Foods
·
2022
·Vol. 11
·期 3
·450
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IF 5.561
Jiaxin Lu,Xiaojing Li,Chao Qiu,David Julian McClements,Aiquan Jiao,Jinpeng Wang,Zhengyu Jin
This study aimed to fabricate food-grade Pickering emulsions stabilized by chitosan-phytic acid-β-cyclodextrin (CS-PA-CD) nanoparticles. The CS-PA-CD nanoparticles were characterized with FITR, XRD, and TGA to prove its successfully crosslinking, then characterized by DLS system and scanning electron microscopy showing the smallest average particle size was 434.2 ± 2.5 nm and it increased with the ratio of PA-CD to CS increasing. Pickering emulsions stabilized by CS-PA-CD nanoparticles was prepared and it showed the best stability at around pH 6. The particle concentration higher than 1.0% (w/v) and the oil fraction above 0.5% (v/v) could reach the emulsion stability. In addition, the Pickering emulsions were stable at various temperature (30–70 °C) and influenced by the certain change of ionic strength (0–500 mM). These CS-PA-CD Pickering emulsions showed great application in the formation of functional foods and pharmaceutical industries.Keywords:chitosan/cyclodextrin;nanoparticles;Pickering emulsions;rheological properties;stability;phytic acid
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BIOMACROMOLECULES
·
2022
·
IF 6.978
Baoer Fan,Naifu Cui,Zhewei Xu,Kun Chen,Panchao Yin,Kan Yue,Wen Tang
Hospital-acquired infections are a serious threat to the recovery of patients. To prevent such infections, an antibacterial coating is an effective method to eliminate bacterial colonization on healthcare-related surfaces. Herein, we report an antibacterial hydrogel composed of silver-containing polyoxometalate (AgP5W30 POM) and carboxymethyl chitosan (CMC). The silver ion is encapsulated inside the POM cage and demonstrates long-lasting bacteriostasis after repeated exposure to both Gram-positive and Gram-negative bacteria. The chemical structure of chitosan derivatives, as well as the concentration and pH, is studied to tune the mechanical properties of the hydrogel. The hydrogel undergoes a gel–sol transition above the critical temperature and possesses self-healing ability. This hydrogel can be readily coated on the surface of versatile bulk materials, which is especially convenient for porous objects and resists the growth of Staphylococcus aureus, Escherichia coli, and methicillin-resistant S. aureus (MRSA). In summary, we envision that the AgP5W30-CMC hydrogel has great potential to serve as an antibacterial coating to decrease the prevalence of hospital-acquired infections.
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Reaction Kinetics Mechanisms and Catalysis
·
2022
·Vol. 135
·期 1
·425-439
·
IF 1.843
Bai Maojuan,Niu Deli,Xia Liquan,Yin Yajie,Wan Jun
In this study, chitosan biochar was prepared by one-step pyrolysis of chitosan and used to activate persulfate to remove phenol with high salinity wastewater. Chitosan biochar was characterized by scanning electron microscope, energy-dispersive spectroscopy, X-ray photoelectron spectroscopy and FTIR spectrum. The effect of chitosan biochar dosage, persulfate dosage, and pH on the phenol removal was explored and optimized. Meanwhile 98% phenol removal rate and 80% phenol mineralization rate were achieved under the optimum conditions. Phenol was successfully oxidized and degraded into water, carbon dioxide and other small molecular organics. The system was different from the general persulfate advanced oxidation system, sulfate radical played a minor role, singlet oxygen played a major role. The leading role of non-radical 1 O 2 in degradation was determined by radical quenching experiments and ESR experiments. By simulating high salt wastewater and studying the effect of common anions and cations on the system, system's stability was also investigated.
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INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
·
2022
·
IF 8.025
Jianbo Zhao,Haixin Jiang,Qiuyu Huang,Jingting Xu,Mengxia Duan,Shan Yu,Zijian Zhi,Jie Pang,Chunhua Wu
Advanced carboxymethyl chitosan (CMCS) based functional films were fabricated by involving some amounts of gliadin/phlorotannin nanoparticles (GPNPs) using a solution casting method. GPNPs were synthesized by an antisolvent precipitation approach, and they presented a spherical morphology with a mean diameter of 145.30 ± 2.06 nm. The effect of GPNPs concentration on the structural, physical, antioxidant and antimicrobial properties of CMCS-GPNPs (C-G) functional films was evaluated. It was found that the added GPNPs were homogeneously distributed over the whole CMCS matrix, allowing to reduce the free volume of the nanocomposite matrix and subsequently improve the physical properties of the final film (evidenced by mechanical and water barrier properties). FT-IR spectra indicated the intermolecular interactions, such as hydrogen bonds and electrostatic interaction, within the matrix of the nanocomposite films were increased. Impressively, the anti-ultraviolet properties, antioxidant activity and antimicrobial behaviors of the as-formed C-G functional films were greatly enhanced compared to the pure CMCS film. All these results suggested that our as-prepared C-G nanocomposite films could be a promising food packaging material.
