DALTON TRANSACTIONS
·
2025
·
IF 3.3
Yuan Xu,Ya-Tao Hu,Jiaping Cao,Dixin Lin,Qiqi Zhong,Yi Wang,Hongdong Shi,Qianling Zhang
To address the challenges associated with low cellular uptake efficiency of metal-based anticancer agents and the suboptimal therapeutic efficacy of photodynamic therapy (PDT), a series of polypyridyl ruthenium(II) complexes (Ru Cn) with tunable carbon chain lengths were rationally designed and synthesized through the incorporation of fatty acid moieties, which confer enhanced lipid solubility and membrane-targeting capabilities. Among these, the octadecanoic acid-modified ruthenium complex (Ru-C18) exhibited superior anticancer activity. Cytotoxicity assays demonstrated that Ru-C18 displayed sub-molar cytotoxic potency under light irradiation. Co-localization studies confirmed its preferential accumulation in lysosomes after cellular internalization. Upon light activation, Ru-C18 efficiently generated singlet oxygen and induced hallmark features of pyroptosis, including plasma membrane blebbing, cellular swelling, and Gasdermin-dependent membrane pore formation. Consequently, Ru-C18 significantly suppressed tumor cell proliferation via activation of the pyroptotic pathway. These findings offer new insights into the rational design of highly effective and selectively targeted photodynamic anticancer agents.
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高影响因子
Food Bioscience
·
2025
·
IF 5.9
Dan Wang,Xiao-Tong Zhai,Na-Na Wu,Jun Li,Ming Zhao,Na Zhang,Bin Tan
The impact of solid-state fermentation by Lactiplantibacillus plantarum CICC 21793 and Lacticaseibacillus rhamnosus CICC 21773 on the structural and functional properties of rice bran dietary fiber (DF) was investigated. Optimal extraction conditions for soluble dietary fiber (SDF) were determined through single-factor and orthogonal tests, achieving a maximum yield of 12.05% for fermented SDF (SSDF). After fermentation, SSDF exhibited a rough, porous surface, whereas fermented insoluble dietary fiber (SIDF) displayed increased folds and concave contours. Although the spectral characteristics of DF remained largely unchanged, the monosaccharide composition was altered. The particle size of DF decreased, the crystal structure exhibited increased disorder, and thermal stability decreased as a result of fermentation. Furthermore, the physical and chemical properties of SIDF were improved as follows: water swelling capacity (2.48 mL/g), oil holding capacity (7.44 g/g), and water holding capacity (7.47 g/g). The adsorption properties of SSDF were improved as follows: cation exchange capacity (1237.74 mmol/g), cholesterol adsorption capacity was determined to be 3.61 mg/g under gastric conditions and 4.68 mg/g under intestinal conditions, nitrite ion adsorption capacity (3.38 mg/g). Both fermented SDF and IDF displayed enhanced antioxidant activity, adsorption properties, and effective hypolipidemic and hypoglycemic effects. Solid-state fermentation with Lactiplantibacillus plantarum CICC 21793 and Lacticaseibacillus rhamnosus CICC 21773 effectively modifies DF.
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CERAMICS INTERNATIONAL
·
2025
·
IF 5.6
Kaicheng Yao,Haoqiang Zhang,Rongze Ma,Yanni Lang,Dan Wu,Liang Xu,Aning Ma,Yongjin Li,Dacheng Zhou,Zhiguo Song,Yugeng Wen,Yong Yang,Jin Han,Jianbei Qiu
Upconversion luminescence (UCL) of chiral inorganic nanostructured composite material and their applications have been challenging. This paper reports a successful preparation of Er 3+ /Yb 3+ co-doped chiral inorganic nanostructured BiOCl/Zn composite material (D-BYE-Zn) using a hydrothermal method and subsequent air annealing. The D-BYE-Zn phosphor significantly increased the intensity of UCL compared with the Er 3+ , Yb 3+ co-doped achiral bismuth oxychloride phosphor (A-BYE) and chiral bismuth oxychloride phosphor (D-BYE). Our study suggests that free electron leaps from the Zn fraction onto BiOCl may be responsible for the enhanced UCL. In addition, the temperature sensitive behavior of the D-BYE-Zn phosphor has been evaluated using the thermally coupled levels (TCLs) and non-thermally coupled levels (NTCLs) of Er 3+ and the maximum relative sensitivities (S R ) obtained are 0.95 % K −1 and 1.65 %K −1 (323 K). Our work provides a new strategy for constructing rare-earth doped chiral inorganic nanostructured composite materials to realize UCL enhancement while promising a wide range of applications in light source temperature measurement.
