ENERGY & FUELS
·
2022
·
IF 4.654
Jun Zhang,Zhen Wu,Yafei Wu,Xiaoling Liu,Xun Li,Yu Zhang,Haian Xia,Fei Wang
Catalytic cracking of fatty acid methyl esters (biodiesel) is an attractive alternative to petroleum processing to produce valuable and versatile aromatics over the Zn-modified HZSM-5(25) catalysts. The catalysts with a Zn loading amount of 0–2.6 wt % were prepared and characterized. The introduction of Zn species presented great effects on the textural property and acidity of the parent HZSM-5(25) zeolite, and the chemical state of Zn species was heavily dependent on the amount of Zn loading. The strong Brönsted acid sites on the 0.5% Zn/HZSM-5(25) catalyst were exchanged by Zn species and formed new Zn-Lewis acid sites, which were identified as [ZnOH]+ and Zn2+ species. These Zn species greatly enhanced the dehydrogenation activation of alkanes to form more alkenes. Besides, they also promoted the further dehydrogenation reactions during aromatization of alkenes, thus improving the formation of H2 (>4 wt %) and increasing the production of aromatics (>40 wt %). The dominant components in the organic liquid product were monocyclic aromatics including benzene, toluene, and xylenes. Moreover, the 0.5% Zn/HZSM-5(25) catalyst exhibited an excellent stability, adaptability, and regeneration.
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高影响因子
BMC Chemistry
·
2019
·Vol. 13
·期 1
·1-15
·
IF 0
Guo J.,Ma Yu L.,Yu Jia Y.,Gao Yu J.,Ma Ning X.,Wu Xiao Y.
Herein, 2-(2-methoxyphenoxy)-1-phenylethanol (β- O -4), 2-methoxyphenyl anisole (α- O -4) and 4-phenoxyphenol (4- O -5) were selected as typical lignin model compounds. Given the effectiveness of traditional acid–base catalysts for lignin depolymerisation, a novel Ni/CaO–H-ZSM-5(60) catalyst was prepared to investigate the difficulty level of C–O bond of three model compounds cleavage in ethanol. It was observed that Ni/CaO–H-ZSM-5(60) had prominent performance on the C–O bond cleavage at very mild conditions (140 °C, 1 MPa H 2 ). Among them, the C–O bond of α- O -4 and β- O -4 could be completely cleaved within 60 min. Although the C–O bond of 4- O -5 had high bond energy, 41.2% of conversion was occurred in 60 min. The introduction of CaO could regulate the acidity of H-ZSM-5 to enhance the ability to break C–O bonds. Moreover, the possible pathways of C–O ether bonds in three lignin model compounds cleavage were proposed in order to selectively obtain target products from the raw lignin degradation.
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RSC Advances
·
2015
·Vol. 5
·期 102
·84014-84021
·
IF 3.84
Shurong Wang,Haizhou Lin,Jingping Chen,Yuan Zhao,Bin Ru,Kunzan Qiu,Jinsong Zhou
5-Hydroxymethylfurfural (HMF) is a bio-based platform chemical that may be converted into various chemicals and fuels. In the present study, we developed an advanced low-boiling single-phase reaction system for producing HMF from glucose. It consists of water and 1,2-dimethoxyethane (DMOE) and uses AlCl3 as catalyst. Our results show that introduction of DMOE can substantially enhance HMF production because of the polar aprotic solvent effect provided by DMOE. Under optimal conditions, a high HMF yield (58.56%) was obtained. GC-MS of the liquid-phase products revealed that HMF and furans comprised 80% and ∼90% of the detected products. Formation of liquid-phase products, including furans, oxygenated aliphatics, cyclopenten-1-ones, and pyrans is discussed. Further study of the humins formed during glucose conversion showed the effective inhibition of humin formation by DMOE. The structure of humins was characterized by FTIR spectroscopy. Finally, HMF production from disaccharides (sucrose, maltose and cellobiose) and polysaccharide (cellulose) using the water–DMOE system resulted in good yields, demonstrating that our single-phase water–DMOE solvent system has good potential use in HMF production from glucose and complex carbohydrates.