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SCIENCE OF THE TOTAL ENVIRONMENT
·
2023
·
IF 9.8
Wenxin Song,Zhimin Gao,Chengsi Hou,Xiaoxiang Cheng,Jinchuan Lian,Tao Yang,Zhiwei Zhou,Daoji Wu,Heng Liang
Ultrafiltration (UF) is extensively used for algae removal because of its ability to retain algal cells with high efficiency, but it still faces the problem of membrane fouling and low retention capacity of dissolved organics. Hence, a strategy of coagulation with chitosan quaternary ammonium salt (HTCC) enhanced by sodium percarbonate (SPC) pre-oxidation was proposed to improve the UF performance. The fouling resistances were calculated by a resistance-in-series model based on Darcy's formula, and the membrane fouling mechanism was evaluated using a pore plugging-cake filtration model. The effect of SPC-HTCC treatment on the properties of algal foulants was explored, and the result showed that the water quality was improved with the maximum removal rates of 78.8 %, 52.4 % and 79.5 % for algal cells, dissolved organic carbon and turbidity , respectively. The SPC could achieve a mild oxidation effect that degraded the electronegative organics attached to algal cells without destroying the cell integrity, making the algal pollutants easier to agglomerate through subsequent HTCC coagulation by forming larger flocs. In terms of membrane filtration, the terminal normalized flux was increased from 0.25 to 0.71, with the reversible and irreversible resistances reduced by 90.8 % and 40.2 %, individually. The synergistic treatment reduced the accumulation of algal cells and algae-derived organics on the membrane surface as inferred from the interface fouling characteristics. The interfacial free energy analysis showed that the synergistic treatment reduced the adhesion of contaminants to the membrane surface, as well as the attraction among pollutants. Overall, the proposed process has high application prospects for algae-laden water purification .
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Carbon Letters
·
2023
·
IF 4.5
Li Guochun,Li Jiaxin,Yang Ziyu
This study reports the synthesis of a novel graphene/chitosan/β-cyclodextrin composite material (GO/CS/β-CD) via a one-step chemical reduction method, which combines the advantages of graphene, chitosan, and β-cyclodextrin. The morphology and structure of the composite were characterized using various techniques, such as scanning electron microscopy (SEM), Fourier transform infrared spectroscopy (FTIR), and Raman spectroscopy. Subsequently, sortase A (SA) was immobilized onto the GO/CS/β-CD for the detection of Staphylococcus aureus . The sensor exhibited a good linear relationship within the concentration range of 30–300 CFU/mL, with a detection limit of 12 CFU/mL. The GO/CS/β-CD composite material showed enhanced properties due to the synergistic effect of graphene, chitosan, and β-cyclodextrin. The immobilization of sortase A onto the composite material improved the sensitivity and selectivity of the sensor for the detection of S. aureus . This study presents a novel graphene/chitosan/β-cyclodextrin composite material with immobilized sortase A, demonstrating enhanced sensitivity and selectivity for the detection of Staphylococcus aureus, which has potential for the development of high-performance sensors in various fields.
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MACROMOLECULAR MATERIALS AND ENGINEERING
·
2023
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IF 3.9
Mengfan Zhang,Xiaotong Peng,Yansheng Huang,Kai Li,Jing Zhang,Pu Xiao,Yingshan Zhou
3D printing is an attractive method to accurately construct artificial organs or alternative materials with complicated structures and functional performance. Naturally derived hydrogels have emerged as promising materials for the preparation of biomimetic 3D organization or scaffolds by 3D printing due to their good biocompatibility, high water content, and fascinating 3D network. However, the poor printing properties and weak structural stability of naturally derived hydrogels limit their applications. In this study, photopolymerizable hydrogels are designed based on maleic chitosan (MCS) and thiolated sodium hyaluronate (SHHA). The Michael addition between MCS and SHHA improves the viscosity of the mixed solution. Moreover, it benefits the 3D printing process, followed by photopolymerization (acrylate-thiol step-chain polymerization and acrylate–acrylate chain polymerization) to form a stable covalent network rapidly. The rheological property, swelling behaviors, microstructure, and in vitro degradation are tuned by adjusting the molar ratio of the thiol group and acrylate group. In addition, MCS/SHHA hydrogel scaffolds with good accuracy and enhanced structural stability are prepared using extrusion-based 3D printing and photopolymerization technology. The hydrogels display excellent cytocompatibility and can support adherence of L929 cells, which can be used as prospective materials for tissue engineering applications.
