NUCLEAR MEDICINE AND BIOLOGY
·
2022
·
IF 2.947
Hongliang Wang,Liu Yang,Keyi Lu,Xiaoshan Guo,Rui Xi,Weixuan Dong,Kaixin Qin,Haiyan Liu,Hua Wei,Yan Cheng,Zhifang Wu,Sijin Li
Objective Given the limitation of biomarkers to predict the renal function progression in diabetic nephropathy , N-(6-[ 18 F]Fluoropyridin-3-yl)glycine (6-[ 18 F]FPyGly) was used to evaluate renal function progression in a rat model of diabetic nephropathy. Methods Twenty male Sprague-Dawley rats were randomly divided into four groups, including the healthy control group (HC group), diabetic nephropathy group (DNM group), routine diet treated diabetic nephropathy group (RDNM group), and high fat/high sucrose -diet-fed diabetic nephropathy group (HDNM group). All renal function parameters were determined from animal PET renograms . P and T max represent the curve peak counts and the time to the curve peak counts of 6-[ 18 F]FPyGly in kidneys after injection, C 1/2 and the 15 min/Peak ratio represent the time from peak to 1/2 peak in the clearance phase, and the ratio of the curve counts at 15 min to the curve peak counts. Results P, T max , C 1/2 , and 15 min/peak ratio of each rat were significantly correlated with S-Cr, BUN . There were significant differences in T max , P, serum creatinine (S Cr), and blood urea nitrogen (BUN) levels between HC and DNM groups. P and the 15 min/Peak ratio were significantly different among DNM, RDNM, and HDNM groups, while T max and C 1/2 were only significantly different between DNM and RDNM or HDNM groups. There only was a significant difference in BUN between the DNM and HDNM groups. Conclusion The renal function parameters P, T max , C 1/2 and 15 min/peak value obtained by dynamic renal imaging based on 6-[ 18 F]FPyGly could reflect changes of renal function in rats, which had a good correlation with S Cr and BUN, and showed more efficient in the diagnosis of diabetic nephropathy and renal function classification than S Cr and BUN.
研究领域:
医学影像
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核医学
·
糖尿病
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肾脏生理
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产品关联
DOI
PubMed
高影响因子
Case Studies in Construction Materials
·
2025
·
IF 6.6
Xiaer Xiahou,Xingyuan Ding,Keke Yu,Cong Lu
This study investigates the sustainable valorization of recycled polyethylene terephthalate (rPET) fibers through dopamine surface modification for enhanced 3D printed concrete (3DPC). Comprehensive tests on flowability, rheology, buildability, and mechanical anisotropy were conducted to assess the impacts of various MPET fiber content (0–0.5 vol%). The results showed that 0.5 vol% MPET fibers significantly increased dynamic yield stress and plastic viscosity by 247.6 % and 200.0 %, respectively, compared to the control group (P-0), while moderately reducing flowability. The 0.3 vol% content was found to be optimal, enhancing maximum printing heights in hollow cylindrical and rectangular structures by 114.8 % and 130 %, respectively, compared to the control. At this content, the 30-minute early compressive strength reached 66.0 MPa. Quantitative analysis revealed a strong correlation (R² > 0.94) between early strength development parameters and buildability performance, with rate of strength gain exerting greater influence than initial strength. Mechanical anisotropy tests showed that MPET fibers significantly enhanced the flexural strength of 3DPC in the Z-direction of printing. Scanning electron microscopy (SEM) analysis confirmed that dopamine modification significantly enhanced the fiber-matrix interface bonding. This research applies modified recycled PET fibers to enhance 3DPC performance while contributing to sustainability efforts in the construction sector, supporting approaches that integrate material recycling with technical innovation.
