CHINESE JOURNAL OF CHEMICAL ENGINEERING
·
2023
·
IF 3.8
Jinpei Huang,Xingwei Lu,Xuejing Zhang,Yiqiang Jin,Yifeng Zhou
1-Oxa-2-azaspiro [2.5] octane, as one of N-H oxaziridines , is a selective electrophilic aminating agent for N-, S-, C-, and O-nucleophiles. It has the features of stereoselectivity and the absence of formation of strongly acidic or basic byproducts, leading to considerable interest in the development of organic synthetic methods. Currently, the economically feasible route of production of 1-oxa-2-azaspiro [2.5] octane is the reaction of cyclohexanone with ammonia and sodium hypochlorite. However, due to strong exothermic reactions, massive gas release and heterogeneous reaction, the controllability, efficiency and safety of the reaction are in great difficulty using batch technology. In this paper, a microreaction system containing predispersion, reaction and phase separation was introduced into the preparation of 1-oxa-2-azaspiro [2.5] octane. The research results showed that precise control of the process including droplet dispersion, temperature control, reaction time control and fast continuous phase separation, was the key to process intensification. Under optimal conditions, the concentration of 1-oxa-2-azaspiro [2.5] octane in product obtained by microreaciton system (∼2.0 mol·L −1 ) was much higher than that obtained by batch technology (0.2–0.4 mol·L −1 ), which demonstrated that the continuous-flow synthesis would be a more efficient substitute for batch synthesis. Meanwhile, the results of the derivation experiments also showed that the aminating agent solution with higher concentration was more advantageous in the applications.
研究领域:
有机化学
·
化学工程
·
合成化学
✓ 已验证
产品关联
DOI
高影响因子
ACS Nano
·
2023
·
IF 17.1
Weijing Feng,Yintong Teng,Qingping Zhong,Yangmei Zhang,Jianwu Zhang,Peng Zhao,Guoqing Chen,Chunming Wang,Xing-Jie Liang,Caiwen Ou
As the prevalence of vascular calcification (VC), a strong contributor to cardiovascular morbidity and mortality, continues to increase, the need for pharmacologic therapies becomes urgent. Sodium thiosulfate (STS) is a clinically approved drug for therapy against VC; however, its efficacy is hampered by poor bioavailability and severe adverse effects. Plant-derived extracellular vesicles have provided options for VC treatment since they can be used as biomimetic drug carriers with higher biosafety and targeting abilities than artificial carriers. Inspired by natural grapefruit-derived extracellular vesicles (EVs), we fabricated a biomimetic nanocarrier comprising EVs loaded with STS and further modified with hydroxyapatite crystal binding peptide (ESTP) for VC-targeted delivery of STS. In vitro, the ESTP nanodrug exhibited excellent cellular uptake capacity by calcified vascular smooth muscle cells (VSMCs) and subsequently inhibited VSMCs calcification. In the VC mice model, the ESTP nanodrug showed preferentially the highest accumulation in the calcified arteries compared to other treatment groups. Mechanistically, the ESTP nanodrug significantly prevented VC via driving M2 macrophage polarization, reducing inflammation, and suppressing bone-vascular axis as demonstrated by inhibiting osteogenic phenotype trans-differentiation of VSMCs while enhancing bone quality. In addition, the ESTP nanodrug did not induce hemolysis or cause any damage to other organs. These results suggest that the ESTP nanodrug can prove to be a promising agent against VC without the concern of systemic toxicity.
