COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
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2025
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IF 5.4
Xinru Wang,Jinyu Shan,Jie Zhang,Dong Yang,Guangming Tian,Yunzhi Dang,Jianhua Ma
Chronic wounds pose significant challenges in clinical treatment due to persistent inflammation, bacterial infections, and prolonged healing cycles. The development of smart dressings with moisture absorption, antibacterial properties, and stimulus responsiveness is particularly important. This work addresses the issues of low rehydration rate, lack of antibacterial activity in bacterial cellulose (BC) films, the complexity of traditional silver nanoparticle (AgNPs) preparation processes, and the varying hydrophilicity/hydrophobicity requirements of dressings at different stages of wound healing. Through a multi-level structural design, a photothermal-thermoresponsive synergistic intelligent antibacterial material was successfully constructed. Firstly, the introduction of glycerol (Gly) as a plasticizer significantly improved the rehydration rate, water vapor permeability, and flexibility of BC films. To endow the dressing with antibacterial properties, the natural antibacterial agent berberine (Ber) was introduced, and the synergistic effect of polydopamine (PDA) and polyethyleneimine (PEI) enabled the in-situ reduction and uniform loading of AgNPs under mild conditions, thereby achieving broad-spectrum antibacterial properties. The outer layer was grafted with thermoresponsive poly(N-isopropylacrylamide) (PNIPAM), leveraging its lower critical solution temperature (LCST) to meet the varying hydrophilicity/hydrophobicity requirements of dressings at different stages of wound healing. Simultaneously, PNIPAM coating effectively regulated the photothermal conversion efficiency of PDA and prevented the early rapid release of silver ions. The antioxidant capacity of Ber not only inhibited the oxidative deactivation of AgNPs but also effectively cleared reactive oxygen species (ROS) generated during wound healing and photothermal processes, thereby reducing tissue oxidative damage. Based on the synergistic antibacterial effects of Ber and AgNPs, the composite films achieved maximum inhibition zones of 4.2 ± 0.12 mm, 5.4 ± 0.16 mm, 1.9 ± 0.04 mm and 1.6 ± 0.04 mm against E. coli , S. aureus , P. aeruginosa and MRSA respectively. The material combines moisture absorption and permeability, biocompatibility, and long-term antibacterial performance, along with environmentally responsive controlled drug release and ROS clearance functions, offering a new solution for chronic wound treatment and promoting the innovative development of smart wound dressings.
研究领域:
生物医学工程
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材料科学
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伤口护理
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纳米医学
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抗菌材料
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产品关联
DOI
高影响因子
MATERIALS CHEMISTRY AND PHYSICS
·
2019
·
IF 2.781
Jun Wang,Na Huang,Qi Peng,Xiaoyan Cheng,Wuke Li
In this paper, the luminescent temperature/pH dual-responsive nanoparticles based on lanthanide-polyoxometalates were fabricated as a controllable drug delivery system. In the drug delivery carrier, the mesoporous silica acted as the core, and the poly (N-isopropylacrylamide-co-methacrylic acid) and lanthanide-polyoxometalates served as the dual-responsive shell and luminescent labeling, respectively. Composite hydrogels exhibited red luminescence under UV irradiation, which was visible to the naked eye. The releases of doxorubicin hydrochloride (DOX) from the composites were temperature/pH-dependent. DOX can be quickly released in an acidic environment and at high temperatures. Moreover, the drug delivery carrier showed minimal toxicity to HeLa cells and exhibited good biocompatibility. However, DOX loaded drug-delivery system showed the significant toxicity to HeLa cancer cells in vitro. Cell imaging has shown that lanthanide polyoxometalates composites can be used as bioimaging materials for cell monitoring. As a result, the drug delivery systems based on lanthanide-polyoxometalates have potential applications in the field of biomedical science.