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Journal of Environmental Sciences
·
2025
·
IF 6.3
Dong Liu,Xinlei Tao,Songkai Zhu,Fengjie Chen,Xiaoguang Wang,Ao Qian,Bolei Chen,Yong Liang
Water adsorption on carbon surface is common in humid environments and plays a significant role in interfacial redox processes. We report that water adsorption on hydrophobic carbon surface can lead to interfacial charge transfer. Under ambient air conditions, the adsorption of water facilitates the formation of hydrogen radicals and promotes interfacial reactions such as nitrate reduction. The 1 H solid-state nuclear magnetic resonance spectra and Raman spectra of hydrophobic carbon surface indicate that the initial stage of moisture adsorption is characterized by the formation of hydrogen bond network, followed by the adsorption of water molecules. Concurrently, it is observed that the concentration of reduction products on the carbon surface first increases and then stabilizes. We propose that the formation of hydrogen radicals and the progress of interfacial reduction reaction are related to the evolution of hydrogen bond network during water absorption. Using mass spectrometric detection of H 2 18 O in the product during water adsorption, a possible adsorption water favored interfacial reduction pathway was proposed. This research deepens the understanding of relationship between water adsorption and interfacial reactions, providing new insights into observed reduction reaction on surface of fine particles in the atmosphere.
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INORGANICA CHIMICA ACTA
·
2025
·
IF 3.2
Qian Sun,Lu Ren,Jing Wang,Kun Bai,Chang Liu,Yanqi Liu,Dawei Zhang
Coumarin-structured ( E )-7-(diethylamino)-3-(1-(2-(4-methylbenzo[ d ]thiazol-2- yl)hydrazono)ethyl)-2 H -chromen-2-one (HTM) was synthesized in two steps using N , N -diethylsalicylaldehyde, ethyl acetoacetate and 4-methyl-2-hydrazine-benzothiazole as raw materials. The HTM was characterized by FT-IR, 1 H NMR, 13 C NMR and HR-MS. It was found that the probe HTM has rapid and highly selective recognition ability for Cu 2+ in EtOH/H 2 O (1:1, v /v). The spectral characteristics of the probe HTM were investigated using fluorescence spectroscopy and ultraviolet-visible spectroscopy. The results showed that the binding of probe HTM to Cu 2+ produced a significant fluorescence quenching effect, and the influence of other metal ions was negligible. In visible light, when HTM interacts with Cu 2+ , the solution changes from yellow to orange as observed by the naked eye. Subsequently, the binding mechanism of the probe HTM to Cu 2+ was explored by Job's plot, 1 H NMR titration and DFT calculations, and it was found that they cooperated in a 1:1 manner. Linear equations for ultraviolet-visible and fluorescence intensities at different Cu concentrations were fitted, and the detection limits (LOD) were calculated to be 5.22 nM and 3.70 nM, respectively. Experimental studies on the recovery rates of standard additions indicated that the probe HTM could be used for the quantitative detection of Cu 2+ in actual water samples. The potential application of this probe in fingerprint detection was also investigated. In addition, the probe has been successfully applied to Cu 2+ monitoring in living cells.
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JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES
·
2025
·
IF 2.8
Xi Hu,Siye Gao,Hancong Wu,Qingyun He,Jianing Liu,Danyue Zhao,Zhenqiang Wu
This study developed an environmentally friendly method for extracting polyphenols and rubusoside from Rubus suavissimus leaves. Under optimal extraction conditions, the contents of polyphenol and rubusoside reached 91.89 ± 2.39 mg/g and 47.03 ± 1.45 mg/g, respectively. The extract was purified by twelve types of macroporous resins, among which the ADS-7 resin had the highest static adsorption and desorption capacities. Optimized purification parameters for ADS-7 resin were determined by static and dynamic adsorption-desorption experiments and found to be: loading flow rate, 3 BV/h; loading concentration, 10 mg/mL; loading volume, 24 BV; elution solvent, 80 % ( v /v) ethanol; elution speed, 3 BV/h; and elution volume, 20 BV. After purification, the content of polyphenols and rubusoside increased by 2.63 and 2.32 times, respectively. Kinetic and thermodynamic analyses revealed distinct adsorption mechanisms: polyphenols followed a pseudo-second-order model, whereas rubusoside followed a pseudo-first-order model; both exhibited spontaneous (ΔG < 0) and endothermic (ΔH > 0) physisorption. Ultrafiltration-assisted centrifugal fractionation combined with UPLC-ESI-qTOF-MS/MS identified eight potential α-glucosidase inhibitors, including quercetin, apigenin, rutin, ellagic acid, kaempferol-3-O-rutinoside, kaempferol, rubusoside, and steviol. Molecular docking simulations revealed the molecular interactions between these compounds and α-glucosidase. The enriched extract demonstrated enhanced bioactivity, with a 3.35-fold higher α-glucosidase inhibition, and its IC₅₀ values for DPPH and ABTS + radical scavenging decreased from 142.03 μg/mL to 88.45 μg/mL and from 197.63 μg/mL to 107.63 μg/mL, respectively. These results substantiate the effectiveness of the extraction-purification approach for producing R. suavissimus leaf extracts and suggest their potential application as functional hypoglycemic and antioxidant food ingredients.
