MACROMOLECULAR BIOSCIENCE
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2024
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IF 4.4
Xuanrong Sun,Yubei Gong,Ting Xie,Zixi Fu,Dongze Lu,Bin Wei,Yue Cai,Wenlong Yao,Jie Shen
Irinotecan hydrochloride (CPT-11) is one of the first-line drugs used in the clinical treatment of colorectal cancer (CRC). However, the concomitant adverse effect of delayed diarrhea has hindered its clinical use. CPT-11 combined with Thalidomide (THA) therapy is considered a palliative strategy. To optimize the synergistic treatment of CPT-11 and THA, co-loaded liposomes are constructed using cholesterol, lecithin, and 1, 2-Distearoyl-sn-glycero-3-phosphoethanolamine-Poly(ethylene glycol) (DSPE-PEG) as the “immune and gut microbiota regulator.” The co-loaded liposomes, which possess good stability, are prepared by the solvent injection method. After the treatment with the co-loaded liposomes, tumor growth in CRC-bearing mice is significantly inhibited. In particular, the co-loaded liposomes demonstrate favorable diarrhea-relieving effects through the modulation of inflammatory cytokines and gut microbiota. These findings suggest that the co-loaded liposomes have great potential as a combined drug-delivery platform for CRC therapy.
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高影响因子
JOURNAL OF COLLOID AND INTERFACE SCIENCE
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2024
·
IF 9.4
Jiayu Chao,Xiaoling Yang,Yihua Zhu,Jianhua Shen
Electro-Fenton is an effective process for degrading hard-to-degrade organic pollutants, such as tetracycline (TC). However, the degradation efficiency of this process is limited by the activity and stability of the cathode catalyst. Herein, a temperature gradient pyrolysis strategy and oxidation treatment is proposed to modulate the coordination environment to prepare oxygen-doped cobalt monoatomic electrocatalysts (CoNOC). The CoNOC catalysts can achieve the selectivity of 93 % for H 2 O 2 with an electron transfer number close to 2. In the H-cell, the prepared electrocatalysts can achieve more than 100 h of H 2 O 2 production with good stability and the yield of 1.41 mol g catalyst −1 h −1 with an average Faraday efficiency (FE) of more than 88 %. The calculations indicate that the epoxy groups play a crucial role in modulating the oxygen reduction pathway. The O doping and unique N coordination of Co single-atom active sites (CoN (Pd)3 N (Po)1 O 1 ) can effectively weaken the O 2 /OOH* interaction, thereby promoting the production of H 2 O 2 . Finally, the electro-Fenton system could achieve a TC degradation rate of 94.9 % for 120 min with a mineralization efficiency of 87.8 % for 180 min, which provides a reliable option for antibiotic treatment. The significant involvement of OH in the electro-Fenton process was confirmed, and the plausible mineralization pathway for TC was proposed.
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APPLIED CATALYSIS B-ENVIRONMENTAL
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2024
·
IF 20.2
Yihui Li,Ziang Zhao,Min Zhao,Hejun Zhu,Xinzheng Ma,Zheng Li,Wei Lu,Xingkun Chen,Linbin Ying,Ronghe Lin,Yu Meng,Yuan Lyu,Li Yan,Yunjie Ding
Promotional effects of oxygen vacancies of spinel catalysts in CO 2 hydrogenation are reported in early works, but the mechanistic origins remain elusive. Here, CoAl 2 O 4 spinels with varying numbers of oxygen vacancies are deliberately designed by a sol-gel method and different post-treatments. By combining catalytic testing, advanced electron microscopic and spectroscopic characterizations, and computational studies, the unusual oxygen vacancy-dependent catalytic behaviors are rationalized. Our work reveals that i) perfect spinel crystals possessing least oxygen vacancies can effectively constrain the Co 2+ species at working conditions that are less active but selective to CO; and ii) vacancy-rich spinels promote both H 2 and CO 2 activations and COOH* formation, explaining the higher hydrogenation activity, but overwhelming vacancies cause Co 2+ reduction and promote direct CO 2 * dissociation to CO* and deep hydrogenation to CH 4 . These molecular-level understandings reinforce the idea of proper design of oxygen vacancies to achieve activity-selectivity balance.
