Journal of the Taiwan Institute of Chemical Engineers
·
2018
·
IF 3.849
Qiang Huang,Jiao Zhao,Meiying Liu,Yan Li,Jiayuan Ruan,Qing Li,Jianwen Tian,Xiaoli Zhu,Xiaoyong Zhang,Yen Wei
In present work, novel polyacrylamide immobilized molybdenum disulfide (MoS 2 @ [email protected] ) composites were synthesized via the mussel-inspired chemistry and surface initiated atom transfer radical polymerization (SI-ATRP). The as-prepared MoS 2 @ [email protected] composites were characterized by energy dispersive X-ray spectroscopy (EDX), transmission electron microscope (TEM), Fourier transform infrared spectroscopy (FT-IR), thermogravimetric analysis (TGA), and X-ray photoelectron spectroscopy (XPS). Characterization results provide sufficient evidences for the successful functionalization of MoS 2 with PAM. The products were used as adsorbents for removing of copper (II) ions. Results show the introduction of PAM onto MoS 2 could enhance the adsorption capacity of MoS 2 @ [email protected] towards copper (II) ions. The amount of adsorbed copper (II) ions by MoS 2 @ [email protected] composites is 2.5 times that of pristine MoS 2 . The effects of various experimental factors on the adsorption process, including contact time, initial copper (II) ion concentrations, solution pH and temperature, were also studied in this work. The batch experiments show that the adsorption of copper (II) ions onto MoS 2 @ [email protected] is dependent on time, pH and temperature. The optimum solution pH is observed at pH 7 and the increase of temperature is favorable for the adsorption of MoS 2 @ [email protected] towards copper (II). Based on the experiment data, the adsorption kinetics, isotherms and thermodynamics were also investigated. The kinetics and isotherm studies show that pseudo-second-order kinetic and Freundlich isotherm models could well fit with the adsorption data. The thermodynamic results show that the adsorption of copper (II) ions on MoS 2 @ [email protected] is a spontaneous and endothermic process. The adsorption process is mainly governed by the chemisorption involving the electrostatic interaction and/or chemical chelation between copper (II) ions and amino groups on the surface of MoS 2 @ [email protected] Taken together, it is proven that the PAM can be immobilized onto the MoS 2 nanosheets via the mussel-inspired chemistry and SI-ATRP, and it can enhance the adsorption performance of MoS 2 @ [email protected] composites, which might be used as adsorbents to remove heavy metal ions in real environment treatment.
研究领域:
材料科学
·
环境化学
·
聚合物化学
✓ 已验证
DOI
高影响因子
MICROCHIMICA ACTA
·
2024
·Vol. 191
·期 12
·1-12
·
IF 5.3
Wang Yisi,Zhang Junying,Lv Xinxin,Ding Ya,Wang Yaolong,Liu Yuanhua,Wu Chunyong,Yang Gongjun
A highly sensitive and selective label-free impedimetric immunosensor based on AuNPs@pDA@NiCo 2 S 4 @MoS 2 nanocomposite modified on the surface of a screen-printed electrode (SPE) was designed for the detection of interleukin-6 (IL-6). The distribution of NiCo 2 S 4 nanoparticles on MoS 2 nanosheets was able to prevent them from agglomerating. The polydopamine (pDA) layer was coated on the surface of NiCo 2 S 4 @MoS 2 nanosheets by self-polymerization, which improved the stability and biocompatibility of the nanomaterial. The excellent reduction ability of pDA promoted the synthesis of gold nanoparticles (AuNPs), which increased the amount of antibody adsorption and the conductivity of the material. Finally, the antibody (Ab) of IL-6 was immobilized on the surface of AuNPs@pDA@NiCo 2 S 4 @MoS 2 nanocomposite. Electrochemical impedance spectroscopy (EIS) was used to detect the change of impedance before and after the immune response between Ab and IL-6 antigen (IL-6). Under the optimal experimental conditions, the relative change in impedance and the logarithmic concentration of IL-6 showed a good linear relationship in the range 1.00 to 1.00 × 10 6 pg/mL, with a low detection limit of 0.97 pg/mL. In addition, the proposed immunosensor performed with good reproducibility, stability, and specificity. It was successfully applied to the determination of IL-6 in patient’s serum samples of head and neck carcinoma with recoveries of 98.40% to 106.5%. To sum up, the proposed label-free impedimetric immunosensor was successfully constructed for IL-6 detection in real samples. Graphical abstract