研究领域:
药理学
·
纳米技术
·
心血管疾病
·
生物材料
·
药物递送系统
✓ 已验证
产品关联
DOI
PubMed
高影响因子
ACS Applied Polymer Materials
·
2023
·
IF 5
Zhongxi Miao,Chaohua Peng,Long Xia,Hui Xu,Siyuan He,Cheng Chi,Jiahui Zhong,Shuchuan Wang,Weiang Luo,Guorong Chen,Birong Zeng,Lizong Dai
Currently, because of the depletion of petroleum resources and pollution problems associated with the use of petrochemicals, bio-based epoxy thermosets have received wide attention. However, epoxy thermosets derived entirely from bio-based raw materials combining high performances in mechanical properties, fire resistance, and degradation are less reported. In this work, a fully bio-based Schiff base epoxy resin named VA-FA-EP is prepared from vanillin (VA) and 2-furfurylamine (FA). The curing kinetics and behavior of the imine exchange reaction are explored systematically. After being cured by 4,4′-diaminodiphenylmethane (DDM), VA-FA-EP/DDM exhibits excellent mechanical properties with a glass transition temperature of 200.1 °C. VA-FA-EP/DDM has also been proven to have good fire resistance. There are significant reductions of 66.73% and 81.72% in total heat release (THR) and total smoke production (TSP), respectively. The intrinsic flame-retardant mechanism is systematically illustrated. In addition, the VA-FA-EP/DDM has also shown a good degradation property. In summary, this study offers a viable approach for producing eco-friendly fire-safe Schiff base epoxy thermosets utilizing entirely sustainable raw materials.
研究领域:
材料科学
·
化学工程
✓ 已验证
产品关联
DOI
高影响因子
ChemPlusChem
·
2023
·Vol. 88
·期 11
·e202300387
·
IF 3.4
Shuai Chen,Zheng-Quan Nie,Fang-Dao Zhu,Cui-Ting Yang,Jian-Mei Yang,Jun-Nan He,Xiao-Qing Liu,Jin Zhang,Yan Zhao
Graphical An oral gastrointestinal-based anticancer nanocarrier (Am7CD/SDS NPs) was equipped with both pH and temperature sensitivity, which could effectively prevent MTX@Am7CD/SDS NPs from being degraded in the acidic environment mimicking the stomach and small intestine, thus harboring the potential to accumulate at the site of colon lesions and further release drugs under mild conditions. Colon cancer is emerging as one of the most common cancers worldwide, ranking in the top three in morbidity and mortality. Oral methotrexate (MTX) has been employed as a first-line treatment for various cancers, such as colon, breast, and lung cancer. However, the complexity and particularity of the gastrointestinal microenvironment and the limitations of MTX itself, including severe adverse effects and instability, are the main obstacles to the safe delivery of MTX to colon tumor sites. Herein, an innovative oral administrated anticancer therapeutic MTX@Am7CD/SDS NPs equipped with both pH and temperature sensitivity, which could effectively prevent MTX@Am7CD/SDS NPs from being degraded in the acidic environment mimicking the stomach and small intestine, thus harboring the potential to accumulate at the site of colon lesions and further release intestinal drug under mild conditions. In cellular assays, compared with free MTX, MTX@Am7CD/SDS NPs showed a favorable tumor inhibition effect on three tumor cell lines, as well as excellent cell uptake and apoptosis-inducing effect on SW480 cells. Therefore, this work provides a feasible solution for the safe use of MTX in the treatment of colon cancer and even other intestinal diseases.
研究领域:
药剂学
·
肿瘤学
·
生物医学工程
✓ 已验证
产品关联
DOI
PubMed
高影响因子
CHEMICAL ENGINEERING SCIENCE
·
2025
·
IF 4.3
Fan Leng,Lei Li,Yanbo Liu,Weichen Qu,Dandan Han,Songgu Wu,Mingyang Chen,Bowen Tao,Junbo Gong
Ammonium dinitramide (ADN) is a high-energy green oxidizer that holds significant promise for application in solid propellants with low signature; however, its practical application is limited by strong hygroscopicity. Preparing spherical particles is generally considered the prior method for ADN anti-hygroscopic modification and its scale-up preparation. Conventional techniques of preparing spherical ADN typically involve high-temperature melting processes, which entail considerable operational risks. In this study, ADN spherical particles with high sphericity, good powder properties, and adjustable particle size distribution were successfully prepared using a quasi-emulsion solvent diffusion spherical crystallization technology. The spherical products exhibit 47.6 % lower saturated moisture absorption ratio at 25 °C with a relative humidity of 53 % and 96.1 % lower caking strength after one week of storage under low-humidity conditions compared to the raw materials of ADN, which confirms the improved anti‐hygroscopic performance and anti-caking ability. More importantly, the operating temperature of this process can be substantially reduced to 25 °C, representing a 73.1 % decrease compared to the melting temperature of ADN (93 °C). This work presented a novel technique for the safe production of high-quality ADN spherical particles, laying a foundation for their potential application in solid propellants.