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CHEMICAL ENGINEERING SCIENCE
·
2024
·
IF 4.1
Changqu Lin,Lulu Xu,Yue Zhuang,Peipei Ma,Hongli Wu,Haifeng Gan,Fei Cao,Ping Wei
The cleavage of C-C bonds to generate small molecules is a pivotal strategy for integrating shell bio-refinery products into the conventional chemical industry. Herein, we synthesized a novel bifunctional acetylacetone molybdenum-based catalyst with oxygen vacancies and acid sites (Ov-Mo-acac), which catalyze the retro -aldol reaction of N -acetylglucosamine (NAG), consequently the condensation with acetylacetone and dehydration to co-produce furan and pyrrole compounds. Reaction optimization resulted in a remarkable yield of 95 % for N-acetyl-3-acetyl-2-methyl pyrrole (AMAP) and 74 % for 5-(1,2-dihydroxyethyl)-2-methyl-3-acetylfuran (DMAF) from NAG at 90 ℃ for 3 h. XPS, EPR, and Raman confirmed the reduction of molybdenum from the Mo 6+ to Mo 5+ and Mo 4+ , and oxygen vacancies on the surface. Furthermore, the catalyst has Lewis and Brønsted acidic sites, as evidenced by py-FTIR and 1 H MAS NMR. The study offers a new approach to utilizing shellfishery waste and sheds the function of oxygen vacancies on Mo-based catalysts for the retro -aldol reaction of carbohydrates.
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JOURNAL OF ALLOYS AND COMPOUNDS
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2018
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IF 3.779
Yunqing Pi,Peng Zhao,Lingjia Ma,Yangdan Cao,Huiqing Gao,Shuying Dong,Jianhui Sun
The Co(OH) 2 /reduced graphene oxide hybrids (Co(OH) 2 /rGO) was prepared and used as catalyst to enhanced heterogeneous activation of Oxone for the decomposition of Levofloxacin (LVF). The Co(OH) 2 /rGO composites with different Co(OH) 2 loading have been successfully synthesized, where the sample contain 20% Co(OH) 2 exhibited superior activation, attributing to the synergistic effect between Co(OH) 2 and rGO. Meanwhile, the effects of some important reaction parameters on the decomposition of LVF by Co(OH) 2 /rGO/Oxone process were investigated. The results indicated that the decomposition rate of LVF(>94.5%) was increased with the increasing of Oxone concentration, and 20% Co(OH) 2 /rGO dosage neutral pH. Moreover, the Co(OH) 2 /rGO catalyst showed high activity and stability during the repeated experiments.
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CHEMICAL ENGINEERING & TECHNOLOGY
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2018
·Vol. 41
·期 6
·1122-1131
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IF 1.588
Ziyi Zhao,Guijin Liu,Qing Lin,Yanbin Jiang
Paracetamol (PCA) and trimethylglycine (TMG) were co-crystallized and micronized by means of the supercritical anti-solvent (SAS) process to improve the tabletability of PCA. The effects of operating conditions on particle properties were investigated in detail. Characterizations were performed to confirm the co-crystal state of PCA-TMG. The results indicated that the same crystal form with different crystal habits was prepared. The optimal PCA-TMG co-crystals presented a much larger tensile strength, higher drug content of PCA, and smaller particle size than those obtained using the ball milling (BM) process. The SAS-processed PCA-TMG co-crystals showed an enhanced solubility, dissolution rate, and tableting performance compared to that of BM.
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RSC Advances
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2018
·Vol. 8
·期 3
·1378-1384
·
IF 2.936
Zhenzhen Wei,Zhijuan Pan,Faxue Li,Jianyong Yu
Tailoring the wetting properties of nanofibrous membranes and endowing them with expected wettability provides new ways in extending the application field of these materials. In this study, we first performed the in situ fabrication of poly(butylenes succinate-co-terephthalate) (PBST) composite nanofibrous membrane with cyclodextrin polymer (CDP) using a combination of electrospinning and heating processes. Then, the morphologies, crystallization and mechanical properties of the PBST composite membrane were investigated. It was found that the CDP was uniformly dispersed on the PBST nanofibers instead of merely covering the surface of the membrane. Moreover, the introduction of additives brought about a decreased crystallinity and tensile strength of the resultant membrane due to its restraining role in the crystallization of PBST. Furthermore, the wettability of the PBST composite membranes with various amounts of additives was explored and the evolution of water spread on top of the membranes was also recorded. The membrane became superhydrophilic from hydrophobic upon increasing the amount of additives and the water droplet could completely spread within 0.2 s, which was attributed to the enlarged roughness and increased contact area of CDP on the nanofibers. A comparison between the two fabrication methods used for PBST composite nanofibrous membranes is also presented and studies on the preparation and wetting properties may shed light on polymer composite membranes that exhibit potential application in more fields.
