JOURNAL OF POLYMER SCIENCE PART A-POLYMER CHEMISTRY
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2011
·Vol. 49
·期 10
·2303-2313
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IF 3.894
Tianbin Ren,An Wang,Weizhong Yuan,Lan Li,Yue Feng
Star-shaped amphiphilic poly(ε-caprolactone)- block -poly(oligo(ethylene glycol) methyl ether methacrylate) with porphyrin core (SPPCL- b -POEGMA) was synthesized by combination of ring-opening polymerization (ROP) and atom transfer radical polymerization (ATRP). Star-shaped PCL with porphyrin core (SPPCL) was prepared by bulk polymerization of ε-caprolactone (CL) with tetrahydroxyethyl-terminated porphyrin initiator and tin 2-ethylexanote (Sn(Oct) 2 ) catalyst. SPPCL was converted into SPPCLBr macroinitiator with 2-bromoisobutyryl bromide. Star-shaped SPPCL- b -POEGMA was obtained via ATRP of oligo(ethylene glycol) methyl ether methacrylate (OEGMA). SPPCL- b -POEGMA can easily self-assemble into micelles in aqueous solution via dialysis method. The formation of micellar aggregates were confirmed by critical micelle formation concentration, dynamic light scattering, and transmission electron microscopy. The micelles also exhibit property of temperature-induced drug release and the lower critical solution temperature (LCST) was 60.6 °C. Furthermore, SPPCL- b -POEGMA micelles can reversibly swell and shrink in response to external temperature. In addition, SPPCL- b -POEGMA can present obvious fluorescence. Finally, the controlled drug release of copolymer micelles can be achieved by the change of temperatures. © 2011 Wiley Periodicals, Inc. J Polym Sci Part A: Polym Chem, 2011
研究领域:
高分子化学
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材料科学
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药物递送
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高影响因子
ACS Applied Polymer Materials
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2023
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IF 5
Yan Qin,Weihua Su,Guihua Meng,Jianning Wu,Lin Cui,Shengchao Yang,Zhiyong Liu,Xuhong Guo
An intelligent responsive pesticide delivery system has been applied in agriculture to improve the utilization rate of pesticides. When plants are affected by fungi, a large number of reactive oxygen species (ROS) are produced rapidly on the wound surface. Based on this, a ROS responsive star polymer micellar slow-release system was constructed to load carbendazim (MBC) and improve its bioavailability. The star polymer was synthesized by using 3-mercaptopropionic acid, acetone, pentaerythritol (PER), ε-caprolactone (ε-CL), and methoxypolyethylene glycols (mPEG5000, Mw = 5000) and named PER-PCL-TK-mPEG5000. By loading MBC, the drug loading micelle MBC-loaded PER-PCL-TK-mPEG5000 was obtained. The cumulative release amount of MBC-loaded PER-PCL-TK-mPEG5000 containing H2O2 is 1.64 times of that without H2O2 after 120 h release. The inhibitory rate of MBC-loaded PER-PCL-TK-mPEG5000 containing H2O2 against Rhizoctonia solani (R. solani) was 91.6%. The critical micelle concentration (CMC) of PER-PCL-TK-mPEG5000 is 4.37 mg/L, and the result showed that PER-PCL-TK-mPEG5000 and MBC-loaded PER-PCL-TK-mPEG5000 have good stability at 4 °C for 14 d. This study proved that the strategy of designing pesticide vectors according to the target environment can be widely used to protect crops, improve pesticide utilization rate, and protect the environment.
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高影响因子
POLYMER
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2023
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IF 4.6
Xi Zhao,Guoxiang Wang,Yong Gao,Chong Cheng
Mixed shell polymer nanoparticles (MSPNs) have emerged as a very significant research topic in the field of macromolecular science. In this study, a robust method for efficient preparation of MSPNs with various morphologies via polymerization-induced self-assembly (PISA) of Y-shaped ABC miktoarm star copolymers was demonstrated. Poly( ε -caprolactone)- b -poly(methyl methacrylate) diblock copolymers carrying a trithiocarbonate (TTC) group at the diblock joint (PCL-TTC-PMMA) were synthesized via the sequential ring-opening polymerization of ε-caprolactone ( ε -CL) and atom transfer radical polymerization (ATRP) of methyl methacrylate (MMA) using a multifunctional initiator. Subsequently, PCL-TTC-PMMA copolymers acted as both macromolecular chain transfer agents (CTAs) and stabilizers to mediate reversible addition-fragmentation chain transfer (RAFT) dispersion polymerization of 4-vinylpyridene (4-VP) in toluene, producing MSPNs with different morphologies including spheres, short rods , worms and vesicles. The factors influencing the morphologies of MSPNs during PISA, including solid content and the chain length of stabilizers, were investigated. RAFT-based dispersion polymerizations of 4-VP monomers mediated by PCL-TTC-PMMA copolymers were also compared with those mediated by linear PMMA - TTC with approximately the same length of PCL-TTC-PMMA under the identical conditions. Their different PISA behaviors were unraveled.