研究领域:
材料科学
·
化学工程
·
固体推进剂
·
晶体工程
·
功能材料
✓ 已验证
产品关联
DOI
高影响因子
CONSTRUCTION AND BUILDING MATERIALS
·
2025
·
IF 8
Minhang Han,Qianhe Zhai,Kun Wang,Bo Li,Ruixin Hao,Tielin He,Yinghui Tang,Weihua Ji,Chao Ma,Yang Miao
The demand for lightweight and fire-safe thermal insulation materials in civil and industrial applications has been continuously increasing. Silica aerogels are attractive candidates owing to their ultralow density and low thermal conductivity, but their high flammability and insufficient thermal stability limit broader engineering applications. Incorporating inorganic components such as alumina has been considered an effective strategy to enhance skeletal stability, giving rise to silica–alumina aerogels with improved high-temperature resistance. In this work, phytic acid (PA), a naturally occurring phosphorus-rich compound, was employed as both an acid catalyst and modifier to prepare phosphorus-containing silica–alumina aerogels (ASAs/PA) via supercritical drying. The optimized sample (ASAs/PA-2, TEOS/PA = 1:1.5 ×10⁻³) exhibited a low density of 0.0854 g/cm³ and a thermal conductivity of 24.9 mW/m/K. Compared with pure silica aerogels (SA), its peak heat release rate and total heat release were reduced by 82.0 % and 44.1 %, and by 44.4 % and 18.0 % compared with silica–alumina aerogels (ASAs), demonstrating enhanced flame retardancy arising from phosphorus–aluminum combined interactions. Additionally, the total smoke production (TSP) was significantly reduced, with a reduction of over 95 %, confirming the strong smoke-suppression effect of PA. ASAs/PA showed improved stability at 1000 °C, but reduced stability at 800 °C and 1200 °C compared with ASAs, indicating a trade-off between flame retardancy and high-temperature structural stability. These results highlight the potential of PA modified silica-alumina aerogels as lightweight, fire resistant, and sustainable thermal insulation composites for building and engineering applications, while also underscoring the importance of balancing flame retardancy with high temperature structural stability.
研究领域:
材料科学
·
高分子化学与物理
·
纳米复合材料
·
防火工程
·
可持续建筑材料
✓ 已验证
DOI
高影响因子
Applied Materials Today
·
2023
·
IF 8.3
Xiangbo Zhu,Zhiwei Yang,Deqiang Gan,Teng Cui,Honglin Luo,Yizao Wan,Quanchao Zhang
To circumvent the severe cytotoxicity and drug resistance of chemotherapeutics in cancer chemotherapy, we rationally designed an electrospun nanofibrous delivery system for the codelivery of the doxorubicin (DOX) and small interfering ribonucleic acid (siRNA) to improve antitumor activity and mitigate DOX drug resistance. DOX was intercalated into nanolamellar hydroxyapatite (LHAp), which was incorporated into electrospun poly(lactic-co-glycolic acid) (PLGA) nanofibers, and finally, the DOX-intercalated LHAp/PLGA scaffold was coated with polydopamine (PDA) followed by immobilization with siRNA/polyethyleneimine (PEI) complexes. Benefiting from its intrinsic degradability, the scaffold demonstrated pH-responsive release behavior, leading to the simultaneous delivery of DOX and siRNA. Consequently, the codelivery scaffold demonstrated enhanced therapeutic efficiency in vitro and in vivo compared with the scaffold loaded with single drug due to the combined effects of DOX and siRNA and did not show toxicity or side effects in mice. Therefore, it is a safe and effective strategy for preventing postsurgical tumor recurrence.
