Chemical Engineering and Processing-Process Intensification
·
2018
·
IF 2.826
Ding Chen,Peng-fei Feng,Fu-hua Wei
Fe-based metal-organic frameworks(Fe(III)-MOFs)were synthesized by Fe 2 (SO 4 ) 3 and trimesic acid using microwave-assisted ball milling method. The structure of the Fe(III)-MOFs was characterized by X-ray diffraction (XRD), scanning electron microscopy (SEM) and Fourier transform infrared spectrometry (FTIR). The thermostability of the MOFs was analyzed by thermogravimetric analysis (TGA). Fe(III)-MOFs were added in aqueous solutions to remove organic dyes. The removal efficiencies of Orange II, CR and MB reached 95.9%, 98.7%, 95.7% respectively at 10℃ and reached 97.7%, 99.7%, 97.5% respectively at 35℃ in 300 min.
研究领域:
材料科学
·
环境科学
·
化学
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产品关联
DOI
高影响因子
ACS Applied Materials & Interfaces
·
2021
·
IF 9.229
Li Lin,Liangen Shen,Junfeng Zhang,Yiyan Xu,Zheng Fang,Peter Müller-Buschbaum,Qi Zhong
Wearable solar radiation sensors based on ionic hydrogels are facilely prepared to simultaneously monitor the radiation dose for the production of vitamin D and the prevention of sunburn. Tetramethylethylenediamine (TEMED) is neutralized with acrylic acid (AA) to obtain tetramethylethylenediamine acrylate (TEMEDA), which is further polymerized with acrylamide by a free radical reaction. By simply adding MB or NR during the polymerization, the final obtained ionic hydrogels can indicate solar radiation. Due to the extent of discoloration, the discoloration speed of MB and NR is correlated to the radiation dose. This wearable sensor can indicate the solar radiation dose required by the human body to synthesize vitamin D through the discoloration of the ionized hydrogel of MB, whereas those with NR are able to illustrate the threshold of radiation dose that causes potential skin hurt. Therefore, the benefit and drawback of solar radiation can be well balanced by optimizing the exposure time to solar irradiation. In addition, polyurethane cross-linked with a thermoresponsive coating is used as band for this wearable sensor. Due to the hydrophilicity below its transition temperature, the cross-linked band possesses the easy cleaning capability of stains after the daily wear. Such type of wearable sensor can be broadly used for monitoring the solar radiation, especially in outdoor activities.
研究领域:
材料科学
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生物材料
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可穿戴技术
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生物医学工程
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光生物学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Surfaces and Interfaces
·
2023
·
IF 6.2
A.V. Ravindra,M. Chandrika,Andem Sandeep
This work presents the effectual degradation of MB and MO dyes in an aqueous solution under UV light irradiation on nano ZnFe 2 O 4 , NiFe 2 O 4 , and Fe 3 O 4 without using any supplementary oxidants has been reported. Nano ZnFe 2 O 4 , NiFe 2 O 4 , and Fe 3 O 4 are successfully prepared via a co-precipitation technique utilizing biodegradable starch as a surfactant . XRD patterns reveal a pure spinel phase for all the samples. FTIR spectra confirm the successful embedding of the starch surfactant. SEM micrographs exhibit tiny spherical particles of size 5–8 and 4–6 nm for ZnFe 2 O 4 and NiFe 2 O 4 but spherical particles of 8–10 nm and flake-like particles of ∼14 nm thick for Fe 3 O 4 . N 2 sorption studies show type-IV isotherms typical of mesoporous structures. The direct bandgap of these ferrite nanoparticles is 2.03–2.15 eV, related to the metal D-d onsite transfers, which are permitted by spin but prohibited by parity. MB decolorization of 99% is achieved in less than 2 h for all the samples; in contrast, MO decolorization takes relatively longer irradiation. The decolorization kinetics suggests that the pseudo-second-order model is more appropriate to explain the decolorization process of MB and MO by the catalysts. The order of photocatalytic activity evaluated from rate constant (k 1 ) per SSA values is Fe 3 O 4 < ZnFe 2 O 4 < NiFe 2 O 4 for both MB and MO decolorization. NiFe 2 O 4 photocatalyst shows the best effect on the decolorization of both dyes due to its low bandgap and high surface area. All the ferrite catalysts demonstrate high stability with no substantial deterioration of photocatalytic activity even after three cycles. The results of this study endorse that the nano ferrites prepared in this work are potential candidates for the photocatalytic degradation of aqueous solutions of MB and MO.