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INDUSTRIAL & ENGINEERING CHEMISTRY RESEARCH
·
2025
·
IF 3.9
Ziyi Wang,Changyan Guo,Kefu Wang,Jiang Li,Jide Wang
Upgrading waste PET to prepare metal–organic frameworks (MOF) through chemical recycling provides new ideas and methods for PET recycling treatment and high value-added conversion. In this paper, Cobalt-based metal–organic frameworks (Co-MOF) were prepared from PET by one-pot solvothermal method without adding acids or bases. The prepared Co-MOF was used as a heterogeneous catalyst to catalyze the selective oxidation of ethylbenzene (EB) for the preparation of acetophenone (AP). When only tert-butyl hydroperoxide (TBHP) was used as the oxidizing agent without any additional solvents, 89% EB conversion and 94% AP selectivity were achieved, respectively. Moreover, the catalyst showed excellent stability with no significant deactivation under 5 cycles. In addition, the synthesized Co-MOF-10 also exhibits impressive conversion rates of 96% and 93% in benzyl alcohol and styrene oxidation, respectively. Compared with the Co-MOF prepared by commercial terephthalic acid (BDC), the Co-MOF-10 synthesized via the one-pot method using PET exhibits enhanced cost-effectiveness, environmental sustainability, and superior catalytic performance. The present study establishes a foundation for the conversion of plastic PET into valuable MOF and its subsequent application in C–H bond oxidation.
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CHEMICAL ENGINEERING JOURNAL
·
2025
·
IF 13.2
Xu Feng,Xiangyu Gu,Guohui Xuan,Hao Wu,Songgeng Li
Microplastics (MPs), as an emerging pollutant, are widely distributed in water environments and pose considerable environmental and health threats due to their chemical inertness and the toxicity of attached substances. The development of high-efficient and facile adsorbents for MPs removal is of significance. Hence, this study proposed an innovative iron–nitrogen co-doped layered adsorbent derived from glucose via molten salt-assisted pyrolysis. The presence of molten salt promoted the formation of layered structures, providing micron-scale channels for the entrapment of MPs from water. Loading iron alone enhanced electrostatic adsorption between MPs and carbon materials; however, excessive dosage clogged the channel structure. This can be solved by co-doping nitrogen, which facilitated uniform iron dispersion. The co-doped layered adsorbent with iron loading at 1.43 % achieved a removal efficiency of 96.5 % and capacity of 148.39 mg·g −1 for polystyrene (PS) MPs amid low plastic concentration and adsorbent dosage. It also exhibited efficient removal for a wide pH range and high salinity solution, maintaining over 90 % efficiency after multiple cycles. Kinetic analysis revealed a combined physical and chemical adsorption mechanism. The molten salt-assisted synthesis combined with iron–nitrogen co-doping offers a promising, scalable solution for MPs pollution control, paving the way for the development of highly efficient and reusable adsorbents with enhanced performance in environmental remediation.
