npj Flexible Electronics
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2023
·Vol. 7
·期 1
·1-9
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IF 14.6
Shang Chao,Xu Qunhui,Liang Nengmin,Zhang Jianpeng,Li Lu,Peng Zhengchun
Tactile sensing has been a key challenge in robotic haptics. Inspired by how human skin sense the stress field with layered structure and distributed mechanoreceptors, we herein propose a design for modular multi-parameter perception electronic skin. With the stress field sensing concept, complex tactile signals can be transformed into field information. By analyzing the stress field, the real-time three-dimensional forces can be resolved with 1.8° polar angle resolution and 3.5° azimuthal angle resolution (achieved up to 71 folds of improvement in spatial resolution), we can also detect the hardness of object in contact with the electronic skin. Moreover, we demonstrate random assembly of the sensing arrays and integration of our electronic skin onto differently curved surfaces do not lead to any measurement variation of the stress field. This result reveals that the sensing elements in our electronic skin system can be modularly made and exchanged for specific applications.
研究领域:
机器人学
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生物医学工程
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材料科学
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Cell Metabolism
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2025
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IF 30.9
Yu-Zhang Wang,Wei-Hai Chen,Zi-Yi Han,Shi-Man Zhang,Ping Ji,Cheng Zhang,Jun-Long Liang,Xian-Zheng Zhang
Bacteria-based metabolic therapy has been acknowledged as a promising strategy for tumor treatment. However, the insufficient efficiency of wild-type bacteria severely restricts their therapeutic efficacy. Here, we elaborately develop an ʟ-cyst(e)ine-addicted bacteria-nanodrug biohybrid for metabolic therapy through a dual-selection directed evolution strategy. Our evolved strain exhibits a 36-fold increase in ʟ-cystine uptake and a 23-fold improvement in total activity of cysteine desulfhydrases compared with the wild-type strain. By conjugating with DMXAA-loaded liposomes, the engineered bacteria-nanodrug biohybrid not only prevents the influx of nutrients into the tumor by blocking neovasculature but also achieves efficient and durable CySS catabolism locally. The unavailable of Cys species disrupts redox homeostasis and strikingly increases intracellular ROS level, achieving favorable therapeutic outcomes in multiple tumor models. Our study not only highlights the promise of directed evolution strategy in enhancing the stability and efficiency of bacteria-based living biocatalyst but also provides new opportunities for antitumor metabolic therapy.
研究领域:
生物医学工程
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肿瘤学
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合成生物学
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RUSSIAN JOURNAL OF INORGANIC CHEMISTRY
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2025
·
IF 1.5
Wang L. C.,Ye H. D.,Xu C.,Peng H. N.,Zhang X. L.,Chen F. Y.,Peng S. Y.,Wang S. J.
o-Carborane reacts sequentially with n-butyllithium, sulfur and CpCo(CO)I2 under argon to give the half-sandwich 16-e carborane complex CpCo[S2C2B10H10]. CpCo[S2C2B10H10] reacts with PPh3, P(m-Tol)3, P(p-Tol)3 to afford addition products CpCo(PPh3)[S2C2B10H10] (1), Cp(P(m-Tol)3)Co[S2C2B10H10] (2), CpCo(P(p-Tol)3)[S2C2B10H10] (3), respectively. 1, 2 and 3 have been characterized by chemical analysis, mass-spectrometry, IR and NMR spectroscopy, and single crystal X-ray diffraction (CCDC nos. 2390939 (1), 2390940 (2) and 2390938 (3)).
研究领域:
无机化学
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配位化学
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JOURNAL OF COLLOID AND INTERFACE SCIENCE
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2025
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IF 9.7
Chen Tang,Mengying Liu,Yufei Tang,Pengjiao Chong,Lei Dong,Jiayi Ye,Xiaohang Yang,Jiaju Meng,Weiyan Wang,Zhaowei Liu,Kang Zhao
Hydrogels frequently suffer from low-temperature freezing, high-temperature dehydration, and compromised environmental stability. In contrast, organogels demonstrate superior environmental tolerance and structural designability. Herein, a polyurea organogel (denoted PUA-D x T y ) featuring a trident-chain molecular architecture was synthesized through the polymerization of isocyanate and polyetheramine. By varying the number of functional groups per polyetheramine, dynamic control over crosslinking density and mechanical properties was achieved. The optimized PUA-D 8 T 2 sample exhibited a tensile strength of 178.33 kPa and an ultrahigh elongation of 1838 %, representing 2.3-fold and 4.1-fold enhancements over conventional hydrogels, and significantly surpassing many existing organogels. Besides, this organogel also integrates multifunctional capabilities including strong adhesion to diverse substrates, retention of flexibility/elasticity under harsh conditions, excellent solvent recyclability, and autonomous self-healing enabled by dynamic hydrogen-bond networks. A flexible sensor fabricated by coating the gel surface with a graphene conductive layer accurately monitors multiscale human motions (e.g., finger flexion, wrist rotation) and enables encrypted information transmission via Morse code. This work establishes a novel organogel material platform for environmentally stable flexible electronics, demonstrating significant potential in next-generation electronic skins through its synergistic combination of multifunctional capabilities.