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TALANTA
·
2024
·
IF 5.6
Miaomiao Hu,Changchun Wen,Jian Liu,Minzhe Li,Nan Leng,Xiaohuan Guo,Qi Fang,Qinjie Kou,Rong Huang,Xiang-Cheng Lin
5-Hydroxyindole-3-acetic acid (5-HIAA) is a molecular marker that can be used in the early diagnosis of carcinoid tumors, and the development of sophisticated 5-HIAA assays is therefore of great importance. Surface-enhanced Raman spectroscopy (SERS) has been widely used for the rapid and sensitive detection of disease biomarkers. Insufficient specificity for tumor markers and poor spectral reproducibility are the bottlenecks in the practical use of SERS technology. In this study, based on MIL-125 surface-loaded gold nanoparticles (Au@MIL-125), a novel strategy was proposed to obtain Au@MIL-125@molecularly imprinted polymers (MIPs) as functional SERS substrates by wrapping a thin MIP shell around the Au@MIL-125 surface for selective separation followed by a 5-HIAA assay. The Raman peak intensity ratio (I 865 /I 1078 ) was used to quantify 5-HIAA after a SERS spectral calibration with an embedded internal standard (i.e., 4-aminobenzenethiol) to improve the quantitative accuracy. The linear range was from 10 −11 to 10 −7 M, and the limit of detection (LOD) was 5.45 × 10 −13 M. The method of integrating the MIPs with the metal MOF-based nanocomposites was shown to be useful in the analysis of real samples using SERS. The application of SERS for the selective and quantitative detection of analytes in real sample analysis, therefore, has great potential.
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DOI
PubMed
高影响因子
Small
·
2025
·
IF 12.1
Ling Ding,Zewen Shen,Hao Pan,Yana Chen,Yezi Hu,Guixia Zhao,Guangtong Hai,Xiubing Huang
Electrochemical oxidation of 5-hydroxymethylfurfural (HMFOR) to generate high-value chemicals under mild conditions acts as an energy-saving and sustainable strategy. However, it is still challenging to develop electrocatalysts with high efficiency and good durability. Here, nickel foam (NF) supported CoCrCe(7.5%)-LDH (layered double hydroxides) by doping Ce into CoCr-LDH show high 5-hydroxymethylfurfural (HMF) conversion (99%), 2,5-furandicarboxylic acid (FDCA) yield (99%), and Faraday efficiency (100%) at 1.4 V RHE . The CoCrCe(7.5%)-LDH also exhibits remarkable stability with 97% conversion of HMF after 10 cycles. The X-ray absorption near-edge spectroscopy (XANES) and theoretical calculation show that Ce doping into CoCr-LDH is beneficial to the formation of high-valance Co and significantly facilitates the electron transfer, regulates the adsorption behavior of intermediates, reduces the Gibbs free energy barrier and accelerates the reaction rate. This work promotes the use of rare earth elements as electrocatalysts to promote the oxidation of HMF.
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DOI
PubMed
高影响因子
FOOD CHEMISTRY
·
2025
·
IF 9.8
Huajian Ou,Lu Chen,Qiaohui Zeng,Zhiyun Peng,Zihao Lin,Ping Qi,Konglong Feng,Jing Jing Wang
A 5-aminolevulinic acid (ALA)-grafted chitin film (O-CT/ALA film) with a photodynamic inactivation (PDI) against bacteria was previously fabricated, and its preservation efficiency and mechanisms against salmon were explored. Results showed that the PDI-mediated O-CT/ALA film exhibited sustained generation capability of ROS, which had potent antibacterial activity in vitro under blue LED irradiation. Moreover, this film significantly inactivated the native bacteria and suppressed their growth in salmon fillets during storage at 4 °C and 25 °C, extending the shelf-life by >2 days compared to commercial polyethylene film. Consequently, the O-CT/ALA film retained the textural integrity of salmon muscle, stabilized the physicochemical properties of pH value, electrical conductivity, color appearance, and reduced the level of protein and lipid oxidation. Notably, it obviously reduced the accumulation of microbial metabolites and oxidation-related volatile compounds in salmon. Therefore, the PDI-mediated film shows a valid ability in preserving the storage quality of aquatic products.
