of C1V1-expressing neurons. The emission properties of the up-conversion films are optimized for green light emission to stimulate C1V1 opsins. Owing to their minimized surgical footprint and high mechanical compliance, chronically implanted devices enable simultaneous electrophysiological recording and near-infrared optogenetic modulation of neuronal activities in the brain.
研究领域:
神经科学
·
光遗传学
·
材料科学
·
生物医学工程
✓ 已验证
产品关联
DOI
PubMed
高影响因子
OPTICAL MATERIALS
·
2025
·
IF 4.2
Sihan Yang,Xinyu Li,Qian Zhang,Meiting Li,Xuejiao Wang,Nan Wu
Studies have shown that emissions in the NIR-II and NIR-III regions exhibit high tissue penetration, along with superior performance in biological and medical imaging applications. Therefore, developing NIR phosphors capable of simultaneously show emissions in both the NIR-II and NIR-III regions holds significant value. Herein, we developed a novel Cr 3+ /Er 3+ co-doped NaBaScSi 2 O 7 phosphor that demonstrates efficient dual-band emission in both NIR-II and NIR-III regions under visible light excitation, enabled by highly effective Cr 3+ →Er 3+ energy transfer. The energy transfer efficiencies calculated by the emission intensity and fluorescence lifetime are 65.3% and 47.4%, respectively, with the energy transfer mechanism dominated by dipole-dipole interaction. The prepared phosphor can be effectively excited by multiple excitation sources (378 nm, 492 nm, 808 nm, and 980 nm), generating distinct emission responses, highlighting its potential for anti-counterfeiting applications. Additionally, the distinct temperature-dependent optical properties of Cr 3+ and Er 3+ offer a viable approach for non-contact temperature detection, achieving a relative sensitivity of 0.8% K -1 and a temperature resolution of 0.126 K at 498 K. The NIR-II/III pc-LED fabricated by NaBaScSi 2 O 7 : 1%Cr 3+ , 0.2%Er 3+ demonstrates outstanding non-invasive imaging capability and accurate predictions for organic solvents. This study presents a strategy for developing phosphors capable of simultaneous NIR-II/III emission, and significantly advances their multifunctional applications in NIR optical thermometry and NIR pc-LED technologies.
研究领域:
材料科学
·
光学材料
·
生物医学成像
·
固态照明
·
传感器
✓ 已验证
产品关联
DOI
高影响因子
BIOMATERIALS
·
2015
·
IF 8.557
Xiaoran Deng,Yunlu Dai,Jianhua Liu,Ying Zhou,Ping'an Ma,Ziyong Cheng,Yinyin Chen,Kerong Deng,Xuejiao Li,Zhiyao Hou,Chunxia Li,Jun Lin
Combining the multi-modal medical imaging with cancer therapy in one single system has attracted the great interests for theranostic purpose. In this paper, CaF 2 :Yb 3+ /Er 3+ /Mn 2+ -poly(2-Aminoethyl methacrylate) (UCHNs-PAMA) hybrid microspheres were successfully fabricated. The synthetic route to the nanocomposite based on a facile hydrothermal method for fabrication of hollow upconversion (UC) nanospheres at first and then post-filling the PAMA interiorly through photo-initiated polymerization. The UCHNs showed orange fluorescence under 980 nm near infrared (NIR) laser excitation , which provided the upconverting luminescence (UCL) imaging modality . Meanwhile, the presence of functional Mn 2+ and Yb 3+ offered the enhanced T 1 -weighted magnetic resonance (MR) and computed tomography (CT) imaging, respectively. Thanks to introducing amine groups-containing PAMA inside the hollow nanospheres, the Pt(IV) pro-drug, c,c,t-Pt(NH 3 ) 2 Cl 2 (OOCCH 2 CH 2 COOH) 2 (DSP), can be conveniently bonded on the polymer network to construct a nanoscale anti-cancer drug carrier. The UCHNs-PAMA-Pt(IV) nanocomposite shows effective inhibition for Hela cell line via MTT assay . In contrast, Pt(IV) pro-drug and UCHNs-PAMA microspheres behave little cytotoxicity to Hela cells. This should be attributed the fact that the anti-cancer ability can be recovered only when Pt(IV) pro-drug was reduced to Pt(II)-drug in cellular environment. Furthermore, the in vivo experiments on small mice also confirm that the hybrid microspheres have relatively low toxic side effects and high tumor inhibition rate. These findings show that the multifunctional hybrid microspheres have potential to be used as UCL/MR/CT tri-modal imaging contrast agent and anti-cancer drug carriers.
研究领域:
纳米医学
·
生物材料
·
癌症治疗
·
医学影像学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
危险品化学品经营许可证（带存储）