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DOI
高影响因子
APPLIED SURFACE SCIENCE
·
2018
·
IF 4.439
Li Li,Tianyi Zhang,Jianhua Lü,Changli Lü
Carbon dots (CDs), the youngest member in the carbon nanomaterial family, have drawn considerable attention due to their interesting optical, physicochemical and electronic properties as well as broad promising applications. Here, we developed a facile and effective strategy for the preparation of Au nanoparticles stabilized by thermo-responsive poly(N-isopropylacrylamide) (PNIPAM) functionalized carbon dots (Au@CD@P) under the gentle water media. The as-designed dopamine(DA)-terminated PNIPAM can be easily anchored to CDs via mussel-inspired chemistry route. Both CD@P and CDs could well stabilize the Au nanoparticles with interesting assembled structure. The as-prepared Au@CD and Au@CD@P nanohybrids with good dispersibility and stability exhibited the intriguing catalytic activity for reduction of p -nitrophenol ( p -NP). Especially, Au@CD@P as catalyst also played a switching role in regulating the catalytic rate by temperature. In addition, Au@CD@P exhibited excellent recyclability which may have potential in green chemical industry for developing high-activity catalysts and easy production methods.
研究领域:
材料科学
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纳米技术
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催化
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高分子化学
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DOI
高影响因子
NEW JOURNAL OF CHEMISTRY
·
2021
·Vol. 45
·期 13
·5925-5932
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IF 3.591
Cheng Zhou,Yan Chen,Mingjun Huang,Yi Ling,Liming Yang,Guochen Zhao,Jie Chen
A dual temperature-responsive triblock polymer (poly(N-isopropyl acrylamide)-block-poly(N,N-dimethyl acrylamide)-block-poly(acrylamide-co-acrylonitrile)) (P(AM-co-AN)-b-PDMA-b-PNIPAM) (NDAA) was obtained by sequential reversible addition–fragmentation chain transfer (RAFT) polymerization,with the uncharged UCST temperature-sensitive block P(AM-co-AN) and the classic LCST-type temperature-sensitive block PNIPAM. This well-defined thermo-responsive copolymer with tunable compositions exhibits a dual thermal response behavior in water. Properly designing the length of the block can make the block copolymer undergo a phase transition within the envisaged temperature range. When the concentration is 5 wt%, the UCST of the NDAA polymer is around 20 °C, and the LCST is around 31 °C. All three blocks of these polymers are soluble in water within 20–31 °C. At high temperature, PNIPAM hydrophobically aggregates into a core, and NDAA self-assembles into a core1 (PNIPAM)–shell (PDMA)–corona1 (P(AM-co-AN)) structure. In contrast, at low temperatures, P(AM-co-AN) forms hydrogen bonds and is insoluble in water, and NDAA self-assembles into a core2–shell–corona2 structure. In this way, it is possible to prepare spontaneously reversible micellar aggregates in water. After the concentration reaches the lowest critical concentration, the NDAA polymer can undergo a reversible gel behavior, that is, a phase transition occurs near the UCST and LCST. This change in the polarity of the micelle core opens up the possibility of dissolving different compounds in water just by changing the temperature.
研究领域:
高分子化学
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材料科学
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DOI
高影响因子
COMPOSITES PART B-ENGINEERING
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2025
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IF 14.2
Yuze Zhou,Guang Yang,Yumeng Wang,Jiaying Lei,Tengling Ye,Ruipeng Huang,Shaohao Zhan,Dongyan Tang
To address oily wastewater pollution, a dual-responsive composite membrane with switchable superwettability was fabricated by in situ growth of MnO 2 microflowers on carbon fiber cloth (CFC), followed by coordination-driven self-assembly of catechol-functionalized poly(N-isopropylacrylamide) (PNIPAM). The abundant oxygen vacancies (O v ) on MnO 2 microflowers enhanced photothermal conversion efficiency (24.99% for optimal MC 4 ) and provided active sites for robust PNIPAM anchoring via C-O-Mn coordination bonds. The resulting membrane (PMC) exhibited switchable superwettability: underwater superoleophobicity (150.10°) at 25 o C and underoil superhydrophobicity (150.27°) at 45 o C under heating or NIR irradiation. This enabled efficient separation of diverse oily pollutants, including light/heavy oil-water mixtures and emulsions, with high separation efficiency (> 99.5% for mixtures, > 99.2% for emulsions) and exceptional water flux (25239.89 L m −2 h −1 ). Taking advantages of the in situ grown of MnO 2 on CFC and strong chemical anchoring of PNIPAM on MnO 2 , the photo and thermal dual-responsive PMC membrane maintained excellent stability after mechanical (rubbing, bending, soaking) and chemical (acid/alkaline/saline) challenges, demonstrating superior reusability and durability for practical water purification applications.