研究领域:
材料科学
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柔性电子学
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高分子化学
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可穿戴传感器
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软体机器人
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EUROPEAN POLYMER JOURNAL
·
2023
·
IF 6
Chuanyun Zhao,Chenyang Zhang,Peng Wang,Ziwei Chen,Yuhang Wang,Jiadeng Zhu,Chunxia Gao,Qiang Gao
Wet-spinning technology plays an essential role in the development of wearable electronics. Poly(3,4-ethylene dioxythiophene): poly(styrene sulfonate) (PEDOT: PSS) fibers have been widely investigated in this field due to their advantages of being environment-friendly and low-cost. They are mainly wet-spun from a coagulation bath containing ethanol and water with additional metal salts. However, the conductivity of PEDOT: PSS fibers spun by this method is low. Here, we propose a novel coagulation bath made of ionic liquid (IL), ethanol, and water, and the resultant PEDOT: PSS fibers could achieve a conductivity of 118.3 S·cm −1 . Furthermore, the fiber-shaped supercapacitor prepared by such PEDOT: PSS/IL fibers reveals an optimal capacitance retention rate of 97 % even after 10,000 cycles, and the capacitance loss of the supercapacitor is only 7 % at −20 ℃. The sensor derived from the PEDOT: PSS/IL fibers has superb sensing capability, indicating their promising applications for wearable electronics.
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CONNECTIVE TISSUE RESEARCH
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2023
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IF 2.9
Gao-Feng Zhao,Le-Bin Huang
Aims Osteoarthritis (OA) is a chronic inflammatory disease, characterized by degradation of extracellular matrix, apoptosis of chondrocytes and inflammation in articular cartilage. Zinc finger E-box binding homebox 2 (ZEB2), a transcription repressor, has been demonstrated with anti-inflammatory role in some cells. The analysis from GEO data reveals that ZEB2 expression is upregulated in articular cartilage of OA patients and experimental OA rodents. This study aims to confirm the function of ZEB2 in OA process.Material and methods The experimental OA was induced by anterior cruciate ligament transaction (ACLT) in rats, and the adenovirus loaded with ZEB2 coding sequence was intra-articularly injected into rats (1 × 10 PFU). The primary articular chondrocytes were stimulated by interleukin-1β (IL-1β) (10 ng/ml) to mimic the osteoarthritic injury, and transfected with the adenovirus carrying ZEB2 coding or silencing sequence. The apoptosis, content of extracellular matrix, inflammation, and the activity of NFκB signaling in chondrocytes and cartilage were determined.Results ZEB2 was highly expressed in osteoarthritic cartilage tissues and IL-1β-treated chondrocytes. The overexpression of ZEB2 restrained ACLT- or IL-1β administration-induced apoptosis, matrix degradation and inflammation in vivo or in vitro, evidenced by changed levels of cleaved caspase-3/PARP, collagen-II, aggrecan, matrix metalloproteinase 3/13, tumor necrosis factor-α and interleukin-6. Additionally, the phosphorylation of NFκB p65, IκBα and IKKα/β, and the nuclear translocation of p65 was blocked by ZEB2, implying inactivation of this signaling.Conclusions ZEB2 mitigated osteoarthritic symptoms in rats and chondrocytes, and NFκB signaling might be involved. These findings may provide novel insights for clinical treatment of OA.