研究领域:
土木工程
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材料科学
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可持续建筑
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聚合物复合材料
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增材制造
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产品关联
DOI
高影响因子
JOURNAL OF APPLIED POLYMER SCIENCE
·
2023
·Vol. 140
·期 31
·e54238
·
IF 3
Li Liu,Panpan Hao,Ruiqi Zhang,Yujin Zhang,Qing Zhou,Xingmei Lu,Dongxia Yan,Yi Li,Chunyan Shi
Products obtained by alcoholysis of waste PET are promising raw materials for the synthesis of polyurethane elastomers (PUEs). Alcoholysis of PET by low molecular weight diols such as ethylene glycol yields low molecular weight products. The latter need to be polymerized to high molecular weight polyols which are subsequently used as soft segments for the synthesis of PUEs. This work aims to look for suitable high molecular weight diols for the alcoholysis of waste PET to yield high molecular weight products which can be directly used as soft segments for the synthesis of PUEs. This approach allows to save the polymerization step for the formation of high molecular weight polyols. Specifically, polyester diols such as polycaprolactone diol (M n = 2000) were used for the alcoholysis of waste PET. The resulting PUEs exhibited very good mechanical properties: a tensile strength of up to 40.95 MPa, an elongation at break of up to 1219%, and a toughness of up to 237 MJ·m −3 , along with good transparency and thermal stability.
研究领域:
材料科学
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聚合物化学
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环境工程
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产品关联
DOI
高影响因子
ENERGY & FUELS
·
2021
·
IF 3.605
Dong Liu,Qi Zhang,Haiyan Pei,Wei Pan,Yingliang Liu,Shengang Xu,Shaokui Cao
In recent years, low-cost wearable energy storage devices attract much more attention. In this work, the PET/CuS/PPy composite electrodes are fabricated for portable flexible solid-state supercapacitors (FSSC), originating from the insulating PET fabric substrate. In this occasion, the functional layer of copper sulfide (CuS) are designed and chemically deposited on the insulating PET fabric to synchronously develop its dual functions such as high electrical conductivity and large capacitance. As a result, the PET/CuS/PPy electrode shows a high specific capacitance of 5410 mF cm–2 at 2 mA cm–2 and good cyclic stability (retaining 84.1% after 2000 cycles). This excellent recyclable specific capacitance is ascribed to the outstanding homogenous binder-free conductive morphologies of CuS and PPy, forming the rapid electronic and ionic transfer channels. Especially, the synchronous dual functions of CuS including high electrical conductivity and large capacitance play a more important role in the large specific capacitance. The flexible solid state supercapacitor (FSSC) also bears a superior specific capacitance of 1335 mF cm–2 (10.1 F cm–3) at 2 mA cm–2 and an outstanding energy density of 1.4 mW h cm–3 at the power density of 8.4 mW cm–3, together with fine flexibility and cyclic stability. Four serially connected FSSC devices can easily supply the electric power for LED indicator lights, calculators, and electric fans, indicating the prospective practical applications in portable flexible energy storage devices. This work provides a facile approach to develop the synchronous dual roles of CuS, which will have the extensive applications in wearable flexible E-textiles.
研究领域:
材料科学
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电化学
·
能源存储
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纳米技术
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可穿戴电子
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产品关联
DOI
高影响因子
Polymer Chemistry
·
2024
·
IF 4.1
Junyan Zhao,Yu Rao,Hengyuan Zhang,Zhichen Zhu,Lihua Yao,Gaojian Chen,Hong Chen
ZnO–polymer core–shell nanoparticles were successfully prepared using a simple in situ open-to-air PET-RAFT method. The utilization of vinyltriethoxysilane (VTES) modified ZnO NPs as catalysts for polymerization, along with the grafting of polymers onto the ZnO NPs, offers significant antibacterial properties. The cationic monomer methacrylamide guanidine hydrochloride (MAGH) and the glycomonomer 2-methacrylamido glucopyranose (MAG) were grafted onto the ZnO NPs surface, further enhancing the antibacterial properties by promoting contact with bacteria and specific recognition of E. coli FimH proteins, leading to a significant improvement in the antibacterial ability compared with ZnO NPs. By combining the photocatalytic and antibacterial properties of ZnO NPs, the preparation of a core–shell material with good antibacterial properties was successfully achieved, providing a new strategy for the synthesis of antimicrobial materials.
