Nature Communications
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2026
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IF 15.7
Liu Yanhao,Zhao Wan,Zhao Yingming,Zhang Xiangxiang,Zhao Jingjing,Li Shubin,Ren Yongshuo,Han Xiaojun
Bottom-up construction of artificial cells helps elucidate the working mechanism of cells. Signal transduction from extracellular to intracellular artificial cells is essential for autonomous artificial cells. It remains highly challenging to reconstitute G protein-coupled receptor (GPCR) signaling pathways to regulate downstream metabolism in artificial cells. Here, we reconstitute β2-adrenergic receptor, Gs subunit α and adenylate cyclase V into artificial cell membranes to enable signal transduction from extracellular isoproterenol (ISO) to intracellular cAMP (visualization via Epac1-cAMP probes). cAMP production is ISO dose-dependent, with a maximum amplification fold of 22.45 ± 2.14. By encapsulating the glycogenolytic pathway, cAMP activates protein kinase A, triggering phosphorylation of phosphorylase kinase and glycogen phosphorylase to convert glycogen to glucose-1-phosphate (G-1-P). G-1-P is further converted to 6-phosphogluconolactone accompanying with NADPH. ISO stimulation induces G-1-P and NADPH generation, achieving progressive signal amplification. The successful reconstitution of GPCR-mediated signaling pathway in artificial cells paves the way for developing autonomous artificial cells.
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BIOMACROMOLECULES
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2026
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IF 5.4
Yunan Yuan,Jiaxuan Yang,Yijun Wu,Fujiang Li,Yan Rong,Huayu Tian,Chaoliang He
Chemo-immunotherapy has been an emerging synergistic strategy for melanoma treatment. However, major challenges still remain, including side effects of chemotherapeutic agents and insufficient efficacy of immunotherapy. In the present work, we designed a thermosensitive polypeptide hydrogel-based drug delivery system to achieve the codelivery of doxorubicin (DOX) and a Toll-like receptor (TLR)-9 agonist, CpG. The hydrogel system was engineered by incorporating cancer cell membrane enveloped hollow mesoporous silica loaded with DOX and the mPEG-ss-PEI/CpG nanocomplex, resulting in an enhanced therapeutic effect. Drug-loaded hydrogel system exhibited sustained drug release, enhanced immune cell activation, and induction of immunogenic cell death (ICD) of tumor cells. In vivo antitumor studies revealed that the drug-loaded hydrogel effectively inhibited tumor growth, and promoted expansion of CD8+ T cells and maturation of dendritic cells (DCs), facilitating favorable modulation of the tumor microenvironment. Hence, the developed drug-loaded hydrogel system has considerable potential as a platform for combinatorial chemo-immunotherapy in melanoma treatment.
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Advanced Fiber Materials
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2026
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IF 21.3
Zhong Yuanyuan,Ma Lijun,He Pengfei,Huang Liangkang,Lu Yuyan,Li Jianwei
Aerogels have emerged as ideal materials for extreme environments due to their excellent thermal insulation. However, conventional aerogels often suffer from poor mechanical properties, limited thermal stability, and inadequate breathability. Herein, a fluorinated polyimide (FPI) nanofibrous aerogel with ultralight weight, and high mechanical strength is constructed by moisture-assistant electrospinning for self-powered sensing. Due to the rapid phase transition of the charged jet through interaction between the fluorinated polyamic acid solution (FPAA) and water molecules, enabling the interweaving and cross-linking of nanofibers into a fluffy aerogel structure. Furthermore, the resulting FPI nanofibrous aerogels exhibit exceptional thermal insulation property with low thermal conductivity (0.045 W·m −1 ·K −1 ), super-hydrophobicity with water contact angle of 151° and superior moisture permeability of 10150 g/(m 2 ·24 h). Moreover, the FPI nanofibrous aerogels show excellent piezoelectric properties (up to 34 V), rendering them ideal candidates for next-generation wearable electronics, particularly in high-precision physiological signal monitoring applications. In addition, the speech recognition system was able to recognize everyday sentences with precise detection of pauses and intonations. This work presents a novel strategy for designing FPI-based nanofibrous aerogels, paving the way for their practical applications in thermal insulation and self-powered sensing under extreme environmental conditions. Graphical abstract
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Innovative Food Science & Emerging Technologies
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2026
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IF 6.8
Wenjuan Qu,Tongtong Shen,Cunshan Zhou,Haile Ma,Qunhui Jiang,Yicheng Huang
To achieve efficient lipoxygenase (LOX) inactivation, this study developed an innovative catalytic infrared (IR) method using natural gas as an alternative to conventional electric heating. The activity, deactivation kinetics, structure, and catalytic kinetics of LOX were evaluated following IR treatment. Molecular dynamics and docking simulations were employed to assess the inactivation effects of both thermal and radiation components. Both temperature and wavelength effects contributed significantly to LOX denaturation, with an inactivation rate of 95.83% after 9 min at 130 °C. This was evidenced by the disruption of hydrogen bonds and various interactions, the disordering of LOX's secondary structure, and a reduction in LOX-substrate binding energies. The deactivation kinetics followed a Weibull distribution. The catalytic reaction efficiency of LOX decreased 177-fold. The temperature effect was stronger than the wavelength effect. This study provides a quantified mechanism for LOX inactivation by IR, highlighting IR as a promising alternative to conventional methods, offering both energy savings and efficient enzyme deactivation.
