International Journal of Polymeric Materials and Polymeric Biomaterials
·
2017
·
IF 1.515
Yan-Ling Luo,Xue-Yin Zhang,Jing-Yu Fu,Feng Xu,Ya-Shao Chen
Novel poly(N-isopropylacrylamide)/carboxymethyl chitosan/multiwalled carbon nanotube semi-interpenetrating nanohybrid hydrogels were prepared, and the chemical structure and morphology were characterized. The prepared hydrogels showed temperature and pH dual-responsiveness, and the one containing multiwalled carbon nanotubes (MWCNTs)–COOH possessed high maximal swelling ratios. The phase transition produced at pH of 6.8–7.4 and temperature of 35–40°C, hinging on the system compositions and charge ratios. The hydrogels were used to load hydrophilic anticancer drug, with high entrapped efficiency of about 44%. The drug release changed with temperature, pH, and MWCNTs–COOH contents. The designed hydrogels can be used for site-specific target delivery of protein or hydrophilic anticancer drug.
研究领域:
材料科学
·
生物医药工程
·
药剂学
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DOI
高影响因子
PHARMACEUTICAL RESEARCH
·
2013
·Vol. 31
·期 2
·291-304
·
IF 4.742
Yang Xiao-Li,Luo Yan-Ling,Xu Feng,Chen Ya-Shao
Purpose Block copolymer micelles are extensively used as drug controlled release carriers, showing promising application prospects. The comb or brush copolymers are especially of great interest, whose densely-grafted side chains may be important for tuning the physicochemical properties and conformation in selective solvents, even in vitro drug release. The purpose of this work was to synthesize novel block copolymer combs via atom transfer radical polymerization, to evaluate its physicochemical features in solution, to improve drug release behavior and to enhance the bioavailablity, and to decrease cytotoxicity. Methods The physicochemical properties of the copolymer micelles were examined by modulating the composition and the molecular weights of the building blocks. A dialysis method was used to load hydrophobic camptothecin (CPT), and the CPT release and stability were detected by UV–vis spectroscopy and high-performance liquid chromatography, and the cytotoxicity was evaluated by MTT assays. Results The copolymers could self-assemble into well-defined spherical core-shell micelle aggregates in aqueous solution, and showed thermo-induced micellization behavior, and the critical micelle concentration was 2.96–27.64 mg L −1 . The micelles were narrow-size-distribution, with hydrodynamic diameters about 128–193 nm, depending on the chain length of methoxy polyethylene glycol (mPEG) blocks and poly(N-isopropylacrylamide) (PNIPAM) graft chains or/and compositional ratios of mPEG to PNIPAM. The copolymer micelles could stably and effectively load CPT but avoid toxicity and side-effects, and exhibited thermo-dependent controlled and targeted drug release behavior. Conclusions The copolymer micelles were safe, stable and effective, and could potentially be employed as CPT controlled release carriers.
研究领域:
材料科学
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药学
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DOI
PubMed
高影响因子
Journal of Materials Chemistry A
·
2021
·Vol. 9
·期 47
·26839-26851
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IF 12.732
Chenxi Li,Xingxing Ni,Yang Lei,Shangyang Li,Lei Jin,Bo You
Benefiting from a specific multilayered structure, yolk–shell microspheres with void spaces are considered promising electromagnetic shielding materials which do well in enhancing the decay of electromagnetic waves. Commonly reported synthesis methods of yolk–shell nanostructures include sacrificial templates and tedious subsequential treatment. In this work, a novel, green and facile plasmolysis-inspired route was developed to fabricate uniform yolk–shell hydrogel-core@void@MXene-shell (poly(N-isopropylacrylamide)@void@polystyrene@MXene, abbreviated to PNIPAM@void@PS@Ti3C2Tx) nanocomposite microspheres. The void space between the PNIPAM core and the PS supporting layer was created on the basis of the shrinkage of the soft PNIPAM hydrogel core due to the removal of water in the hydrogel. In addition, a microsphere model was developed to predict that the void space can modulate the impedance matching to attenuate the reflection of electromagnetic waves on the surface of the microsphere and enhance the entry of electromagnetic waves. Ultrathin hydrogel-core@void@MXene-shell (PNIPAM@void@PS@Ti3C2Tx) self-supporting films could be prepared via filtration–drying of PNIPAM@PS@Ti3C2Tx nanocomposite microspheres. The 25 μm ultrathin nanocomposite film showed excellent electromagnetic interference (EMI) shielding effectiveness of 72 dB at 9.5 GHz and exhibited a wide absorption spectral range from 8.2 GHz to 12.4 GHz (>30 dB). The electromagnetic parameters of the equivalent medium model are obtained through the retrieval algorithm of the actually measured S-parameters, and models were constructed to simulate and explain the electromagnetic shielding performance.