研究领域:
生物化学
·
生物技术
·
分析化学
·
材料科学
·
医学诊断
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Molecular Catalysis
·
2024
·
IF 3.9
Yuqiu Wu,Fanjin Meng,Jiaolong Fu,Yuyang Zhou,Huan Fan,Xin Ju,Liangzhi Li
D-xylose, a biomass derivative, is used as a substrate to generate D-xylulose and D-ribulose with high-added value through a cascade reaction. During this process, the thermal stability and catalytic efficiency of rate-limiting enzymes during cascade reactions are important issues that must be addressed in industrial applications. In this study, we prepared and validated PDA/SiO 2 microspheres as highly loaded immobilization carriers by oxidative self-polymerization of polydopamine (PDA) on silica (SiO 2 ) microspheres. D-xylose was successfully catalyzed by the co-immobilized D-5-phosphate ribose isomerase B (RpiB) and D-tagatose-3-epimerase (DTE), denoted PDA/SiO 2 -RpiB-DTE, to produce D-ribulose and D-xylulose. After immobilization, the K m of co-immobilized RpiB and DTE decreased, which suggested increased substrate affinity. The half-life of the co-immobilized enzymes was 3.5–8 fold higher than that of the free enzymes at 50–70 °C, and the inactivation rate constant was reduced, demonstrating that immobilization improved significantly the thermal stability. The conversion of D-xylose at 10 mM was 29.98% under optimal conditions, which contained 9.85% D-ribulose and 20.13% D-xylulose. PDA/SiO 2 -RpiB-DTE showed up to 89.10% initial enzyme activity after 3 recycle runs. The thermal stability and recovery aspects were improved by immobilization, which facilitates the use of biomass to produce high-value-added products and further exploitation.
研究领域:
生物技术
·
酶工程
·
生化工程
✓ 已验证
产品关联
DOI
高影响因子
CHEMICAL ENGINEERING JOURNAL
·
2024
·
IF 13.3
Yan Huang,Sixian Chen,Yi Li,Qianbing Lin,Yibo Wu,Qisong Shi
Polyacrylonitrile (PAN) nanofiber-based flexible piezoelectric sensors are recognized for their applicability in wearable electronic devices, personal health monitoring, and motion detection. This research explores the impact of dual fillers, MXene and polydopamine-modified zinc oxide (PDA@ZnO), on the characteristics of PAN-based piezoelectric composite nanofiber films, including planar zigzag conformation content, dielectric, ferroelectric, piezoelectric, and mechanical properties. By integrating PDA@ZnO as a filler, PAN/MXene/PDA@ZnO-5 (PMPO) piezoelectric sensors were developed, showcasing enhanced piezoelectric sensing capabilities. These sensors achieved a sensitivity of 28.56 V/N across a broad linear range, with superior mechanical stability and durability across 3000 loading–unloading cycles, and exhibited swift response and recovery times of 49 ms and 40 ms, respectively. Furthermore, their unique fiber structure and flexibility, when interfaced with the human body, enable the detection of minute physiological movements and the conversion of varied motions into distinct voltage outputs. Thus, these sensors offer considerable promise for applications in human health monitoring and motion posture correction.
研究领域:
材料科学
·
纳米技术
·
生物医学工程
·
可穿戴技术
✓ 已验证
产品关联
DOI
高影响因子
ANALYST
·
2023
·
IF 4.2
Juan Yang,Dongmiao Qin,Na Wang,Yusheng Wu,Kanjun Fang,Biyang Deng
The construction of advanced systems capable of accurately detecting neuron-specific enolase (NSE) is essential for rapidly diagnosing small-cell lung cancer. In this study, an electrochemiluminescence (ECL) resonance energy transfer immunosensor was proposed for the ultra-sensitive detection of NSE. The co-reactants C2O42− and Ru(bpy)32+ were integrated to form a self-enhanced ECL luminophore (Ru-ZnMOF) as the ECL donor. The abundant carboxyl functional groups of Ru-ZnMOF supported antibody 1 via an amidation reaction. Polydopamine-modified zinc dioxide nanoflowers, as ECL acceptors, inhibited Ru-ZnMOF ECL signaling. The linear range of NSE was 10 fg/mL to 100 ng/mL with a detection limit of 3.3 fg/mL (S/N = 3), which is suitably low for determining NSE in real samples.
