CRYSTAL GROWTH & DESIGN
·
2012
·
IF 4.72
Zi-Zhou Wang,Jia-Mei Chen,Tong-Bu Lu
Four cocrystals of (S-ox)(ga) (1), (RS-ox)(ga) (2), (S-ox)(pa) (3), and (RS-ox)(pa) (4) were prepared (S-ox = S-oxiracetam, RS-ox = racemic oxiracetam, ga = gallic acid, pa = 3,4-dihydroxybenzoic acid), and their structures were determined by single X-ray diffraction. In 1/2, two ga molecules link two S-ox/RS-ox molecules through intermolecular hydrogen bonds with a new R22(9) synthon to form a tetramer, the tetramers are further linked by intertetramer hydrogen bonds to generate a 2D sheet, and the adjacent 2D sheets are connected by intersheet hydrogen bonds to form the 3D structure of 1/2. In 3/4, the ox molecules form a 1D helical chain through intermolecular hydrogen bonds, and the helical chains are further linked by pa molecules through intermolecular hydrogen bonds to form a 2D sheet. The results of hygroscopic stability experiments indicate that the hygroscopic stability of S-ox is much enhanced after the formation of cocrystal 1.
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ENVIRONMENTAL HEALTH PERSPECTIVES
·
2025
·Vol. 133
·期 5
·057009
·
IF 9.8
Shiqi Li,Yun Fan,Min Tang,Xiaorong Wu,Shengjun Bai,Xiancheng Yang,Xueer Zhang,Chuncheng Lu,Chenbo Ji,Paul A Wade,Xu Wang,Wei Gu,Guizhen Du,Yufeng Qin
Background: Bisphenol S (BPS) is a substitute for bisphenol A in various commercial products and is increasingly used globally due to restrictions on bisphenol A usage. Consequently, there are increasing public health concerns that substantial effects mediated by synthetic chemicals may impact human health. Recently, epidemiology studies reported associations between bisphenol exposure and nonalcoholic fatty liver disease [metabolic dysfunction-associated steatotic liver disease (MASLD)]. However, the causal relationship and the molecular mechanisms affecting hepatocellular functions are still unknown. Objectives: Our study aimed to understand the molecular mechanism by which BPS exposure caused hepatic lipid deposition. Methods: C57BL/6J mice were exposed to BPS for 3 months, and its effects were assessed by histology. RNA sequencing (RNA-seq), assay for transposase-accessible chromatin with high-throughout sequencing (ATAC-seq), and cleavage under targets and tagmentation (CUT&Tag) were used to investigate mechanistic details. ATF3 liver-specific knockout mice and cells were used to validate its functions in BPS-induced hepatotoxicity. Results: Here, mice that were chronically exposed to BPS showed significant lipid deposition in the liver and dyslipidemia and were predisposed to MASLD, accompanied with a reprogrammed liver transcriptional network and chromatin accessibility that was enriched for the Atf3 binding motif. Comparing to the control group, we identified numerous differential Atf3 binding sites associated with signaling pathways integral to lipid catabolism and synthesis in the BPS exposure group, resulting in a drastic surge in lipid accumulation. Moreover, knocking out Atf3 in vitro and in vivo significantly attenuates BPS-induced hepatic lipid accumulation via the regulation of chromatin accessibility and gene expression. Besides, inhibiting JunB also eliminates BPS-induced Atf3 upregulation and lipid accumulation. Conclusion: Our study reveals a novel mechanism, through which BPS upregulates JunB and Atf3 to impair hepatic lipid metabolism, and provides new insights into the hepatotoxicity of BPS. https://doi.org/10.1289/EHP17057
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CURRENT ORGANIC SYNTHESIS
·
2025
·Vol. 22
·期 5
·614-619
·
IF 2.5
Dejun Zhou,Keyang Wang,Yuying Zhang,Xiaoyue Liu,Xiaoxia Mao
BackgroundTimolol maleate is clinically used for the treatment of hypertension, angina pectoris, tachycardia, and glaucoma.ObjectiveThe aim of this study was to enhance the safe use of timolol maleate and investigate a synthesis method for 3-S-timolol, a newly identified impurity in timolol API (Active Pharmaceutical Ingredients).Methods(S)-3-(tert-butylamino)propane-1,2-diol (1) was used as a raw material. 3-S-timolol maleate (7) was synthesized through a five-step reaction. Overall yield was 57.7%, with a purity of 98%.ResultsThe structure of the target compound was confirmed via analysis of its 1H nuclear magnetic resonance, 13C nuclear magnetic resonance, and high-resolution mass spectrometry spectra.ConclusionThe synthesis method was straightforward and yielded a high-purity product suitable for use as a reference in the analysis and identification of timolol maleate-related substances.