研究领域:
环境科学
·
材料科学
·
化学
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产品关联
DOI
高影响因子
ACS Applied Materials & Interfaces
·
2016
·
IF 7.145
Jinjin Guo,Junchun Wang,Junqing Zhao,Zilin Guo,Yuzhong Zhang
In this work, a novel electrochemical immunoassay protocol has been reported for simultaneous determination of multiple tumor biomarkers based on DNA hybridization chain reaction (HCR) for signal amplification. Alpha-fetoprotein (AFP) and prostate specific antigen (PSA) were selected as model biomarkers. The immunoassay protocol contained primary antibodies immobilized on gold nanoparticles (Au NPs), secondary antibodies conjugated with DNA concatemer from HCR of primer, auxiliary probe, and signal probe labeled with signal molecules (methyleneblue (MB) and ferrocene (Fc)). In the presence of target biomarkers, the sandwich immunocomplex was formed between the primary antibodies and secondary antibodies bioconjugates carrying numerous signal molecules. As a result, two well-resolved reduction peaks, one was at −0.35 V (corresponding to MB) and other was at 0.33 V (corresponding to Fc; both vs SCE), were obtained in differential pulse voltammetry, and peak currents changed were related to the level of biomarkers. Under optimal conditions, the electrochemical immunoassay exhibited a wide linear response range (0.5 pg mL–1 to 50 ng mL–1) and low detection limits (PSA, 0.17 pg mL–1; AFP, 0.25 pg mL–1) (at S/N = 3). In addition, the immunoassay was evaluated by analyzing simulate human serum sample, and the recoveries obtained were within 99.4–107.6% for PSA and 97.9–108.2% for AFP, indicating the immnuoassay could be applied to the simultaneous detection of AFP and PSA in human serum samples.
研究领域:
生物化学
·
分析化学
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纳米技术
·
癌症研究
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生物医学工程
✓ 已验证
DOI
PubMed
高影响因子
JOURNAL OF CONTROLLED RELEASE
·
2020
·
IF 7.727
Xue Yang,Fang Gao,Wenan Zhang,Huipeng Li,Xinzhi Huang,Jiajia Wei,Jiayi Bian,Ying Yang,Chenggen Qian,Minjie Sun
Invasion and metastasis of tumor cells is one of the major obstacles in cancer therapy. The process of tumor metastasis and diffusion is coordinated by multiple pathways associated with chemokine signals and migration microenvironment. In our previous work, chemokine CXC receptor 4 (CXCR4) antagonists showed significant anti-metastatic effects by blocking the CXCR4/stromal cell-derived factor-1(SDF-1) axis in pancreatic cancer and breast cancer. Here, we proposed to achieve migration chain-treatment for metastatic tumors by introducing a cell adhesion molecules CD44 inhibitor (Star miR-34a) to deprive of cell migration capability on the basis of CXCR4 antagonism (cyclam monomer , CM). Dextrin modified 1.8 k PEI with CM-end was prepared to deliver therapeutic miR-34a (named DPC/miR-34a) for efficient anti-metastasis by downregulating adhesion protein CD44 and targeting the CXCR4/SDF-1 axis. Additionally, reduced expression of the anti-apoptotic protein Bcl2 caused by miR-34a could enhance the anti-tumor efficacy of DPC/miR-34a nanoplex administration. Compared with inhibition of the CXCR4/SDF-1 axis or CD44 expression, the multidimensional therapy (DPC/miR-34a) exhibited considerable suppression of cancer cell invasion as assessed by an in vitro cell invasion assay and in vivo anti-metastasis model. Moreover, DPC/miR-34a demonstrated a superior antitumor and anti-metastatic efficacy both in lung metastatic model and orthotopic MDA-MB-231 tumor models, thus providing an efficient approach for combating metastatic tumors.
