Journal of Agriculture and Food Research
·
2024
·
IF 4.8
Minghao Jiang,Qiongfang Jiang,Huimin Yang,Yue Zhang
W/O/W double emulsion systems offer the ability to co-deliver water-soluble and oil-soluble bioactives, making them a promising choice for multifunctional delivery applications. This study focused on the development of a whey protein isolate-based W/O/W emulsion encapsulating fish oil and anthocyanins, with the addition of sodium alginate (SA) into the external aqueous phase. The physicochemical properties, emulsion stability, anthocyanins encapsulation efficiency (EE), and anthocyanins release during simulated gastrointestinal digestion were studied. The results indicated that the physical stability of W/O/W emulsions improved with increasing SA, attributed to the higher viscosity and the protective coating of SA on the WPI-stabilized interface. However, the EE of anthocyanins in SA-reinforced W/O/W emulsions was found to be lower. Excessive SA concentration, such as 1.0%, was observed to be unfavorable to maintaining the internal W 1 /O interface integrity. Overall, the double emulsion structure effectively regulated the release of anthocyanins throughout the digestion process. The study concluded that W/O/W emulsions containing 0.75% SA achieved optimal stability and controlled-release characteristics. These findings offer valuable insights into fabricating double emulsions for multifunctional delivery purposes, showcasing their potential applications in the food and pharmaceutical industries.
研究领域:
食品科学
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药学
·
生物技术
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DOI
高影响因子
AICHE JOURNAL
·
2025
·
IF 4
Jinlin Mei,Zhentao Liu,Zhengkai Cao,Aocheng Wang,Xiaoyang Kong,Aijun Duan,Chunya Wang,Chunming Xu,Xilong Wang
Hierarchical Y/SBA-15 meso-microporous composites (YS- x ) and corresponding highly dispersed catalysts (Ni/YS- x ) were prepared and applied to the production of jet fuel range hydrocarbons by the selective hydrogenation of oleic acid. Small particle size and electron-deficient Ni δ+ are detrimental to the C C bond activation of the η 1 (C)-acyl conformation and inhibit the decarbonylation/decarboxylation pathway. Besides, the activation ability of the C C bond is regulated to avoid excessive cleavage by the acidity and diffusion properties of the hierarchical Ni/YS- x catalysts, thus affecting their hydroisomerization and hydrocracking properties. The abundant acid sites are beneficial to the selective activation of the C O bond of the η 2 (C, O)-aldehyde conformation and the promotion of the reductive deoxygenation pathway. The optimal Ni/YS-1 shows the highest iso / n -alkane ratio ( i / n = 6.26) and superior jet fuel range hydrocarbons yield (48.8%, 340°C), which is a benefit from its outstanding acid–metal balance and worthy diffusion property.
研究领域:
催化
·
多孔材料
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化学反应工程
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能量转换
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表面化学
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产品关联
DOI
高影响因子
CHEMISTRY & BIODIVERSITY
·
2021
·Vol. 18
·期 11
·e2100301
·
IF 2.408
Zhuojin Yang,Yi Zheng,Nafisa Tursumamat,Mingyan Zhu
Isorhamnetin is a natural flavonoid which shows a variety of biological activities such as antioxidant, anti-inflammatory and antitumor. In order to identify the cellular binding protein of isorhamnetin as potential anti-cancer target, we first synthesized 3′- O -substituted quercetin as isorhamnetin homologues and evaluated the growth inhibitory activity of these derivatives on breast, colon and prostate cancer cell lines. The preliminary results showed that the 3′- O modification did not affect the cytotoxic activity of the scaffold. Analysis of the co-crystal structure and the docking pose of isorhamnetin with reported binding protein of isorhamnetin or quercetin indicated the 3′- O -substitution groups located outside of the binding pocket, which is in accordance with activity of 3′- O derivatives. Then a biotin conjugate of isorhamnetin with a tetraethylene glycol (PEG) 4 linker at the 3′ position was synthesized and the resulting probe retained the anti-proliferative activity on cancer cell lines, while the cellular fluorescence analysis showed the distribution of probe inside the cells which indicated the probe had limited cell permeability. Finally, pull down assay both in situ inside cells and in the cell lysates indicated the isorhamnetin biotin probe was capable of protein labeling in cell lysates. These findings provide the isorhamnetin 3′- O -biotin probe as a tool to reveal the target proteins of isorhamnetin. Graphical
研究领域:
药理学
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癌症研究