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COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
·
2025
·
IF 5.4
Lei Wu,Ruiting Xue,Sujing Zou,Xiqiang Mao,Jun Li,Yang Li,Jian Yang,Ximei Fan
Plasmonic/semiconductor heterojunctions have shown remarkable potential for advancing photochemical reactions, yet the reliance on noble metals in conventional plasmonic systems imposes prohibitive costs for solar-driven applications. Herein, we report the plasmonic semiconductor (WO 3 -OV) with full spectral response by pre-irradiation for the first time. The near-infrared light effectively excites the surface plasmon resonance (SPR) of WO 3 -OV, generating high-energy hot electrons capable of multi-electron transfer processes. Coupling WO 3 -OV with a band-matched semiconductor (TiO 2 ) establishes an internal electric field (IEF) at the heterointerface, which synergistically enhances charge separation and prolongs carrier lifetimes. Crucially, oxygen vacancies (OVs) in WO₃-OV serve dual roles: (1) as plasmonic centers for NIR photon harvesting and (2) as catalytic active sites for toluene oxidation. The synergistic effect of heterojunction and plasmonic was elucidated through comprehensive in situ characterization and theoretical calculation. The rational integration of LSPR, defect engineering, and interfacial charge control provides a universal framework for designing high-efficiency photocatalytic systems for environmental remediation and energy conversion.
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Acta Pharmaceutica Sinica B
·
2020
·
IF 7.097
Meng Yuan,Xiaobing Chen,Yitang Sun,Li Jiang,Zhongni Xia,Kaixiong Ye,Hong Jiang,Bo Yang,Meidan Ying,Ji Cao,Qiaojun He
The membrane protein claudin-3 (CLDN3) is critical for the formation and maintenance of tight junction and its high expression has been implicated in dictating malignant progression in various cancers. However, the post-translational modification of CLDN3 and its biological function remains poorly understood. Here, we report that CLDN3 is positively correlated with ovarian cancer progression both in vitro and in vivo. Of interest, CLDN3 undergoes S -palmitoylation on three juxtamembrane cysteine residues, which contribute to the accurate plasma membrane localization and protein stability of CLDN3 . Moreover, the deprivation of S -palmitoylation in CLDN3 significantly abolishes its tumorigenic promotion effect in ovarian cancer cells. By utilizing the co-immunoprecipitation assay, we further identify ZDHHC12 as a CLDN3-targating palmitoyltransferase from 23 ZDHHC family proteins. Furthermore, the knockdown of ZDHHC12 also significantly inhibits CLDN3 accurate membrane localization, protein stability and ovarian cancer cells tumorigenesis . Thus, our work reveals S -palmitoylation as a novel regulatory mechanism that modulates CLDN3 function, which implies that targeting ZDHHC12-mediated CLDN3 S -palmitoylation might be a potential strategy for ovarian cancer therapy.
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TETRAHEDRON LETTERS
·
2018
·
IF 2.125
Rongxing Zhang,Shengzhou Jin,Yuanxing Wan,Sen Lin,Zhaohua Yan
A novel, efficient, and green protocol to construct C–S bond has been developed via HBr/H 2 O 2 -mediated sulfenylation of styrenes and 4-hydroxycoumarins leading to unsymmetrical sulfides. Various unsymmetrical sulfides were prepared in one step with moderate to good yields using environmentally-friendly H 2 O 2 as oxidant and HBr as catalyst. Based on the preliminary experimental results, a plausible reaction mechanism was proposed for HBr/H 2 O 2 -mediated formation of C–S bond with thiosulfates .