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高影响因子
ACS Biomaterials Science & Engineering
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2015
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IF 0
Qiu Li,Yiguang Jin,Miao Li,Jun-Xing Dong
Tumor targeting and controlled drug release at the target are the key problems for cancer pharmacotherapy. A simply structured pH-responsive nanocarrier was prepared to achieve the above aims in this study. A four-armed star copolymer, tetra-(methoxy-poly(ethylene glycol)-poly(2-(N,N-diethylamino)ethyl methacrylate)-poly(ε-caprolactone) pentaerythritol ((mPEG-pDEA-PCL)4-PET, PDCP), was synthesized via the ring-opening polymerization, atom transfer radical polymerization and click chemistry, which formed a monomolecular nanocarrier in water. Its size and zeta potential were strongly pH-dependent from 71 nm and 2.1 mV at pH 8 to 127.5 nm and 25.4 mV at pH 5. The morphological change of pDEA chains was the basic reason. The chains were protonated at lower pH so as to freely extend to the aqueous media, though they were hydrophobic at higher pH to coat on the surface of hydrophobic cores. The star-shaped PDCP had a large hydrophobic core to load hydrophobic drugs (e.g., paclitaxel). High effective drug entrapment in the blood circulation and rapid drug release at the tumor tissues was achieved in PDCP due to its pH-responsive function. The MCF-7 cytotoxicity of the paclitaxel-loaded PDCP nanocarriers at pH 6.5 was similar to free paclitaxel. And the PDCP nanocarriers were well internalized by the MCF-7 cells according to the flow cytometry and laser confocal microscopy. The paclitaxel-loaded PDCP nanocarriers showed the comparable in vivo anticancer effect to the paclitaxel solution (Taxol) although the former’s toxicity was much lower than the latter. The star-shaped pH-responsive monomolecular PDCP nanocarriers are suitable to deliver hydrophobic anticancer drugs for cancer therapy with tumor targeting and controlled drug release.
研究领域:
药学
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生物医学工程
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肿瘤学
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PubMed
ADVANCES IN POLYMER TECHNOLOGY
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2013
·Vol. 32
·期 4
·
IF 1.096
Li Xia,Zhiping Zhou,Jiangdong Dai
A novel hyperbranched multiarm star block copolymers was synthesized. The atom transfer radical polymerization initiators were anchored on the surfaces by the reaction of amino-functionalized silica modified by 3-aminopropyltriethoxysilane with α -bromoisobutyryl bromide. The composites (SNs- g -HPCMS- b -PHEMA- b -PNIPAAm) with silica nano particles as core and hyperbranched star block copolymers as arms was prepared by iron(III)-mediated surface-initiated polymerization with FeCl 3 ·6H 2 O as catalyst, triphenylphosphine as ligand, ascorbic acid as reducing agent, N , N -dimethylformamide as solvent, and 4-chloromethylstyrene, 2-hydroxyethylmethacrylate, and N -isopropylacrylaminde as monomers, respectively. The resultant products were characterized by Fourier-transform infrared spectroscopy, N 2 adsorption/desorption measurements, thermogravimetric analysis, differential scanning calorimeter, and transmission electron micrographs. With aspirin as the model drug, the drug-release behavior of the hybrid materials was studied. The release behavior could be controlled by the temperature, which will have potential applications in biomedicine and biotechnology. © 2013 Wiley Periodicals, Inc. Adv Polym Technol 2013, 32, 21375; View this article online at wileyonlinelibrary.com . DOI 10.1002/adv.21375
研究领域:
高分子化学
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生物医学工程
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纳米技术
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高影响因子
JOURNAL OF BIOMATERIALS SCIENCE-POLYMER EDITION
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2014
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IF 1.357
Yan-Ling Luo,Jing-Yu Fu,Feng Xu,Ya-Shao Chen,Bin Zhang
Thermo-sensitive poly(N-isoproplacrylamide)m-block-hydroxyl-terminated polybutadiene-block-poly(N-isoproplacrylamide)m (PNIPAMm-b-HTPB-b-PNIPAMm, m = 1 or 2) block copolymers, AB4 four-armed star multiblock and linear triblock copolymers, were synthesized by ATRP with HTPB as central blocks, and characterization was performed by 1H NMR, Fourier transform infrared, and size exclusion chromatography. The multiblock copolymers could spontaneously assemble into more regular spherical core–shell nanoscale micelles than the linear triblock copolymer. The physicochemical properties were detected by a surface tension, nanoparticle analyzer, transmission electron microscope (TEM), dynamic light scattering, and UV–vis measurements. The multiblock copolymer micelles had lower critical micelle concentration than the linear counterpart, TEM size from 100 to 120 nm, and the hydrodynamic diameters below 150 nm. The micelles exhibited thermo-dependent size change, with low critical solution temperature of about 33–35 °C. The characteristic parameters were affected by the composition ratios, length of PNIPAM blocks, and molecular architectures. The camptothecin release demonstrated that the drug release was thermo-responsive, accompanied by the temperature-induced structural changes of the micelles. MTT assays were performed to evaluate the biocompatibility or cytotoxicity of the prepared copolymer micelles.