研究领域:
材料科学
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电磁工程
·
纳米技术
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产品关联
DOI
高影响因子
Materials Today Nano
·
2026
·
IF 8.2
Le Yin,Mu Hu,Yajie Liu,Yang You,Yuan Wang,Shaojun Yuan
Efficient separation of oil–water emulsion remains a persistent challenge in wastewater treatment, as conventional membranes often suffer from fouling, poor recyclability, and lack of dynamic control. Here, we report a light-triggered thermo-responsive superwetting nanofiber membrane (PPZ@GO) that combines electrospun PNIPAM/PVDF nanofibers with graphene oxide (GO) and in situ grown bimetallic CoZn–ZIF frameworks. In this hybrid design, PVDF provides mechanical robustness, PNIPAM enables reversible thermo-responsive wettability, GO facilitates rapid photothermal heating, and CoZn–ZIF imparts hierarchical roughness and enhanced interfacial functionality. The optimized [email protected] % membrane exhibits rapid photothermal heating to 48.6 °C within 20 s under simulated solar light, enabling reversible wettability switching between underwater superoleophobicity (light off, below LCST) and under-oil superhydrophobicity (light on, above LCST). This dual-mode response allows on-demand separation of both oil-in-water and water-in-oil emulsions, achieving fluxes above 2000 L m −2 h −1 and 1000 L m −2 h −1 , respectively, with separation efficiencies exceeding 99 %. The membrane further demonstrates excellent antifouling resistance, mechanical durability, and stable performance across repeated cycles. By integrating photothermal conversion with thermo-responsive switching in a nanofibrous MOF–polymer scaffold, this work provides a versatile strategy for designing smart, energy-efficient membranes, offering broad potential for next-generation oily wastewater remediation and advanced separation technologies.
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产品关联
DOI
高影响因子
EUROPEAN POLYMER JOURNAL
·
2015
·
IF 3.005
Hongwei Zhang,Qijian Niu,Ning Wang,Jun Nie,Guiping Ma
In this research a thermo-sensitive drug loaded core–shell fibers were prepared by UV photo-polymerization combined with electrospinning technology. The biodegradable polymer polylactic acid (PLA) was used as the core with electrospinning and the N-isopropylacrylamide (NIPAM) was selected to be shell of the fibers via UV photo-polymerization, respectively. Combretastatin A4 (CA4) was used as the model drug loaded in PLA (core structure) to test the thermo-sensitivity of the core–shell fibers. SEM was performed to observe the morphology of the fibers. TEM was carried out to confirm the core–shell structure of the fibers. Furthermore, XPS and FTIR results demonstrated that the core–shell structure had been fabricated as designed. Water contact angle (WCA) test indicated that the fibers show different wettability when the temperature was below or above the lower critical solution temperature (LCST). Moreover, in vitro drug release test was conducted to explore the difference of the drug release when the temperature was at 25 °C and 40 °C. The cell culture studies showed that the prepared core–shell structure nanofibers have a potential application in the biomedical fields as tissue engineering.
研究领域:
生物材料
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药物递送
·
组织工程
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高分子科学
·
纳米医学
✓ 已验证
DOI
高影响因子
JOURNAL OF MEMBRANE SCIENCE
·
2026
·
IF 8.8
Miaolu He,Yiming Jin,Jie Lian,Yue Hu,Yaqiang Yuan,Yilin Yang,Lujie Nie,Jiajing Hao,Rui Miao,Jin Wang,Xudong Wang,Lei Wang
Forward osmosis (FO) has emerged as a promising technology for lithium resource recovery owing to its low energy consumption. However, conventional FO membranes, typically featuring thick separation layers and defect-prone porous structures, suffer from low lithium recovery rates and processing efficiency. Herein, a thermos-responsive UiO-67-PNIPAM composite was constructed as a functional interlayer to dynamically regulate aqueous-phase monomer transport during interfacial polymerization. By leveraging the temperature-responsive nature of PNIPAM and controlling the organic-phase temperature, a vertical temperature gradient was established within the interlayer due to uneven heat transfer. In the upper, warmer region, PNIPAM adopts a collapsed conformation with reduced amide accessibility, exhibiting weak interaction with m-phenylenediamine, thereby enabling rapid monomer release. In the lower, cooler region, extended PNIPAM chains, with amide groups fully exposed, enhance interactions with m-phenylenediamine and hinder its diffusion to the reaction interface. This synergistic regulation promoted a self-terminating IP process, culminating in an ultrathin and dense separation layer. Furthermore, elevated temperature facilitated the escape of dissolved gases from both phases, leading to the formation of pronounced ridge-and-valley structures on the separation layer. This morphology increased the effective water permeation area and water storage capacity. As a result, the UiO-67-PNIPAM interlayer membrane achieved a water flux of 28.30 L m −2 h −1 in FO mode, representing a 100.28% improvement over the conventional membrane. Its reverse salt flux was significantly reduced to 1.44 g m −2 h −1 , a decrease of 47.26%. In lithium recovery tests, the membrane exhibited a high lithium recovery rate, demonstrating its strong potential for efficient lithium extraction.
