JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
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2024
·
IF 5.7
Syed Muhammad Zaigham Abbas Naqvi,Jingkai Zhao,Muhammad Naveed Tahir,Muhammad Awais,Yanyan Zhang,Junfeng Wu,Shakeel Ahmed,Linze Li,Vijaya Raghavan,Jiandong Hu
This study explores the development and application of gold and 4-mercaptopyridine (MPY) perovskite-engineered robust nanofibers (GLAMPER-NFs) for the ultrasensitive detection of Abscisic acid (ABA) under Raman spectroscopy, a crucial plant hormone. The GLAMPER-NFs composite material, consisting of MAPbCl3 nanofibers integrated with MPY-coated gold nanostructures, demonstrates exceptional performance in surface-enhanced Raman scattering (SERS)-based sensing. The study elucidates the material structure and properties through comprehensive characterization using scanning electron microscopy (SEM), UV–vis spectroscopy, fluorescence spectroscopy, Fourier transform infrared, and Raman spectroscopy. The SEM analysis reveals uniform nanofibers with diameter of 107.8 ± 3.06 nm, while spectroscopic studies confirm the successful synthesis and integration of the composite components. The SERS-based detection of ABA showcases remarkable sensitivity, with a linear detection range (R2 = 0.9957) spanning 7 orders of magnitude (10–14–10–7 M) and presented a limit of detection of 10–11 and enhancement factor of 1.08 × 107. This surpasses the performance of existing sensing platforms, demonstrating clear spectral responses even at femtomolar concentrations. The synergistic effects of the perovskite structure, plasmonic gold nanoparticles, and MPY linking molecules contributed exceptional sensing capabilities to the GLAMPER-NFs material. Fluorescence studies further corroborate the sensitivity and provide insights into the photophysical interactions between ABA and the composite material. This research advances the understanding of perovskite-based hybrid materials and presents a promising GLAMPER-NFs as SERS substrate for ultrasensitive plant hormone detection, with potential applications in agricultural monitoring and plant science research.
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MATERIALS SCIENCE IN SEMICONDUCTOR PROCESSING
·
2025
·
IF 4.6
Yixuan Bao,Yuping Zhang,Shilei Wang,Xuemei Liu,Jun Ma,Xiaoting Li,Yang Liao
The widespread use of 2,4-dichlorophenol (2, 4-DCP) in the paper manufacturing, dye synthesis, textile processing, and agriculture applications has led to its persistent accumulation in the ecosystems, posing significant risks to environmental safety and human health. This study developed a MIL-101(Fe)-derived porous carbon material for efficient degradation of 2, 4-DCP through potassium persulfate (PDS)-based advanced oxidation processes. Characterization demonstrated that the synthesized material, compared with its MIL-101(Fe) precursor, possessed enhanced specific surface area and pore size distribution, which could synergistically promote both adsorption and catalytic degradation of 2, 4-DCP. The optimized 700Fe-C/PDS system (0.3 g/L catalyst, 0.5 mM oxidant) achieved 95.99 % degradation rate for 50 mg/L 2, 4-DCP within 90 min, showing rapid degradation ability. Notably, the material maintained >94.34 % degradation efficiency for 2, 4-DCP after five times of reuse without requiring pH adjustment, highlighting exceptional stability and practical applicability. Reactive oxygen species quenching experiments and electron paramagnetic resonance (EPR) analysis elucidated that both radical and non-radical pathways contributed to the degradation process, with 1 O 2 playing a dominant role in the system. Furthermore, the catalyst demonstrated remarkable generalizability, eco-friendliness and effectively degradation for 2, 4-DCP in real municipal wastewater effluent and other organic pollutants including tetracycline, ciprofloxacin, acetamiprid, and sulfamethoxazole. This work provides an efficient, stable, and easily recyclable catalytic material, offering a new strategy for addressing diverse organic contaminants in complex water matrices.