研究领域:
分析化学
·
生物医学工程
·
癌症诊断
·
纳米技术
·
生物化学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
CHEMICAL ENGINEERING JOURNAL
·
2024
·
IF 13.3
Wei Ji,Yewen Xiao,Feng Xiao,Linlin Li,Minmin Chen,Hualin Wang
Membrane separation technology is a promising alternative for oily wastewater purification. However, developing membrane for the purification of biochemical oily wastewater is still challengeable. To this aim, a novel multifunctional photocatalytic membrane of PTPB-8 is fabricated by sequentially loading of TiO 2 , polydopamine (PDA), and BiOBr onto polyacrylonitrile (PAN) nanofibers in situ . PTPB-8 is of water contact angle (WCA) ∼ 0° and underwater oil contact angle (UOCA) 154.7 ± 2.5°, allowing it with outstanding separation and anti-fouling capability, and good reusability for emulsion separation under gravity (i.e., separation efficiency >90 %, permeation flux >300 L m -2 h −1 , and flux recovery rate >82 % for n-hexane-in-water emulsion after 15 cycles). Under simulated solar light, the ternary heterojunction TiO 2 @PDA@BiOBr is catalytically active with generating active species and the charge transfer pathway follows the mechanism of Z-type heterojunction. Consequently, PTPB-8 can kill E. coli and S. aureus by ∼ 100 % and degrade tetracycline by >90 %. The application trial results have demonstrated the great potential of PTPB-8 in the purification of biochemical oily wastewater containing bacteria and antibiotics. This study will also give a new idea for enhancing the photocatalytic activity of heterojunctions by PDA decoration.
研究领域:
环境工程
·
水处理
·
光催化
·
材料科学
✓ 已验证
产品关联
DOI
高影响因子
ELECTROCHIMICA ACTA
·
2024
·
IF 5.5
Xusen Cheng,Yanping Wang,Yunfeng Qiu,Yanxia Wang,Miao Yu,Zhuo Ma,Tiedong Sun,Shaoqin Liu
Metal oxides rich in oxygen vacancies (O v ) possess excellent intrinsic conductivity, variable valence metal center and high capacitance, which were potential candidates as microbial fuel cells anode. However, their high bacterial toxicity greatly hindered the activity of biofilm. To solve this issue, in this work, polydopamine (PDA) covered capacitive O v doped Co 3 O 4 nanosheets were designed and successfully grown on carbon cloth (CC). The introduction of O v significantly promoted the charge storage, the net charge and the accumulated charge were 217.1 and 2680.3 C/m 2 , respectively, surpassed Co 3 O 4 anode without O v . In addition, O v also decreased the charge-transfer resistance ( R ct ), effectively accelerating EET. The R ct of PDA/O v -Co 3 O 4 @CC was 29.51 Ω, lower than CC (382.10 Ω). The cover of PDA prevented the direct contact between metal ions and microorganisms, greatly enhanced the bacterial viability. The power density of MFCs with PDA/O v -Co 3 O 4 @CC anode was 2.77 W/m 2 , 1.45 times higher than that of bare CC (1.90 W/m 2 ). In addition, PDA/O v -Co 3 O 4 @CC anode displayed excellent coulombic efficiency and daily COD removal amount (23.5 % and 147.6 mg/L/d), higher than the control groups. The community analysis showed the abundance of Geobacter on PDA/O v -Co 3 O 4 @CC anode was 91 %, higher than other anodes. Present study developed a facile and effective PDA coating strategy to simultaneously enhance the biocompatibility and capacitance of O v -rich metal oxides, which will be a promising method for the preparation of high performance MFCs anode.
