COLLOIDS AND SURFACES B-BIOINTERFACES
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2026
·
IF 5.9
Han-jun Qin,Si-ying He,Shu-bi Zhao,Ting-hui Xiao,Feng-ting Cui,Ling-Yu Zhang,Gao-yang Chen,Jing-yu Chen,Da-mao Dai,Xue-yan Liu,Xin-jia Hu
Infectious bone defects (IBD), characterized by persistent bacterial infection and impaired bone regeneration, remain a major clinical challenge. Although numerous biomaterials have been developed, most fail to simultaneously achieve antibacterial efficacy and osteogenic promotion. Here, we innovatively designed a strontium ion (Sr²⁺)-coordinated asiatic acid/silk fibroin (AA-Sr/SF) composite hydrogel that synergistically integrates a natural bioactive compound, inorganic ions, and a protein matrix. This unique strategy endows the hydrogel with dual antibacterial and osteoinductive functions. Systematic characterization demonstrated its excellent mechanical stability, controlled degradability, and sustained release behavior. Functional assays revealed that AA-Sr/SF effectively inhibited Staphylococcus aureus while significantly enhancing osteoblast differentiation. In vivo, the hydrogel reduced bacterial burden in infected defects, facilitated new bone formation, and restored bone mass. Transcriptomic analysis further suggested that AA-Sr/SF promotes osteogenesis via activation of the BMP4–ID2/ID3 axis and calcium signaling pathway. Collectively, this study introduces a multifunctional hydrogel integrating antibacterial, osteogenic, and translational advantages, offering a promising material-based strategy for the precise treatment of infectious bone defects.
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高影响因子
INORGANIC CHEMISTRY
·
2026
·
IF 4.6
Yu Qiu,Haonan Liu,Yujie Zhang,Hongping Wu,Hongwei Yu
The rational design of noncentrosymmetric (NCS) borates remains challenging because subtle variations in the arrangement of microscopic functional units can profoundly influence macroscopic symmetry and nonlinear optical (NLO) behavior. Herein, we report two new alkaline-earth borate fluorides, Sr2Mg3(BO3)2F4 and Ba2Mg3(BO3)2F4, featuring identical [BO3] triangles and Mg-O/F polyhedra, but crystallizing in distinct space groups, namely P1̅ for Sr2Mg3(BO3)2F4 and Fdd2 for Ba2Mg3(BO3)2F4. Structural analysis indicates that replacing Sr2+ with the larger Ba2+ cation modifies the local coordination environment around the alkaline-earth cation and the distortion of the Mg-O/F framework, which results in the reorganization of [BO3] units from an antiparallel arrangement to a cooperative polar alignment. Property measurements indicate that Ba2Mg3(BO3)2F4 exhibits a significant second-harmonic generation response, suitable birefringence, and a short UV cutoff edge down to 190 nm. A structure-property relationship study confirms that the [BO3] units are the primary source of the optical response. This work not only provides a promising deep-ultraviolet NLO crystal but also reveals a cation-mediated symmetry engineering strategy to design NCS borates.
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高影响因子
CERAMICS INTERNATIONAL
·
2025
·
IF 5.6
Wen-Zhong Lu,Burhan Ullah,Wen Lei,Tauqeer Ahmad
SrTiO 3 is a quantum paraelectric with cubic symmetry that resists long-range ferroelectricity, but targeted substitution and defect ordering can unlock polar states. Here, we report novel ferroelectricity and high microwave permittivity in a novel Sr (1-1.5 x ) Ce x TiO 3 (SCTO@ x for x = 0.5) (SCTO) solid solution. XRD and Rietveld refinement reveal stabilization of an orthorhombic Pmmm phase, supported by TEM superlattice reflections linked to TiO 6 tilts and antiparallel A-site displacements, while energy landscape analysis confirms this orthorhombic configuration as the strain-relieved ground state. Raman spectra show defect-activated E g and A 1g modes from oxygen-vacancy ordering, and XPS identifies a Ce 3+ /Ce 4+ ↔ Ti 3+ /Ti 4+ redox equilibrium with abundant vacancies. SEM/AFM reveal dense twin-striped grains that grow in size coarsen with sintering, reducing disorder. Dielectric spectra show a low-temperature relaxor response and a high-temperature transition: at 1270 °C both are diffuse and frequency-dependent, whereas at 1300 °C the high-temperature anomaly sharpens into a frequency-independent displacive ferroelectric transition (T C ∼ 449 °C, T CW ∼486 °C), supported by slim P–E loops, higher remanence, and TEM-confirmed domains. The coexistence of relaxor fluctuations with long-range ferroelectric order highlights a crossover from defect-induced short-range polarization to domain-driven coherence, which directly enhances microwave permittivity (ε r ∼82, Q × f∼12800 GHz, and τ f ∼ 205 ppm/°C) by combining soft-mode contributions with reduced extrinsic losses. These findings establish that reduction-controlled defect ordering stabilizes orthorhombic ferroelectricity absent in pristine SrTiO 3 , providing a clear design pathway for functional dielectrics through defect-engineered lattice symmetry.