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化学
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分子生物学
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DOI
PubMed
高影响因子
CHEMICAL ENGINEERING JOURNAL
·
2025
·
IF 13.2
Ruifang Ma,Wenxing Yang,Zeqi Tong,Zongliang Yu,Yongjin Zou
This study synthesized a NiCo₂O₄–bacterial cellulose (BC)–reduced graphene oxide (GO) composite material suitable for flexible supercapacitors using a two-step hydrothermal method. The BC@GO framework consisted of two carbon-based materials: BC retained a 3D interconnected nanofiber network after carbonization, while GO provided a layered structure. This multi-scale porous structure enabled high specific capacitance, mechanical flexibility, and electrochemical stability in the composite. In a three-electrode system, the composite material exhibited a specific capacitance of 1386.4 F g −1 at a current density of 1 A g −1 , with a capacitance retention rate of 73.4 % from 1 to 10 A g −1 . Finally, this study fabricated a high-performance semi-solid flexible asymmetric supercapacitor (FASC) using NiCo₂O₄/BC@GO as the cathode, activated carbon (AC) as the anode, and polyacrylic acid gel as the electrolyte. The fabricated NiCo₂O₄/BC@GO//AC FASC achieved a high energy density of 29.6 Wh kg −1 (19.7 Wh m −2 ) at 7948 W kg −1 (53 kW m −2 ) and 54.8 Wh kg −1 (365 Wh m −2 ) at 836 W kg −1 (5.6 kW m −2 ), with a capacitance retention of 92.2 % after 10,000 cycles. Two fully charged FASCs devices connected in series simultaneously powered 18 LED lights for approximately 50 s. The FASC exhibited exceptional specific capacitance and cycling stability, surpassing other controls in flexible mechanical performance, indicating its potential for flexible semi-solid supercapacitor applications.
研究领域:
材料科学
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电化学
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纳米技术
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储能
·
柔性电子
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DOI
高影响因子
INORGANIC CHEMISTRY
·
2025
·
IF 4.7
Xiaoyan Liu,Pengyu Guo,Zhiwei Liu,Borong Zhang,Sijia Li,Xin Liu,Yunling Liu
Although the one-step separation of ethylene from C2 hydrocarbons remains a significant challenge, one-step C2 separation provides a revolutionary breakthrough in cost savings and efficient energy utilization. Recent advances in metal–organic frameworks (MOFs) for achieving one-step C2 separation have been widely recognized. In this work, for the first time, the potential relationship between the structure and properties of MOF materials previously used for one-step C2 separation was revealed from a mathematical statistical perspective. Additionally, the importance of N/O sites in enhancing the selectivity of C2H6/C2H4 separation is elucidated as a supplementary finding. Guided by the above findings, a pillar-layered MOF (JLU-MOF167) was synthesized using a mixed-ligand strategy. The unprecedented layer structure, composed of triazole units and multiple Cd units, provides an optimal thickness that creates a large number of N/O sites. Simultaneously, the tortuous channels between the pillars ensure sufficient interaction space between the molecules and the framework. The excellent structural design enables JLU-MOF167 to exhibit outstanding performance in both C2H2/C2H4 and C2H6/C2H4 separations as well as dynamic separation capabilities. Furthermore, theoretical calculations confirm the critical role of high-density N/O sites in facilitating one-step C2 separation.
研究领域:
材料科学
·
化学工程
·
分离技术
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无机化学
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计算化学
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产品关联
DOI
PubMed
高影响因子
APPLIED CATALYSIS B-ENVIRONMENTAL
·
2021
·
IF 19.503
Sijin Zuo,Shengcai Zhu,Jiaying Wang,Weiping Liu,Juan Wang
A N/O-codoped carbon-based catalyst (N/O-C-8) designed with dual reaction sites (pyridinic N and carbonyl group) was fabricated in this work, for persulfate based advanced oxidation reaction. The pyridinic N served as the adsorption site for target molecule, via series of high resolution XPS analysis and DFT calculation. Meanwhile, the carbonyl group functioned as the persulfate activation site, to generate oxidative 1 O 2 . Engineering and isolating the two reaction sites on catalyst surface can greatly shorten the migration distance from 1 O 2 to target organic molecule, resulting in good catalytic removal efficiency. As demonstrated, during a 4-hour continuous flow experiment, our catalyst showed stable and efficient removal of tetracycline, with a flow rate of 4 mL/min. The study provides keen insights into the design of effective non-metal based catalysts for practical water remediation.
