JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
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2017
·
IF 3.154
Hongbao Lu,Shuangyu Xu,Wenjuan Zhang,Chunmei Xu,Beixing Li,Daxia Zhang,Wei Mu,Feng Liu
Botanical nematicides have recently received increasing interest because of the high risks of some traditional nematicides to human health and the environment. This study evaluated the nematicidal activity of a plant volatile, trans-2-hexenal, against Meloidogyne incognita. This compound exhibited higher activity in a fumigation experiment than in the aqueous phase in vitro. Both in pot tests and in field trials, trans-2-hexenal showed significant efficacy against M. incognita while maintaining excellent plant growth, especially at doses of 1000 and 500 L ha–1, which were superior to that of abamectin at 180 g ha–1 via hole application treatment but not significantly different from fumigation with 400 kg ha–1 of dazomet. Furthermore, plants treated with 500 L ha–1trans-2-hexenal had fruit yields 20.2 and 45% greater than the control group. On this basis, trans-2-hexenal may be a potential alternative fumigation agent for controlling M. incognita on tomato crops.
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International Journal of Environmental Research and Public Health
·
2016
·Vol. 13
·期 11
·1085
·
IF 2.035
Yiyang Jia,Te Liu,Liting Zhou,Jian Zhu,Juan Wu,Di Sun,Jin Xu,Qi Wang,Huaiji Chen,Feng Xu,Yuezhu Zhang,Tianrong Zhang,Hongbo Liu,Lin Ye
The most widely used plasticizer, di-(2-ethylhexyl) phthalate (DEHP), is known to affect lipid metabolism and adipogenesis. We studied the effects of dietary DEHP exposure on metabolism in rats as well as the role of the JAK/STAT pathway in this process. Eighty rats were exposed to DEHP (0, 5, 50 and 500 mg/kg/d) through dietary intake for 4 weeks. We then collected blood samples, liver, and adipose tissues to detect modifications in the levels of serum lipids, leptin, adiponectin and insulin. JAK3, STAT5a and PPARγ expression were detected at both the gene and protein levels. The activation of JAK3 and STAT5a was also detected. The DEHP-exposed rats had increased body weight, serum lipid, insulin, and leptin levels. Moreover, the JAK3/STAT5a pathway was activated in the adipose tissue; however, this pathway was not activated in the liver. The mRNA of SREBP-1c in the liver was increased significantly among each of the groups, in contrast to the levels found in the mature SREBP-1c protein form. Furthermore, the expression ofFABP4,AcoxandFASnwas decreased in the liver, but increased in adipose tissue. Thus, we conclude that exposure to DEHP reduces the hydrolysis of lipid and promotes triglyceride accumulation by oppositely regulating the activation state of JAK/STAT pathway in the liver and adipose tissue, resulting in the disorder of body lipid metabolism and obesity.Keywords:di-(2-ethylhexyl) phthalate;JAK/STAT;lipid metabolism;adipose tissue
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ZEITSCHRIFT FUR ANORGANISCHE UND ALLGEMEINE CHEMIE
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2024
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IF 1.1
Zhiwei Zhang,Yilin Ma,Encheng Liu,Junjie Cheng,Fengfeng Chen,Bin Ling,Ningyu Di,Junkuo Gao
Curing agents for epoxy resin (EP) are one of the most important branches in the polymer materials field due to their enormous potential in many fields, but constructing them in a well-controlled curing temperature remains challenging. Herein, a novel curing agent is constructed by the zirconium metal-organic framework (UiO-66) and [P 4442 ] 2 [IDA] through an impregnation method. [P 4442 ] 2 [IDA]@UiO-66 is utilized as a functional nanofiller and curing agent to construct the [P 4442 ] 2 [IDA]@UiO-66/EP nanocomposites. The chemical structures of [P 4442 ] 2 [IDA]@UiO-66 were investigated by XRD, SEM, DSC, and TG characterizations. The various [P 4442 ] 2 [IDA]@UiO-66 with different loading amounts of [P 4442 ] 2 [IDA] were used to investigate the curing behaviors of the EP-51. The DSC results confirm that the curing temperature of the [P 4442 ] 2 [IDA]@UiO-66/EP is higher than that of [P 4442 ] 2 [IDA]/EP. In addition, the kinetic parameters and the activation energy of the curing reaction were acquired according to the fitting of Kissinger equation and Ozawa equation. The drying time of [P 4442 ] 2 [IDA]@UiO-66/EP system at 40 °C was enhanced 17 times compare to that of [P 4442 ] 2 [IDA]/EP system. This study opens new avenues for the rational design of EP nanocomposites by employing ionic liquids@MOFs composite materials as curing agent for wide engineering applications.