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SCIENCE OF THE TOTAL ENVIRONMENT
·
2024
·
IF 8.2
Guohui Wang,Qixin Zhang,Lailai Qin,Kaixuan Tan,Chunguang Li,Lianshun Li,Tinggui Yang,Xiaojuan Liu
A novel metal-organic framework (MOF) material, MIL-100(Fe)-DMA, was synthesized using the solvothermal method. The structure of the MOF was characterized using scanning electron microscopy-energy dispersive X-ray spectroscopy, N 2 adsorption–desorption isotherms, X-ray diffraction analysis, Fourier-transform infrared spectroscopy, X-ray photoelectron spectroscopy, and Mössbauer spectroscopy. Batch adsorption experiments were performed to investigate the effects of initial Sr 2+ and Cs + concentrations, adsorption time, pH, and coexisting cations on the adsorption performance of the material. The adsorption mechanism was further elucidated using adsorption kinetics and isotherm models. The results indicated that the adsorption of Sr 2+ and Cs + does not significantly affect the MOF material structure. As reaction time and initial ion concentration increased, the adsorption capacity of MIL-100(Fe)-DMA for Sr 2+ and Cs + increased rapidly and then gradually reached equilibrium. Optimal adsorption occurred under alkaline conditions, with maximum adsorption capacity observed at pH = 8. The adsorption process for Sr 2+ and Cs + was well described by the pseudo-second-order kinetic model, the Weber–Morris model, and the Langmuir adsorption isothermal model. The adsorption process was mainly identified as monolayer chemical adsorption, influenced by multiple factors. Characterization combined with density functional theory calculations revealed that the unsaturated carboxylic acid groups on the surface of the MOFs play a crucial role in the interaction with Sr 2+ and Cs + .
研究领域:
材料科学
·
环境科学
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JOURNAL OF RADIOANALYTICAL AND NUCLEAR CHEMISTRY
·
2025
·
IF 1.6
Tian Duan,Wang Zhe,Zhang Jiaqian,Luo Ying,Zhang Zhenlong,Li Chao,Ye Kai,Peng Chaoliang,Chen Yiming,Lin Wenxue,Zhang Jingyan
This study examines attapulgite-bentonite-pyrite (AB 7 Fe) and zeolite-bentonite-pyrite (ZB 7 Fe) mixtures as buffer and backfill materials for nuclide migration using soil column experiments and COMSOL modeling. The results indicated that ZB 7 Fe possessed higher adsorption capacities for cesium (Cs) and strontium (Sr) compared to AB 7 Fe. Conversely, AB 7 Fe demonstrated superior retardation performance, more effectively slowing nuclide migration. After 1000 years, Cs and Sr concentrations in AB 7 Fe surpassed those in ZB 7 Fe. Additionally, nuclide migration increased with higher initiation pressure, dispersion, and diffusion coefficients. This research is crucial for improving the long-term safety of nuclear waste repositories.