研究领域:
材料科学
·
环境工程
·
电化学
·
微生物学
✓ 已验证
产品关联
DOI
高影响因子
BIOMATERIALS
·
2023
·
IF 14
Yuquan Li,Junxu Yang,Xiaoming Chen,Hao Hu,Nihan Lan,Jinmin Zhao,Li Zheng
Mitochondrial reactive oxygen species (mROS) play a crucial role in the process of osteoarthritis (OA), which may be a promising target for therapy of OA. In this study, novel mitochondrial-targeting and SOD-mimic Mn 3 O 4 @PDA@Pd-SS31 nanozymes with near-infrared (NIR) responsiveness and synergistic cascade to scavenge mROS were designed for the therapy of OA. Results showed that the nanozymes accelerated the release of Pd and Mn 3 O 4 under NIR irradiation, exhibiting enhanced activities of SOD and CAT mimic enzymes with reversed mitochondrial dysfunction and promoted mitophagy to effectively scavenge mROS from chondrocytes, modulate the microenvironment of oxidative stress, and eventually inhibit the inflammatory response. Nanozymes were excreted in vivo through intestinal metabolic pathway and had good biocompatibility, effectively reducing the inflammatory response and relieving articular cartilage degeneration in OA joints, with a reduction of 93.7 % and 93.8 % in OARSCI scores for 4 and 8 weeks respectively. Thus, this study demonstrated that the mitochondria targeting and NIR responsive Mn 3 O 4 @PDA@Pd-SS31 nanozymes could efficiently scavenge mROS, repair damaged mitochondrial function and promote cartilage regeneration, which are promising for the treatment of OA in clinical applications.
研究领域:
生物医学工程
·
纳米技术
·
骨科
·
药学
✓ 已验证
DOI
PubMed
高影响因子
CHEMICAL ENGINEERING JOURNAL
·
2025
·
IF 13.2
Dongze Ren,Mingjie Liu,Min Cao,Shan Wang,Sixing Fan,Mozhen Liu,Jianbin Zhang,Huijun Sun
Osteoarthritis (OA) is an irreversible degenerative disease of articular cartilage that commonly occurs in the middle-aged and elderly people. However, effective intervention for early and middle-stage OA is still limited due to its complex and multifactorial nature. Excessive reactive oxygen species (ROS) and the inflammatory microenvironment are considered to play crucial roles in the occurrence and development of OA. Here, a novel HPB@LA@PDA nanoplatform is designed, which utilizes the mimicking enzyme activity of hollow prussian blue (HPB) nanozymes and antioxidant activity of lipoic acid (LA), to synergistically scavenge ROS and remodel the OA microenvironment. HPB@LA@PDA was firstly synthesized and the characterizations were confirmed by TEM, DLS, XPS, FTIR, UV–Vis, and XRD methods. It exhibited excellent multienzyme-like (SOD, GPx, CAT and POD-like) activities and antioxidant activities, converting •O 2 − , H 2 O 2 , •OH and reactive nitrogen species into harmless products. Importantly, at both the cellular and animal levels, we found HPB@LA@PDA could effectively scavenge excess ROS, protect against ROS-induced oxidative stress, apoptosis and ferroptosis, and ameliorate mitochondrial dysfunction, reduce inflammatory expression, and inhibit macrophage polarization in the chondrocytes. Finally, the results of in vivo study demonstrated that HPB@LA@PDA exhibited good biocompatibility and excellent therapeutic efficacy in the OA rat model. Micro-CT scaning, histopathological and immunofluorescence staining and western blotting analysis confirmed that HPB@LA@PDA attenuated the progression of OA by way of scavenging reactive oxygen species and remodelling the inflammatory microenvironment. The combination of drug and nanoenzyme vehicle offers a promising prospect for the treatment of various inflammatory diseases, including OA.
研究领域:
纳米医学
·
骨科
·
药理学
·
生物化学
·
炎症研究
✓ 已验证
产品关联
DOI
高影响因子
Biomaterials Science
·
2023
·
IF 6.6
Ruijia Han,Yajun Min,Guanlin Li,Shilu Chen,Maobin Xie,Zheng Zhao
Concurrent treatment of tumor recurrence and bone defects after surgical resection of osteosarcoma remains a clinical challenge. Combination therapy based on local drug delivery systems shows great promise in the treatment of osteosarcoma. In this study, curcumin modified polydopamine nanoparticle loaded silk fibroin doped with nano-hydroxyapatite (CM-PDA/SF/nHA) nanofibrous scaffolds were developed to induce bone defect regeneration and chemo-photothermal synergistic effects against osteosarcoma. These scaffolds exhibited good photothermal conversion efficiency and photostability. Moreover, the results of ALP staining and alizarin red S (ARS) staining indicated that the CM-PDA/SF/1%nHA scaffolds had the most obvious promotion effect on early osteogenic differentiation. The results of in vitro and in vivo anti-osteosarcoma activity showed that the CM-PDA/SF/1%nHA scaffolds exhibited higher anti-osteosarcoma activity compared to the control and SF scaffolds. In addition, the CM-PDA/SF/1%nHA scaffolds could promote the proliferation and differentiation of bone marrow mesenchymal stem cells in vitro and new bone production in vivo. Thus, these results suggested that the CM-PDA/SF/1%nHA scaffolds could improve bone defect regeneration and achieve chemo-photothermal synergistic effects against osteosarcoma.