研究领域:
材料科学
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化学工程
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环境科学
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纳米技术
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高分子科学
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表面工程
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产品关联
DOI
高影响因子
Materials Horizons
·
2023
·Vol. 11
·期 3
·835-846
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IF 13.3
Xiaoyong Zhang,Haoran Ding,Zhaozhao Li,Yongping Bai,Lidong Zhang
Poly(N-isopropylacrylamide) (PNIPAM) is capable of improving the reversibility and responsiveness of flexible electronics. However, its phase transition-induced volume variation and poor adhesiveness remain limitations for expending its applications. Herein, a pressure-sensitive adhesive (PSA), which is a type of mesh scaffold, is constructed inside the network of PNIPAM, providing the hydrogel with a constant volume in response to different temperatures, in situ tunable mechanical properties, and superior adhesiveness. The reversible density of the mesh scaffold adjusts the aggregation state of the hydrogel chains, whereupon it is capable of changing its mechanical modulus from 6.7 kPa to 45.3 kPa. This mechanical mechanism contributes to hydrogel-based flexible devices for multiple applications, especially in pressure-related sensors. The mesh scaffold restricts the phase-transition-induced volume variation, which allows the hydrogel sensor to stably monitor the external pressure at various temperatures. The high adhesion enables the effective interfacial interaction with the skin, avoiding the loss of sensing signals during the detection of human body movements. When it is assembled into an electronic device, it can transmit information and recognize sign language via Morse code. Thus, herein, we report a hydrogel sensor that is promising for pressure detection in temperature-unstable environments, especially for managing the health of patients who require emergency medical care through sign language recognition.
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DOI
PubMed
高影响因子
JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES
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2024
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IF 2.8
Guohua Teng,Hezhao Bai,Chen Zhang,Jingyi Yang,Xiaoye Wang,Yu Zhu,Fei Tian
A magnetic composite (Fe 3 O 4 @SiO 2 @PNIPAM-co-NHMA) with high adsorption capacity and recoverability was developed for the enrichment and determination of flavonoids in Scutellaria Radix ( SR ). A magnetic solid-phase extraction (MSPE) technique using Fe 3 O 4 @SiO 2 @PNIPAM-co-NHMA absorbent in combination with high-performance liquid chromatography (HPLC) was developed for selectively enrichment and determination of the biologically active flavonoids in the aqueous extract of SR , including baicalein, baicalin, wogonoside and wogonin. Under the optimized experimental conditions, the magnetic adsorbent could adsorb up to 77.0 ± 0.98 % − 98.15 ± 0.15 % of four representative flavonoids from SR , with elution rates varying from 55.10 ± 0.25 % to 91.94 ± 1.85 %. The limits of detection (LOD) and limits of quantitation (LOQ) were 0.01–0.35 μg/mL and 0.03–0.98 μg/mL, respectively. In addition, it remained effective after six replicates, demonstrating its potential as a recoverable adsorbent for enriching flavonoids in traditional Chinese medicine.