研究领域:
环境科学
·
核废物管理
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Metals
·
2024
·Vol. 14
·期 6
·627
·
IF 2.6
Chang Liu,Shichang Zhang,Xinpeng Wang,Lifeng Chen,Xiangbiao Yin,Mohammed F. Hamza,Yuezhou Wei,Shunyan Ning
Crown ethers are famous for the highly selectively grab Sr(II) from concentrated nitric acid solution due to the size match, but they suffer from the high leakage into the liquid phase caused by the presence of a large number of hydrophilic groups. To reduce their leakage, two novel porous silica-based adsorbents, (DtBuCH18C6 + Dodec)/SiAaC-g-ABSA and (DtBuCH18C6 + Dodec)/SiAaC-g-3-ABSA, were prepared by vacuum impregnation with organic contents of about 55.9 wt.% and 56.1 wt.%, respectively. The two adsorbents have good reusability and structural stability, and the total organic carbon leakage rates in 2 M HNO3solution are lower than 0.56 wt.% and 0.29 wt.%, respectively. Batch adsorption experiments revealed that the two adsorbents possessed good adsorption selectivity towards Sr, withSFSr/Mover 40, except that ofSFSr/Bain 2 M HNO3solution. The adsorption equilibrium of Sr in 2 M HNO3solution was reached within 1 h, with saturated adsorption capacities of 36.9 mg/g and 37.5 mg/g, respectively. Furthermore, the XPS results indicate that the adsorption mechanism is the coordination of the crown ether ring with Sr. This work not only develops two novel adsorbents for the separation of Sr in nitric acid environments; it also provides a method for effectively reducing the water solubility of crown ethers.
研究领域:
化学工程
·
材料科学
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RARE METALS
·
2026
·Vol. 45
·期 4
·e70258
·
IF 12.1
Yin-Chuan Wang,Zhao-Rui Lv,Shuo-Fu Liang,Meng Zhang,Hong-Jin Xue,Yi-Feng Xiong,Yong-Gang Li,Gui-Yong Xiao,Yu-Peng Lu
en This link goes to a English section zh This link goes to a Chinese section Constructing a porous scaffold with the essential features of natural cancellous bone, including structural architecture and biochemical cues, is one of the pivotal factors for effective bone regeneration. In this study, a biomimetic composite porous Gelatin fibrous scaffold (SrHA/Gelatin) incorporating ultralong strontium-doped hydroxyapatite nanofibers was fabricated via thermally induced phase separation and paraffin sphere leaching technologies. The porous scaffold exhibited an interconnected macroporous network with a fibrous framework. SrHA nanofibers incorporated into the scaffold created an extracellular matrix-like microenvironment although simultaneously providing excellent elasticity, mechanical resilience, and abundant sites for cell anchoring. Importantly, substitution of Ca 2+ by Sr 2+ in the hydroxyapatite (HA) crystal lattice accelerated nanofiber degradation and enabled the sustained release of Ca 2+ and Sr 2+ ions, thereby establishing a dynamic osteoinductive microenvironment. In vitro studies showed that the SrHA/Gelatin scaffold significantly enhanced adhesion, proliferation, and migration of bone marrow mesenchymal stem cells, as well as upregulated expression of the osteogenic gene compared with Gelatin and HA/Gelatin scaffolds. Furthermore, in vivo experiments revealed that the scaffold induced robust trabecular bone formation and defect bridging in rat calvarial defects, whereas only limited repair was observed in the control group. This study demonstrates that the SrHA/Gelatin porous scaffold integrates mechanical robustness, structural biomimicry, and dynamic ionic release, representing a promising candidate for bone defect repair. 摘要 en This link goes to a English section zh This link goes to a Chinese section 构建具备天然松质骨关键特征(结构和生化信号)的多孔支架,是实现有效骨再生的核心因素之一。本研究通过热诱导相分离与石蜡球浸出技术,制备了含超长锶掺杂羟基磷灰石纳米纤维的仿生复合明胶多孔纤维支架(SrHA/Gelatin)。该多孔支架呈现出互连大孔网络与纤维化骨架结构。复合于支架中的SrHA纳米纤维既模拟了细胞外基质微环境,又赋予了支架优异的弹性、机械回弹性及充足的细胞锚定位点。更重要的是,Sr 2+ 取代羟基磷灰石(HA)晶格中的Ca 2+ 不仅促进了纳米纤维的降解,也确保了Ca 2+ 和Sr 2+ 的持续释放,进而构建了动态成骨诱导微环境。相关体外实验表明,SrHA/Gelatin支架较Gelatin和HA/Gelatin支架能更显著促进骨髓间充质干细胞的黏附、增殖与迁移,并上调成骨相关基因的表达; 体内实验显示,该支架在大鼠颅骨缺损模型中可诱导大量骨小梁形成及广泛骨桥接,而对照组中仅可观察到有限的修复效果。本研究证实了所构建的集力学稳定性、结构仿生特性与动态离子释放功能于一身的SrHA/Gelatin多孔支架是一种极具应用前景的骨缺损修复材料。