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Scientific Reports
·
2025
·Vol. 15
·期 1
·1-11
·
IF 3.9
Chen Yuan-Bin,Xiong Siyi
The Na 5 Tm 1 − x (Y 1/3 Yb 2/3 ) x (MoO 4 ) 4 ceramics (x=0-0.18) were successfully synthesized via the solid-state reaction method. XRD analysis revealed that they possessed a single-phase tetragonal scheelite structure belonging to the space group I4₁/a(88). SEM analysis demonstrated that the samples sintered at 600 °C exhibited a dense microstructure, with a relative density as high as 94.9% and an average grain size ranging from 2.172 μm to 2.424 μm. The relative density serves as an external factor influencing ε r and Q×f, while τ f is related to bond valence. The ionicity of the Tm-O bond, and the lattice energy and bond energy of the Mo-O bond are the intrinsic factors determining ε r , Q×f, and τ f , respectively. Raman spectroscopy provided an intuitive characterization of the vibrational properties of the [MoO 4 ] 2− tetrahedra within the ceramics. Although the pure phase Na₅Tm(MoO 4 ) 4 ceramic exhibited optimal dielectric properties (ε r =8.025, Q×f=18,967 GHz, and τ f = -101 ppm/°C) at 625 °C, the Na 5 Tm 0.91 Y 0.03 Yb 0.06 (MoO 4 ) 4 ceramic sintered at 600 °C demonstrated superior dielectric properties (ε r =7.82, Q×f=34,752 GHz, and τ f = -71.9 ppm/°C).
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RAPID COMMUNICATIONS IN MASS SPECTROMETRY
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2017
·Vol. 31
·期 21
·1779-1784
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IF 1.998
Xina Cheng,Xueting Ye,Dan Liu,Nan Zhao,Huiyuan Gao,Ping Wang,Guangbo Ge,Xiaozhe Zhang
Rationale The matrix plays an essential role in defining detection limits and ionization yields of analytes in matrix-assisted laser desorption/ionization mass spectrometry (MALDI-MS) analysis. Small molecule MALDI-MS analyses commonly suffer from the high background interference generated from matrices. Moreover, the inhomogeneous crystallization of some matrices, such as 2,5-dihydroxybenzoic acid (DHB), is to the detriment of the quality or repeatability of detection. We have found that N -butyl-4-hydroxy-1,8-naphthalimide (BHN) can provide improved performance as a matrix for small molecule analysis. Methods BHN was evaluated in the low-mass region for its ionization efficiency, repeatability and background interference using O -acetyl-L-carnitine hydrochloride, Aβ35-40, Aβ35-42, and oxytocin as the model analytes. In addition, the modification effects of BHN on DHB were investigated for the in situ analysis of endogenous compounds in rat brain slices using Fourier transform ion cyclotron resonance (FTICR)-MS. Results BHN is capable of ionizing small molecules, including O -acetyl-L-carnitine hydrochloride and peptides, with high repeatability and low background interference signals. A low concentration of BHN (3 mM) modifies the crystallization state of DHB but still retains its ionization performance. The determination of small molecules desorbed from tissue slices was significantly improved by using a binary matrix of DHB and BHN, yielding superior signal-to-noise ratio and signal intensities. Conclusions The new matrix BHN has exhibited suitability for the analysis of small molecules. Compared with the conventional matrices, CHCA and DHB, BHN provides a clean background in the low-mass region. In combination with DHB, the ability of BHN to form highly homogenous crystalline particles shows the clear beneficial effects of BHN for the reproducibility of MS detection.
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Journal of Extracellular Vesicles
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2025
·Vol. 14
·期 4
·e70068
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IF 14.5
Jiangbin Chen,Qi Tan,Zimo Yang,Wenjuan Chen,E. Zhou,Minglei Li,Jingjing Deng,Yali Wu,Jiatong Liu,Juanjuan Xu,Mengfei Guo,Yang Jin
Dendritic cell (DC)-derived extracellular vesicles (DEVs) are promising candidates for cancer vaccines, but their therapeutic effects still need further optimization. In this study, we utilized neoantigens, lipopolysaccharide and IFN-γ to induce the maturation of DCs, and then isolated DEVs derived from these mature DCs. We showed that the immune checkpoint inhibitor (anti-CTLA-4 antibody, aCTLA-4) can improve the immunostimulatory function of DEVs by directly activating T cells through immune checkpoint signal blockade. The cytokine interleukin-12 (IL-12), as one of the third signals for T cell activation, can also enhance the capability of DEVs to activate T cells directly. Based on these findings, we designed the engineered DEVs conjugated with IL-12 and aCTLA-4 (DEV@IL-12-aCTLA-4) to improve the therapeutic potential of DEVs by providing sufficient immune regulatory signals. Moreover, the carrier property of DEVs also contributes to the delivery of IL-12 and aCTLA-4 to lymph nodes. This indicates that the conjugation of DEVs with IL-12 and aCTLA-4 constitutes a complementary approach, where IL-12 and aCTLA-4 help to enhance the T cell activation effect of DEVs, and DEVs facilitate the delivery of IL-12 and aCTLA-4. Our results showed that DEV@IL-12-aCTLA-4 can enhance the Th1 immune response and reverse exhausted CD8 + T cells in the tumour microenvironment, effectively inducing robust T cell immune responses and inhibiting tumour growth in tumour-bearing mice. Overall, this study expands the theoretical foundation of DEVs and provides a universal strategy for optimizing cancer combination immunotherapy by reprogramming DEVs.