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DOI
PubMed
高影响因子
BMC Pharmacology & Toxicology
·
2024
·Vol. 25
·期 1
·1-15
·
IF 2.8
Wang Tianyan,Tao Ting,Liu Yi,Dong Jie,Ni Shanhong,Liu Yun,Li Yanli,Xu Ning,Sun Zengxian
Background and purposes It is unclear whether the parent Saxagliptin (SAX) in vivo is the same as that in vitro, which is twice that of 5-hydroxy Saxagliptin (5-OH SAX). This study is to construct a Pharmacokinetic-Pharmacodynamic (PK-PD) link model to evaluate the genuine relationship between the concentration of parent SAX in vivo and the effect. Methods First, we established a reliable Ultra Performance Liquid Chromatography-Mass Spectrometry (UPLC-MS/MS) method and DPP-4 inhibition ratio determination method. Then, the T2DM rats were randomly divided into four groups, intravenous injection of 5-OH SAX (0.5 mg/kg) and saline group, intragastric administration of SAX (10 mg/kg) and Sodium carboxymethyl cellulose (CMC-Na) group. Plasma samples were collected at different time points for subsequent testing. Finally, we used the measured concentrations and inhibition ratios to construct a PK-PD link model for 5-OH SAX and parent SAX. Results A two-compartment with additive model showed the pharmacokinetic process of SAX and 5-OH SAX, the concentration-effect relationship was represented by a sigmoidal E max model and sigmoidal E max with E 0 model for SAX and 5-OH SAX, respectively. Fitting parameters showed SAX was rapidly absorbed after administration ( T max =0.11 h, t 1/2, ka =0.07 h), widely distributed in the body (V ≈ 20 L/kg), plasma exposure reached 3282.06 ng*h/mL, and the elimination half-life was 6.13 h. The maximum plasma dipeptidyl peptidase IV (DPP-4) inhibition ratio of parent SAX was 71.47%. According to the final fitting parameter EC 50 , EC 50, 5−OH SAX =0.46EC 50, SAX(parent) , it was believed that the inhibitory effect of 5-OH SAX was about half of the parent SAX, which is consistent with the literature. Conclusions The PK-PD link model of the parent SAX established in this study can predict its pharmacokinetic process in T2DM rats and the strength of the inhibitory effect of DPP-4 based on non-clinical data.
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DOI
PubMed
高影响因子
SENSORS AND ACTUATORS B-CHEMICAL
·
2025
·
IF 7.7
Shenghui Xia,Chen Chen,Jinhong Liu,Yu Zhang,Hui Zhang,Thomas Thundat,Ajit Khosla
Nitrogen dioxide (NO 2 ) is a highly toxic air pollutant that endangers human health, environmental sustainability, and ecosystems. To address this issue, we designed an inorganic heterogeneous interface by integrating ZSM-5 molecular sieves with MXene via a facile synthesis route. This unique architecture synergizes the dual cross-channel framework of ZSM-5 and the high electrical conductivity and abundant surface functional groups of MXene. This combination greatly enhances electron transfer kinetics, interfacial NO 2 adsorption, and gas sensing properties. The optimized MXene/ZSM-5 nanocomposite achieves an ultra-low NO 2 detection limit of 1 ppm. Its response is 79.78 % higher than that of original MXene. The nanocomposite also exhibits excellent stability and significant anti-interference properties. Correlation studies confirm consistent performance across humidity and atmospheric conditions. Density functional theory (DFT) calculations elucidated the charge transfer pathways and adsorption mechanisms at the atomic level that enhance sensitivity. By pioneering the MXene/ZSM-5 interface and systematically investigating its gas interaction kinetics, this work provides fundamental insights for designing next-generation MXene-based gas sensors.