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高影响因子
PHYSICAL CHEMISTRY CHEMICAL PHYSICS
·
2016
·Vol. 18
·期 31
·21491-21499
·
IF 4.449
Meilin Lv,Yawei Wang,Lingwei Lu,Ruinan Wang,Shuang Ni,Gang Liu,Xiaoxiang Xu
The crystal structure of photocatalysts generally plays a pivotal role in controlling their electronic structure as well as catalytic performance. In this work, a series of double perovskite compounds A2InTaO6 (A = Sr or Ba) and their Ni doped counterparts were investigated with the aim of understanding how doping and structural modification will affect their photocatalytic activity. Our results show that Ni doping is effective in improving the optical absorption of these wide band gap semiconductors and accommodating the Sr cation in the A sites leads to severe structural distortion, i.e. the In(Ni)–O–Ta bond angle deviates largely from 180°. A better photocatalytic performance was observed for samples with Ni doping and Ba in the A sites. The best photocatalytic hydrogen production rate recorded was ∼293.6 μmol h−1 for Ba2In0.9Ni0.1TaO6 under full range irradiation, corresponding to an apparent quantum efficiency of 2.75%. DFT calculations reveal the role of Ni doping by forming additional spin-polarized bands inside the intrinsic band gap of the native perovskite. The better photocatalytic activity of Ba2In0.9Ni0.1TaO6 can then be understood as a result of a reduced band gap as well as a linear In(Ni)–O–Ta bond arrangement that is favorable for the strong metal–oxygen–metal interactions.
研究领域:
材料科学
·
光催化
·
钙钛矿化学
·
能源材料
·
固态化学
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高影响因子
JOURNAL OF BIOMATERIALS SCIENCE-POLYMER EDITION
·
2019
·
IF 2.121
Huilin Ye,Junjin Zhu,Dan Deng,Shue Jin,Jidong Li,Yi Man
Membranes play pivotal role in guided bone regeneration (GBR) technique for reconstruction alveolar bone. GBR membrane that is able to stimulate both osteogenic and angiogenic differentiation of cells may be more effective in clinic practice. Herein, we fabricated the Sr-doped calcium phosphate/polycaprolactone/chitosan (Sr-CaP/PCL/CS) nanohybrid fibrous membrane by incorporating 20 wt% bioactive Sr-CaP nanoparticles into PCL/CS matrix via one-step electrospinning method, in order to endow the membrane with stimulation of osteogenesis and angiogenesis. The physicochemical properties, mechanical properties, Sr2+ release behavior, and the membrane stimulate bone mesenchymal stem cell (BMSCs) differentiation were evaluated in comparison with PCL/CS and CaP/PCL/CS membranes. The SEM images revealed that the nanocomposite membrane mimicked the extracellular matrix structure. The release curve presented a 28-day long continuous release of Sr2+ and concentration which was certified in an optimal range for positive biological effects at each timepoint. The in vitro cell culture experiments certified that the Sr-CaP/PCL/CS membrane enjoyed excellent biocompatibility and remarkably promoted rat bone mesenchymal stem cell (BMSCs) adhesion and proliferation. In terms of osteogenic differentiation, BMSCs seeded on the Sr-CaP/PCL/CS membrane showed a higher ALP activity level and a better matrix mineralization. What’s more, the synergism of the Sr2+ and CaP from the Sr-CaP/PCL/CS membrane enhanced BMSCs angiogenic differentiation, herein resulting in the largest VEGF secretion amount. Consequently, the Sr-CaP/PCL/CS nanohybrid electrospun membrane has promising applications in GBR.