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Journal of Environmental Chemical Engineering
·
2024
·
IF 7.4
Fangcong Lin,Leiping Wang,Xiaorong Dai,Zun Man,Yang Meng,Dongtao Chu,Yuting Yang,Wei Wang,Hang Xiao,Kaiying Wang
Effective treatment of hydrogen sulfide (H 2 S) is crucial for minimizing nuisance odors from intensive livestock and poultry operations. The development of high-performance desulfurizers holds practical significance in this context. Herein, a novel CuO-CaCO 3 co-impregnated biochar desulfurizer (Cu x Ca y /BC T ) was synthesized by impregnation-pyrolysis method, using waste tea stalks and metal salts as raw materials, and it is intended for the treatment of H 2 S at room temperature. The optimized Cu 0.75 Ca 0.25 /BC 800 shows an excellent H 2 S removal capacity of 182.67 mg/g, which is 31 times and 5.6 times that of inactivated biochar (BC 800 ) and copper-oxide-impregnated biochar (Cu 0.75 /BC 800 ). The desulfurization mechanism of Cu 0.75 Ca 0.25 /BC 800 involves synergistic effect of reactive adsorption and catalytic oxidation . CaCO 3 ’s alkaline adsorption sites and copper-mediated activation of superoxide radicals (∙O 2 - ) were critical in this reaction. Besides, Cu 0.75 Ca 0.25 /BC 800 demonstrated excellent reusability, retaining approximately 85 % of its initial H 2 S removal capacity after seven cycles of desulfurization and regeneration. This study aims to develop a metal oxide- and carbonate-impregnated biochar-based desulfurizer, with the goal of advancing the technology for catalytic removal of H 2 S in a more environmentally friendly and effective manner.
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FOOD AND CHEMICAL TOXICOLOGY
·
2024
·
IF 3.9
Canyang Wang,Yanxin Liu,Yayu He,Juan Li,Yi Cao
Oral exposure to nanoparticles (NPs) may affect intestinal microbiota, and this effect may be further changed by co-contaminates. In the present study, we investigated the combined effects of TiO 2 NPs and fipronil (FPN) on microbiota in mouse intestines. Mice were intragastric exposed to 5.74 mg/kg TiO 2 NPs, 2.5 mg/kg FPN, or both of them, once a day, for 30 days. The results showed that individual exposure to TiO 2 NPs or FPN decreased body weight and induced pathological changes in intestines. The exposure was also associated with increased cleaved caspase-3 protein, oxidative stress and decreased tight junction protein expression. Furthermore, the levels of diamine oxidase (DAO), lipopolysaccharide (LPS) and inflammatory cytokines in serum were also elevated, indicating increased intestinal barrier permeability. As expected, both TiO 2 NPs and FPN decreased the diversity and altered the composition of microbiota. However, the observed effects were not further enhanced after the co-exposure to TiO 2 NPs and FPN, except that Romboutsia was only significantly increased after the co-exposure to TiO 2 NPs + FPN. We concluded that oral exposure to TiO 2 NPs and FPN showed minimal synergistic effects on microbiota in mouse intestine.
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INTERNATIONAL JOURNAL OF HYDROGEN ENERGY
·
2024
·
IF 8.1
Wen Liu,Furong Ye,Yahao Zhao,Peng Liu,Changcun Han,Meng-Dai Luoshan,Jiayi Tian,Zhengwang Cheng,Yizhong Huang
In the quest for effective photocatalysts for hydrogen production via photocatalytic water splitting, ZnIn 2 S 4 has garnered considerable attention due to its high photocatalytic hydrogen evolution capability. In this study, boron-doped ZnIn 2 S 4 was successfully synthesized via a hydrothermal method , with a small amount of cobalt phosphate (Co-Pi) decorated on its surface. The hydrogen evolution rate of boron-doped ZnIn 2 S 4 was determined to be 5.2 mmol g −1 h −1 , surpassing that of pure ZnIn 2 S 4 by 1.68 times. Moreover, with the addition of Co-Pi to boron-doped ZnIn 2 S 4 , the hydrogen production rate escalated to 29.7 mmol g −1 h −1 , which is 9.58 times higher compared to pure ZnIn 2 S 4 . UV–vis analysis revealed that boron doping introduced new energy levels into ZnIn 2 S 4 , effectively narrowing the bandgap and enhancing light absorption wavelength range. Furthermore, PL and XPS analyses indicate that Co-Pi effectively captures photogenerated holes (h + ) in ZnIn 2 S 4 , retaining photogenerated electrons and overcoming the disadvantage of electron-hole pair recombination in ZnIn 2 S 4 . The doping and loading of Co-Pi as a cocatalyst ultimately contribute to enhancing hydrogen production efficiency, thereby significantly improving the photocatalytic hydrogen evolution capability of ZnIn 2 S 4 . This study provides a scalable idea for designing composite catalysts in which doping and co-catalysts work together.
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