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APPLIED CATALYSIS B-ENVIRONMENTAL
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2026
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IF 21.1
Yuqing Feng,Hongxia Liu,Yongxing Shang,Yingsen Fang,Shumei Gao,Ping Sun,Bitao Xiong,Hui Wang,Hui Liu,Mingbao Feng
Single-atom catalysts (SACs) are an effective strategy for maximizing the efficiency and reducing the costs of advanced oxidation processes (AOPs). Herein, a novel SAC with Fe−N 3 C sites was synthesized for emerging periodate (PI)-based AOPs. The optimized catalyst demonstrates superior performance, achieving 100 % removal of diclofenac (DCF) within 20 min via predominant singlet oxygen ( 1 O 2 ). Compared to the Fe−N 4 configuration, the Fe−N 3 C site enables an unprecedented 152.9-fold increase in the pollutant degradation rate, surpassing most reported catalysts. Density functional theory (DFT) calculations reveal that the Fe−N 3 C sites reduce the oxophilicity of the Fe centers, thereby lowering the energy barrier for 1 O 2 desorption and promoting its preferential generation. The DCF degradation pathway was further elucidated by Fukui constants. Furthermore, the Fe−N 3 C/PI system exhibits excellent stability with negligible leaching of Fe ions and strong resistance to common wastewater components. This work provides new insights into the design of efficient SACs and the construction of PI-based AOPs for water decontamination.
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Journal of Environmental Chemical Engineering
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2026
·Vol. 14
·期 2
·121264
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IF 7.2
Chun Wang,Jialin Wei,Zhiyuan Qiao,Jingwen Chu,Feng Xu,Yang Ye,Haolong Xue,Dawei Ji,Jingjing Yan,Changfa Xiao
This study fabricated a thermally self-cleaning nanofiltration membrane through molecular design and multi-scale assembly. PNIPAM-PEI microgels, synthesized by grafting PNIPAM and PEI, were deposited on a PPTA ultrafiltration substrate via layer-by-layer self-assembly. The deposition cycles were systematically optimized, followed by interfacial polymerization to form a polyamide separation layer. Characterization confirmed that five deposition cycles yielded a compact thermo-responsive intermediate layer and resulted in an interpenetrating [PEMs-PNIPAM]-PA structure. The resultant composite NF membrane exhibited excellent separation performance, with rejections of CaCl 2 and MgSO 4 reaching 97.3 % and 98.7 %, respectively, at 25 ℃, along with intelligent thermo-responsive behavior. When heated above the LCST, dehydration and contraction of the PNIPAM core drove the expansion of PA layer pores, activating a “pore expansion” self-cleaning mechanism, with full structural regeneration upon cooling. A 180-hour long-term test verified that high-temperature backwashing at 60 ℃ effectively restored the flux and retention of the fouled membrane. This work offers a new strategy for developing smart nanofiltration membranes with self-cleaning capability.
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CHEMICAL ENGINEERING JOURNAL
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2026
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IF 13.2
Jiujing Xu,Cheng Chen,Zhiyu Zhao,Leihong Zhao,Wei Yu,Liguo Shen,Hongjun Lin
Nanofiltration (NF) membranes are crucial for dye desalination, yet their performance is often constrained by the inherent trade-off between water permeance and dye/salt selectivity. Achieving high permeance without sacrificing effective dye–salt separation remains a critical challenge. Herein, we present fumaryl chloride (FC), a linear and flexible aliphatic acyl chloride, as an alternative to trimesoyl chloride (TMC) for interfacial polymerization with piperazine (PIP) to address this challenge. Owing to its lower reactivity yet higher diffusion coefficient, FC enables the formation of a thinner, smoother, and less densely packed polyamide selective layer. Structural analyses indicate that the linear configuration of FC facilitates the assembly of loosely packed polymer chains. This architecture accelerates water transport while preserving effective dye/salt selectivity. The resulting FC-PIP membrane achieves a high water permeance of 104.6 L m −2 h −2 bar −1 and a DR80/Na 2 SO 4 selectivity of 118.3, which is 22.9 times higher than that of the conventional TMC-PIP membrane. This work provides a molecular-level strategy for designing NF membranes for dye desalination with balanced permeability and selectivity.
