Frontiers in Bioengineering and Biotechnology
·
2022
·
IF 6.064
Jiang Mingyue,Chen Le,Chen Bo,Yu Qinghua,Zhang Xianming,Jing Weihong,Ma Limei,Deng Tao,Yang Zhangyou,Yu Chao
Curcumin (CUR) is a natural bioactive compound that has attracted attention as a “golden molecule” due to its therapeutic properties against several types of tumors. Nonetheless, the antitumor application of CUR is hampered due to its extremely low aqueous solubility and chemical instability. Herein, a novel type of CUR-loaded polymeric micelles with intracellular K+-responsive controlled-release properties is designed and developed. The polymeric micelles are self-assembled by poly (N-isopropylacrylamide-co-acryloylamidobenzo-15-crown-5-co-N, N-dimethylacrylamide)-b-DSPE (PNDB-b-DSPE) block copolymers, and CUR. CUR is successfully loaded into the micelles with a CUR loading content of 6.26 wt%. The proposed CUR-PNDB-DSPE polymeric micelles exhibit a significant CUR release in simulated intracellular fluid due to the formation of 2 : 1 ‘‘sandwich’’ host–guest complexes of 15-crown-5 and K+, which lead to the hydrophilic outer shell of micelles to collapse and the drug to rapidly migrate out of the micelles. In vitro, the B16F10 cell experiment indicates that CUR-PNDB-DSPE micelles exhibit a high cellular uptake and excellent intracellular drug release in response to the intracellular K+ concentration. Moreover, CUR-PNDB-DSPE micelles show high cytotoxicity to B16F10 cells compared to free CUR and CUR-PEG-DSPE micelles. The polymeric micelles with intracellular K+-responsive controlled release properties proposed in this study provide a new strategy for designing novel targeted drug delivery systems for CUR delivery for cancer treatment.
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PubMed
高影响因子
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
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2022
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IF 4.831
Min Shen,Tingting Pan,Juewei Ning,Fangyuan Sun,Mengyu Deng,Jianxiang Liao,Fengyu Su,Yanqing Tian
The concentration of potassium ion is an important indicator for human health, and its abnormality is often accompanied by various diseases. However, most tools currently used to study potassium ion transport are low throughput. Herein, we reported a new K + fluorescent nanoprobe CP1-KS with high selectivity and sensitivity to K + (fluorescence enhanced factor was up to 9.91 at 20 mM K + ). The polymeric fluorescent probe CP1-KS was composed of the small-molecular K + indicator KS and amphiphilic copolymer CP1. This sensor can be easily and uniformly dispersed in cell culture medium and is suitable for high throughput analysis. To assess the utility of the probe CP1-KS in biological field, this probe was employed as an extracellular fluorescent probe to monitor the efflux of K + from cells ( E coli , B. Subtilis 168, Hela and MCF-7 cells) under various stimulation including lysozyme, nigericin, digitonin, and ATP. Results demonstrated that CP1-KS is an effective analysis tool for extracellular K + concentration. We believe that the nanoprobe has great potential in antibacterial drug screening, K + ionophore function, K + channel activity, cell membrane permeability analysis or other K + related field in the future.