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ChemistrySelect
·
2025
·Vol. 10
·期 21
·e06152
·
IF 2
Shuai Wang,BingXi Song,Ze Su,Yijie Cai,Long Liu,Chang Su,Yanqiang Zhang
Graphical A new ionic liquid plasticizer [NTAZ][NTf 2 ] was synthesized. Compared with the traditional plasticizer DOA, [NTAZ][NTf 2 ] can significantly improve the energy of the propellant formulation. Energetic plasticizer is an important means to improve the energy performance of solid propellants, but there is no suitable energetic plasticizer for HTPB/TDI system. In this work, a nitrate-functionalized ionic liquid plasticizer of 1-Methyl-4-(8-(Nitrooxy)octyl)-1,2,4-triazolium bis((trifluoromethyl)sulfonyl)imide ([NTAZ][NTf 2 ]) was synthesized, and the energy was increased by the combination of nitrate functional group and 1,2,4-triazole cation. The hydrogen bond between the anion and the cation and HTPB achieves a good plasticizing effect. When 6% [NTAZ][NTf 2 ] was added to HTPB/TDI system, the glass transition temperature decreased from −63.41 °C to −64.84 °C, the tensile strength increased from 0.52 MPa to 0.79 MPa, and the storage modulus increased from 64.02 MPa to 110.32 MPa. When 4% DOA is replaced by the same amount of [NTAZ][NTf 2 ] in the HTPB formulation system, the specific impulse is increased from 261.0 s to 271.4 s. This study will guide the design and application of new energetic solid propellant plasticisers, both theoretically and experimentally.
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JOURNAL OF ETHNOPHARMACOLOGY
·
2025
·
IF 5.4
Yifei Wang,Xiaolong Wang,Wenhao Li,Hanwen Huang,Chenyu Di,Qifeng Yang
Ethnopharmacological relevance Trametes robiniophila Murr (Huaier), a traditional Chinese medicine (TCM), has shown promising effects as a complementary therapy in the treatment of multiple kinds of cancers. Aim of the study This study aimed to systematically evaluate whether Huaier could enhance the antitumor effects of palbociclib, a highly selective CDK4/6 inhibitor. Materials and methods A breast cancer xenograft mouse model was constructed to assess the anticancer effects of Huaier and palbociclib. Transcriptomic analysis was performed to identify the differentially expressed genes and associated pathways. Flow cytometry, immunofluorescence and immunohistochemical staining were then conducted to observe the infiltration of immune cells in the tumor microenvironment (TME). The composition of the gut microbiota was explored through 16S rDNA sequencing, and a pseudosterile mouse model was established to verify the contribution of the gut microbiota to the antitumor effects of Huaier and palbociclib. Results Oral administration of Huaier enhanced the antitumor effects of palbociclib in breast cancer. Transcriptomic analysis of tumor tissues revealed that the differentially expressed genes were related to immune functions. Indeed, the addition of Huaier to palbociclib therapy further increased the ratio of CD8 + /CD3 + T cells and the abundance of GzmB + CD8 + T cells in the TME. Mechanistically, sequencing of 16S rDNA revealed that Huaier reshaped the gut microbiota composition in favor of Akkermansia , which positively modulated antitumor immune responses. The pseudosterile mouse model verified the necessity of the gut microbiota for the synergistic effect of Huaier on palbociclib. Furthermore, butyrate, a metabolite of Akkermansia , synergized with palbociclib to suppress tumor progression and promote the infiltration of CD8 + T cells in the TME. Conclusions Our data suggested that Huaier augmented the antitumor effects of palbociclib by increasing the abundance of Akkermansia in gut microbiota, which contributed to the enhancement of anti-tumor immunity. Consequently, combining palbociclib with Huaier may serve as a promising strategy for the treatment of breast cancer.