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POLYMER INTERNATIONAL
·
2013
·Vol. 63
·期 3
·537-545
·
IF 2.125
Yewei Xu,Xiangwang Cui,Fanghua Zhu,Xuan Luo,Qiang Yin,Lin Zhang
Six new bis(benzimidazolyl) monomers containing ether, sulfonyl and ketone groups were synthesized efficiently. A series of poly( N -arylenebenzimidazole)s were prepared using an aromatic nucleophilic displacement reaction that removed the N–H sites from the novel bis(benzimidazolyl) derivatives with activated aromatic difluorides in sulfolane. The reaction was carried out at 210 °C in the presence of anhydrous potassium carbonate. All resulting polymers showed essentially amorphous patterns. This was consistent with the calculated results. Differential scanning calorimetry and thermogravimetric measurements showed that the polymers had high glass transition temperatures (>240 °C), good thermostability and high decomposition temperatures (>400 °C). These novel polymers also showed easy solubility. © 2013 Society of Chemical Industry
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DYES AND PIGMENTS
·
2024
·
IF 4.1
Xiang Long,Hongxiang Liu,Jing Hu,Shaogui Wu
Herein, we report a facile one-step solvothermal synthesis of nitrogen and sulfur co-doped fluorescent carbon dots (N,S-CDs) using benzoic acid as the carbon source and sulfonamide as the doping agent. The synthesized N,S-CDs exhibit stable photoluminescence with an impressive fluorescence quantum yield of 16.8 %. These N,S-CDs maintain their luminescent properties under various challenging conditions, including high salt concentrations, elevated temperatures, UV radiation exposure, acidic or alkaline environments, long-term storage, and different solvents. Notably, the photoluminescence of N,S-CDs is excitation-wavelength dependent, with emission wavelengths tunable from 470 nm to 585 nm. Furthermore, the N,S-CDs display distinct fluorescent hues in aqueous and ethanolic media, presenting a novel dual-switch anti-counterfeiting ink system. Leveraging the sensitivity of N,S-CDs to gentamicin, we have developed a facile and rapid detection method for this antibiotic, which has been successfully applied to the analysis of authentic milk samples. This research contributes a novel and efficient protocol for the fabrication of high-performance carbon dots, thereby expanding their potential applications in food analysis and anti-counterfeiting technologies.
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APPLIED CATALYSIS B-ENVIRONMENTAL
·
2024
·
IF 20.2
Yating Ai,Jiajie Hu,Xianqiang Xiong,Sónia A.C. Carabineiro,Yuesheng Li,Nikolay Sirotkin,Alexander Agafonov,Kangle Lv
Efficient interfacial charge transfer and robust interface interactions are crucial to achieve superior spatial separation of carriers and develop advanced heterogeneous photocatalysts . This study describes the synthesis of a novel S-scheme heterojunction of ZnO/In 2 S 3 , with S−O covalent bonds , achieved through a hydrothermal method . The optimized heterojunction shows exceptional photocatalytic activity , achieving a H 2 generation rate of 2488 μmol g −1 h −1 and a degradation efficiency of 86 % for tetracycline hydrochloride (TCH) within 2 h. These values surpass those of In 2 S 3 alone by 35 and 1.4 times, respectively. Various techniques, including electron spin resonance, X-ray photoelectron spectroscopy, Kelvin probe force microscopy and density functional theory calculations confirm the S-scheme heterojunction. The establishment of a chemical S−O bond between In 2 S 3 and ZnO facilitates an atomic level interfacial pathway, enabling efficient transportation of interfacial electrons.