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PubMed
高影响因子
BRITISH JOURNAL OF PHARMACOLOGY
·
2022
·Vol. 179
·期 18
·4563-4574
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IF 9.473
Rongcai Ye,Chunlong Yan,Huiqiao Zhou,Chuanhai Zhang,Yuanyuan Huang,Meng Dong,Hanlin Zhang,Jun Lin,Xiaoxiao Jiang,Shouli Yuan,Li Chen,Rui Jiang,Ziyu Cheng,Kexin Zheng,Anni Yu,Qiaoli Zhang,Lin-hu Quan,Wanzhu Jin
Background and Purpose Polycystic ovary syndrome (PCOS) is a common metabolic and endocrine disease affecting women of reproductive age. Due to its complex aetiology, there is no currently effective cure for PCOS. Brown adipose tissue (BAT) activity is significantly decreased in PCOS patients, and BAT activation has beneficial effects in animal models of PCOS. Here, we investigated the effect of ginsenoside compound K (CK) in an animal model of PCOS and its mechanism of BAT activation. Experimental Approach Primary brown adipocytes, Db/Db mice and dehydroepiandrosterone (DHEA)-induced PCOS rats were used. The core body temperature, oxygen consumption, energy metabolism related gene and protein expression were assessed to identify the effect of CK on overall energy metabolism. Oestrous cycle, serum sex hormone, ovarian steroidogenic enzyme gene expression and ovarian morphology were also evaluated following CK treatment. Key Results Our results indicated that CK treatment could significantly protect against body weight gain in Db/Db mice via BAT activation. Furthermore, we found that CK treatment could normalize hyperandrogenism, oestrous cyclicity, normalize steroidogenic enzyme expression and decrease the number of cystic follicles in PCOS rats. Interestingly, as a potential endocrine intermediate, C-X-C motif chemokine ligand-14 protein (CXCL14) was significantly up-regulated following CK administration. In addition, exogenous CXC14 supplementation was found to reverse DHEA-induced PCOS in a phenotypically similar manner to CK treatment. Conclusion and Implications In summary, CK treatment significantly activates BAT, increases CXCL14 expression and ameliorates PCOS. These findings suggest that CK might be a potential drug candidate for PCOS treatment.
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PubMed
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JOURNAL OF ALLOYS AND COMPOUNDS
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2022
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IF 6.371
Dengyang Wang,Qing Wang,Mingxiu Tan,Shasha Wang,Shaohua Luo,Pengqing Hou,Yahui Zhang,Shengxue Yan,Xin Liu
Carbon quantum dots (CQDs) as a multifunctional carbon nanomaterial have drawn great attention in the field of energy attribute to quantum size, various functional groups and unique physicochemical properties. In this work, the CQDs were prepared from soybean by a simple hydrothermal method , then further pyrolyzed into honeycomb carbon (HC), spherical pore carbon (SC) and bulk porous carbon (BC) with the assistance of templates, respectively. As the anode materials in potassium ion battery (PIBs), HC delivered a high specific capacity of 280.5 mAh g −1 at 0.1 A g −1 and a superior rate performance (136 mAh g −1 at 5 A g −1 ), ascribing to its abundant surface active sites of potassium ion storage and special structures conducive to potassium ion diffusion. This study provides an excellent anode for PIBs from a simple route to construct CQDs-derived carbon.
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JOURNAL OF MATERIALS SCIENCE-MATERIALS IN ELECTRONICS
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2021
·Vol. 33
·期 2
·596-606
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IF 2.478
Hu Haisheng,Jiang Qun,Li Yunfei,Liu Meitang
The K + -doped (Na 1− x K x )GdF 4 :Er 3+ ,Yb 3+ upconversion materials were successfully synthesized by solvothermal method. The doping of K + was testified to have great influences on improving upconversion properties as it directly affects the morphology of the material matrix. In addition, by coating the doped material with a homogeneous shell layer, a newly developed core–shell (Na 0.9 K 0.1 )GdF 4 :Er 3+ ,Yb 3+ @NaGdF 4 nanomaterials were produced. Surprisingly, its light emission intensity was 2 times of that for the uncoated material, although the crystal structure and the emission color of the nanoparticles did not change. The upconversion mechanism has also been studied, and the results show that there is a two-photon mechanism of (Na 1− x K x )GdF 4 :Er 3+ ,Yb 3+ . The work provides a new strategy for enhancing the luminescence density of upconversion materials by coating a homogeneous shell after doping.
