CHEMICAL ENGINEERING JOURNAL
·
2025
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IF 13.2
Chunxia Yao,Wei Song,Xuesheng Wang,Sai Huang,Yangyang Lu,Jiaxin Zhou,Weiguo Song,Zhijie Zhang
This study presents an innovative nanocomposite film with multiple synergistic sterilization modes, which aims to enhance the freshness of fruits and reduce wastage by capitalizing on the availability of sunlight. In detail, α-Fe 2 O 3 /g-C 3 N 4 (FOCN) nanocomposite with excellent visible-light-harvesting ability and photodynamic antibacterial activity was fabricated, which was then filled within a chitosan (CS) matrix, resulting in a novel antibacterial film for food preservation. The obtained α-Fe 2 O 3 /g-C 3 N 4 /chitosan (FOCN/CS) film exhibited impressive antibacterial activities, with sterilizing rate of 99.7 % ± 0.6 % against Escherichia coli ( E. coli ) and 97.6 % ± 0.4 % against Staphylococcus aureus ( S. aureus ) with short processing time (10 min) under visible light illumination. Based on this, the FOCN/CS film demonstrated excellent food preservation performance, which significantly prolonged the shelf life of strawberries, baby bok choy and pork. Such satisfactory preservation ability originates from the synergistic effect of α-Fe 2 O 3 and g-C 3 N 4 , which formed S-type heterojunction and bestow the FOCN/CS film with superior photodynamic antibacterial activity. Therefore, the film provides a novel microbiological control barrier for food preservation, with the potential to effectively reduce microbiologically induced food spoilage problems.
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MATERIALS SCIENCE IN SEMICONDUCTOR PROCESSING
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2019
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IF 2.722
Manoj Pudukudy,Qingming Jia,Hong Wang,Shaoyun Shan,Ramesh Rajendran
The influence of synthesis conditions on the formation of α and β polymorphs of AgVO 3 , their crystalline, structural, textual and optical properties and photocatalytic activity for dye degradation was investigated. The as-prepared polymorphs were characterized by using XRD , FTIR , EDX , SEM, TEM, HRTEM , XPS , BET and UV–vis. analyses. The analytical results indicated that a metastable α-AgVO 3 was formed in the precipitation method, whereas it was irreversibly converted into thermodynamically stable β-AgVO 3 by a hydrothermal method at 120 °C. The hydrothermal treatment was found to be decisive for the formation of β-form with high crystallinity and phase purity. The increase of hydrothermal temperature to 150 °C and 180 °C could not contributed to a significant variation in the crystalline, structural, textural and optical properties of the β-AgVO 3 . Moreover, a plausible mechanism for the phase transformation was briefly discussed. A combination of the needle and rod-like nanostructures of α form was completely changed to nanorods in β form after hydrothermal treatment. The optical band gap of α and β AgVO 3 polymorphs was found to be 1.91 eV and 1.98 eV respectively. The photocatalytic activity of the silver vanadates for the degradation of Rhodamine B indicated that β-AgVO 3 nanorods were better than α-AgVO 3 polymorphs. This could be attributed to the significant effects of its stable crystalline structure rather than specific surface area . Moreover, due to the reduced grain boundaries in β-form, their electron-hole recombination rate was lowed compared to α form. The degradation efficiency reached to 56% within 180 min under visible light irradiation. However, the increase of hydrothermal temperature does not have a significant effect in the photocatalytic activity. Moreover, the β-AgVO 3 nanorods were successfully reused for five cycles of photodegradation .
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ORGANIC & BIOMOLECULAR CHEMISTRY
·
2020
·Vol. 18
·期 34
·6724-6731
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IF 3.412
Fazhou Yang,Ziyan Liu,Hao Liu,Yu Shangguan,Hao Deng,Jiaxing Huang,Yumei Xiao,Hongchao Guo,Cheng Zhang
A copper-catalysed cascade ester amidation/radical cyclization of 2-amino-1,4-naphthoquinones with α-bromocarboxylates to afford benzo[f]indole-2,4,9(3H)-triones is described, and the reaction has a broad substrate scope and the desired products are obtained in mostly moderate to good yields. Mechanism-probing experiments indicate that the otherwise challenging radical coupling reaction of α-bromocarboxylates with 2-amino-1,4-naphthoquinones is facilitated by a 5-endo radical cyclization.