研究领域:
材料科学
·
生物材料
·
组织工程
·
生物医学工程
·
再生医学
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APPLIED SURFACE SCIENCE
·
2012
·
IF 2.103
Yang Xiaowei,Zeng Yanwei,Cai Tongxiang,Hu Zhenxing
The polystyrene shells have been successfully grown on the barium strontium titanate (BST) nanocrystals, which were synthesized by microwave-activated glycothermal method, via a solvent-free surface-initiated atom transfer radical polymerization (SI-ATRP) after the 2-bromo-2-methylpropionic acid molecules (Br-MPA) were anchored at the surface of BST nanocrystals through ligand exchange with hydroxyl groups on their surfaces. These surface modified BST nanocrystals can then be perfectly dispersed in styrene monomer and act as macroinitiators for ATRP to yield BST@PS core-shell structured nanoparticles, which endow the BST nanocrystals with exceptionally good dispersibility and stability in hydrophobic solvents. The BST@PS core-shell structures were characterized by X-ray diffraction (XRD) technique and transmission electron microscopy (TEM). Fourier transform infrared spectroscopy (FT-IR), Raman spectroscopy (Raman), differential scanning calorimetry (DSC) and gel permeation chromatography were also employed to probe the Br-MPA and PS on the BST nanocrystals. It has been shown that after the BST nanocrystals are surface-modified with Br-MPA, the polymerization of styrene can steadily occur at the surface of BST nanocrystals to form a uniform polystyrene shell and its thickness can reach ∼10 nm when the polymerization reaction is extended to 36 h, while no changes are found to take place with the BST nanocrystals. Compared with typical high molecular weight PS ( M n = 6700), the as-obtained PS possess a relatively low molecular weight ( M n = 5473) and a lower glass transition temperature ( T g ∼ 93 °C). The research results demonstrate a viable strategy for the preparation of polymer-coated functional metal oxides nanocrystals, potentially useful in biological and nanoelectronic applications.
研究领域:
材料科学
·
化学工程
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高影响因子
MATERIALS LETTERS
·
2015
·
IF 2.489
Xiwei Liu,Jianke Sun,Yinghong Yang,Feiyu Zhou,Zhongjie Pu,Li Li,Yufeng Zheng
The microstructure, mechanical properties , in vitro degradation behavior and hemocompatibility of novel Zn–1Mg–0.1Sr and Zn–1Mg–0.5Sr (wt%) ternary alloys were evaluated with pure Zn as control. The results indicated that Zn–Mg–Sr alloys exhibited much higher yield strength (YS), ultimate tensile strength (UTS), hardness and corrosion rate than those of pure Zn. But their elongation and hemolysis rates were reduced. Furthermore, the hot-rolled Zn–1Mg–0.1Sr alloy presented the superior mechanics performance (196.84±13.20 MPa, 300.08±6.09 MPa, 22.49±2.52%, 104.31±10.18 for YS, UTS, Elongation and hardness, respectively), appropriate corrosion rate (0.15±0.05 mm/year) and excellent hemocompatibility (hematolysis rate of 1.10±0.2% and no signs of thrombogenicity), showing a preferable candidate as the biodegradable implant material .
研究领域:
材料科学
·
生物医学工程
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高影响因子
JOURNAL OF LUMINESCENCE
·
2023
·
IF 3.6
Rui-Qi Su,Qiang-Qiang Zhu,Hang Mei,Shuangqiang Fang,Yue Zhai,Pei Liang,Hong Zhang,Le Wang
Nitride red-emitting materials exhibit severe luminance saturation and are thus not suitable for achieving enhanced color rendering in laser lighting applications. The silicate luminescent material (Sr,Ba) 3 SiO 5 :Eu 2+ displays excellent stability and can emit orange-red light when excited by blue laser light, making it a promising candidate for realizing high-performance laser lighting. In this study, (Sr,Ba) 3 SiO 5 :Eu 2+ phosphor-in-glass (PiG) films were prepared on a sapphire substrate, and the influences of preparation temperature, mass ratio of phosphor to glass frit (PtG ratio), and film thickness on the application performance of PiG film were analyzed. The (Sr,Ba) 3 SiO 5 :Eu 2+ PiG film with a PtG ratio of 1:1 and a film thickness of ∼50 μm prepared at 475 °C exhibited optimal comprehensive luminescence performance. This film exhibited a luminous saturation threshold of 5.98 W/mm 2 , a maximum luminous flux of 372.3 lm, and a luminous efficiency of 62.3 lm/W at the luminous saturation threshold. The maximum luminous flux of the (Sr,Ba) 3 SiO 5 :Eu 2+ PiG film was 77.6% higher than that of the CaAlSiN 3 :Eu 2+ nitride PiG film. Finally, through the incorporation of green-emitting YAGG:Ce 3+ phosphor into the (Sr,Ba) 3 SiO 5 :Eu 2+ PiG film, laser-driven white light with a luminous flux of 531.7 lm and a high color rendering index (CRI) of 83.4 was realized.
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危险品化学品经营许可证（带存储）