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REACTIVE & FUNCTIONAL POLYMERS
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2017
·
IF 3.151
Zhenfeng Huang,Runqi Liuyang,Chengyun Dong,Yufeng Lei,Anqiang Zhang,Yaling Lin
Polymeric quaternary ammonium salts (PQAS) have been widely used to prevent microbial contamination, but little is known about their activity against phytopathogenic fungi. Our previous report described the synthesis of two novel PQAS, namely a homopolymer of (2-methacrylamido) propyltetrabenzyldimethylammonium chloride (PQD-BC) and dimethylaminopropyl benzyl chloride-grafted polysiloxanes (PDMS-g-BC); we demonstrated their structure-activity relationship against phytopathogenic fungi such as R . solani and Fusarium oxysporum f. sp. cubense tropical race 4 (Foc4). Here, we analyzed the structure-activity relationship and toxicity mechanism of these compounds at the molecular level against Foc4 compared with the low molecular-weight quaternary ammonium salt benzalkonium chloride (BC). The results revealed that PQD-BC and PDMS-g-BC application inhibited the growth of Foc4 in a concentration-dependent manner and that PDMS-g-BC exhibited higher activity than PQD-BC. In addition, these polymers were found to induce cell death in Foc4 by disrupting the cellular structure integrity, such as the loss of the cell wall and plasma membrane integrity and oxidative stress (lipid peroxidation), leading to the release of intracellular contents and inducing mitochondrial dysfunction and interference with genomic DNA . The newly elucidated mechanism provides possible applications in which PQAS can be used against phytopathogenic fungi.
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JOURNAL OF ETHNOPHARMACOLOGY
·
2022
·
IF 5.195
Rongchun Wang,Qingyu Ren,Daili Gao,Yam Nath Paudel,Xia Li,Lizhen Wang,Pengyu Zhang,Baokun Wang,Xueliang Shang,Meng Jin
Ethnopharmacological relevance Gastrodia elata Blume ( G. elata ), a traditional Chinese herb, known as “Tian Ma”, is widely used as a common medicine and diet ingredient for treating or preventing neurological disorders for thousands of years in China. However, the anti-depressant effect of G. elata and the underlying mechanism have not been fully evaluated. Aim of the study The study is aimed to investigate the anti-depressant effect and the molecular mechanism of G. elata in vitro and in vivo using PC12 cells and zebrafish model, respectively. Material and methods Network pharmacology was performed to explore the potential active ingredients and action targets of G. elata Blume extracts (GBE) against depression. The cell viability and proliferation were determined by MTT and EdU assay, respectively. TUNEL assay was used to examine the anti-apoptotic effect of GBE. Immunofluorescence and Western blot were used to detect the protein expression level. In addition, novel tank diving test was used to investigate the anti-depressant effect in zebrafish depression model. RT-PCR was used to analyze the mRNA expression levels of genes. Results G. elata against depression on the reticulon 4 receptors (RTN4R) and apoptosis-related targets, which were predicted by network pharmacology. Furthermore, GBE enhanced cell viability and inhibited the apoptosis in PC12 cells against CORT treatment. GBE relieved depression-like symptoms in adult zebrafish, included increase of exploratory behavior and regulation of depression related genes. Mechanism studies showed that the GBE inhibited the expression of RTN4R-related and apoptosis-related genes. Conclusion Our studies show the ameliorative effect of G. elata against depression. The mechanism may be associated with the inhibition of RTN4R-related and apoptosis pathways.