研究领域:
纳米技术
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材料科学
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高分子化学
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生物医学工程
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产品关联
DOI
高影响因子
Acta Biomaterialia
·
2017
·
IF 6.319
Yayun Peng,Dongzhi Yang,Weifei Lu,Xiongwei Hu,Hao Hong,Ting Cai
Various carbonaceous nanomaterials , including fullerene , carbon nanotube , graphene, and carbon dots , have attracted increasing attention during past decades for their potential applications in biological imaging and therapy. In this study, we have developed a fullerene-based tumor-targeted positron emission tomography (PET) imaging probe. Water-soluble functionalized C 60 conjugates were radio-labeled with 64 Cu and modified with cyclo (Arg-Gly-Asp) peptides (cRGD) for targeting of integrin α v β 3 in glioblastoma. The specificity of fluorescein-labeled C 60 conjugates against cellular integrin α v β 3 was evaluated in U87 MG (integrin α v β 3 positive) and MCF-7 cells (integrin α v β 3 negative) by confocal fluorescence microscopy and flow cytometry. Our results indicated that cRGD-conjugated C 60 derivatives showed better cellular internalization compared with C 60 derivatives without the cRGD attachment. Moreover, an interesting finding on intra-nuclei transportation of cRGD-conjugated C 60 derivatives was observed in U87 MG cells. In vivo serial PET studies showed preferential accumulation of cRGD-conjugated C 60 derivatives at in U87 MG tumors. In addition, the pharmacokinetic profiles of these fullerene-based nanoparticles conjugated with cRGD and 1,4,7-triazacyclononane-1,4,7-triacetic acid (NOTA) fit well with the three compartment model. The renal clearance of C 60 -based nanoparticles is remarkably fast, which makes this material very promising for safer cancer theranostic applications. Statement of significance Safety is one of the major concerns for nanomedicine and nanomaterials with fast clearance profile are highly desirable. Fullerene is a distinct type of zero-dimensional carbon nanomaterial with ultrasmall size, uniform dispersity , and versatile reactivity. Here we have developed a fullerene-based tumor-targeted positron emission tomography imaging probe using water-soluble functionalized C 60 conjugates radio-labeled with 64 Cu and modified with cyclo (Arg-Gly-Asp) peptides (cRGD) for glioblastoma targeting. The improved tumor targeting property along with fast renal clearance behavior of C 60 -based nanoparticles makes this material very promising for future safer cancer theranostic applications.
研究领域:
纳米医学
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生物医学工程
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分子影像
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癌症治疗
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放射学
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产品关联
DOI
PubMed
高影响因子
ACS Sustainable Chemistry & Engineering
·
2022
·
IF 9.224
Hongcai Su,Yanjun Hu,Hongyu Feng,Lingjun Zhu,Shurong Wang
The massive consumption of plastic is posing severe pollution-related challenges globally. As the most abundant polyester plastic, polyethylene terephthalate (PET) waste represents a largely untapped resource for generating chemicals and fuels. However, the current widespread use of alkali/organic solvents and the complex processing of PET reduce its environmental sustainability. Herein, a novel and simple one-pot strategy was first reported for the catalytic conversion of PET into H2 fuel and terephthalic acid in a pure-water system under mild conditions. A high H2 yield of 19.97 mol/kgPET and carbon conversion efficiency of 97.22% were obtained for the Ru-5ZnO/mesoporous carbon (MEC) catalyst at a low temperature of 250 °C. This process proceeds through tandem catalytic reactions with an initial PET depolymerization step, followed by in situ aqueous phase reforming (APR) of ethylene glycol of Ru. Remarkably, ZnO inhibited the deactivation of Ru/MEC in the PET depolymerization stage, causing an increase in H2 production from the in situ APR stage. Importantly, this strategy was successfully applied to four types of real-world PET waste and their mixtures, demonstrating that it has considerable potential in practical applications and provides a sustainable and clean solution to the plastic waste problem.