研究领域:
高分子化学
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药物递送系统
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生物材料
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DOI
PubMed
高影响因子
MACROMOLECULAR CHEMISTRY AND PHYSICS
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2020
·Vol. 222
·期 3
·2000379
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IF 2.335
Hanhong Li,Zhenqi Cheng,Yang Wang,Dong Zhou,Mingji Su,Xianxun Wang,Peixin He,Yuhong Zhang
As matters stand, chemotherapy is faced with high toxic and side effects, high risks, and long treatment cycles. Thus, stability, high encapsulation efficiency, intelligent controllability, and good biocompatibility are of great importance for drug delivery vehicles. Herein, a novel doxorubicin hydrochloride (DOX)-loaded micelle-like nanoparticle with pH responsive star-shaped polycaprolactone–polyethyleneglycol copolymer (sPCL–PEG–CT, sPP) is developed through esterification with inositol–polycaprolactone (sPCL) and carboxylated polyethylene glycol (TC–PEG–CT). sPP nanomicelles (sPP NMs) have a high encapsulation efficiency of greater than 85%, an average size of 95 nm, and a zeta potential of −18 mV. In addition, in vitro release tests show that ≈70% of the drug is released from sPP/DOX NMs into phosphate buffer saline solution (PBS) (pH 5.0) at 37 °C for 12 h. More importantly, the cumulative release is ≈90% for 170 h, displaying a more sustainable drug release behavior. The work explores a new synthesis route of star-shaped polycaprolactone–polyethyleneglycol copolymer NMs. The sPP NMs have a promising future in drug carrier, especially for hydrophobic drugs.
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高影响因子
PHYTOCHEMISTRY
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2018
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IF 3.186
Xuchao Jia,Haihui Xie,Yueming Jiang,Xiaoyi Wei
Thirteen flavonoids were isolated from the fresh sweet fruit of Averrhoa carambola L. (Oxalidaceae), commonly known as star fruit, and their structures were determined by spectroscopic and chemical methods. 8-Carboxymethyl-(+)-epicatechin methyl ester , pinobanksin 3- O -β- d -glucoside, and carambolasides M–Q were undescribed structures. (+)-Epicatechin, aromadendrin 3- O -β- d -glucoside, helicioside A, taxifolin 3′- O -β- d -glucoside, galangin 3- O -rutinoside, and isorhamnetin 3- O -rutinoside were reported from this species for the first time. Pinobanksin 3- O -β- d -glucoside and carambolasides M–Q showed more potent 2,2′-azinobis-(3-ethylbenzthiazoline-6-sulphonic acid) (ABTS) radical cation scavenging activity (IC 50 = 5.3–2.3 μM) than l -ascorbic acid (10.5 μM). Further, (+)-epicatechin, pinobanksin 3- O -β- d -glucoside, isorhamnetin 3- O -rutinoside, and carambolasides O–Q exhibited weak porcine pancreatic lipase inhibitory activity.