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CARBOHYDRATE POLYMERS
·
2023
·
IF 11.2
Jiaqi Wang,Yuanhang Li,Xiaotong Li,Jiangbo Pan,Di Wang,Shuangying Wei,Chengyu Wang,Jian Li
Biological macromolecules had been studied as ligands in recent years, which not only give the complexes excellent polymer properties, but also have many advantages such as biodegradability. Carboxymethyl chitosan (CMCh) is excellent biological macromolecular ligand because of its abundant active amino and carboxyl groups, and it can smoothly transfer energy to Ln 3+ after coordinating. To further study the energy transfer mechanism of CMCh-Ln 3+ complexes, CMCh-Eu 3+ /Tb 3+ complexes with different Eu 3+ /Tb 3+ ratios were prepared by using CMCh as a ligand. The morphology, structure, and properties of CMCh-Eu 3+ /Tb 3+ were characterized and analyzed by infrared spectroscopy, XPS, TG and Judd-Ofelt theory, thus the chemical structure of CMCh-Eu 3+ /Tb 3+ was determined. The mechanism of energy transfer was explained in detail, also the Förster resonance transfer model is confirmed, and the hypothesis of energy transfer back was verified by the characterization and calculation methods of fluorescence spectra, UV spectra, phosphorescence spectra and fluorescence lifetime. Finally, CMCh-Eu 3+ /Tb 3+ with different molar ratios were used to prepare a series of multicolor LED lamps, and it extends the application range of biological macromolecules as ligands.
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CERAMICS INTERNATIONAL
·
2023
·
IF 5.2
Xiuqiong Chen,Hongcai Wang,Xiuying Sun,Yanan Bu,Huiqiong Yan,Qiang Lin
Ceramic nanoparticles , hydroxyapatite (HAP) and titania (TiO 2 ) nanoparticles were commonly used as the reinforcing agent for biological materials due to their high chemical stability, low toxicity, outstanding biocompatibility and good bioactivity, which will be beneficial to enhance the physical, chemical and biological properties of composite hydrogels. To fundamentally improve the bio-applicability of alginate hydrogels, we attempted to fabricate titania/hydroxyapatite-promoted biomimetic alginate-chitosan-gelatin (Alg/TiO 2 /HAP-CS-GT) composite hydrogels by physical blending method using HAP nanoparticles as both the reinforcing agent and the endogenous cross-linking agent, followed by surface modification through alternately electrostatic assembly of chitosan (CS) and gelatin (GT). Meanwhile, the effects of the addition of TiO 2 nanoparticles on the pore structure , mechanical properties , swelling, biodegradability, biological mineralization ability and biological activity of Alg/TiO 2 /HAP-CS-GT composite hydrogels were mainly studied. Experimental results showed that the resultant Alg/TiO 2 /HAP-CS-GT composite hydrogels exhibited good 3D morphology with the porosity in the range of 86.90%–77.62% and pore size ranging from 210 μm to 90 μm. Moreover, the compressive strength and modulus of Alg/TiO 2 /HAP-CS-GT composite hydrogels were significantly improved with increasing of TiO 2 nanoparticles content and reached up to 0.329 ± 0.012 MPa and 0.558 ± 0.035 MPa, respectively. Fourier transform infrared spectroscopy (FT-IR), X-ray diffraction (XRD) and thermogravimetric analyses (TGA) implied that the interfacial interaction between TiO 2 nanoparticles and polymer in Alg/TiO 2 /HAP-CS-GT composite hydrogels was inferred to be the hydrogen bond interaction. Furthermore, the addition of TiO 2 nanoparticles could effectively regulate the swelling, in vitro biodegradation and biomineralization , and biological activity of the composite hydrogels. In particular, Alg/TiO 2 /HAP-CS-GT composite hydrogels could exhibit good cell adhesion and cell proliferation activity. When the addition amount of TiO 2 nanoparticles was 1.0% (w/v), Alg/TiO 2 /HAP-CS-GT composite hydrogels exhibited the highest cell proliferation activity. In addition, with increasing of TiO 2 content, the relative alkaline phosphatase (ALP) activity of cells on the Alg/TiO 2 /HAP-CS-GT composite hydrogels gradually increased, indicating that the addition of TiO 2 nanoparticles could also effectively promote cell differentiation. On account of these excellent physical, chemical and biological activities of Alg/TiO 2 /HAP-CS-GT composite hydrogels, they were expected to be applied in the field of tissue engineering.