研究领域:
环境科学
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化学工程
·
材料科学
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催化
·
可持续能源
✓ 已验证
DOI
高影响因子
ACS Chemical Neuroscience
·
2022
·
IF 5.78
Guolong Huang,Yifan Qiu,Lei Bi,Huiyi Wei,Guocong Li,Zhijun Li,Peizhen Ye,Min Yang,Yanfang Shen,Hao Liu,Lu Wang,Hongjun Jin
The P2X7 receptor (P2X7R) is a key neuroinflammation target in a variety of neurodegenerative diseases. Improved radiosynthesis was developed according to the previously reported P2X7R antagonist GSK1482160. Biodistribution, radiometabolite, and dynamic positron emission tomography/computed tomography-magnetic resonance imaging (PET/CT-MRI) of the lipopolysaccharide (LPS) rat model and the transgenic mouse model of Alzheimer’s disease (AD) revealed a stable, low uptake of [18F]4A in the brain of healthy rats but a higher standardized uptake value ratio (SUVR) in LPS-treated rats (1.316 ± 0.062, n = 3) than in sham (1.093 ± 0.029, n = 3). There were higher area under curves (AUCs) in the neocortex (25.12 ± 1.11 vs 18.94 ± 1.47), hippocampus (22.50 ± 3.41 vs 15.90 ± 1.59), and basal ganglia (22.26 ± 0.81 vs 15.32 ± 1.76) of AD mice (n = 3) than the controls (n = 3) (p < 0.05). Furthermore, 50 min dynamic PET in healthy nonhuman primates (NHPs) indicated [18F]4A could penetrate the blood–brain barrier (BBB). In conclusion, [18F]4A from this study is a potent P2X7R PET tracer that warrants further neuroinflammation quantification in human studies.
研究领域:
神经科学
·
分子生物学
·
医学影像学
·
药理学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
ENVIRONMENTAL SCIENCE & TECHNOLOGY
·
2024
·
IF 10.8
Xiu Huang,Yong Li,Zhao Shu,Li Huang,Qian Liu,Guibin Jiang
Plastic pollution is a significant environmental concern globally. Plastics are normally considered chemically inert and resistant to biodegradation. Although many papers have reported enzyme-induced biodegradation of plastics, these studies are primarily limited to enzymes of microbial origin or engineered enzymes. This study reveals that poly(ethylene terephthalate) (PET, ∼6000 Da and 100 kDa) particles and plastic bottle debris (PBD, 24.9 kDa) can be efficiently degraded by a mammal-origin natural phase II metabolic isozyme, glutathione S-transferase (GST), under mild conditions. The degradation efficiency of PET plastics reached 98.9%, with a degradation rate of 2.6 g·L–1·h–1 under ambient or physiological conditions at 1 atm. PET plastics can be degraded by GST with varying environmental or biological factors (i.e., temperature, light irradiation, pH, and presence of humic acid or protein). We suggest a novel mechanism for PET degradation other than hydrolysis, i.e., the mechanism of cleavage and release of PET plastic monomers via nitridation and oxidation. This finding also reveals a novel function of GST, previously thought to only degrade small molecules (<1000 Da). This method has been successfully applied in real human serum samples. Additionally, we have tested and confirmed the ability to degrade PET of a mammal-origin natural digestive enzyme (trypsin) and a human-derived natural metabolic enzyme (CYP450). Overall, our findings provide a potential new route to plastic pollution control and contribute to our understanding of the metabolism and fate of plastics in organisms.
研究领域:
环境科学
·
生物化学
·
生物技术
·
酶学
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产品关联
DOI
PubMed
高影响因子
ACS Applied Materials & Interfaces
·
2020
·
IF 8.758
Qi Wang,Lingjuan Hu,Zhe Cui,Peng Fu,Minying Liu,Xiaoguang Qiao,Xinchang Pang
Silicon quantum dots (SiQDs) are explored for the first time as an efficient photocatalyst for visible-light-regulated reversible addition-fragmentation chain transfer (RAFT) polymerization. The fluorescence quenching confirmed the photoinduced electron transfer (PET) between SiQDs and RAFT reagents. Besides all features of controlled radical polymerization, the SiQDs catalyzed PET-RAFT polymerization also exhibit good temporal control, high chain-end fidelity, and versatility with diverse monomers. Moreover, amino-functionalized SiQDs can be easily coated on the surface of substrates (silicon wafer) owing to the electrostatic interaction, and play a dual role of polymer–substrate connector and photocatalyst for the surface-initiated PET-RAFT polymerization. The SiQD-coated wafer was also proved to be an efficient recycle photocatalyst for PET-RAFT polymerization.