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BIOORGANIC CHEMISTRY
·
2021
·
IF 5.275
Lian Xu,Li-Chao Wang,Bing-Mei Su,Xin-Qi Xu,Juan Lin
(2 S , 3 R )-4-methylsulfonylphenylserine [(2 S , 3 R )-MPS], a key chiral precursor for antibiotics florfenicol and thiamphenicol, could be asymmetrically synthesized by l -threonine transaldolase (LTTA) coupled with an acetaldehyde elimination system. The low efficiency of acetaldehyde elimination system blocked further accumulation of (2 S , 3 R )-MPS. To address this issue, strengthening acetaldehyde elimination system and enzyme self-assembly strategy were combined to accelerate biosynthesis of (2 S , 3 R )-MPS. The new multi-enzyme cascade with intensified acetaldehyde elimination system BL21 (PsLTTAD2/ScADH/BtGDH) could produce (2 S , 3 R )-MPS with a titer of 157.6 mM, 1.7-folds than that produced by the original system BL21 (PsLTTAD2/ApADH/CbFDH). Moreover, self-assembly of PsLTTAD2 and ScADH by respective fusion of SpyTag and SpyCatcher were carried out to develop a self-assembled multi-enzyme cascade BL21 (ST-PsLTTAD2/SC-ScADH/BtGDH). As a result, the yield of (2 S , 3 R )-MPS was up to 248.1 mM with 95% de . As far as we knew, that represented the highest yield of (2 S , 3 R )-MPS by enzymatic synthesis, and therefore was a promising and green route for industrial production of this valuable compound.
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Canadian Journal of Chemistry
·
2021
·Vol. 99
·期 10
·
IF 1.118
Xiaoxia Li,Shuaida Zhu,Qi Jia,Haixia Zhao,Yuqi Cao,Yuying Ma,Shuangqi Hu,Xiong Cao
In this work, it is shown that MoO3-x has a positive effect on the thermal decomposition of ammonium perchlorate based molecular perovskite (H2DABCO)[NH4(ClO4)3] (DAP-4). MoO3-x was prepared by heat treatment, and the morphology, structure, and thermal decomposition performance were characterized. The morphology and structure characterization results showed that MoO3-x was an irregular layered structure material and the Mo element was mainly in the +6 chemical valence state, with a small amount of Mo5+. Thermal analysis results showed that the thermal decomposition peak temperature of DAP-4 was effectively reduced from 394.4 °C to 353.7 °C, 321.4 °C, and 312.5 °C in the presence of 1%, 5%, and 10% MoO3-x, respectively. It is particularly worth noting that the maximum heat release rate of the DAP-4/10% MoO3-x mixture was increased by 4.9 times compared with pure DAP-4. Through the two classic thermal decomposition kinetic methods, Kissinger and Starink, the reliable kinetic parameters of DAP-4/MoO3-x were obtained. The increase of the reaction rate constant k indicated that the maximum thermal decomposition reaction rate of DAP-4 was effectively improved. This work provided a feasible technology for using MoO3-x as an effective catalyst to improve the thermal performance of DAP-4.
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Journal of Environmental Chemical Engineering
·
2020
·
IF 4.3
Wenjun Liu,Zhaohui Li
Metallic Au nanoparticles (NPs) are active catalysts in many chemical reactions. However, small-size Au NPs are difficult to obtain since they tend to agglomerate due to their high surface energies. Herein, we reported a facile and green hydrothermal process, using graphene oxide (GO) as the RGO precursor, HAuCl 4 as Au precursor and L-cysteine (L-cys) as both cross-linker and reducing agent, to fabricate an Au/RGO composite aerogel. During the hydrothermal process, the reduction of GO/HAuCl 4 , the oxidation of L-cys to produce disulfide linkage, and the self-assembly of RGO aerogel occurs simultaneously, leading to the resultant RGO aerogels uniformly and intimately embedded with disulfide protected ultrasmall Au NPs with an average size of 1.3 nm. The as-obtained Au/RGO composite aerogel exhibited superior catalytic performance for reduction of 4-nitrophenol (4-NP) to 4-aminophenol (4-AP), with a total transformation of 4-NP achieved in 4 min. The much higher activity over Au/RGO aerogel as compared with unsupported thiol-capped Au NPs can be attributed to the synergistic effect of metallic Au and RGO. Moreover, Au/RGO composite aerogel also showed high stability and can be easily separated from the reaction systems for recycling. No obvious decrease of catalytic reduction activity was observed over the Au/RGO aerogel after five cycles. Considering the high price of metallic Au, the embedding of Au NPs in three-dimensional RGO aerogels to facilitate its recycling is extremely appealing for its practical applications.
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