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MICROCHEMICAL JOURNAL
·
2025
·
IF 5.1
Qian Bi,Hongmei Zhang,Han He,Qian Li,Baoting Dou
Doxorubicin (DOX) is a frequently prescribed chemotherapy medication for a range of cancers. It is essential to monitor the levels of doxorubicin in human biological fluids to ensure effective treatment. An efficient electrochemical sensor for amplified detection of DOX is developed in this work. The strand displacement reaction is initiated when the blocking probe, which attaches to the terminal toehold sequence of the immobilization probe, is released due to the selective recognition of DOX with the aptamer probe. The secondary toehold region is then available for hybridization with the methylene blue (MB)-labeled signal probe, causing the blocking probe to be displaced and activating the molecular machine. Consequently, the blocking probe is reused in a cyclical manner, with numerous signal probes being attached to the sensor surface, resulting in a significant increase in current for quantitative analysis. This technique successfully detected DOX in human serum samples with high selectivity and sensitivity, reaching a detection limit of 670 fM. The proposed research offers a novel approach to identifying various biomarkers, with the potential to significantly advance clinical diagnosis and drug research.
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CNS Neuroscience & Therapeutics
·
2025
·Vol. 31
·期 10
·e70634
·
IF 5
Xuan Xu,Sha‐Sha Fan,Jiang Li,Hao Wu,Junwen He,Yang He,Xiang‐Yu Meng,Yin Shen
This study's framework begins with large‐scale data integration, leveraging the ROSMAP cohort for multi‐omics discovery (genotyping, DNA methylation, transcriptomics, miRNA) and the ADNI cohort for validation. This data feeds into a comprehensive analytical pipeline where differential expression analysis and an ensemble of 10 machine learning algorithms identify robust mitochondrial biomarkers of AD risk and brain resilience. To explore their biological context, a ceRNA network is constructed, and the key findings are subjected to a rigorous two‐tiered validation: in vivo confirmation of gene expression in an AD mouse model, followed by in vitro functional assessment of mitochondrial health (ROS, membrane potential) in an H 2 O 2 ‐induced oxidative stress model in HT22 cells. This holistic discovery‐to‐validation workflow establishes a robust platform for identifying novel therapeutic targets and advancing our molecular understanding of AD.
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FOOD CHEMISTRY
·
2025
·
IF 9.8
Guoli Chang,Fei Zhang,Zihan Qin,Wenyan Hong,Degui He,Haixia Lu,Junli Zhu
Zhejiang rosy vinegar (ZRV), a popular condiment in southeastern China, has a flavor profile and bioactivity that are not yet fully understood. This study aimed to determine the flavor characteristics and functional properties of ZRV from different regions. Sensory evaluation and electronic nose analysis revealed regional flavor variations. GC–MS identified 80 volatile compounds, while GC-IMS detected 22 volatile compounds. OPLS-DA models identified 17 GC–MS and 8 GC-IMS biomarkers, predominantly including 9 esters, 4 alcohols, and 4 aldehydes. Based on the analysis of odor activity values, five characteristic flavors in ZRV were identified, including acetic acid, benzaldehyde, 3-methylbutyl acetate, phenethyl acetate, and 2,4,5-trimethyl-1,3-dioxolane. Non-volatile compounds such as polyphenols, flavonoids, tartaric acid, and amino acids (isoleucine, valine, and proline) significantly enhanced antioxidant activity. The research establishes a theoretical framework for improving ZRV quality control and brand identity by mapping regional flavor signatures and bioactive components.