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DOI
高影响因子
Journal of Materials Chemistry C
·
2025
·
IF 5.1
Fan Chang,Xiaochun Gu,Bo Wang,Jingyue Zhang,Zongze Lv,Ning Ma,Xu Zhu,Xinyue Zhang
In recent years, global warming has precipitated a series of challenges to human living comfort. While some techniques can offer mitigation, their energy-intensive nature renders them unsuitable for widespread adoption in underdeveloped regions. To address these shortcomings, a cost-effective smart window with indoor temperature regulation was developed. It was fabricated by integrating {Mo154} with a blend of polyvinyl alcohol/poly(N-isopropyl acrylamide) (PVA/PNIPAM) hydrogel. Based on the temperature induced phase transformation ability of PNIPAM, the composite hydrogel can be used to regulate the indoor temperature. Concurrently, PVA can mitigate the problem of volume shrinkage from PNIPAM phase transition. More importantly, the {Mo154} can reduce the lower critical solution temperature (LCST) of Mo-PVA/PNIPAM hydrogel, as well as provide photothermal properties for intelligently sensing the outside temperature. The smart window can display a favorable sunlight modulation property (ΔTsol = 80.8%) and a rapid heating rate response to light exposure. Due to the presence of the {Mo154}, the smart window became opaque to block sunlight when the indoor temperature exceeded 28.9 oC. This feature can keep indoor cooling in the hot summer without any energy consumption. Moreover, the Mo-PVA/PNIPAM-based smart window also demonstrated favorable durability, maintaining its functionality after 100 times heating (40 oC)-cooling (20 oC) cycles, which can support long time usage and suit for the underdeveloped areas with limited electric energy.
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DOI
高影响因子
Polymers
·
2019
·Vol. 11
·期 11
·1832
·
IF 3.164
Weili Peng,Zeping Zhang,Minzhi Rong,Mingqiu Zhang
A kind of core-shell hybrid nanoparticle comprised of a hollow mesoporous silica nanoparticles (HMS) core and a copolymer shell bearing N-(3,4-dihydroxyphenethyl) methacrylamide (DMA) and N-isopropylacrylamide (NIPAM) as responsive moieties was prepared. Moreover, the factors that could impact the surface morphology and hierarchical porous structure were discussed. In the presence of Fe3+, catechol-Fe3+complexes were formed to achieve pH-responsive polymer shell, combining with thermal-sensitiveness of poly(N-isopropylacrylamide). Doxorubicin (DOX) was applied as a model drug and the behaviors of its loading/release behaviors were investigated to prove the idea. The results exhibited a significant drug loading capacity of 8.6% and embed efficiency of 94.6% under 1 mg ml–1DOX/PBS solution. In fact, the loading capacity of drug can be easily improved to as high as 28.0% by increasing the DOX concentration. The vitro cytotoxicity assay also indicated that the as-prepared nanoparticles have no significant cytotoxicity on RAW 264.7 cells. The in vitro experiment showed that the cumulative release of DOX was obviously dependent on the temperature and pH values. This pH/temperature-sensitive hollow mesoporous silica nanosphere is expected to have potential applications in controlled drug release.Keywords:hollow mesoporous silica microspheres;thermo-responsive;pH-responsive;catechol-Fe3+;controlled release
研究领域:
材料科学
·
生物医学工程
·
药物递送系统
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产品关联
DOI
PubMed
高影响因子
COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
·
2025
·
IF 5.4
Xiangyu Teng,Shengkun Xu,Xuehao Feng,Zhizheng Gao,Zhixing Ge,Bentao Zou,Wenguang Yang
The movement patterns of diverse organisms inspire the design of flexible actuators. We hypothesized that mimicking biological structures could endow soft robots with versatile functions. In this research, we engineered a biomimetic light - driven swimming soft robot. By emulating the mechanics of boat paddles and elephant trunks, we developed a flexible paddle and a dexterous gripper. This enables the robot to effectively grasp and transport small objects. We further hypothesized that introducing molybdenum disulfide (MoS₂) into hydrogels could render them photoresponsive. We successfully created a temperature sensitive, photoresponsive composite hydrogel. Its volume can be precisely controlled through light exposure, mimicking the contraction and relaxation of muscles. The paddling motion and gripping functions of the bionic gripper are achieved by modulating the irradiation with Near-Infrared (NIR) light. This study offers significant insights into the development of light-driven soft robotic systems.
