Advanced Optical Materials
·
2024
·Vol. 12
·期 22
·2300413
·
IF 8
Weirong Wang,Zhi Chen,Guanliang Yu,Yeming Zhang,Chun Jiang,Jianrong Qiu
Broadband near-infrared (NIR) emitting materials have gained considerable attention for their applications in lighting, displays, sensing, bio-imaging, and optical amplification. Recently, numerous excellent broadband NIR emitting materials are developed by introducing Cr 3+ , Bi + , or Ni 2+ ions to various hosts. However, there is a notable absence of reports on ultra-broadband NIR emitters spanning the entire telecommunication window as well as the NIR-I (700–1000 nm) and NIR-II (1000–1700 nm) biological windows activated by vanadium ions. Herein, the study presents, for the first time to the best of the knowledge, ultra-broadband NIR emission ranging from 850 to 1600 nm (peaking at ≈1000 nm) at room temperature in vanadium-doped phosphate glass. Detailed spectra and microscopic structure analysis reveal that two V 3+ -emitting centers predominantly contribute to the ultra-broadband emission, corresponding to 3 T 2 ( 3 F)→ 3 A 2 ( 3 F) spin-allowed and 3 T 2 ( 3 F)→ 1 E( 1 D) spin-forbidden electron transitions of tetrahedrally coordinated V 3+ ions. Notably, the tunability of NIR emission peak is demonstrated by adjusting the local glass structure or the vanadium doping content. Moreover, glass-converted light-emitting diodes (gc-LEDs) are fabricated from vanadium-doped glass, and the potential applications are demonstrated. The work opens new avenues for the design and fabrication of broadband NIR-emitting materials and opto-electronic devices.
研究领域:
材料科学
·
光学
·
光子学
·
生物医学工程
✓ 已验证
产品关联
DOI
高影响因子
BIOMATERIALS
·
2020
·
IF 10.317
Dan Wang,Bin Xue,Tymish Y. Ohulchanskyy,Yubin Liu,Artem Yakovliev,Roman Ziniuk,Mengze Xu,Jun Song,Junle Qu,Zhen Yuan
Hypoxia is one of the hallmarks of solid tumor, which heavily restricts the clinical cancer therapy treatments, especially for the oxygen (O 2 ) -dependent photodynamic therapy (PDT). Herein, an intelligent multi-layer nanostructure was developed for decreasing the O 2 -consumption and elevating the O 2 -supply simultaneously. The cell respiration inhibitor –atovaquone (ATO) molecules were reserved in the middle mesoporous silicon layer, and thus were intelligently released at the tumor site after the degradation of gatekeeper of MnO 2 layer, which effectively inhibit tumor respiration metabolism to elevate oxygen content. Meanwhile, the degradation of MnO 2 layer can generate O 2 , further boosting oxygen content. Moreover, the inner upconversion nanostructures as the near infrared (NIR) light-transducers enable to activate photosensitizers for deep-tissue PDT. Systematic experiments demonstrate that this suppressing O 2 -consumption and O 2 -generation strategy improved oxygen supply to boost the singlet oxygen generation to eradicate cancer cells under NIR light excitation. Better still, superior trimodality imaging capabilities (computed tomography (CT), NIR-II window fluorescence , and tumor microenvironment-responsive T1-weighted magnetic resonance (MR) imaging) of the nanoplatform were evaluated. Our findings offer a promising aproach to conquer the serious hypoxia problem in cancer therapy by turning down the O 2 metabolism aveneue and simultaneously generating O 2 .