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Journal of Science-Advanced Materials and Devices
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2026
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IF 6.8
Huan Xie,Shaoyun Chen,Bo Qu,Xiaoying Liu,Wenjie Li,Rui Wang,Linxi Hou,Dongxian Zhuo
In recent years, light-curing 3D printing technology has been extensively adopted across various fields due to its advantages, including high precision and efficiency. As the key material in this technology, the properties of photosensitive resin directly influence the mechanical strength, thermal stability, and functional characteristics of the printed parts. Bismaleimide (BMI) resin exhibits excellent heat resistance, dielectric properties, and mechanical strength. However, its inherent brittleness and poor processability have limited its application in 3D printing. To address these challenges, this study synthesized a BAG oligomer containing flexible siloxane segments and photosensitive groups via a Michael addition reaction. This oligomer was incorporated into a photosensitive resin system to develop a novel BMI resin tailored for light-curing 3D printing. The effects of varying BAG content on the resin’s rheological behavior, 3D printing compatibility, mechanical performance, thermal stability, dynamic thermomechanical properties, water absorption, and dielectric characteristics were systematically investigated. The results demonstrated that at a BAG oligomer content of 10 wt%, the resin achieved optimal overall performance, with tensile strength and flexural strength reaching 56.9 MPa and 148.8 MPa, respectively. Additionally, impact strength increased continuously with higher BAG content, peaking at 11.5 kJ/m 2 . The maximum decomposition temperature (T max) rose to 421.4°C, accompanied by a notable increase in char residue. Dynamic mechanical analysis indicated an increase in storage modulus to 1704.5 MPa and cross-linking density, although the glass transition temperature (T g ) experienced a slight decline. While the addition of BAG marginally elevated the dielectric constant (D k ), it significantly reduced dielectric loss (D f ) to 0.010, underscoring favorable dielectric properties. In summary, this work develops and validates a BMI-based photosensitive resin that simultaneously meets the critical requirements for printability, mechanical performance, thermal stability, and dielectric properties, presenting a formulation with practical potential for broadening the use of BMI in light-curing 3D printing.
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COLLOIDS AND SURFACES B-BIOINTERFACES
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2026
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IF 5.6
Dechan Lu,Xiaoqi Zhou,Dandan Su,Jundong Li,Huizhen Lin,Rongmao Qiu
Abnormal serum creatinine levels are a key clinical biomarker for kidney dysfunction, making its accurate monitoring essential for early diagnosis and prevention. Current commercial kits based on the creatine kinase method are often affected by matrix interference, limiting their reliability in clinical settings. To address this issue, we developed a pH- assisted ratiometric surface-enhanced Raman scattering (SERS) approach for precise creatinine detection in biological samples. We synthesized core-shell nanoparticles (Au@MPA@Ag NPs) with 3-mercaptopropionic acid (MPA) as the internal standard. Under optimized alkaline conditions (pH = 9), the adsorption of creatinine onto the substrate was significantly enhanced, leading to a strong and reproducible SERS response. Moreover, the internal standard-calibrated Raman intensity exhibited a strong linear correlation with creatinine concentration, achieving the limit of detection as 3.3 μM. As a proof of concept, this method was successfully applied to quantify creatinine in human serum. The recovery rates ranged from 98% to 107%, demonstrating high consistency with results obtained using a commercial creatinine assay kit. This method provides a clinically accurate and reliable for creatinine monitoring, offering strong potential for point-of-care testing.