研究领域:
环境科学
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催化
·
水处理
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DOI
高影响因子
APPLIED CATALYSIS B-ENVIRONMENTAL
·
2025
·
IF 21.1
Ye Chen,Xiaokang Sha,Junpo Guo,Xupo Liu,Meinan Chang,Jiayao Qiu,Jingru Zhang,Bowen Cai,Jiashu Tang,Yi Liu,Huaiyu Shao,Deli Wang
Rational design of heteroatom-doped catalysts with prominent reaction kinetics holds immense potential for enhancing biomass electrooxidation processes. Here, we introduce a F-doped NiO nanosheet architecture enriched with F-Ni δ+ -O coordination motifs as an advanced electrocatalyst for the oxidation of 5-hydroxymethylfurfural (HMF). XPS depth profiling and differential charge density calculations reveal that the distinctive F-Ni δ+ -O configuration induces asymmetric charge redistribution at Ni sites, effectively reducing the activation energy for Ni 3+ OOH species and their subsequent interaction with HMF. Meanwhile, pH-dependent and in-situ Raman measurements demonstrate that F sites function as proton relays, facilitating proton transfer and enabling efficient proton-coupled electron transfer kinetics. The synergistic electronic and proton effects endow excellent catalytic performance, with an oxidation current density of 66.45 mA cm −2 and a reaction rate of 5.23 × 10 −4 s −1 , far higher than that of the original NiO. Notably, the catalyst retains over 95 % Faradaic efficiency and yield of 2,5-furandicarboxylic acid (FDCA) after twenty consecutive cycles. This work establishes a dual regulation strategy via heteroatom doping to simultaneously modulate electronic configuration and proton transfer dynamics, offering novel insights into the design of high-performance electrocatalysts for biomass valorization.
研究领域:
电催化
·
材料科学
·
可再生能源
·
可持续化学
·
生物质转化
✓ 已验证
产品关联
DOI
高影响因子
APPLIED CATALYSIS B-ENVIRONMENTAL
·
2025
·
IF 21.1
Dong Yan,Xuetao Cheng,Xiaoxiao Dong,Han Wang,Xingchen Chang,Chenghui Xia,Yongcheng Jin,Chun-Chao Hou
Electrolysis of seawater driven by renewable energy holds great promise for sustainable hydrogen production. However, both catalyst corrosion caused by competitive Cl − adsorption and sluggish reaction kinetics are major challenges in seawater electrolysis. Here, inspired by the concept of hard and soft acids and bases (HSAB), a unique interfacial W-O-Co electron bridge is constructed on the catalyst surface to achieve the electronic coupling of hard-acid W site and borderline-acid Co site via the oxygen bridge, which demonstrates exceptional performance for both the hydrogen evolution reaction (HER) and the oxygen evolution reaction (OER) in alkaline water and seawater, as well as high anti-corrosion stability. Remarkably, WO 3 /CoP electrode requires low overpotentials of merely 154 mV (alkaline freshwater) and 189 mV (alkaline seawater) for HER, and 334 mV (alkaline freshwater) and 343 mV (alkaline seawater) for OER to achieve 100 mA cm −2 , respectively. When deployed our bifunctional catalyst as both anode and cathode in an alkaline anion-exchange membrane seawater electrolyzer, the system achieves 1 A cm −2 at a low cell voltage of 1.80 V and maintains stable electrolysis for over 250 h at 100 mA cm −2 . Theoretical and experimental investigations reveal that the hard-acid W site of the electronic W-O-Co bonded bridge prefers adsorption of hard-base OH - rather than soft-base Cl - , thereby mitigating Cl - interference and suppressing chloride corrosion. Simultaneously such interfacial W-O-Co bridging significantly accelerates charge transfer from Co site to W site, thereby regulating the electronic structures of catalysts and optimizing the sorption behaviors of reaction intermediates. This work provides a feasible anti-corrosion engineering strategy to design efficient and robust electrocatalysts for practical seawater electrolysis.