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JOURNAL OF THE AMERICAN CERAMIC SOCIETY
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2021
·Vol. 104
·期 9
·4782-4787
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IF 3.784
Lilian Yang,Youling Hou,Guishang Pei,Yuntao Xin,Xuewei Lv
Sodium-ion batteries (NaIBs) have attracted extraordinary attentions as a promising scalable energy storage alternative to current lithium-ion batteries (LIBs), owing to their natural abundance and low costs. Sodium trititanate (Na 2 Ti 3 O 7 ) is a promising material as the material of NaIBs with low potential and high theoretical capacitance. In order to better understand their service performance when utilized in rechargeable NaIBs, studies on thermodynamic properties of Na 2 Ti 3 O 7 are indispensable. However, an extensive literature review revealed that the heat capacity of Na 2 Ti 3 O 7 is established with divergences, especially for high-temperature region. Therefore, the 99.5% purity of Na 2 Ti 3 O 7 powder was first Synthesized through solid-state reaction with sodium carbonate (Na 2 CO 3 ) and titanium dioxide (TiO 2 ) as raw materials. The as-prepared samples were used to measure the heat capacity from 573 to 1323 K which was carried out with multihigh temperature calorimeter (MHTC) 96 line. The temperature dependence of heat capacity was modeled as a function: Cp =255.51073 + 0.06059 T − 3.86912 × 106 T −2 (J mol −1 K −1 ) (298.15 - 1403 K), and then used for computing changes in enthalpy, entropy, and Gibbs free energy. Heat capacity of Na 2 Ti 3 O 7 from 0 to 1403 K was given for future application of Na 2 Ti 3 O 7 in rechargeable batteries.
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CALPHAD-COMPUTER COUPLING OF PHASE DIAGRAMS AND THERMOCHEMISTRY
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2021
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IF 2.017
Lilian Yang,Guishang Pei,Youling Hou,Yuntao Xin,Xuewei Lv
Sodium hexatitanate (Na 2 Ti 6 O 13 ) was reported as an anode side material for Sodium ion batteries owing to low material cost, high energy efficiency, good thermal stability and long cycle life. Therefore, studies pertaining to the thermodynamic properties of Na 2 Ti 6 O 13 are indispensable for improving its service performance. However, a significant number of literature reviews concerning thermodynamic properties indicated that heat capacity of Na 2 Ti 6 O 13 at high temperatures should be confirmed. In this study, the 99.5% purity of Na 2 Ti 6 O 13 sample was successfully prepared via solid-state reaction using TiO 2 and Na 2 CO 3 as initial materials. Heat capacity of the as-synthesized samples in the temperature range of 573–1523 K was measured using a multi-high temperature calorimeter 96 line. Heat capacity, Cp, from 298.15 to 1573 K was modeled as a polynomial formula with a prediction error of 3%: Cp = 474.08143 + 0.06286T-8.04068 × 10 6 T −2 (J⋅mol −1 ⋅K −1 ). In combination with the low-temperature data, heat capacity of Na 2 Ti 6 O 13 from 0 to 1573 K was given in present study. Values of changes in enthalpy, Gibbs free energy and entropy in the temperature range of 298.15–1573 K were calculated based on the temperature dependence of heat capacity.
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REACTIVE & FUNCTIONAL POLYMERS
·
2020
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IF 3.333
Da Xu,Chenyi Zhou,Yunhe Zhang,Jinhui Pang,Zhenhua Jiang,Haibo Zhang
Polyaramid is an indispensable high-performance material for its excellent thermal stability and mechanical strength . But its ultra high melting temperature which is higher than its decomposition temperature and the strong solvent resistance makes it difficult to process. In this work, we prepared a new series of soluble polyamides , poly(arylene ether naphthalene amide)s (PENA), by introducing both naphthalene and phenyl ether groups to the main chain of the polyaramid. The relationship between phenyl ether content and properties of PENAs were investigated. These PENAs have good solubility and can be made into strong and tough films by solvent casting method. Among them, poly(mono arylene ether naphthalene amide)PMENA, which contains mono-ether structure in the polymerization unit, shows the best performance with a tensile strength of 118 MPa and an elongation at break of 45%. Furthermore, PMENA also has good and stable dielectric properties with a high permittivity of 4.7, and low dielectric loss of 0.03 at 1 kHz, at room temperature .