研究领域:
分析化学
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药学
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纳米技术
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中医药
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产品关联
DOI
PubMed
高影响因子
POLYMER
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2021
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IF 4.43
Bing-Zi Yang,Shu-Ya Zhang,Ping-Hua Wang,Chun-Hua Liu,Yuan-Yuan Zhu
Hydrogel actuators belong to a type of smart soft materials which can take place anisotropic thrust and/or displacement under various environmental stimuli including thermal, light, pH, humidity etc . Robust strength and rapid response are of critical importance to high-performance hydrogel actuators. Here we report the syntheses and investigations of mechanical properties for series novel organic-inorganic hydrogels by using vinyl functionalized silicon nanoparticles (SiNPs) as the cross-linker. The doped SiNPs significantly enhance the mechanical strength of polyacrylamide (PAAm) hydrogels. Furthermore, the SiNPs composite poly- N -isopropylacrylamide (PNIPAm) hydrogels exhibit rapid response in deswelling and swelling behaviours. The excellent mechanical and responsive properties are attributed to the enhanced rigidity via SiNPs doping into the hydrogel network and the improved water diffusion through mPEG branch chains on the surface of nanoparticles , respectively. As a proof of concept, a bilayer PNIPAm@PAAm hydrogel actuator is facilely synthesized via an in-situ polymerization process. This composite hydrogel actuator shows extremely fast response rate of directional bending in hot water, about 6 times faster than the control without doping of SiNPs. This work demonstrates that these SiNPs composite hydrogels provide enhanced mechanical and responsive performances and may expand the future applications in smart hydrogel materials.
研究领域:
材料科学
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纳米技术
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智能材料
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高分子化学
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DOI
高影响因子
Molecular Catalysis
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2026
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IF 4.3
Wenhui Li,Jiajia Chen,Jiaolong Fu,Zhi Chen,Xin Ju,Liangzhi Li
Design and fabrication of multifunctional charge-tunable hydrogel carriers. • Molecular docking reveals hydrogen bonding mechanisms in charge-assisted non-covalent immobilization. • PASP/PNIPAM-immobilized enzymes retain 89.7% initial activity after six cycles. • A novel biocatalytic pathway for D-xylose enables efficient rare sugar production. Immobilization of enzymatic cascades is an important tool for the efficient production of value added products, such as rare sugars from biomass monosaccharides. However, there is a lack of biocompatible and inexpensive immobilization carriers with high reusability in immobilizing multiple enzyme proteins currently. In this study, poly-N-isopropylacrylamide (PNIPAM) hydrogels were fabricated and employed to immobilize the enzymatic cascade of glucose isomerase (GI) and D-tagatose-3epimerase (DTE) for the conversion of D-xylose to rare sugar products, D-xylulose and D-ribulose. To attain stable protein attachment and high reusability, PNIPAM microspheres were further grafted by polyaspartic acid (PASP), polyethylene glycol (PEG), polylysine (PL), and anionic polyacrylamide (APAM), obtaining composite hydrogels with tailored surface charges to achieve effective non-covalent immobilization. The enzymatic cascades immobilized by modified PNIPAM hydrogels demonstrated improved thermal stability in the range of 40–70 °C with prolonged enzyme half-lives, and higher conversion of D-xylose. After 6 recycles, PASP/PNIPAM-GI-DTE retained 89.7% initial activity which was superior in enzyme immobilization by PNIPAM. Molecular simulation studies revealed that PASP/PNIPAM formed stable hydrogen bonds with GI and DTE, rationalizing its superior performance. This work proved charge aided immobilization of proteins as a feasible strategy for the production of biomass derived high value chemicals, and provided a practical protocol for industrial scale biomanufacturing. Download: Download high-res image (204KB) Download: Download full-size image
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DOI
高影响因子
ACS Sustainable Chemistry & Engineering
·
2025
·
IF 7.3
Huimin Li,Huanhuan Dong,Xudong Wu,Lei Li,Wenli Zhou,Zhaoyang Li,Qing Wang,Ke Chen,Tao Chen,Wenkun Zhu
Atmospheric Water Harvesting (AWH) is considered a promising approach aimed at addressing global water scarcity by extracting water from the air, which is particularly suitable for arid and water scarce regions. Here, we report an ultrahygroscopic polymer hydrogel bead (SC-LiCl/PNIPAM, SCLP) composed of renewable biomasses, hygroscopic salt, and temperature sensitive materials to extract water vapor from arid climates. Sodium alginate and carboxymethyl cellulose endow a 3D porous structure with enlarged polymer–air interfaces, enabling efficient water capture and vapor transport. Thermoresponsive poly(N-isopropylacrylamide) (PNIPAM) can achieve phase transition under daylight conditions to assist the release water collected by hydrogels via hydrophobic interactions. Impressively, SCLP hydrogel beads display a maximum water uptake of up to 9.93 g/g–1 at a relative humidity of 90% and also demonstrate excellent water absorption and release properties in natural conditions. By virtue of plant cultivation experiments and 16S rRNA (16S rRNA), the introduction of SCLP hydrogel beads can effectively capture water from the atmosphere to alter the distribution of dominant populations of soil communities and enhance the activity of defensive enzymes, thereby alleviating the wide impact of drought stress on plant growth. This work provides a feasible prospect for large-scale manufacturing of hygroscopic hydrogels and the ecological restoration of barren slope areas.