研究领域:
肿瘤学
·
分子生物学
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药学
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癌症治疗
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产品关联
DOI
PubMed
高影响因子
Nanomaterials
·
2025
·Vol. 15
·期 14
·1131
·
IF 4.3
Xing Wei,Gaopeng Jia,Ru Chen,Yalong Zhang
In this study, the BPTCD/g-C3N4heterojunction photocatalyst was successfully prepared by the hydrothermal method. BPTCD (3,3′,4,4′-benzophenone tetracarboxylic dianhydride) is immobilised on the surface of g-C3N4by non-covalent π-π stacking. The BPTCD/g-C3N4heterojunction photocatalyst is an all-organic photocatalyst with significantly improved photocatalytic performance compared with g-C3N4. BPTCD/g-C3N4-60% was able to effectively degrade MO solution (10 mg/L) to 99.9% and 82.8% in 60 min under full spectrum and visible light. The TOC measurement results indicate that MO can ultimately be decomposed into H2O and CO2through photocatalytic action. The photodegradation of methyl orange by BPTCD/g-C3N4composite materials under sunlight is mainly attributed to the successful construction of the heterojunction structure and its excellent π-π stacking effect. Superoxide radicals (•O2−) were found to be the main active species, while•OH and h+played a secondary role. The synthesised BPTCD/g-C3N4also showed excellent stability in the activity of photodegradation of MO in wastewater, with the performance remaining above 90% after three cycles. The mechanism of the photocatalytic removal of MO dyes was also investigated by the trap agent experiments. Additionally, BPTCD/g-C3N4-60% demonstrated exceptional photodegradation performance in the degradation of methylene blue (MB). BPTCD/g-C3N4heterojunctions have great potential to degrade organic pollutants in wastewater under solar irradiation conditions.
研究领域:
材料科学
·
环境化学
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光催化
·
有机半导体
·
废水处理
✓ 已验证
产品关联
DOI
PubMed
高影响因子
CHEMICAL ENGINEERING JOURNAL
·
2022
·
IF 16.744
Yuehua Shi,Yu Shi,Zhaoyang Wang,Jiahe Zhang,Ran Hao,Gangwan Zhang,Xiaolong Zhao,Leyong Zeng
To achieve safe and efficient tumor therapy, it was a powerful strategy of constructing an intelligent tumor microenvironment (TME)-responsive nanoprobe. In this study, by coating ultrasmall gold nanoparticles (AuNPs) and manganese dioxide (MnO 2 ) on mesoporous prussian blue (MPB), [email protected] @MnO 2 nanoprobe with H 2 O 2 self-generation was developed for magnetic resonance (MR) imaging, photothermal therapy (PTT) and enhanced chemodynamic therapy (CDT). The results indicated that the prepared [email protected] @MnO 2 possessed uniform size and good biocompatibility. Using glucose-responsive self-supplying H 2 O 2 of ultrasmall AuNPs, and glutathione (GSH)-responsive Mn 2+ release from MnO 2 degradation, the accelerated hydroxyl free radicals (·OH) generation efficiency (80.0 % to 90.84 %) and enhanced MR relaxation (1.93 to 9.96 mM −1 ·s −1 ) were achieved. Importantly, the prepared [email protected] @MnO 2 exhibited excellent photothermal performance with a photothermal conversion efficiency of 42.62 %. Moreover, the intracellular H 2 O 2 /·OH generation was demonstrated, and the in vitro CDT/PTT was enhanced, by which the cell viability was reduced to 6.4 %, stronger than 18.8 % of [email protected] 2 . By modeling MDA-MB-435 tumor-bearing nude mice, the combined CDT/PTT of [email protected] @MnO 2 nanoprobe greatly inhibited the tumor growth, and after 15 days, the tumor completely disappeared. This work provided a promising strategy to develop TME-responsive self-supplying H 2 O 2 nanoprobe, achieving MR imaging and enhanced antitumor efficacy.