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CHEMISTRY OF MATERIALS
·
2024
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IF 7.2
Meng Cao,Jisheng Song,Haonan Ren,Fan Yang,Rong Chen
With the development of integrated circuit miniaturization, the RC delay caused by the interconnect resistance of metal wires and the capacitance of interlayer dielectric materials limits the high integration and miniaturization of electronic devices. As a promising low-k dielectric material, metal–organic frameworks (MOFs) can effectively alleviate this problem. In this work, we report an atomic regulation strategy of ultralow k MIL-53 film, achieved by converting an Al2O3 seed layer deposited via atomic layer deposition (ALD) and subsequently modifying through atomic layer infiltration (ALI). Thanks to the linear relationship between the thickness of the MIL-53 film and the Al2O3 seed layer prepared by ALD, precise nanoscale control of the MIL-53 films was realized. To meet both mechanical and dielectric property requirements, ALI modification is introduced, effectively regulating Young’s modulus and hardness of MIL-53 films from 19.5 and 0.17 GPa to 29.1 and 0.36 GPa, respectively, while the dielectric constant can be tuned from 1.93 to 2.59. The reconciliation of these properties is achieved by regulating the porosity of the MIL-53 framework through the additional Al–O clusters during the ALI. Furthermore, the superhydrophobic properties (140.7°) and the nearly constant dielectric constant after 9 months of aging reflect its potential as a dielectric insulating material. The proposed preparation and modification strategy of MOF films based on atomic regulation has broad potential for application in low-k interconnect integrated circuits.
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CERAMICS INTERNATIONAL
·
2016
·
IF 2.758
R.Q. Yin,P. Zheng,J.C. Wang,B.W. Dai,L.M. Zheng,J. Du,L. Zheng,J.X. Deng,K.X. Song,H.B. Qin
Lead-free piezoelectric ceramics Sr 1.85 Ca 0.15 Na 1− x K x Nb 5 O 15 (0.00≤ x ≤0.40) were prepared using the conventional solid state reaction method. The structural, dielectric and piezoelectric properties were systematically studied. All the ceramics are single orthorhombic tungsten bronze phase at room temperature, and the lattice constants increase with K + content. The dielectric spectra of each composition had two dielectric anomalies. The Curie temperature T c gradually decreases from 291 °C to 266 °C as x increase from 0.00 to 0.40, and the transition temperature T s from orthorhombic phase to tetragonal phase increases from 39 °C to 109 °C. With increasing K + contents, the piezoelectric coefficient d 33 increases rapidly initially, reaches a maximum and then gradually decreases. The highest piezoelectric performance was obtained at x =0.10, with piezoelectric coefficient d 33 =114 pC/N. Mechanisms that lead to the enhancement of d 33 were discussed from the viewpoint of polarization and crystal structure.
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FLUID PHASE EQUILIBRIA
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2014
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IF 2.241
Keyi Wu,Yonghong Hu,Wenge Yang,Tuan Zhang,Qirun Guo,Shouhai Yang,Ying Shi
The solubility of N-Ethylcarbazole in methanol, ethanol, n-propanol, isopropanol, 1-butanol, 1-pentanol and petroleum ether was measured over the temperature range of 279.15–319.15 K at around 4 K intervals under atmospheric pressure. Experimental result showed that the solubility of N-Ethylcarbazole in seven solvents increased with the increasing temperature and they were in good agreement with the calculated solubility of the modified Apelblat equation and the λh equation. The thermodynamic properties of the solution process, including the Gibbs energy , enthalpy, and entropy were calculated by the van’t Hoff analysis. The values of both the standard molar enthalpy change and standard molar Gibbs energy change of solution were positive, which indicated that the process was endothermic.
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Polymer Chemistry
·
2015
·Vol. 6
·期 19
·3685-3693
·
IF 5.52
Yao Li,He Wang,Chunyu Zhang,Yingchao Zhang,Zhanchen Cui,Donghang Yan,Zuosen Shi
This study describes a general approach to design and synthesize a series of novel high-k polymers containing π-conjugated structures with cyano groups for use as a dielectric layer in organic thin-film transistors (OTFTs). The polymer dielectric films have been evaluated based on surface morphology, dielectric constant, leakage current density and compatibility with organic semiconductors, which can be readily fabricated via solution processes in an ambient atmosphere. The characterization confirms that the π-conjugated structures with cyano groups can provide a high dielectric constant (high-k) and a low electrostatic loss. With these polymer dielectric layers, para-sexiphenyl (p-6P)/vanadyl-phthalocyanine (VOPc) OTFTs exhibit excellent performances with a threshold voltage of −3.22 V, a charge carrier mobility of 0.49 cm2 V−1 s−1, and an on/off current ratio >106.
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危险品化学品经营许可证（带存储）