研究领域:
环境科学
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材料科学
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高分子科学
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农业工程
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生态修复
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产品关联
DOI
高影响因子
ENZYME AND MICROBIAL TECHNOLOGY
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2016
·
IF 2.624
Jian Qin Zhou,Ting He,Jian Wen Wang
Microbial transglutaminase (mTG) is widely utilized in the PEGylation of pharmaceutical proteins. mTG immobilization can be achieved via covalent bonding on solid supports. However, the catalytic efficiency of mTG immobilized on solid supports was significantly reduced by mass transfer limitation. To overcome this limitation, mTG was covalently immobilized on the thermo-responsive carboxylated poly( N -isopropylacrylamide) (pNIPAM). The pNIPAM-mTG conjugate exhibited reversibly solubility in aqueous solution with a low critical solution temperature (LCST) at 39 °C, i.e., it was insoluble above 39 °C and soluble below 39 °C. The pH dependence of the pNIPAM-mTG conjugate was similar with that of the native mTG. Upon conjugation to pNIPAM, the optimal temperature of mTG shifted down from 50–55 °C to 40–45 °C, and the thermal stability of the conjugate was elevated. The easy separation of the pNIPAM-mTG conjugate with its substrate and the catalytic efficiency of the pNIPAM-mTG conjugate were demonstrated by employing the pNIPAM-mTG conjugate to cross-link bovine serum albumin (BSA) and catalyze PEGylation of therapeutic protein, cytochrome c (Cyt C), respectively. The thermo-responsive mTG is suitable to modify proteins in food processing and biomedical engineering.
研究领域:
生物技术
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生物化学
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食品加工
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生物医学工程
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产品关联
DOI
PubMed
高影响因子
Science China-Chemistry
·
2013
·Vol. 57
·期 3
·417-425
·
IF 1.327
Yin Jun,He YaGuang,Li Wei,Wu ZongQuan,Ding YunSheng
We report on the fabrication of a class of surface-enhanced Raman scattering (SERS) active thermometers, which consists of 60 nm gold nanoparticles, encoded with Raman-active dyes, and a layer of thermoresponsive poly( N -isopropylacrylamide) (PNIPAM) brush with different chain lengths. These SERS-active nanoparticles can be optimized to maintain spectrally silent when staying as single particles in dispersion. Increasing temperature in a wide range from 25 °C to 55 °C can reversibly induce the interparticle self-aggregation and turn on the SERS fingerprint signals with up to 58-fold of enhancement by taking advantage of the interparticle plasmonic coupling generated in the process of thermo-induced nanoparticles self-aggregation. Moreover, the most significative point is that these SERS probes could maintain their response to temperature and present all fingerprint signals in the presence of a colored complex. However, the UV-vis spectra can distinguish the differences faintly and the solution color shows little change in such complex mixture. This proof-of-concept and Raman technique applied here allow for dynamic SERS platform for onsite temperature detection in a wide temperature range and offer unique advantages over other detection schemes.
研究领域:
纳米技术
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材料科学
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分析化学
·
温度传感
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产品关联
DOI
高影响因子
危险品化学品经营许可证（带存储）