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INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
·
2023
·
IF 8.2
Tenghe Zhang,Yingying Guo,Yu Chen,Xu Peng,Sara Toufouki,Shun Yao
A quaternized chitosan (QCS)@poly(ionic liquid) (PIL) hydrogel adhesive was prepared by in-situ ultraviolet (UV)-induced copolymerization of 1-vinyl-3-butyl imidazolium bromide ([BVIm][Br]) and methacryloyloxyethyl trimethylammonium chloride (DMC) in QCS aqueous solution without using any crosslinkers, which was stably crosslinked by reversible hydrogen bonding together with ion association and exhibited excellent adhesion, plasticity, conductivity and recyclability properties. Moreover, its thermal/pH-responsive behaviors and intermolecular interaction mechanism of thermal-triggered reversible adhesion were discovered, meanwhile good biocompatibility, antibacterial properties, repeated stickiness and degradability were also proved. The results showed that the newly developed hydrogel could make various tissues, organic, inorganic or metal materials adhered tightly within 1 min; after 10 binding-peeling cycles, the adhesive strength to glass, plastic, aluminum and porcine skin still remained beyond 96 %, 98 %, 92 % and 71 % of the original, respectively. The adhesion mechanism involves ion dipole interaction, electrostatic interaction, hydrophobic interaction, coordination, cation-π interaction, H-bonding and van der Waals force. For above merits, the new tricomponent hydrogel is expected to be applied in biomedical field to achieve adjustable adhesion and on-demand peeling.
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ACS Applied Materials & Interfaces
·
2023
·
IF 9.5
Xueyu Jiang,Fanwei Zeng,Lina Zhang,Aixi Yu,Ang Lu
Trade-off of high-strength and dynamic crosslinking of hydrogels remains an enormous challenge. Motivated by the self-healing property of biological tissues, the strategy of combining multiple dynamic bond mechanisms and a polysaccharide network is proposed to fabricate biomimetic hydrogels with sufficient mechanical strength, injectability, biodegradability, and self-healing property for bone reconstruction engineering. Stable acylhydrazone bonds endowed hydrogels with robust mechanical strength (>10 kPa). The integration of dynamic imine bonds and acylhydrazone bonds optimized the reversible characteristic to protect the cell during the injection and mimicked ECM microenvironment for cell differentiation as well as rapid adapting bone defect area. Furthermore, due to the slow enzymatic hydrolysis kinetics of chitosan and the self-healing properties of resulting networks, hydrogels exhibited a satisfactory biodegradation period (>8 weeks) that highly matches with bone regeneration. Additionally, rBMSC-laden hydrogels exhibited splendid osteogenic induction and bone reconstruction without prefabrication scaffolds and incubation, demonstrating tremendous potential for clinical application. This work proposes an efficient strategy for the construction of a low-cost multifunctional hydrogel, making polysaccharide-based hydrogels as the optimal carrier for enabling cellular functions in bone repair.
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CARBOHYDRATE POLYMERS
·
2023
·
IF 11.2
Jianqun Wang,Wenxia Xu,Wenxuan Zhang,Junlong Da,Lixue Liu,Xiaowei Huang,Chubo Yang,Yuanbo Zhan,Han Jin,Ying Li,Bin Zhang
Hydrogels are widely used as wound dressings for wound healing, but when hydrogels absorb wound exudate, swelling occurs and compresses the surrounding tissue, affecting healing. A chitosan injectable (CS/4-PA/CAT) hydrogel based on catechol and 4-glutenoic acid was prepared to avoid swelling and promote wound healing. After cross-linking by UV light, pentenyl groups formed hydrophobic alkyl chains which give the hydrogel a hydrophobic network and thus control its swelling. CS/4-PA/CAT hydrogels retained their non-swelling for a long time in PBS solution at 37 °C. CS/4-PA/CAT hydrogels had good injectable and adhesive properties, and had a good killing effect on E. coli and S. aureus and could remove the bacterial biofilms of E. coli and S. aureus . CS/4-PA/CAT hydrogels had good in vitro coagulation function by absorbing red blood cells and platelets. When used in a whole skin injury model, CS/4-PA/CAT-1 hydrogel stimulated fibroblast migration, promoted epithelialization and accelerated collagen deposition to promote defect healing, and showed good hemostatic effects in liver and femoral artery defects in mice. In summary, the non-swelling injectable hydrogel with free radical scavenging, rapid hemostasis, and antibacterial effects would be a promising treatment for defect repair.
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