研究领域:
纳米技术
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生物医学工程
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癌症治疗
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材料科学
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医学成像
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产品关联
DOI
高影响因子
ANALYTICA CHIMICA ACTA
·
2023
·
IF 6.2
Hui Zhang,Jianhui Xie,Qun Feng,Jiamin Ye,Ruoyu Chen,Jingchun Yao,Guimin Zhang,Jizhong Yan,Kewu Zeng,Pengfei Tu
Natural products has been used for the prevention and treatment of diseases for a long history. Research on the bioactive components from natural products and their interaction with target proteins are essential for drug discovery. However, studying the binding ability of natural products' active ingredients to target proteins is usually time-consuming and laborious due to their complex and diverse chemical structures. In this study, we have developed a high resolution micro-confocal Raman spectrometer-based photo-affinity microarray (HRMR-PM) technology for the investigation of active ingredients-target protein recognition strategy. The novel photo-affinity microarray was constructed by photo-cross-linking the small molecule with the photo-affinity group (4-[3-(Trifluoromethyl)-3H-diazirin-3-yl]benzoic acid, TAD) on the photo-affinity linker coated (PALC) slides under 365 nm ultraviolet irradiation . The small molecules on the microarrays with specific binding ability might immobilize target protein, which were characterized by high resolution micro-confocal Raman spectrometer. Using this method, more than a dozen components of Shenqi Jiangtang granules (SJG) were made into small molecule probe (SMP) microarrays. As a result, 8 of them had been identified to have α-glucosidase binding ability according to characteristic Raman shift at about 3060 cm −1 . These compounds were further verified by different small molecule-protein interaction analysis methods, including contact angle D-value, surface plasmon resonance (SPR) and molecular docking . The results showed that Ginsenosides Mb, Formononetin and Gomisin D exhibited the strongest binding ability. In conclusion, the HRMR-PM strategy for investigating the interaction between target proteins and small molecules has the advantages such as high throughput, low sample consumption and fast qualitative characterization. This strategy is universal which can be applied in the study of in vitro binding activity of various types of small molecules to target proteins.
研究领域:
药学
·
分析化学
·
药物发现
·
蛋白质组学
·
天然产物
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产品关联
DOI
PubMed
高影响因子
ADVANCED FUNCTIONAL MATERIALS
·
2020
·Vol. 30
·期 14
·1909806
·
IF 16.836
Qi-Wen Chen,Xin-Hua Liu,Jin-Xuan Fan,Si-Yuan Peng,Jia-Wei Wang,Xia-Nan Wang,Cheng Zhang,Chuan-Jun Liu,Xian-Zheng Zhang
A photothermal bacterium (PTB) is reported for tumor-targeted photothermal therapy (PTT) by using facultative anaerobic bacterium Shewanella oneidensis MR-1 ( S. oneidensis MR-1) to biomineralize palladium nanoparticles (Pd NPs) on its surface without affecting bacterial activity. It is found that PTB possesses superior photothermal property in near infrared (NIR) regions, as well as preferential tumor-targeting capacity. Zeolitic imidazole frameworks-90 (ZIF-90) encapsulating photosensitizer methylene blue (MB) are hybridized on the surface of living PTB to further enhance PTT efficacy. MB-encapsulated ZIF-90 (ZIF-90/MB) can selectively release MB at mitochondria and cause mitochondrial dysfunction by producing singlet oxygen ( 1 O 2 ) under light illumination. Mitochondrial dysfunction further contributes to adenosine triphosphate (ATP) synthesis inhibition and heat shock proteins (HSPs) down-regulated expression. The PTB-based therapeutic platform of PTB@ZIF-90/MB demonstrated here will find great potential to overcome the challenges of tumor targeting and tumor heat tolerance in PTT.
研究领域:
癌症治疗
·
纳米技术
·
生物医学工程
·
光疗
✓ 已验证
产品关联
DOI
高影响因子
CARBOHYDRATE POLYMERS
·
2019
·
IF 6.044
Xuejing Zhang,Shiwei Niu,Gareth R. Williams,Jianrong Wu,Xia Chen,Hong Zheng,Li-Min Zhu
In this study, we report a novel pH and temperature responsive paclitaxel-loaded drug delivery system based on chitosan and di(ethylene glycol) methyl ether methacrylate. This was functionalized with hyaluronic acid to permit active targeting of CD44-overexpressing human breast cancer cells. The resultant HA-CS-g-PDEGMA-PTX nanoparticles (NPs) have small and uniform sizes (˜170 nm), a high drug loading (13.6 ± 1.3%) and high encapsulation efficiency (76.2 ± 8.5%). Cell viability and confocal microscopy experiments demonstrated that the NPs could effectively target and kill MDA-MB-231 human breast cancer cells, but were much less toxic to healthy human umbilical vein endothelial cells. In vivo biodistribution studies in mice showed that the NPs accumulated in the tumor site, while free drug was distributed more widely and rapidly cleared from the body. Histopathological studies revealed that the NPs led to enhanced apoptosis in the tumor site, which resulted in reduced tumor growth. The NPs prepared in this work have great potential for the treatment of breast cancers, and further offer a platform with which to target other cancers.