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CHEMICAL ENGINEERING JOURNAL
·
2025
·
IF 13.2
Hongyan Lu,Ying Cheng,Xiangling Pu,Xingtao Zhao,Ruolan Li,Ruiqi Sun,Xiaoman Xie,Mingyue Wu,Shuo Zhang,Qiong Pan,Jin Chai
Simultaneously alleviating oxidative stress and remodeling inflammatory microenvironment holds great promise for treating inflammatory bowel disease (IBD). Nevertheless, the efficacy of conventional therapies remains limited by poor targeting, insufficient modulation of the inflammatory microenvironment and serious adverse effects. Here, inspired by the intrinsic biological properties of metal-curcumin (Cur) complexes, a nanozyme-mediated ion-exchange strategy was proposed to enhance the targeted therapeutic effect of Cur for IBD. Specifically, copper-doped mesoporous polydopamine nanoparticles (Cu-mPDA) with dual enzyme-like activities were served as drug carriers to encapsulate water-soluble zinc-curcumin (Zn-Cur) and further modified with hyaluronic acid (HA), yielding Zn-Cur/Cu-mPDA@HA. Encouragingly, Zn-Cur/Cu-mPDA@HA could degrade in inflammatory microenvironment, releasing Zn-Cur and Cu 2+ , which subsequently in situ generate Cu-Cur with high antioxidant activity by ion-exchange reaction. Notably, Zn-Cur/Cu-mPDA@HA not only exhibited favorable targeting specificity toward M1 macrophages in inflamed colon tissues, but also displayed enhanced abilities to scavenge ROS, inhibit pro-inflammatory factors secretion and promote macrophages repolarization from the pro-inflammatory M1 state to the anti-inflammatory M2 subtype. Mechanistically, Zn-Cur/Cu-mPDA@HA suppressed the TLR4/MyD88/NF-κB pathway, breaking the inflammation-free radical vicious cycle, thereby attenuating chronic inflammation and fostering a favorable microenvironment for intestinal barrier restoration. Such a nanozyme-mediated ion-exchange and in situ drug generation strategy offers a new insight for designing nanomedicines for the treatment of IBD and other inflammatory diseases.
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Nature Communications
·
2025
·Vol. 16
·期 1
·1-24
·
IF 15.7
Zheng Liu-Ting,Yan Zeng-Shuai,Li Xin-Yue,Chang Jia-Jia,Tan Xiao-Qi,Wang Yu-Xing,Ding Hong-Ming,Liu Qin,Ma Yu-Qiang,Huo Da
Membraneless organelles form by phase separation and regulate cell behavior. We show that cholesterol-patterned AuNPs program nanomaterial-induced stress granules (NSGs) by lowering G3BP1 condensation barriers through a solid–liquid–liquid triphasic sequence: nanomaterials recruit hnRNPC, which then engages G3BP1 to nucleate gel-like condensates. We map NSG microenvironments (temperature, polarity, pH, and proteasome activity), uncover dual disassembly—a slow VCP/19S-dependent route and a rapid SUMO/20S-dependent backup—and show that NSGs remodel chemo-plasticity: they mitigate doxorubicin/cisplatin toxicity in normal tissues yet sensitize tumors to nocodazole in vivo. Local induction and selective dissolution of NSGs thus offers a strategy to decouple efficacy from toxicity. Our results establish design rules linking nanomaterial surface chemistry to condensate programming and provide actionable levers to steer therapeutic outcomes.
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APPLIED SURFACE SCIENCE
·
2025
·
IF 6.9
Dongyun Que,Zihan Li,Fan Chen,Youwei Zeng,Junchi Liu,Yuyuan Yao
Designing highly efficient iron-based catalysts with adsorption and degradation of pollutants is a great challenge in the field of environmental remediation. Herein, a dual strategy of anchoring-separation was adopted to prepare novel iron-based nitrogen doped porous carbon catalysts (Fe-pNC). Arginine was innovatively selected as the anchoring agent to coordinate with Fe 3+ and even form oligomers with glucose, which was conducive to the dispersion of iron species during high-temperature pyrolysis. Fe-pNC achieved high iron loading of 16.48 wt% and large specific surface area of 480.19 m 2 /g. The Freundlich model determined a maximum SMX adsorption capacity (Qm) of 82.38 mg/g for Fe-pNC, surpassing most of recently reported SMX adsorbents. Interestingly, even after multiple PMS regenerations, Fe-pNC still exhibited excellent adsorption performance. Surprisingly, Fe-pNC exhibited better adsorption performance at low temperature, achieving 90.58 % adsorption rate at 0 °C. More importantly, the Fe-pNC/PMS system achieved 99.11 % SMX removal in 15 min with a superior apparent rate constant (k obs ) of 0.54 min −1 . Of particular significance, Cl − markedly enhanced the catalytic efficacy of the Fe-pNC for SMX removal, remarkably enhancing the catalytic degradation performance even at high concentrations. Quenching experiments combined with electron paramagnetic resonance (EPR) detections demonstrated that single-linear oxygen 1 O 2 ) and superoxide radicals (O 2 •− ) were the major reactive oxygen species (ROSs). This study provides a significant guidance into developing efficient iron-based catalysts for adsorption and removal of organic pollutants.
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