研究领域:
软体机器人
·
材料科学
·
仿生学
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产品关联
DOI
高影响因子
TALANTA
·
2020
·
IF 5.339
Bingxue Hu,Da-Wen Sun,Hongbin Pu,Qingyi Wei
A universal surface-enhanced Raman scattering (SERS) substrate with tuneable plasmonic behaviour and long-term stability was synthesized and characterized, and the substrate was applied in the sensitive detection of fungicide malachite green (MG) in fish fillets. Temperature-responsive poly (N-isopropyl acrylamide) (pNIPAM) template and anisotropic Au nanorods (NRs) were synthesized to prepare pNIPAM @ Au NRs nano-hybrids with dynamically optical and SERS properties and high stability. Results showed that excitation wavelength-dependent SERS efficiency could be tailored by temperature-induced swelling and collapse of the nano-hybrids, thus anticipated optical and SERS properties of the composites could be obtained. Furthermore, the SERS performance, uniformity, long-term stability analysis, and MG in fish evaluation showed that the detection of MG in fish tissues was realized with a limit of detection of 1.58 × 10 −9 M (0.73 ng/g), and the pNIPAM @ Au NRs composites could serve as effective SERS substrates allowing trace level detection of contaminants for the food industry.
研究领域:
材料科学
·
分析化学
·
食品安全
✓ 已验证
DOI
PubMed
高影响因子
EUROPEAN POLYMER JOURNAL
·
2021
·
IF 4.598
Bingxin Liu,Jianzhi Liu,Yueqin Yu
In view of global warming and following fossil energy consumption caused by the using of heavy-loaded air conditioners, smart windows, which can intelligently regulate solar radiation, became a highly anticipated strategy to slow down the pressure. As most of the traditional hydrogel-based smart windows abruptly switch between transparent and opaque making a sudden change in temperature and light, we established a poly- N -isopropylacrylamide (PNIPAM) thermo-responsive hydrogel system with additional cross-linking of chitosan and Al 3+ , which exhibited a smooth thermo-response during heating and a novel recovery hysteresis during cooling. By enabling additional gentle transition in translucency, we are able to retain a comfortable indoor temperature/lightness balance during an increase in outdoor temperature, in avoidance of sudden indoor darkness at elevated temperature. By enabling additional control in the thermo-response hysteresis, this methodology provides a solution to continuously shield the dazzling afternoon sunshine until a comfortable outdoor temperature is reached. And the response degree and response temperature can be adjusted by the contents of chitosan and Al 3+ , respectively, so that the material can be customized personally. Moreover, we discovered that the hydrogel-based smart window system constructed by this methodology bears notably enhanced strength, toughness and conductivity, making it a comprehensively promising candidate for customizable smart windows.
研究领域:
材料科学
·
能源效率
·
智能材料
·
环境工程
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产品关联
DOI
高影响因子
MACROMOLECULAR RESEARCH
·
2021
·Vol. 29
·期 7
·453-461
·
IF 2.227
Hu Yan,Yang Yang,Tian Fei,Xu Pingping,Du Rongcheng,Xia Xuehuan,Xu Shimei
It has attracted much attention to develop a gradient hydrogel for real mimic of the extracellular matrix. Despite simplicity and ease of electrophoresis preparation method, some drawbacks limit the application of the method including toxic organic crosslinker residual, specific ionic monomer types, as well as narrow gradient gaps. In this work, we successfully prepared gradiently crosslinked nonionic PNIPAm/Laponite nanocomposite (NC) hydrogels with controllable gradient structures by adjusting the intensity of the direct current electric field. The results showed that the stiffness, surface property and thermosensitivity of the hydrogel changed with gradient distributions of Laponite. The average stiffness gradients varied from 0.18 kPa/mm, 0.41 kPa/mm to 1.28 kPa/mm by simply adjusting the intensity of the direct current electric field from 0.13 V/mm, 0.20 V/mm to 0.27 V/mm accordingly. The stiffness reached in a range of 13.8∼33.0 kPa. The growth behaviors of human cervical cancer cells (HeLa cells) on the gradient NC hydrogel surface were discussed. Spreading and proliferation, as well as morphology of HeLa cells were closely related to the stiffness of the gradient NC hydrogels. This work develops a stiffness-controllable gradient NC hydrogel and opens up a new insight into the better understanding of cells behaviors in different tissues and organs in vivo .
研究领域:
材料科学
·
生物医学工程
·
细胞生物学
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产品关联
DOI
高影响因子
危险品化学品经营许可证（带存储）