研究领域:
药学
·
纳米技术
·
癌症研究
·
生物材料
·
药物递送系统
✓ 已验证
DOI
高影响因子
Journal of Materials Chemistry B
·
2020
·Vol. 8
·期 9
·1960-1970
·
IF 5.344
Ye Yang,Shiqi Yin,Chao He,Xizheng Wu,Jiarui Yin,Jue Zhang,Lang Ma,Weifeng Zhao,Chong Cheng,Changsheng Zhao
Recently emerged hemoperfusion absorbents, e.g. ion-exchange resin, activated carbon, and other porous materials, provide numerous novel possibilities to cure chronic liver failure (CLF) and renal failure (CRF). However, the limited adsorption performance and unsatisfactory blood compatibility significantly impede the development of the absorbents. Hence, designing safe and self-anticoagulant hemoperfusion absorbents with robust toxin clearance remains a considerable challenge. Here, brand new Kevlar-based composite gel beads for hemoperfusion are prepared by interface assembly based on π–π interaction. First, Kevlar nanofiber–graphene oxide (K–GO) beads are produced by liquid–liquid phase separation. Then, sodium p-styrenesulfonate (SS) is adsorbed onto the K–GO interface by π–π interaction and initiated to achieve the composite gel (K–GO/PSS) beads with an interfacial crosslinked structure. Such composite gel beads possess superior mechanical strength and self-anticoagulation capability, owing to the dual-network structure and heparin-mimicking gel structure, respectively. Furthermore, the K–GO/PSS beads show robust adsorption capacities for different kinds of toxins due to their strong charge and π–π interactions. A simulated hemoperfusion experiment in vitro demonstrates that the concentrations of the toxins in the blood can be restored to normal values within 30 minutes. In general, we envision that such composite gel beads will provide new strategies for future clinical CLF and CRF treatments.
研究领域:
材料科学
·
生物医学工程
·
血液透析技术
✓ 已验证
DOI
PubMed
高影响因子
Journal of Energy Storage
·
2026
·
IF 9.8
Fei Song,Yinghao Xia,Hui Wang,Dejian Cheng,Guangzhao Zhang,Jingyuan Wang,Yong Zeng,Heyu Tang,Ao Jiao,Yu Yang,Yonghong Deng,Chaoyang Wang
Polyethylene separators (PE) are widely used in lithium-ion batteries due to their good electrochemical stability and low cost. However, PE separators have issues including high-temperature shrinkage and poor electrolyte wettability, which reduce the safety and electrochemical performance of batteries. In this work, we synthesized a large-sized microsphere binder (SNE) and designed an inorganic ceramic/polymer composite coating strategy. The prepared single-layer PE/SNE separator exhibits a unique micro-convex structure, where microspheres with diameters slightly larger than the thickness of the ceramic layer are partially exposed outside the composite coating. The electrodes and separators are hot-pressed to make the microspheres viscoelastic, which effectively bonds the electrodes, prevents sliding, and strengthens the interface to reduce interface impedance. Compared to traditional PVDF-coated ceramic separators, PE/SNE separators feature simple production processes, lower cost, and environmental friendliness. The ceramic-coated optimized PE/SNE separator can maintain shrinkage of <1% at 130 °C/0.5 h and improves the ionic conductivity (0.83 mS/cm) and lithium-ion transference number (t Li + = 0.62). Due to the optimized hot-pressed interface and improved overall performance of the PE/SNE separator, the NCM622//Li cell has a discharge capacity of 118 mAh/g at 5C, and the NCM622//graphite full cell has a capacity retention rate of 81% after stable cycling for 1500 cycles at 2C. This approach offers a promising method for developing lithium-ion battery separators with enhanced safety and cycling performance.
✓ 已验证
产品关联
DOI
高影响因子
JOURNAL OF POWER SOURCES
·
2016
·
IF 6.333
Jinglun Wang,Yongjin Mai,Hao Luo,Xiaodan Yan,Lingzhi Zhang
Two fluorosilanes with oligo(ethylene oxide) unites were synthesized through hydrosilylation of chlorosilane with allyl substituted oligo(ethylene oxide) ether followed by fluorination with potassium fluoride . The synthesized fluorosilane compounds exhibited lower viscosity, higher dielectric constant and higher oxidation potential, compared with their non-fluorination counterparts. Difluoro(3-(2-(2-methoxyethoxy)ethoxy)propyl)methylsilane (DFSM 2 ), one of the two compounds, was evaluated as high-voltage and thermal stable electrolyte co-solvent with the conventional carbonate-based electrolytes. Using an optimized electrolyte of 1M LiPF 6 in EC/DFSM 2 /EMC (2/3/5 in vol .) with addition of 5 wt % fluoroethylene carbonate (FEC), high-voltage LiCoO 2 (LCO)/graphite full cell displayed outstanding cycling stability of 92.5% capacity retention after 135 cycles at 4.4 V upper cutoff voltage. Characterized by differential scanning calorimetry (DSC) analysis, the DFSM 2 -based electrolyte demonstrated higher thermal stability with lithiated graphite anode and delithiated LCO cathode, thus better safety feature compared with the conventional electrolyte.