研究领域:
癌症治疗
·
纳米技术
·
生物医学工程
·
光动力疗法
·
医学成像
✓ 已验证
产品关联
DOI
PubMed
高影响因子
RSC Advances
·
2017
·Vol. 7
·期 17
·10564-10569
·
IF 3.108
Xiaowen Zhang,Yang Li,Zhongliang Hu,Zhi Chen,Jianrong Qiu
The second near-infrared window (NIR-II, 1000–1400 nm) is ideal for fluorescence imaging owing to negligible tissue scattering and minimal autofluorescence. NIR-II luminescence nanophosphors are promising materials for fluorescence imaging. Mn5+ is emerging as a new luminescent indicator owing to its typical NIR-I (800 nm) to NIR-II (1190 nm) downconversion luminescence. Herein, we report a facile synthesis approach to prepare Mn5+ doped Ba3(MO4)2 (M = V, P) nanoparticles with a remarkably sharp emission peak around 1190 nm in the NIR-II region for the first time to our knowledge. The developed two-step approach based on efficient anion exchange reaction is able to not only stabilize the valence but also keep the controlled morphology and uniform size. It is highly possible that the general approach will provide a new perspective on synthesizing special valence ion doped nanosized materials.
研究领域:
材料科学
·
生物医学工程
·
光学成像
✓ 已验证
产品关联
DOI
高影响因子
Laser & Photonics Reviews
·
2023
·
IF 11
Chunli Zhao,Yuan Gao,Jing Wang,Jianbei Qiu
Lead-free rare-earth-based perovskites have received widespread attention for their unique optical properties, although achieving efficient broadband near-infrared (NIR) emission with these materials remains a challenge. Here the synthesis of a rare earth-based double perovskite (Cs 2 NaScCl 6 ) by an improved solid phase method is reported. The doping of Cr 3+ led to the formation of [CrCl 6 ] 3− octahedron, which exhibited a broadband NIR emission peaked at 950 nm and a half-peak width of 162 nm. It is worth noting that with the same actual Cr 3+ content, the luminous intensity of Cs 2 NaScCl 6 synthesized by the improved solid-phase synthesis is four times higher than the product synthesized by the hydrothermal method. an efficient Cl − -Cr 3+ charge transfer sensitization facilitated by localized electrons in [CrCl 6 ] 3− octahedron is the mechanism for the strong NIR emission of Cr 3+ is proposed. Calculations based on density functional theory and Bader charge analysis support the notion that electrons in [CrCl 6 ] 3− octahedrons are strongly localized in Cs 2 NaScCl 6 :Cr 3+ , which is conducive to the Cl − –Cr 3+ charge transfer process, resulting the internal quantum efficiency of 100% and external quantum yield as 42.3%. The highly efficient ultra-broadband NIR emission with excellent stability offers many opportunities for applications in the field of NIR night vision and bio-imaging.
研究领域:
材料科学
·
光学
·
纳米技术
·
光子学
✓ 已验证
产品关联
DOI
高影响因子
ACS Applied Materials & Interfaces
·
2024
·
IF 8.3
Dejia Chen,Yixuan Xu,Yating Wang,Xin Li,Dalong Yin,Lifeng Yan
Stable organic radicals, with unique electronic transitions from the ground state (D0) to the doublet excited state (D1), show promise as high-fluorescence quantum yield dyes. While organic small-molecule photosensitizers (PSs) have advanced for tumor photodynamic therapy (PDT), opportunities exist to enhance their performance and functionality. Herein, we synthesized Thiele’s fluorocarbon derivative diradicaloid TFC-I with nearly 100% PLQY and integrated it into amphiphilic polypeptide nanoparticles, P-TI, using a precursor-doping approach. P-TI demonstrated notable features including high photostability, aggregation-induced emission, bright near-infrared fluorescence, substantial quantum yield (37% PLQY), robust near-infrared two-photon absorption (∼400 GM cross section), and superior ROS generation compared to commercial PSs. In vitro and in vivo experiments confirmed that P-TI performed well in mitochondria-targeted PDT, two-photon fluorescence imaging, and biosafety. This work highlights the use of organic stable radicals with precursor-doping for efficient PDT and deep tumor tissue imaging.