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MICROCHIMICA ACTA
·
2026
·Vol. 193
·期 11
·712
·
IF 5.4
Jin Yuan,Zhang Yanhong,Yao Jinxia,Ma Nanke,Li Guangli
Moxifloxacin (MOX) residues require reliable trace detection. Herein, an electrochemical sensor based on an α‑ZrP/phosphorus‑nitrogen co‑doped hollow carbon spheres (α‑ZrP/PNHC) composite is reported, where PNHC serves as a conductive scaffold to disperse α‑ZrP nanosheets and provide abundant transport pathways. Density functional theory (DFT) computations indicate that phosphorus atoms substitute into the carbon sites at the shoulder position next to pyridinic‑N, thereby injecting electrons into the carbon lattice and gently lowering the Lewis basicity of those pyridinic‑N centers. For the P‑doped pyridinic‑N site, the calculated adsorption energy amounts to − 0.745 eV, representing a moderate and ideal strength for stable enrichment without active site locking. Importantly, XPS data experimentally corroborate these findings, after P‑doping, the fraction of pyridinic‑N rises from 22.94% to 24.40%. This enrichment of pyridinic‑N, together with its moderate adsorption energy and open configuration, provides the ideal balance between stable enrichment and active site accessibility. Owing to these synergistic structural and electronic effects, the α‑ZrP/PNHC/GCE sensor delivers a broad linear detection interval (0.03–10 μM), a low limit of detection (0.023 μM), outstanding selectivity, acceptable reproducibility, and reliable stability. Recovery experiments in tap water and honey give values ranging from 97.29% to 103.70%, verifying the method’s practical utility. This work offers a highly sensitive sensing platform for MOX and provides DFT‑guided insights into the rational design of heteroatom‑doped carbon‑based composites. Graphical abstract
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Silicon
·
2026
·
IF 4.1
Liu Yuan,Liu Yuanfei,Fu Jie,Ma Chengliang
This study presents a cost-effective and environmentally friendly approach for fabricating large-area, low-defect Si₃N₄ ceramic substrate materials using tape casting combined with reaction-bonding sintering at 1900 °C. High-purity Si powder and a non-toxic Duramax™ B-1000 binder system were employed as raw materials. Orthogonal experiments (L9(3 4 ) array) optimized key parameters: 45 wt% solid content, 12.0 wt% binder, 0.4 wt% ammonium citrate dispersant, and a PEG-600 plasticizer to binder ratio (R) of 0.7. These conditions produced defect-free green tapes with smooth surfaces, minimal shrinkage, and balanced strength-flexibility properties. During re-sintering, the addition of 4 wt% Si 3 N 4 seeds maximized performance, yielding ceramics with 92.69% relative density, 15.6 GPa Vickers hardness, 6.6 MPa·m 1/2 fracture toughness, 636.1 MPa flexural strength, and 60.74 W·m −1 ·K −1 thermal conductivity. Microstructural analysis revealed elongated β-Si 3 N 4 grains, confirmed by XRD. This work demonstrates a scalable fabrication route for high-performance Si 3 N 4 substrates using economical and eco-conscious processing.
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Catalysis Science & Technology
·
2026
·
IF 4
Shixuan Li,Dongha Huang,Jiao He,Vasanthakumar Vasudevan,Boqing Chen,Wenjie Zhang,Tingting Wu,Xiao Wu,Xiao yan Xiang,Jinqing Lin
Nitrogen doping serves as a viable strategy to improve the activity of heterogeneous Fenton-like catalysts, whereas the practical deployment of Fenton-like technology is restricted by the complexity of nitrogen-doping procedures. Herein, a in-situ nitrogen-doped Fenton-like catalyst was synthesized through calcination from an in-situ iron-incorporated hyper-cross-linked polymer, where aniline functions as both carbon and nitrogen source while FeCl3 serves dual roles as catalyst for the polymerization and iron precursor. The resulting α-Fe2O3/N-CHCP materials were systematically evaluated for methylene blue (MB) degradation via heterogeneous Fenton-like reactions. Comprehensive characterization demonstrates that nitrogen doping effectively modulates the electronic structure of the carbon matrix, facilitating enhanced charge transfer kinetics and promoting efficient ≡Fe3+/≡Fe2+ cycling for superior H2O2 activation. The optimized α-Fe2O3/N-CHCP-2 catalyst exhibits exceptional catalytic performance, achieving complete removal of MB (100 mg L−1) within 15 min under neutral conditions (pH 7.3) with a high apparent rate constant (kobs) of 0.4732 min−1 significantly surpassing the N-free α-Fe2O3/CHCP catalyst (kobs = 0.0159 min−1). The α-Fe2O3/N-CHCP-2 catalytic system also demonstrates remarkable operational flexibility, maintaining high efficiency across a broad pH range (3-10) and in the presence of some common inorganic coexisting ions. Mechanistic investigations, supported by quenching experiments and EPR spectroscopy, reveal that hydroxyl radicals (•OH) are the predominant reactive species, whereas superoxide radicals (•O2−) contribute secondarily to the degradation process. This work establishes an effective synthetic approach for constructing advanced in-situ N-doping and metal-nitrogen-carbon coordination systems with optimized interfacial electron transfer properties, offering promising applications in advanced oxidation processes for wastewater remediation.