研究领域:
材料科学
·
聚合物化学
·
纳米技术
·
光化学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
JOURNAL OF APPLIED POLYMER SCIENCE
·
2021
·Vol. 138
·期 47
·51395
·
IF 3.125
Jinsheng Zhou,Yugui Sun,Zixiang Huang,Zhongkuan Luo,Huiyuan Hu
Polyvinyl alcohol (PVA) hydrogel was modified with NIPAAm via a green, efficient, and industrially applicable photo induced electron transfer-reversible addition-fragmentation chain transfer (PET-RAFT) polymerization catalyzed by organic dye. The hydrophilicity of PVA-g-pNIPAAm became temperature sensitive due to the introduction of pNIPAAm polymer brushes. It was surprising that PVA-g-pNIPAAm became superhydrophilic (WCA = 4.3°) at 25°C while the grafting yield was 39.3%. In addition, no cytotoxic for primary human eyelid fibroblast cells was observed according to ISO 10993.5:2009. Antifouling properties of PVA-g-pNIPAAm were significantly improved due to the increase of surface steric repulsion effect. Drug release property of PVA-g-pNIPAAm was more controllable than PVA hydrogel. Thus, organic dye catalyzed PET-RAFT polymerization could be applied to construct functional surface on biomaterials, and PVA-g-pNIPAAm hydrogel with lower cytotoxic, higher antifouling, and drug release properties had great potential in drug delivery.
研究领域:
材料科学
·
生物医学工程
·
高分子化学
·
药剂学
✓ 已验证
产品关联
DOI
高影响因子
CATALYSIS TODAY
·
2025
·
IF 5.3
Yan Fang,Chengcheng Cai,Hiromi Yamashita,Xufang Qian,Yixin Zhao
Electrocatalytic CO 2 reduction reaction (CRR) to produce value-added chemicals offers a sustainable strategy to address energy crisis and climate change. However, the conventional CRR is always coupled with the anodic oxygen evolution reaction (OER), suffering from large overpotential, and high energy consumption. To overcome this, we proposed an alternative system by pairing CRR with the electrocatalytic oxidation of ethylene glycol (EGOR), a product derived from the depolymerization of polyethylene terephthalate (PET) plastic waste. This novel coupled system enabled the simultaneous production of formate on both electrodes, achieving the dual utilization of plastic waste and CO 2 . In this study, we developed a commercially viable system combining a robust NiOOH electrocatalyst synthesized through a facile electrodeposition for EGOR with a low-cost Bi 2 O 3 electrocatalyst for CRR. The NiOOH electrocatalyst achieved Faradaic efficiencies over 88 % for EG oxidation into formate within a broad potential window (1.4–1.8 V RHE ), while Bi 2 O 3 delivered Faradaic efficiencies more than 90 % for CO 2 -to-formate conversion within −0.8 to −1.2 V RHE . When integrated in a two-electrode configuration, the EGOR/CRR system produced formate at both electrodes with Faradaic efficiencies above 85 % across a wide cell voltage (2.0–2.6 V), requiring a ∼300 mV lower cell potential compared to the OER/CRR system. This coupled system reached commercial-level current densities above 200 mA cm −2 or 400 mA cm −2 at 3.0 V when implemented in the flow cell or the MEA cell, respectively. These results demonstrated the potential to use waste-derived reactants and commercially accessible eletrocatalytsts to realize energy-efficient and scalable conversion into formate.
研究领域:
电化学
·
催化
·
环境科学
·
能量转换
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材料科学
·
化学工程
✓ 已验证
产品关联
DOI
高影响因子
危险品化学品经营许可证（带存储）