研究领域:
生物医学工程
·
材料科学
·
肿瘤学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Journal of Materials Chemistry B
·
2015
·Vol. 3
·期 35
·7046-7054
·
IF 4.726
Liru Cui,Feng Zhang,Qian Wang,Huiming Lin,Chunyu Yang,Ting Zhang,Ruihan Tong,Na An,Fengyu Qu
A novel near infrared (NIR)-triggered anticancer drug delivery system has been successfully constructed. Firstly, upconversion nanoparticles (UCNPs, NaYF4:Tm,Yb@NaYF4) were synthesized as a core and mesoporous silica (mSiO2) as a shell to assemble the core–shell nanostructure (UCNP@mSiO2) as the host. Supramolecular nanovalves based on α-cyclodextrin (α-CD) torus encircling a pimelic acid thread and being held in place by a cleavable stopper (nitrobenzyl alcohol) were used as nanoscopic caps to block the pore and inhibit drug diffusion. Upon irradiation with a 980 nm laser on the nanocomposites, the emitted ultraviolet light (UV, 360 nm) photocleaved the o-nitrobenzyl (ONB) photolabile group, causing these α-CD caps to dissociate from the stalk and release the drug. The “Ladder” pulsatile release-profiles, regulated by varying the intensity and time duration of NIR irradiation, further reveal the light-triggered release performance. In addition, without NIR irradiation, few immaturities ensure the high pharmacological efficacy. Moreover, the elaborate cell experiments, by using HeLa as model cancer cells, were also carried out to reveal the good biocompatibility, fast uptake and NIR light-sensitive toxicity. Therefore, the novel NIR light-triggered drug delivery system displays great potential for cancer therapy.
研究领域:
生物医学工程
·
纳米医学
·
癌症治疗
✓ 已验证
DOI
PubMed
高影响因子
Nanomaterials
·
2019
·Vol. 9
·期 1
·91
·
IF 4.034
Chuan Zhang,Yuzhuo Wang,Yue Zhao,Hou Liu,Yueqi Zhao,Xiangwei Li,Quan Lin
The chemotherapy of stimuli-responsive drug delivery systems (SDDSs) is a promising method to enhance cancer treatment effects. However, the low efficiency of chemotherapy drugs and poor degradation partly limit the application of SDDSs. Herein, we report doxorubicin (DOX)-loading mixed micelles for biotin-targeting drug delivery and enhanced photothermal/photodynamic therapy (PTT/PDT). Glutathione (GSH)-responsive mixed micelles were prepared by a dialysis method, proportionally mixing polycaprolactone-disulfide bond-biodegradable photoluminescent polymer (PCL-SS-BPLP) and biotin-polyethylene glycol-cypate (biotin-PEG-cypate). Chemically linking cypate into the mixed micelles greatly improved cypate solubility and PTT/PDT effect. The micelles also exhibited good monodispersity and stability in cell medium (~119.7 nm), low critical micelles concentration, good biodegradation, and photodecomposition. The high concentration of GSH in cancer cells and near-infrared light (NIR)-mediated cypate decomposition were able to achieve DOX centralized release. Meanwhile, the DOX-based chemotherapy combined with cypate-based NIR-triggered hyperthermia and reactive oxygen species could synergistically induce HepG2 cell death and apoptosis. The in vivo experiments confirmed that the micelles generated hyperthermia and achieved a desirable therapeutic effect. Therefore, the designed biodegradable micelles are promising safe nanovehicles for antitumor drug delivery and chemo/PTT/PDT combination therapy.Keywords:photothermal therapy;photodynamic therapy;biodegradable;stimuli-responsive drug delivery systems;cypate
研究领域:
癌症治疗
·
药物递送系统
·
生物医学工程
·
高分子化学
✓ 已验证
DOI
PubMed
高影响因子
ADVANCED FUNCTIONAL MATERIALS
·
2024
·
IF 18.5
Yiyue Hong,Mengyang Wang,Daorun Hu,Yujia Wang,Shuaifei Ji,Jiangbing Xiang,Hongliang Zhang,Huating Chen,Yan Li,Mingchen Xiong,Wei Pi,Qianyi Wang,Xinling Yang,Yingying Li,Chaochen Shui,Xiaolei Wang,Xiaobing Fu,Xiaoyan Sun