研究领域:
电化学
·
材料科学
·
氢能
·
催化
·
可再生能源
✓ 已验证
产品关联
DOI
高影响因子
APPLIED CATALYSIS B-ENVIRONMENTAL
·
2025
·
IF 21.1
Cangpeng Shan,Qinwei Jia,Yan Zhang,Guoshuai Liu,Xinyu Hou,Yunchong Wang,Rui Han,Caixia Liu,Weichao Wang,Qingling Liu
Removing industrial source CO through catalytic oxidation and providing heat for denitrification units have significant economic and environmental benefits. Sulfur poisoning of catalysts is the bottleneck to stabilize the system operation. To overcome this problem, we fabricated sulfate modified Pt/TiO 2 by appropriate NH 4 HSO 4 deposition, which survived in the SO 2 environment with the concentration as high as 1000 ppm SO 2 , and exhibited an outstanding stability with over 90% CO conversion at 200 °C for 500 h under a typical steel sintering flue gas condition. Experimental and theoretical explorations confirmed that the electronic structure of PtO x clusters was optimized through Pt-O-S bridges after sulfate modification. The O 2p band center closer to the Fermi level and the smaller energy difference between Pt 5d and O 2p band centers led to more active lattice oxygen of PtO x clusters. The more stable π back bonding between Pt 5d and CO 2p and weaker hybridization between Pt and the π⁎ (Ssp2-Osp2)2 orbital of SO 2 indicated enhanced CO adsorption while weakened SO 2 adsorption on Pt sites. The above factors simultaneously improved the low-temperature activity and sulfur resistance for CO oxidation over sulfate modified Pt/TiO 2 . This work provides new insights for the design of sulfur-resistant catalysts and the understanding on the effect of sulfates on catalytic activity.
研究领域:
催化化学
·
环境化学
·
材料科学
·
化学工程
✓ 已验证
产品关联
DOI
高影响因子
ANALYTICA CHIMICA ACTA
·
2025
·
IF 6
Xiaoqian Yuan,Yuchen Cui,Yaqin Nan,Ruijun Tang,Xinru Wang,Yanmei Xu,Xinghua Jin,Yiwen Wang,Ding Cheng,Youxin Li
Background Cyclodextrins (CDs) and their derivatives have been widely used as chiral selectors in HPLC. However, many derivatized CDs lack specificity for certain drugs and often exhibit limited resolution. Furthermore, their synthesis typically involves complex multi-step procedures, hindering scalability and cost-efficiency. To overcome these limitations, this study aims to develop a simple and scalable boric acid-modified β-cyclodextrin polymer (BA-β-CDP), targeting chiral substances with O/N atoms in chiral and/or adjacent carbons. Results BA-β-CDP was synthesized on a large scale using inexpensive reagents and a random substitution strategy, avoiding tedious protection-purification steps. Structural and chromatographic compatibility was confirmed by nine characterization techniques. In HPLC using the chiral mobile-phase additive (CMPA) method, BA-β-CDP enabled the efficient separation of 25 racemates. Among them, 24 achieved complete or baseline separation, and 10 exhibited resolution (Rs) values > 10. Typical cases included bisoprolol (Rs = 48.19), propranolol (Rs = 45.50), chlorpheniramine (Rs = 38.36), and metoprolol (Rs = 20.26). Additionally, the material demonstrated excellent batch-to-batch reproducibility, recyclability, and reusability. Significance and novelty This work presents a practical and cost-effective chiral selector. The synergistic mechanism offers strong and specific recognition toward chiral substances with O/N atoms in chiral and/or adjacent carbons. This approach represents a novel strategy for efficient and economical HPLC-based enantioseparation using widely accessible materials and methods.