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PubMed
高影响因子
COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
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2018
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IF 2.829
Weiwei Liu,Shuangkun Zhang,Zhi Qiao,Qi Li,Xiaoyu Li,Haiqiao Wang
A series of PEG-based star polymers with hexa(eugenol) cyclotriphosphazene (HECTP) core and controlled number of PEG arms have been prepared in high yields via simple thiol-ene click reaction combining Dicyclohexylcarbodiimide/4-Dimethylaminopyridine (DCC/DMAP) esterification under very mild experimental conditions, and their potential for application as surfactants was investigated. The surface activities, including the critical micelle concentration (CMC) and surface tension at CMC, of the polymer aqueous solutions were studied. The results showed that PEG-based star polymers with two arms have good surface activities such as low surface tension (low to 36.1 mN/m), good emulsification ability, due to their structural features similar to Gemini surfactants . Whereas, the PEG-based star polymers with more than two arms exhibited very low CMC values (low to 0.004 mg/ml) and strong emulsification ability, therefore they could be utilized as surfactants to form high internal phase emulsions (HIPEs). Using these new PEG-based star polymers as surfactants, a very low surfactant concentration (0.01 wt %) was sufficient to form oil-in-water emulsions with long-term stability more than 6 months. Although further studies are necessary to clarify the interfacial properties , this work opens a new study field for this kind of important organic-inorganic hybrid materials.
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高影响因子
CHINESE CHEMICAL LETTERS
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2016
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IF 1.947
Zhi-Wei Yu,Shu-Xi Gao,Kai Xu,You-Xiong Zhang,Jun Peng,Ming-Cai Chen
Organic/inorganic hybrid polymers have been widely studied for their potential use in nanocontainers and nanocarriers. In this article, one star-shaped hybrid polymer, polyhedral oligomeric silsesquioxane (POSS) grafted poly( N , N -(dimethylamino)ethyl methacrylate) (POSS- g -PDMA), was synthesized via reversible addition-fragmentation chain transfer polymerization (RAFT). The pH stimuli-responsive character of POSS- g -PDMA in aqueous solution were also studied.
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高影响因子
COMPOSITES SCIENCE AND TECHNOLOGY
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2017
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IF 4.873
Ailian Wang,Hao Xu,Xu Liu,Shi Wang,Qian Zhou,Jie Chen,Liaoyun Zhang
Here, two type of composite star polymer electrolytes enhanced by carbon nano-tube (CNT) or fullerene (C 60 ) prepared through a solution-casting technique are investigated. The as-prepared free-standing carbon nano-composite polymer electrolyte membranes exhibit excellent comprehensive performances including high thermal stability (initial thermal degradation temperatures about 383 °C) and good electrochemical properties . However, different carbon nanomaterials bring different influence on electrochemical performances of composite polymer electrolytes. The ionic conductivity of carbon nanotube composite polymer electrolyte (HBPS-(PMMA- b -PPEGMA) 30 /CNT/LiTFSI) is higher than that of fullerene composite polymer electrolyte. The highest ionic conductivity of HBPS-(PMMA- b -PPEGMA) 30 /CNT/LiTFSI electrolyte can reach 1.06 × 10 −5 S cm −1 at 30 °C and lithium-ion transference number reaches 0.52. In addition, two types of carbon nano-composite star polymer electrolytes both exhibit wide electrochemical window with oxidation potential above 5.2 V, good interfacial stability and interfacial compatibility. Moreover, assembled Li/LiFePO 4 cells based on HBPS-(PMMA- b -PPEGMA) 30 /CNT/LiTFSI electrolytes possess good specific capacity with the highest value of 133 mAhh g −1 , while the cells based on HBPS-(PMMA- b -PPEGMA) 30 /C 60 /LiTFSI electrolytes show a great cycle stability.
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高影响因子
NEW JOURNAL OF CHEMISTRY
·
2024
·Vol. 48
·期 48
·20332-20342
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IF 2.7
Guanghao Mao,Huaxin Yang,Shuhang Deng,Wenyu Cao,Ping Deng,Yan Yu
A pair of star-like conjugated isomers (Tetra-8-IQ and Tetra-9-IQ) with indolo[2,3-b]quinoxaline as the star arm and tetraphenylethylene as the star core have been designed and synthesized. A comparative study has been conducted on the structural characteristics, electronic energy levels, spectral absorption, aggregation-induced emission, acid-stimulus response, and fluorescent applications of the two isomers. The results show that Tetra-8-IQ has lower lowest unoccupied molecular orbital/highest occupied molecular orbital energy levels, more redshifted optical absorption, and stronger fluorescence emission than Tetra-9-IQ. The two isomers are novel organic fluorescent materials as they both possess aggregation-induced emission characteristics and reversible acidichromism features. Tetra-8-IQ and Tetra-9-IQ were successfully applied in filter paper test strips and PMMA-based blending film to achieve fluorescent switch signals. Based on these findings, the INHIBIT and IMPLICATION molecular logic gates were successfully established, where acid and base were adopted as the input stimuli.
研究领域:
有机化学
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材料科学
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光化学
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DOI
高影响因子
危险品化学品经营许可证（带存储）