研究领域:
电化学
·
能源材料
·
电池技术
·
有机合成
·
电解质化学
✓ 已验证
DOI
高影响因子
JOURNAL OF POWER SOURCES
·
2018
·
IF 6.945
Qingfeng Fu,Xin Liu,Jingrong Hou,Yiran Pu,Chunfu Lin,Liang Yang,Xiangzhen Zhu,Lei Hu,Shiwei Lin,Lijie Luo,Yongjun Chen
Ti 2 Nb 2 x O 4+5 x compounds are very popular negative-electrode materials for lithium-ion batteries due to their high specific capacities, safe operating potentials and high cycling stability. Nevertheless, their poor electronic conductivities and insufficient Li + diffusion coefficients limit the rate capabilities. Herein, we explore highly conductive CrNb 11 O 29 with a high theoretical capacity (401 mAh g −1 ) and an open Wadsley–Roth shear structure as a new intercalating negative-electrode material having the same advantages of Ti 2 Nb 2 x O 4+5 x but a high rate capability. CrNb 11 O 29 nanorods (CrNb 11 O 29 -R) with lengths of 500–1000 nm and very small diameters of 30–50 nm are prepared based on a novel hydrothermal method . Due to the free electrons in Cr-3d orbitals and the large ionic radius of Cr 3+ , CrNb 11 O 29 exhibits a high electronic conductivity and large Li + diffusion coefficients , respectively. In-situ X-ray diffraction analyses confirm its high structural stability . These conductivity, structural and architectural advantages in CrNb 11 O 29 -R lead to its significant pseudocapacitive contribution (82.0% at 1.1 mV s −1 ), prominent rate capability (high reversible capacities of 343 mAh g −1 at 0.1C and 228 mAh g −1 at 10C), and outstanding cycling stability (only 8.9% capacity loss at 10C over 400 cycles).
研究领域:
材料科学
·
电化学
·
能源存储
·
纳米材料
·
固态化学
·
电池技术
✓ 已验证
DOI
高影响因子
Science China-Chemistry
·
2019
·Vol. 62
·期 7
·889-896
·
IF 6.085
Wang Zhaolei,Jiang Xue,Liu Wenbin,Lu Guolin,Huang Xiaoyu
A new kind of bifunctional magnetic-fluorescent nanoparticles (NPs) with abundant carboxyls on the surface has been prepared by covalently combining glutathiose (GSH)-modified CdTe quantum dots (QDs) with Fe 3 O 4 @SiO 2 NPs. The silica-coated Fe 3 O 4 NPs were functionalized with amino groups by (3-aminopropyl)triethoxysilane to provide Fe 3 O 4 @SiO 2 -NH 2 NPs, which was then chemically conjugated with GSH-modified CdTe QDs to form bifunctional magnetic-fluorescent NPs, Fe 3 O 4 @SiO 2 -NH-CO-CdTe-QDs NPs. The properties and morphologies of Fe 3 O 4 @SiO 2 -NH-CO-CdTe-QDs NPs were investigated by FTIR, Xray diffraction, transmission electron microscopy (TEM), absorption and fluorescence spectroscopy and vibrating sample magnetometry. TEM images display that Fe 3 O 4 @SiO 2 -NH-CO-CdTe-QDs NPs possess spherical core-shell structure with a uniform size about 50 nm. The bifunctional NPs were found to exhibit good magnetic and strong fluorescent properties favorable for their application in the detection of latent fingerprints. Furthermore, the carboxyls on the surface of NPs have good absorptions with water in air and the residues of fingerprints so as to not only avoid dust flying to protect the health of operators, but also improve the efficiency of detection.
研究领域:
纳米生物技术
·
法医科学
·
分析化学
·
材料科学
·
分子影像
·
表面功能化
✓ 已验证
DOI
高影响因子
危险品化学品经营许可证（带存储）