研究领域:
药学
·
纳米技术
·
癌症研究
·
药物递送系统
✓ 已验证
产品关联
DOI
PubMed
高影响因子
MEDICINAL CHEMISTRY RESEARCH
·
2025
·
IF 3.1
Wu Xinhua,Wu Lifang,Li Zhaoquan,Tian Wei,Li Tao
Three series of (dimethyl-, dibutyl-, and diphenyl-) new organotin(IV) complexes based on chlorine substituted aryl ligands were synthesized and characterized by UV, 1 H NMR, 13 C NMR, 119 Sn NMR, HRMS, and X-ray crystallography analysis. MTT results showed that chlorine substitution at different positions on the aryl group exhibited different anticancer activities. Among them, 5-chloro substituents > 3,5-dichloro substituents > 3-chloro substituents on the aryl ring of salicylaldehyde on Schiff base ligand. In addition, different substituents on the tin atom also demonstrated extreme differences in anticancer activities, where dibutyltin > diphenyltin > dimethyltin. Interestingly, the complex LTDB2 exhibited excellent anti-proliferative activity against breast cancer MDA-MB-231 cells (superior to cisplatin) and lower toxicity against human embryonic kidney HEK-293 cells in vitro. Flow cytometry showed that LTDB2 not only induced apoptosis, but also induced cell cycle arrest in G2 phase. These findings provide new insights for further research and development of novel organotin(IV) complexes as anticancer drugs. Complex LTDB2 exhibited excellent anti-proliferative activity against breast cancer MDA-MB-231 cells in vitro and was superior to cisplatin. Flow cytometry showed that LTDB2 not only induced apoptosis, but also induced cell cycle arrest in G2 phase.
研究领域:
化学
·
药理学
·
肿瘤学
·
材料科学
✓ 已验证
DOI
高影响因子
Frontiers in Chemistry
·
2021
·
IF 5.221
Wang Weicai,Liu Xiaofan,Ding Lairong,Jin Hyung Jong,Li Xuemei
Hypoxia is not only the reason of tumor metastasis but also enhances the spread of cancer cells from the original tumor site, which results in cancer recurrence. Herein, we developed a self-assembled RNA hydrogel that efficiently delivered synergistic DNA CpG and short hairpin RNA (shRNA) adjuvants, as well as MnO2 loaded-photodynamic agent chlorine e6 (MnO2@Ce6), and a chemotherapy drug doxorubicin (DOX) into MDA-MB-231cells. The RNA hydrogel consists of one tumour suppressor miRNA (miRNA-205) and one anti-metastatic miRNA (miRNA-182), both of which showed an outstanding effect in synergistically abrogating tumours. The hydrogel would be dissociated by endogenous Dicer enzyme to release loaded therapeutic molecules, and in the meantime induce decomposition of tumor endogenous H2O2 to relieve tumor hypoxia. As a result, a remarkable synergistic therapeutic effect is achieved through the combined chemo-photodynamic therapy, which simultaneously triggers a series of anti-tumor immune responses. Besides, the hydrogel as the carrier which modified aptamer to targeted MDA-MB-231 has the advantages of good biocompatibility and low cytotoxicity. This strategy could be implemented to design any other microRNA (miRNA) as the carrier, combined with other treatment methods to treat human cancer, thereby overcoming the limitations of current cancer therapies.
研究领域:
癌症生物学
·
纳米技术
·
治疗学
·
药学
·
生物医学工程
✓ 已验证
DOI
PubMed
高影响因子
危险品化学品经营许可证（带存储）