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CHEMICAL ENGINEERING JOURNAL
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2023
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IF 15.1
Jiaqi Zhang,Christopher Hurren,Zhentan Lu,Dong Wang
Accurate and rapid detection of bacteria in complex environmental samples using simple and portable devices is still a major challenge. This research presents a simple nanofiber-based platform for highly sensitive colorimetric/fluorometric detection of Escherichia coli ( E. coli ). Nanofiber membranes (NFM) were loaded with target molecules (fluorescent and chromogenic substrate) via chemical modification to prepare functional NFM (NFM-MUG and NFM-XG). The β -glucuronidase secreted by E. coli during the metabolic process triggered the functionalized NFM to produce biological signals and color change. The intensity of bio-signals and color was shown to enable quantitative and qualitative detection of E. coli . The nanofiber-based platforms exhibited high stability and a wide detection range (10 2 -10 7 CFU/mL). The limit of detection (LOD) of NFM-MUG and NFM-XG sensors for E. coli were 26 and 69 CFU mL −1 , respectively. The sensing time required for NFM-MUG and NFM-XG was 15 mins and 30 mins respectively. The nanofiber-based platforms also exhibited high specificity and low interference from ionic compounds and pH changes. Notably, this assay was easily combined with a smartphone app as a portable device for on-site detection of E. coli , showing a great promise in the field of environmental and food safety testing.
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Journal of Materials Chemistry A
·
2023
·Vol. 11
·期 34
·18247-18261
·
IF 11.9
Dongdong Lu,Mingning Zhu,Xiaoyuan Li,Zilong Zhu,Xin Lin,Chuan Fei Guo,Xiaodong Xiang
Electronic skins (e-skins) have shown great potential in “bionic-machine” technologies. The development of bio-compatible e-skins that mimic the functions of the human skin, which is sensitive to multiple external stimuli, remains a challenge and a highly pursued goal. In this work, we report the synthesis, characterization, and performance-optimization of a thermo-sensitive and conductive hydrogel that displays multimodal sensing capacity. The optimal composition of a hydrogel with a volume phase transition temperature (VPTT) of 38 °C and a transition width of 15 °C was developed. This gel has an elastic modulus similar to that of the human skin, a large stretchability of 1900%, and a high gauge factor of 9.8. The gel is also puncture-resistant, self-healable, and self-adhesive. The as-fabricated hydrogel can sense multimodal stimuli, including force and temperature, with high sensitivity. We demonstrate that the gel possesses important attributes as a candidate for e-skin to monitor physiological signals including temperature, bending, and pressure in real time.
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RSC Advances
·
2022
·Vol. 12
·期 46
·30174-30180
·
IF 4.036
Danqing Liu,Xingxing Lv,Chaoyue Zhao,Jiayue Li,Jinmei Huang,Ling Weng,Liangcan He,Shaoqin Liu
Foodborne or water-borne pathogens pose great threats to human beings and animals. There is an urgent need to detect pathogens with cheap, rapid and sensitive point-of-care diagnostic assays. Herein, we report the electrochemiluminescent (ECL) behaviors of NaBiF4 : Yb3+/Er3+ upconversion nanoparticles (UCNPs) which were synthesized via a fast and environment-friendly method at room temperature for the first time. The UCNPs together with K2S2O8 exhibit high ECL intensity and stable cathodic signals. Further, the Au nanoparticles (Au NPs) and Anti-E. coli O157 : H7 antibody were assembled on the surface of UCNPs successively to construct a novel ECL immunosensor for the detection of deadly E. coli O157 : H7. The as-prepared ECL immunosensor reveals high sensitivity to E. coli O157 : H7 in a linear range of 200–100 000 CFU mL−1, and the minimum detection limit could reach up to 138 CFU mL−1. The designed UCNP-based biosensor demonstrates high specificity, good stability and remarkable repeatability, and the strategy will provide a sensitive and selective method for rapid detection of E. coli O157 : H7 in food safety and preclinical diagnosis.