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JOURNAL OF MEDICINAL CHEMISTRY
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2024
·
IF 6.8
Bo Wang,Shu-Wu Wang,Ying Zhou,Shao-Peng Wang,Ya Gao,Hui-Min Liu,Shi-Kun Ji,Sai-Qi Wang,Yi-Chao Zheng,Cheng Zhang,Adil Mardinoglu,Hong-Min Liu,Xiao-Bing Chen,Xing-Jie Dai
LSD1 (histone lysine-specific demethylase 1) has been gradually disclosed to act as an immunomodulator to enhance antitumor immune response. Despite the identification of numerous potent LSD1 inhibitors, there remains a lack of LSD1 inhibitors approved for marketing. Novel LSD1 inhibitors with different mechanisms are therefore needed. Herein, we reported a series of novel quinazoline-based LSD1 inhibitors. Among them, compound Z-1 exhibited the best LSD1 inhibitory activity (IC50 = 0.108 μM). Z-1 also acted as a selective and cellular active as an LSD1 inhibitor. Furthermore, Z-1 promoted response of gastric cancer cells to T-cell killing effect by decreasing PD-L1 expression and further attenuated the PD-1/PD-L1 interaction. In vivo, Z-1 exhibited significant suppression effect on the growth of gastric cancer cells without obvious toxicity. Therefore, Z-1 represents a potential novel immunomodulator that targets LSD1, providing a lead compound with new function mechanism for gastric cancer treatment.
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Journal of Materials Chemistry C
·
2024
·Vol. 12
·期 45
·18391-18400
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IF 5.7
Meidan Que,Shenghui He,Lili Gao,Boyue Zhang,Yabo Wang,Jin Chen,Bo Li,Wei Huang,Peng Zhong
The dynamic nature of formamidine lead iodide quantum dots (FAPbI3 QDs) limits their practical application by causing the appearance of ionic vacancy defects on the surface of QDs, which would then allow for significant trap-assisted non-radiative recombination of charge carriers. Herein, we explore a feasible surface modification strategy for passivating vacancy defects. Different lead salts are employed in the post-treatment procedure of quantum dot films. Based on both experimental and theoretical findings, Pb(NO3)2 passivation comprises Pb2+ and FA+. On the quantum dot surface, the O atoms from NO−3 form strong chemical bonds with FA+, and the O–C⋯O–N structure, defined by a dual-anchored configuration, contributes to the establishment of a stable crystal structure by exhibiting optimal bond lengths (3.486 Å and 3.775 Å, respectively) and a higher binding energy (10.51 eV). Finally, FAPbI3 quantum dot solar cells simultaneously achieve both exceptional environmental stability and a champion photoelectric conversion efficiency of 12.11%. This work provides valuable insights into surface chemical engineering of quantum dots, paving the way for high-performing photovoltaic devices.
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JOURNAL OF CHEMICAL THERMODYNAMICS
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2024
·
IF 2.2
Xuyao Tang,Yang Wang,Junwei Cui,Ke Zhang,Shengshan Bi
In this work, n -hexane, cyclohexane and 2-methylpentane were selected to represent linear-alkane, cycloalkane and branched-alkane, respectively. Based on the dynamic light method (DLS), the viscosity, interfacial tension and diffusion coefficient of n -hexane/CO 2 , cyclohexane/CO 2 and 2-methylpentane/CO 2 systems under saturation condition were measured in order to explore the change trend of thermophysical properties of the systems with the same carbon atom number but different molecular structures. The experiments were conducted at the temperatures of 303, 343 and 383 K and at pressures up to 5.64 MPa. The expanded uncertainties（ k = 2）of dynamic viscosity, interfacial tension and diffusion coefficient were 3 %, 3 % and 4.4 % respectively. The experimental results show that n -hexane and 2-methylpentane with similar molecular structure have more similar value of the properties. The effects of different alkane structures on system viscosity, interfacial tension, and diffusion coefficient were explained at the molecular level through radial distribution function, interface thickness, and CO 2 coordination number. At 303.15 K and 4 MPa, the peak radial distribution function of CO 2 /cyclohexane is 1.845, which is greater than that of CO 2 /n-hexane and CO 2 /2-methylpentane molecules. It has been proven that the arrangement of CO 2 /cyclohexane is more orderly, resulting in higher viscosity and lower diffusion coefficient of the system. The interface thickness of CO 2 /cyclohexane is 6.13 nm, which is smaller than CO 2 / n -hexane (7.53 nm) and CO 2 /2-methylpentane (6.3 nm). The smaller the interface thickness, the more compact the structure, the stronger the intermolecular forces, and the greater the interfacial tension. At 303.15 K and 2 MPa, the number of CO 2 coordination sites within 1 nm around liquid phase alkanes is 3.96, which is smaller than 4.78 for cyclohexane and 6.62 for 2-methylpentane. Prove that the coordination number is directly proportional to the diffusion coefficient and inversely proportional to viscosity and interfacial tension.