Efficient wound repair with skin appendage regeneration following severe trauma poses a challenge due to the scarcity of skin grafts and decreased drug effectiveness in protease-rich wound microenvironments. Here, a multifunctional artificial skin (NIR-mFAS) with photothermal-triggered drug delivery capabilities is designed to actively and comprehensively improve the regenerative potential of full-thickness wounds. The antibacterial chitosan/silk fibroin hydrogel matrix of artificial skin, cross-linked by electrostatic interactions, effectively encapsulates and sustains the release of epidermal growth factor (EGF) to accelerate re-epithelialization and neovascularization by promoting the migration and proliferation of repair cells. Subsequently, the photothermal responsive polydopamine nanoparticles (PDA-NPs) dispersed in the matrix enable precise control over the release of BMP4 under the irradiation of 1064 nm NIR, thereby inhibiting scarring by reducing myofibroblasts during the proliferative stage. Importantly, the concurrent controlled release of CHIR99021 can modulate cell fate by inducing the conversion of myofibroblasts into dermal papilla-like cells, leading to hair follicle and sebaceous gland regeneration. The NIR-mFAS functions as an advanced delivery system for achieving high-quality wound healing with appendage regeneration and offers a smart therapeutic approach that can be applied to other treatments requiring coordinated delivery of multiple pharmacological agents.
研究领域:
生物医学工程
·
再生医学
·
药学
·
材料科学
·
组织工程
✓ 已验证
产品关联
DOI
高影响因子
Polymers
·
2024
·Vol. 16
·期 8
·1152
·
IF 4.7
Shijun Long,Chang Liu,Han Ren,Yali Hu,Chao Chen,Yiwan Huang,Xuefeng Li
Shape-shifting polymers are widely used in various fields such as intelligent switches, soft robots and sensors, which require both multiple stimulus-response functions and qualified mechanical strength. In this study, a novel near-infrared-light (NIR)-responsible shape-shifting hydrogel system was designed and fabricated through embedding vinylsilane-modified carbon nanotubes (CNTs) into particle double-network (P-DN) hydrogels by micellar copolymerisation. The dispersed brittle Poly(sodium 2-acrylamido-2-methylpropane-1-sulfonate) (PNaAMPS) network of the microgels can serve as sacrificial bonds to toughen the hydrogels, and the CNTs endow it with NIR photothermal conversion ability. The results show that the CNTs embedded in the P-DN hydrogels present excellent mechanical strength, i.e., a fracture strength of 312 kPa and a fracture strain of 357%. Moreover, an asymmetric bilayer hydrogel, where the active layer contains CNTs, can achieve 0°–110° bending deformation within 10 min under NIR irradiation and can realise complex deformation movement. This study provides a theoretical and experimental basis for the design and manufacture of photoresponsive soft actuators.
研究领域:
材料科学
·
智能材料
·
软体机器人
·
传感器技术
✓ 已验证
产品关联
DOI
PubMed
高影响因子
POLYMER
·
2025
·
IF 4.5
Jiahuan Wang,Yuanyang Xu,Dongfei Zhang,Wenkai Liu,Zhen Li,Jiehua Li,Feng Luo,Hong Tan
Multifunctional biomaterials are vigorous development in recent period. Implanting biomaterials with minimal invasion and antibacterial activity are relentless demand. Herein, copper ion-loaded polydopamine nanoparticles (Cu(II)@PDA NPs) were incorporated into shape memory polyurethane (SMPU) to obtained 4D printable nanocomposites with excellent near-infrared (NIR) light responsiveness and antibacterial properties, which are crucial for tissue engineering applications. Firstly, a series of well-dispersed Cu(II)@PDA/PU nanocomposites were successfully prepared, and their structure and properties were systematically investigated. The nanocomposites showed robust mechanical properties and good biocompatibility. Then, under 808 nm NIR laser irradiation, the nanocomposites exhibited significant photothermal effects. Typically, it reached temperature of 53.5 °C for Cu(II)@PDA 0.5 /PU in 10 min under NIR. So that, it achieved 92.7 % antibacterial efficiency to avoid implant infection. Finally, the 4D printing capability of the shape memory nanocomposite was demonstrated, which showed rapid shape recovery within 16 s. Due to their multifunctionality, the nanocomposites hold great potential for use in minimally invasive implant biomaterials.