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ACS Applied Materials & Interfaces
·
2023
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IF 9.5
Xiaojiong Zhao,Haocheng Jiang,Ping Sun,Ruichao Wei,Saihua Jiang,Jianying Hu,Shuidong Zhang
Hydrogels have attracted significant attention in various fields, such as smart sensing, human–machine interaction, and biomedicines, due to their excellent flexibility and versatility. However, current hydrogel electronic skins are still limited in stretchability, and their sensing functionality is often single-purpose, making it difficult to meet the requirements of complex environments and multitasking. In this study, we developed an MXene nanoplatelet and phytic acid-coreinforced poly(vinyl alcohol) (PVA) composite, denoted as MXene–PA–PVA. The strong hydrogen bonds formed by the interaction of the different components and the enhancement of chain entanglement result in a significant improvement in the mechanical properties of the PVA/PA/MXene composite hydrogel. This improvement is reflected in an increase of 271.43% in the maximum tensile strain and 35.29% in the maximum fracture stress. Moreover, the composite hydrogel exhibits excellent adhesion, water retention, heat resistance, and conductivity properties. The PVA/PA composite material combined with MXene demonstrates great potential for use as multifunctional sensors for strain and temperature detection with a strain-sensing sensitivity of 3.23 and a resistance temperature coefficient of 8.67. By leveraging the multifunctional characteristics of this composite hydrogel, electronic skin can accurately monitor human behavior and physiological reactions. This advancement opens up new possibilities for flexible electronic devices and human–machine interactions in the future.
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JOURNAL OF HAZARDOUS MATERIALS
·
2023
·
IF 13.6
Ivan Sazykin,Ekaterina Naumova,Tatiana Azhogina,Maria Klimova,Shorena Karchava,Ludmila Khmelevtsova,Elena Chernyshenko,Alla Litsevich,Margarita Khammami,Marina Sazykina
Glyphosate is the most widely used herbicide in the world. There is still no complete clarity about the degree of its genotoxicity and mutagenicity . In addition, its effect on bacterial biofilms, the main life form of soil microbial communities , has not been adequately studied. Toxicity and mutagenicity, as well as changes in the bacterial biofilm biomass, physiological activity, and the number of living cells in its composition in the presence of glyphosate were assessed using the Escherichia coli model. To assess damage to cellular components under the action of this pesticide, luminescent whole-cell bacterial lux-biosensors were used. Changes in the level of mutagenesis were studied by the method of rifampicin mutants. High integral toxicity of glyphosate, the average level of increased oxidative stress and protein damage were shown with the help of bacterial biosensors . All the studied concentrations of the pesticide completely or partially suppress the matrix and structure of the E. coli CDC F-50 biofilm formation, as well as the bacterial cells metabolic activity in the biofilm. At the concentrations of 6.7 and 0.67 g/L, glyphosate suppresses mutagenesis, probably due to general suppression of metabolism, and at the concentration of 0.0067 g/L, it enhances mutagenesis by six times compared with the spontaneous level. Suppression of bacterial biofilms formation, toxic effects on microorganisms , and mutagenesis enhancement by glyphosate can lead to negative consequences for natural microbiomes.
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JOURNAL OF THE SCIENCE OF FOOD AND AGRICULTURE
·
2020
·Vol. 101
·期 8
·3186-3192
·
IF 2.614
Xia Jiaojiao,Zou Bin,Zhou Ruoyu,Adesanya I Onyinye
BACKGROUND In order to improve the stability of vitamin E and broaden its scope of application, an effective solution is to convert vitamin E into its derivatives. This work developed a new Candida rugosa lipase (CRL) nanogel based on modification of ionic liquid with vinyl functional groups. This novel CRL nanogel was used in the preparation process of vitamin E succinate based on the principle of non-aqueous enzymology. At the same time, various factors including enzyme concentration, substrate molar ratio, reaction temperature and reaction time, that affect the yield of vitamin E succinate were optimized and analyzed. RESULTS Different solvents with various hydrophobicity parameters (Log P values) from −1.3 to 3.5 were studied, it was found that dimethyl sulfoxide (DMSO) had the lowest Log P value among organic solvents but vitamin E succinate had the highest yield in DMSO. Furthermore, the effect of different operating conditions, such as molar ratios of substrate, enzyme concentration, reaction temperature and reaction time was studied. Under the optimal process conditions (enzyme concentration 6 mg mL −1 , substrate molar ratio 4:1, reaction temperature 55 °C and reaction time 15 h), the product yield was 62.58 ± 1.16%. CRL and CRL nanogel were characterized using Fourier-transform infrared (FTIR) spectroscopy and scanning electron microscopy (SEM). It was shown that CRL nanogel influenced the catalytic behavior of lipase significantly by changing the structure and surface properties of CRL. CONCLUSION Novel lipase nanogel was an excellent biocatalyst for enzymatic synthesis of vitamin E succinate. © 2020 Society of Chemical Industry
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