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INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
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2024
·
IF 7.7
Hu Xu,Mukan Ji,Dawei Xu,Yongqin Liu
Cellobiose 2-epimerase (CE) catalyzes the conversion of the lactose into its high-value derivatives, epilactose and lactulose, which has great prospects in food applications. In this study, CE sequences from the Qinghai-Tibet Plateau gene catalogue, we screened these for structural flexibility through molecular dynamics simulation to identify potential psychrophilic CE candidates. One such psychrophilic CE we termed psyCE demonstrated exceptional epimerization activity, achieving an optimum activity of 122.2 ± 1.6 U/mg. Its kinetic parameters (K cat and K m ) for epimerization activity were 219.9 ± 5.6 s −1 and 261.9 ± 18.1 mM, respectively, representing the highest K cat recorded among known cold-active CEs. Notably, this is the first report of a psychrophilic CE. The psyCE can effectively produce epilactose at 8 °C, converting 20.3 % of 200 mM lactose into epilactose within four hours. These findings suggest that psyCE is highly suitable for cryogenic food processing, and glaciers may serve as a valuable repository of psychrophilic enzymes.
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INTERNATIONAL JOURNAL OF HYDROGEN ENERGY
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2024
·
IF 8.1
Yijie Yang,Yanjun Yu,Yuanhang Wu,Hongyi Chen,Jie Yang,Yu Luo,Yuan Hu,Congshu Huang,Hui Li,Jianzhi Wang
Designing ultrahigh energy density and mass-loading of electrocatalysts for hydrogen evolution is highly desirable but remains a great challenge. Herein, a 3D high-rise architectural structure consisting of dense Ni(OH) 2 nanoparticles on CuMoO 4 nanocube heterostructure arrays on Ni foam (Ni(OH) 2 /CuMoO 4 /NF) is developed via a hydrothermal reaction, calcination and electrodeposition method. Benefitting from the optimized electronic configuration, hierarchical high-rise architecture, and large specific surface area and mesoporous, the Ni(OH) 2 /CuMoO 4 /NF exhibits superior hydrogen evolution reaction (HER) activity in 1.0 M KOH solution. Ni(OH) 2 /CuMoO 4 /NF only requires low overpotential of 70 mV achieving a current density of 10 mA cm −2 with a low Tafel slope of 80 mV dec −1 , and superior long-term stability toward HER. This work provides a new structural design to high-rise architectural structures for efficient catalytic application.
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JOURNAL OF SOLID STATE CHEMISTRY
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2024
·
IF 3.2
Yin Xie,Zhuozheng Wang,Yan Cui,Liang Qiao,Kebin Chi,Dejun Shi,Yang Bai,Zhijie Wu,Shengbao He
2-Methoxyethanol (2-Me) is a promising solvent for large-area perovskite film preparation. Understanding the competing processes of α and δ-FAPbI 3 in 2-Me is crucial for advancing the application of 2-Me in FAPbI 3 film coating. In this study, FAPbI 3 microcrystals are fabricated by inverse temperature crystallization method at 100 °C, and are used as a platform to investigate the competing formation of α and δ-FAPbI 3 in 2-Me. Perovskite inks are analyzed using Raman, FTIR and DLS, and it is found that cluster ratio is closely related to the kinetic formation of δ-FAPbI 3 . The formation of α-FAPbI 3 can be significantly promoted when clusters are dissociated with additives (excess FAI or I 2 ). These findings provide valuable insights into the influence of precursor inks on perovskite phases.