研究领域:
生物材料学
·
组织工程学
·
纳米医学
✓ 已验证
产品关联
DOI
高影响因子
ACS Photonics
·
2026
·
IF 6
Jun-Liang Li,Ke-Lei Zu,Chang-Sheng Shi,Bin Xu,Jian Xu,Yin-Fen Ma,Ji-Xiong Zhao,You-Mei Wang,Hai-Liang Long,Qi Zhan,Feng Qiu,Mei Leng,Yong-biao Zhao,Zheng-Hong Lu
Infrared (IR)-to-visible upconversion devices integrate IR photodetection and visible light emission into a single device. Such devices selectively emit visible photons from regions irradiated by IR photons, enabling simplified and low-cost pixel-less imaging. Recently, the integration of colloidal quantum dots (CQDs)-based IR photodetection units with organic semiconductor–based visible emitters has attracted significant attention. These quantum dot organic upconversion devices (QOUDs) benefit from solution processability and tunable infrared absorption. However, their performance has so far been limited by inefficient coupling between the absorption and emission units as well as the relatively low efficiency of the photodetection layer. In this work, a high-performance QOUD is demonstrated by incorporating an improved interconnection layer (ICL) and introducing a photomultiplication (PM) mechanism. A photon-to-photon efficiency of 23% is achieved, which is 143 times higher than that of a gain-free device. The low-barrier interconnection is achieved by using an ultrathin MoO3 ICL, which provides favorable energy level alignment. The turn-on voltage of the QOUD under infrared illumination was greatly reduced to 1.9 V. In addition, the PM effect originates from the absorption layer, where defect states trap photogenerated carriers and induce image-charge-assisted carrier injection from the electrode. The QOUD is further demonstrated for pixel-less IR imaging, combining low turn-on voltage with high PM and showing strong potential for practical infrared imaging applications.
✓ 已验证
产品关联
DOI
高影响因子
Matter
·
2024
·
IF 17.3
Huizhen Ma,Ling Liu,Hua He,Si Sun,Shuyu Yang,You Huang,Yuan Li,Kexin Tan,Haile Liu,Shuhu Liu,Yonghui Li,Changlong Liu,Pengfei Liu,Hao Wang,Xiao-Dong Zhang
Ligand-protected metal clusters are essential in optics, catalysis, and biomedicine due to their unique electronic transfers and rapid renal clearance, but their stability and photostability are still highly challenged. Here, we develop atomically precise Ag 29 clusters with 900–1,200 nm emissions that exhibit ultrahigh structural stability for 2 months and distinct photostability for 140 min via Pt single-atom engineering. The density functional theory shows that Ag 29 behaves as a molecular-like semiconductor with a direct band gap of 1.3 eV. Meanwhile, the Pt single atom introduces rich 5 d states in the highest occupied molecular orbital, leading to a continuous electron supply that ensures high photostability. We acquire numerous images of blood vessels, which enables machine learning to predict high-resolution near-infrared II (NIR-II) images. The NIR-II light sheet microscopy achieves a large field of view and deep-tissue imaging without photobleaching and accurately surveils the pathological progression of intestinal injury at the depth of 2.4 μm.
研究领域:
生物医学工程
·
材料科学
·
光学成像
✓ 已验证
DOI
高影响因子
危险品化学品经营许可证（带存储）