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CHEMICAL ENGINEERING JOURNAL
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2026
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IF 13.2
Chenyang Wang,Hou-Yong Yu,Somia Yassin Hussain Abdalkarim,Meijin Jin,Xiaohua Wang,Zengwen Yao,Dengteng Ge,Cheng Zeng,Shengjian Wang,Haojie Zang
Polyamide 612 (PA612) naturally shows hydrophilicity, limited UV resistance, and poor antibacterial performance, which restricts its use in advanced applications. To overcome these limitations, aldehyde-functionalized CNC was first prepared via sodium periodate (NaIO 4 ) oxidation, followed by the fabrication of a fully bio-based nanoparticle (CNC@PDA/CO) through a gradient self-polymerization strategy, which was subsequently incorporated into PA612 using a facile solution-casting process. Interestingly, with only 3 wt% nanoparticle content, the composites achieved a 1687% increase in ultraviolet protection factor (UPF), a water contact angle of 114.1°, and antibacterial zones of 4.3 mm and 4.2 mm against Escherichia coli and Staphylococcus aureus , respectively. These impressive multifunctional improvements result from strong interfacial interactions driven by covalent bonds and hydrogen-bond networks through Schiff base and Michael addition reactions. This work offers a scalable, sustainable, and high-performance method for developing bio-based PA612 composites, showing great potential for next-generation high-barrier and antimicrobial packaging materials.
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Heliyon
·
2024
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IF 3.4
Jianhua Cui,Songting Yu,Man Xu,Juncheng Ma,Wenjuan Cui,Xueying Cao,Qingshan He,Wenxiao Luo,Haiyun Huang,Xiaomei Lin
This article has been retracted: please see Elsevier policy on article withdrawal ( https://www.elsevier.com/about/policies-and-standards/article-withdrawal ). This article has been retracted at the request of the Editor. Post-publication, an investigation conducted by Elsevier's Research Integrity & Publishing Ethics team on behalf of the journal identified references that are irrelevant to the article. The authors were asked to comment upon the presence of these references in their work but were unable to satisfactorily address the reason for the references. Consequently, the Editor no longer has confidence in the integrity and the findings of the article and has decided to retract it. The scientific community takes a very strong view on this matter and apologies are offered to readers of the journal that this was not detected during the submission process. The authors have not responded to the retraction notice.
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Health Policy and Technology
·
2021
·Vol. 10
·期 2
·100522
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IF 1.931
Zhun Xiang,Han Liu,Xuecheng Gao,Qianying Jin,Kun Qiao,Xingming Li,Xinran Qi,Hanlin Zhang,Keyun Tang
Objectives To understand the public's awareness of patient safety and willingness to participate, and to provide references for national medical institutions to carry out patient safety education and formulate patient safety management measures. This study aimed to investigate public recognition of patient safety and willingness to safety reporting and to provide references for national medical institutions to carry out patient safety education and formulate patient safety management measures with evidence-based information on construction, management, and patient-education of the reporting system of patient safety. Methods Information including demographic characteristics, recognition of patient safety, comments on the Patient for Patient Safety program, comments on the spontaneous reports, and willingness to participate in spontaneous reports were collected by questionnaire and were presented in descriptive analysis. The chi-square test was used to analyze the association between the subjects’ willingness to participate in the patient safety report and related factors. The impact of these associated factors on the willingness to participate in the patient safety report was evaluated and were analyzed using Ordinal Logistic Regression. Odds ratios (OR) and 95% confidence intervals (CI) were reported. Results A total of 27,493 people were surveyed validly in this study, of which 56.8% (95%CI: 56.21%-57.39%) of the respondents expressed their willingness to participate in the report, and 40.3% (95%CI: 39.72%-40.88%) expressed their willingness under certain conditions Participating, only 2.9% (95%CI: 2.62%-3.18%) are unwilling to participate. The results of multiple logistic regression found that factors that promote increased reporting willingness include gender (answer "male" OR=1.129, 95%CI: 1.068-1.191), and patient safety understanding (answer "very well" OR=1.590, 95%) CI: 1.439-1.756), patient participation in the evaluation of the effect of improving patient safety (think "large" OR=1.966, 95% CI: 1.790-2.162), evaluation of the effect of patient safety voluntary reports (think "the effect will be great" OR =6.166,95%CI:5.376-7.071, considered "moderate" OR=2.286, 95%CI: 2.000-2.614); factors that reduce willingness to report include age (answer "below 20" OR=0.717,95% CI: 0.592-0.868); occupation (answer "medical staff" OR=0.741, 95%CI: 0.696-0.788); patient safety status evaluation (answer "general" OR=0.668, 95%CI: 0.523-0.852). Conclusions This study found that the public's recognition of patient safety and attitude towards safety reporting had significant effects on their willingness to participate in spontaneous reports. Pertinent measures, such as education of the public and construction of the reporting system, are expected to promote patient safety in China.
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危险品化学品经营许可证（带存储）