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SYNTHETIC METALS
·
2015
·
IF 2.252
Hua Ye,Baofeng Zhao,Dongyun Li,Dongcheng Chen,Gaozhan Xie,Shi-Jian Su,Wei Yang,Yong Cao
A series of blue-light-emitting conjugated polymers based on electron-donating trifluoren-2-ylamine and electron-deficient dibenzothiophene- S,S -dioxide were synthesized via typical Suzuki coupling reactions. Their thermal, photophysical and electrochemical properties were fully studied. Owing to the excellent thermal stability, film-forming ability as well as the favorable energy levels of the polymers, highly efficient non-doped single-layer blue devices by using these polymers as an emitting layer (EML) were achieved. Among them, the device based on PSFOFN1 showed the highest maximum current efficiency (CE max ) of 1.99 cd/A. Moreover, the device presented small efficiency roll-off with current efficiency (CE) of 1.97 cd/A at high brightness up to 100 cd/m 2 . In addition, the Commission Internationale de L’Eclairage (CIE) coordinates of all the devices are very close to the deep blue region. Our findings suggest the potential applications of the polymers in full-color flat-panel displays and organic lighting.
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Frontiers in Chemistry
·
2019
·
IF 3.782
Chen Lizhu,Yu Yingjia,Duan Gengli,Wang Xin,Shen Baohua,Xiang Ping
Objective: Chiral analysis is a crucial method to differentiate selegiline intake from drug abuse. A dried urine spot (DUS) analytical method based on spotting urine samples (10 μL) onto dried spot collection cards, and followed by air-drying and extraction, was developed and validated for the determination of selegiline, desmethylselegiline, R/S-methamphetamine, and R/S-amphetamine.Methods: Methanol (0.5 mL) was found to be the ideal extraction solvent for target extraction from DUSs under orbital-horizontal stirring on a lateral shaker at 1,450 rpm for 30 min. Determinations were performed by direct electrospray ionization tandem mass spectrometry (ESI-MS/MS) under positive electrospray ionization conditions using multiple reaction monitoring mode. The chromatographic system consisted of a ChirobioticTM V2 column (2.1 × 250 mm, 5 μm) and a mobile phase of methanol containing 0.1% (v/v) glacial acetic acid and 0.02% (v/v) ammonium hydroxide.Results and conclusions: The calibration curves were linear from 50 to 5,000 ng/mL, with r > 0.995 for all analytes, imprecisions ≤ 15% and accuracies between −11.4 and 11.7%. Extraction recoveries ranged from 48.6 to 105.4% with coefficients of variation (CV) ≤ 13.7%, and matrix effects ranged from 45.4 to 104.1% with CV ≤ 10.3%. The lower limit of quantification was 50 ng/mL for each analyte. The present method is simple, rapid (accomplished in 12 min), sensitive, and validated by a pharmacokinetic study in human urine collected after a single oral administration of SG.
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SENSORS AND ACTUATORS B-CHEMICAL
·
2016
·
IF 4.758
Zongen Liu,Jiecheng Xiao,Xianwei Wu,Liqing Lin,Shaohuang Weng,Min Chen,Xiaohui Cai,Xinhua Lin
This work reports a facile and effective approach for preparing graphene quantum dots co-doped with nitrogen and sulfur (N-S/GQDs). The proposed method comprised pyrolysis of citric acid with glutathione and dialysis treatment. The fabricated N-S/GQDs exhibited blue luminescence and a high fluorescence quantum yield of 36.3%. N-S/GQDs can be sensitively quenched by Fe 3+ , which was absorbed on the edge of N-S/GQDs through the coordination interaction between Fe 3+ and N, S elements. The subsequent introduction of pyrophosphate ion (PPi) resulted in the recovery of the fluorescence of Fe 3+ -quenched N-S/GQDs. The stronger coordination reactivity between Fe 3+ and PPi induced changes in fluorescence. PPi concentration was facilely quantified through the recovered amplitudes of the fluorescence intensities of N-S/GQDs. Under the optimized experimental condition, increased fluorescence intensity showed a linear relationship to PPi concentration (1 μM to 1000 μM) in serum samples. Additionally, the proposed method featured sensitive and selectivity for the detection of PPi in synovial fluid, suggesting the potential application for simple and accurate clinical diagnosis of arthritic diseases.
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