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高影响因子
Coatings
·
2025
·Vol. 15
·期 9
·1012
·
IF 2.8
Shijian Sun,Mengquan Liu,Zheng Li,Junqiang Cheng,Dechuan Li
Hollow dendritic Na4La2(CO3)5crystals doped with Sm3+ions were synthesized with sodium carbonate using a hydrothermal method. The unique lifetime of Sm3+enables the optical measurement of luminescent ion content. The X-ray diffraction spectrum indicates that the nanocrystals maintain structural stability with a hexagonal arrangement, even when the concentration of Sm3+reaches 50 at.%. As the concentration of Sm3+increases, the emission intensity of Na4(La1−xSmx)2(CO3)5first rises and then falls. The maximum emission intensity of the fluorescent powder occurs at a Sm3+concentration of 0.04. Beyond this concentration, concentration quenching takes place, primarily due to electric dipole–dipole interactions. Using an excitation wavelength of 404 nm and monitoring at 596 nm, the fluorescence lifetime of Na4(La1−xSmx)2(CO3)5shows a strong dependence on Sm3+concentration, which can be described by a precise equation. Over the range of Sm3+concentrations from 0.005 to 1, the lifetime decreases from 3.126 ms to 0.023 ms. Therefore, optical monitoring of fluorescent powders is crucial for confirming the composition of coatings used in applications such as solid-state lighting and anti-counterfeiting, by utilizing the relationship between lifetime and doping concentration.
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高影响因子
CELL
·
2021
·
IF 41.584
Liming Yan,Yunxiang Yang,Mingyu Li,Ying Zhang,Litao Zheng,Ji Ge,Yucen C. Huang,Zhenyu Liu,Tao Wang,Shan Gao,Ran Zhang,Yuanyun Y. Huang,Luke W. Guddat,Yan Gao,Zihe Rao,Zhiyong Lou
The capping of mRNA and the proofreading play essential roles in SARS-CoV-2 replication and transcription. Here, we present the cryo-EM structure of the SARS-CoV-2 replication-transcription complex (RTC) in a form identified as Cap(0)-RTC, which couples a co-transcriptional capping complex (CCC) composed of nsp12 NiRAN, nsp9, the bifunctional nsp14 possessing an N-terminal exoribonuclease (ExoN) and a C-terminal N7-methyltransferase (N7-MTase), and nsp10 as a cofactor of nsp14. Nsp9 and nsp12 NiRAN recruit nsp10/nsp14 into the Cap(0)-RTC, forming the N7-CCC to yield cap(0) ( 7Me GpppA) at 5′ end of pre-mRNA. A dimeric form of Cap(0)-RTC observed by cryo-EM suggests an in trans backtracking mechanism for nsp14 ExoN to facilitate proofreading of the RNA in concert with polymerase nsp12. These results not only provide a structural basis for understanding co-transcriptional modification of SARS-CoV-2 mRNA but also shed light on how replication fidelity in SARS-CoV-2 is maintained.
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PubMed
高影响因子
TRIBOLOGY INTERNATIONAL
·
2022
·
IF 5.62
Pengjiao Zu,Yisheng Zhang,Yi Li,Songwei Zhang,Jun Li,Litian Hu
2-mercapto-5-methyl-1,3,4-thiadiazole (MMT) based ionic liquids were synthesized, their corrosion inhibition behavior and tribological performance were systematically evaluated. Electrochemical experiments showed MMT based ILs exhibited surprising corrosion inhibition efficiencies. The ILs adsorption behavior obeys Langmuir isotherm. Friction tests demonstrated MMT based ILs performed excellent lubrication properties, compared to [BMIM][BF 4 ]. Combining with analysis of SEM and XPS , it can be concluded that the prominent lubrication performance ascribed to the coexistence of adsorption layer and tribo-film. Therefore, versatile ILs designed in this paper have gathered two significant abilities for industrial applications, which are high corrosion inhibiting performance and excellent lubricating properties. This work is instructive for structure design of multifunctional ILs and will promote industrial application of MMT based ILs in the future.
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SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
·
2011
·Vol. 82
·期 1
·340-344
·
IF 1.77
Yong Xiang Wu,Jing Cao,Hai Yan Deng,Jun Xiang Feng
A novel fluoroionophore 1 based on 3,4-dimethylthieno[2,3-b]thiophene bearing two monoaza-15-crown-5 ethers at 3- and 4-positions was prepared. UV–vis and fluorescence responses of compound 1 upon the addition of alkali and alkaline earth metal cations were evaluated in acetonitrile solution. Receptor 1 showed unique response for Ba 2+ due to the formation of an intramolecular sandwich complex.
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高影响因子
危险品化学品经营许可证（带存储）