研究领域:
分析化学
·
药物化学
·
手性技术
·
分子识别
·
药剂学
·
有机合成
✓ 已验证
产品关联
DOI
PubMed
高影响因子
NANOTECHNOLOGY
·
2023
·Vol. 34
·期 25
·255402
·
IF 3.5
Chenhui Xu,Furong Xiong,Yao Wang,Jianwei Nai,Wang Zhang
The integration of ultrathin two-dimensional (2D) semiconductors with other conductive 2D materials to form hybrid electrocatalysts with abundant heterointerfaces can enhance the electrocatalytic activity by facilitating interfacial charge transfer. However, the hybrid electrocatalysts with weak interfacial bonding have limited effect on the electrocatalytic performance because the intrinsic activity of interfacial sites cannot be altered by weak interfacial interactions. As a proof-of-concept, we design ultrathin 2D–2D heterostructures with bridge-bonded Ni–O–Ti ligands based on single-layered Ti3C2Tx MXene and metal hydroxides, and further reveal the structure-activity correlation between interfacial bonding and electrocatalytic oxygen evolution reaction by combining theoretical and experimental studies. Density functional theory calculations reveal the modulation of the electronic structure of interfacial metal sites after the formation of bridged interfacial Ni–O–Ti bonding. Compared with the hydrogen-bond-linked heterostructure, the ultrathin 2D–2D heterostructure with bridge-bonded Ni–O–Ti ligands shows enhanced intrinsic activity and stability towards electrocatalytic oxygen evolution with a very low overpotential of 205 mV at 10 mA cm−2 and the long-term durability. This work provides a new understanding and approach for the design and development of 2D hybrid catalysts with highly efficient electrocatalytic activity.
研究领域:
材料科学
·
电化学
·
催化
·
理论化学
✓ 已验证
DOI
高影响因子
Current Protocols
·
2023
·Vol. 3
·期 11
·e923
·
IF 0
Xuan Chen,Long Xie,Chenglong Zhang,Shen Tian,Zeyu Tang,Weiwei Tian,Patrick Lu,Xianbin Yang
Although small interfering RNA (siRNA) is a key player among gene inhibition therapeutics, there are many obstacles to the development of siRNA drugs due to inherent properties of oligonucleotides, including the unsatisfactory stability of unmodified siRNA, poor pharmacokinetic distribution, and the toxicity induced by off-target effects. To maximize treatment potency, chemical modification of siRNA has undoubtedly been the most successful strategy by far. Widely applied modifications include phosphorothioate linkages, 2′- O -methyl modifications, and 2′-fluoro modifications, among others. To extend the family of chemical modifications for oligonucleotides, 2′- O -cyanoethylated RNA analogs were developed through the replacement of the 2′-hydroxyl group with a 2′- O -cyanoethyl group (-OCH 2 CH 2 CN). This modification can provide several advantages over unmodified RNA, such as increased stability, improved binding affinity to complementary DNA or RNA strands, and resistance to degradation by cellular nucleases. The 2′- O -cyanoethyl-modified RNAs not only are applied in RNA silencing machinery but also act as research tools for studying RNA structure and function or for developing RNA-based diagnostics. Therefore, the efficient synthesis, deprotection, purification, and characterization of 2′- O -cyanoethylated RNAs deserves more attention. This protocol describes the chemical synthesis of 2′- O -cyanoethylated nucleotides and the solid-phase synthesis, deprotection, and purification of 2′- O -cyanoethylated RNAs. © 2023 Wiley Periodicals LLC. Basic Protocol 1 : Preparation of 6- N -dimethylformamidyl-5′- O -dimethoxytrityl-2′- O -cyanoethyl adenosine 3′-(2-cyanoethyl N , N -diisopropyl)phosphoramidite Basic Protocol 2 : Preparation of 4- N -acetyl-5′- O -dimethoxytrityl-2′- O -cyanoethyl cytidine 3′-(2-cyanoethyl N , N -diisopropyl)phosphoramidite Basic Protocol 3 : Preparation of 2- N -dimethylformamidyl-5′- O -dimethoxytrityl-2′- O -cyanoethyl guanine 3′-(2-cyanoethyl N , N -diisopropyl)phosphoramidite Basic Protocol 4 : Preparation of 5′- O -dimethoxytrityl-2′- O -2-cyanoethyl uridine 3′-(2-cyanoethyl N , N -diisopropyl)phosphoramidite Basic Protocol 5 : Solid-phase synthesis of 2′- O -cyanoethylated RNA analogs Basic Protocol 6 : Deprotection and purification of synthesized 2′- O -cyanoethyl-RNAs
研究领域:
分子生物学
·
生物化学
·
药物化学
·
RNA治疗学
·
有机合成
✓ 已验证
DOI
危险品化学品经营许可证（带存储）