研究领域:
生物医学工程
·
组织工程
·
癌症治疗
·
材料科学
·
纳米技术
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Materials
·
2020
·Vol. 13
·期 17
·3872
·
IF 3.057
Qunling Fang,Kezhu Xu,Jianfeng Zhang,Qingshan Xiong,Jinyu Duan,Shouhu Xuan
The bacteria, which usually contaminate water environment, often cause terrible infectious diseases thus seriously threaten people’s health. To meet the increasing requirement of the public health care, an easily separable nanomaterial with sustainable anti-bacteria performance is required. This work reports a Fe3O4@PDA/Ag/PDA core-shell nanosphere in which the Ag nanocrystals immobilized on the magnetic carrier are protected by an external polydopamine (PDA) layer. The magnetic hybrid nanospheres are constructed by a tunable coating method and the particle parameters can be effectively controlled by the experimental condition. The antibacterial potential of the nanospheres is evaluable by using theStaphylococcus aureusandEscherichia colias the models. The results indicate the Fe3O4@PDA/Ag/PDA core-shell nanospheres have a high antibacterial performance by measuring the minimum inhibitory concentration and the minimum bactericidal concentration. Finally, the product is expected to have a sustainable activity because the protecting PDA layer reduce the releasing rate of the Ag+ions and the materials can be magnetically recovered from the media after the disinfection procedure.Keywords:core-shell;magnetic;Ag;antibacterial;polydopamine
研究领域:
材料科学
·
微生物学
·
纳米医学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
ACS Applied Materials & Interfaces
·
2025
·
IF 8.2
ChuanYao Zhai,WenHao Wang,AnQuan Ma,HuanYu Liu,TianTian Zhu,Yan Zhang,TianJiao Yu,ZiQing Yang,Jing Lan,ZhiFeng Wang
Guided bone regeneration (GBR) is a prominent focus in biomedical materials research, yet few studies address practical clinical needs. GBR membranes must fulfill the “PASS” principles to be effective in surgery, but existing membranes often fall short in balancing antibacterial activity, controlled degradation, osteoinductive potential, and mechanical support. In this study, we employed laser powder bed fusion (LPBF) to fabricate a porous WE43 magnesium alloy scaffold suitable for large alveolar bone defects. We then used electrospinning and layer-by-layer (LBL) self-assembly to create a silk fibroin-based barrier membrane loaded with epigallocatechin gallate (EGCG) and polydopamine (PDA) for combined antibacterial and osteogenic functions. Laboratory tests confirmed that the WE43-F scaffolds and the EGCG/PDA-loaded membranes (SFE) are both biocompatible and bioresorbable. In vitro, they enhanced new bone formation by upregulating alkaline phosphatase (ALP) and RUNX2 gene expression while effectively inhibiting Escherichia coli and Staphylococcus aureus. In a rat maxillary defect model, the WE43-F/SFE composite system demonstrated superior bone regeneration, yielding the largest area of new bone and the most mature collagen–bone matrix, with a bone volume to total volume ratio (BV/TV) of 28.06%. In this study, we assembled WE43-F scaffolds with PDA-EGCG electrospun membranes to create a biodegradable GBR system that delivers synergistic antibacterial and osteogenic effects. Its antimicrobial efficacy and bone-regenerative capacity were confirmed through in vitro assays, cell culture experiments, antibacterial testing, and a rat mandibular defect model.
研究领域:
生物医学工程
·
材料科学
·
组织工程
·
骨科
·
牙科材料
·
再生医学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
危险品化学品经营许可证（带存储）