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BMC BIOLOGY
·
2024
·Vol. 22
·期 1
·1-19
·
IF 4.4
Jiang Hexiang,Sun Yi,Li Fengyang,Yu Xibing,Lei Siyu,Du Sulan,Wu Tong,Jiang Xuan,Zhu Junhui,Wang Jun,Ji Yalu,Li Na,Feng Xin,Gu Jingmin,Han Wenyu,Zeng Lei,Lei Liancheng
Background Ribosomal protein SA (RPSA) of human brain microvascular endothelial cells (HBMECs) can transfer from the cytosol to the cell surface and act as a receptor for some pathogens, including Streptococcus suis serotype 2 (SS2), a zoonotic pathogen causing meningitis in pigs and humans. We previously reported that SS2 virulence factor enolase (ENO) binds to RPSA on the cell surface of HBMECs and induces apoptosis. However, the mechanism that activates RPSA translocation to the cell surface and induces ENO-mediated HBMEC apoptosis is unclear.Results Here, we show that RPSA localization and condensation on the host cell surface depend on its internally disordered region (IDR). ENO binds to the IDR of RPSA and promotes its interaction with RPSA and vimentin (VIM), which is significantly suppressed after 1,6-Hexanediol (1,6-Hex, a widely used tool to disrupt phase separation) treatment, indicating that ENO incorporation and thus the concentration of RPSA/VIM complexes via co-condensation. Furthermore, increasing intracellular calcium ions (Ca2+) in response to SS2 infection further facilitates the liquid-like condensation of RPSA and aggravates ENO-induced HBMEC cell apoptosis.Conclusion sTogether, our study provides a previously underappreciated molecular mechanism illuminating that ENO-induced RPSA condensation activates the migration of RPSA to the bacterial cell surface and stimulates SS2-infected HBMEC death and, potentially, disease progression. This study offers a fresh avenue for investigation into the mechanism by which other harmful bacteria infect hosts via cell surfaces’ RPSA.
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COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
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2024
·
IF 4.9
Worku Lakew Kebede,Dong-Hau Kuo,Xiaoyun Chen
Environment and energy are presently some of the highest priority topics for mankind that need to be addressed. Organic pollutants are toxic and carcinogenic for human and aquatic life hence their presence in water even in low concentrations can cause serious health problems. Photodegradation of organic pollutants by utilizing oxide-based heterostructure photocatalysts is the promising approach to carry out remediation efficiently ascribed to the advanced optoelectronic and structural superiority of oxide photocatalysts. The Zn(O,S)/Mo(O,S) 2 composites were synthesized via a facile solvothermal method at low temperatures. Several methods were used to characterize the composite morphology, structure, electrical conductivity, chemical composition, and optical characteristics. The heterostructured Zn(O,S)/Mo(O,S) 2 oxysulfide was employed successfully in the photocatalytic degradation of organic pollutants. Among the as-prepared samples, the 30-ZnMoOS composite catalyst was found to have the highest photodegradation performance on various organic dye pollutants. The photocatalytic activity of the as-synthesized Zn(O,S)/Mo(O,S) 2 samples was assessed on the photodegradation of different kinds of organic dyes under visible light irradiation. The photocatalytic degradation efficiency of 30-ZnMoOS composite over 10 ppm neutral red (NR), methylene blue (MB), rhodamine B (Rh B), and methyl orange (MO) was found to be 99.6 %, 99.9 %, 99.5 %, and 98.8 % within 40, 45, 180, and 180 min, respectively, under visible light illumination. In the present photocatalytic system, the superoxide ( . O 2 - ) anions, hydroxyl ( . OH) radicals, and holes (h + ) are proposed to be the direct reactive species causing the photodegradation of organic dyes.
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JOURNAL OF APPLIED POLYMER SCIENCE
·
2024
·Vol. 141
·期 24
·e55510
·
IF 2.7
Jinlu Wang,Xiao Ruan,Kaixin Shen,Yijia Wang,Yan Zhang,Jiyan Liu,Xueqing Liu
In the present paper, crosslinked polyvinyl alcohol (PVA) membranes with high transparency and excellent flame retardancy were obtained by blending 2-methyl-2,5-dioxo-1,2-oxaphospholane (OP) with a PVA water solution at the molecular scale. Fourier transform infrared spectrometry and differential scanning calorimetry were used to investigate the crosslinking reaction. The surface morphology and micromechanical assessments of the membrane were examined using nanoindentation. The limited oxygen index (LOI) and vertical flame microscale combustion calorimetry, thermogravimetric analysis, scanning electron microscopy (SEM), energy-dispersive spectroscopy (EDS), and x-ray photoelectron spectroscopy (XPS) were employed to evaluate the flame retardancy and reveal the corresponding mechanisms. It was found that OP reacted with PVA below 120°C. The crosslinked membranes have a rougher surface and higher hydrophilicity and lower hardness and modulus than pure PVA does. The crosslinked membranes exhibit enhanced flame retardancy and high transparency. The membrane passes the UL 94 V 0 rating with an LOI of 27.6% and achieves a transmittance of 90.2% when the OP content is 20 wt.%. The SEM, EDS, and XPS results demonstrate that the interaction between OP and PVA effectively promotes the formation of a continuous and stable char in the condensed phase.
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