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COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY B-BIOCHEMISTRY & MOLECULAR BIOLOGY
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2026
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IF 2.5
Qianwen Liu,Jing Wang,Xiaofeng Jin,Hongyu Cheng,Guanyu Zhong,Song Wu,Yang Yang,Yanchun Sun
The global expansion of carbonate-alkaline water bodies poses a major challenge to sustainable aquaculture, but the metabolic basis of splenic immune dysfunction in fish under carbonate-alkaline stress remains unclear. Here, crucian carp ( Carassius auratus ) were exposed to carbonate-alkaline stress (20 and 40 mmol/L NaHCO 3 ) and exogenous α-ketoglutarate (AKG) supplementation for 30 days. Histopathological examination, ultrastructural observation, biochemical assays, and metabolomic analyses were employed to investigate the mechanisms of splenic immune dysfunction and AKG's regulatory effects. The results indicated that carbonate-alkaline stress induced oxidative stress, characterized by increased reactive oxygen species (ROS) concentrations and decreased glutathione (GSH)-dependent antioxidant capacity, accompanied by histopathological damage. Additionally, ATP concentrations significantly decreased, with concurrent mitochondrial structural abnormalities. Metabolomics analysis revealed that carbonate-alkaline stress caused a series of metabolic disorders, including those associated with the glycolysis pathway, GSH metabolism, and purine metabolism. Notably, exogenous AKG supplementation alleviated this damage. AKG regulated redox homeostasis by decreasing ROS concentrations and increasing GSH-dependent antioxidant capacity. Meanwhile, acting as an intermediate of the tricarboxylic acid (TCA) cycle, AKG restored energy supply, characterized by increased ATP concentrations. In conclusion, this study elucidates the underlying metabolic mechanisms of splenic immune dysfunction in crucian carp under carbonate-alkaline stress and demonstrates that AKG alleviates impaired splenic immune function by modulating redox balance and energy metabolic homeostasis. These findings provide novel insights into modulating immune dysfunction in fish exposed to carbonate-alkaline environments through metabolic interventions.
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INTERNATIONAL IMMUNOPHARMACOLOGY
·
2026
·
IF 5.6
Lei Zhu,Guan Zhang,Jiasai Kang,Xinru Xu,Haoshu Zhang,Yingying Pu,Yong Huang,Dewen Tong,Qian Du
Background Folium Isatidis (Da Qing Ye), a traditional Chinese medicine, exhibits broad-spectrum antiviral and immunomodulatory properties and has been widely used in treating respiratory diseases. Porcine circovirus type 2 (PCV2), a widespread swine virus, causes respiratory disease complex in piglets and leads to substantial economic losses in the global swine industry. This study aimed to evaluate the anti-PCV2 activity of Folium Isatidis . Materials and methods The anti-PCV2 activity of Folium Isatidis was first validated through both in vivo and in vitro experiments. Potential targets of Folium Isatidis were identified using TCMSP, BATMAN-TCM, and SwissTargetPrediction databases, and intersected with PCV2-related targets. Mechanism exploration involved PPI network analysis, GO annotation, and KEGG enrichment. Molecular docking analyzed component-target interactions, followed by experimental validation of the core component. Finally, the anti-PCV2 effect of the core component was verified through in vitro and in vivo experiments. Results A total of 135 overlapping targets between Folium Isatidis components and PCV2-related disease targets were identified. Key targets, including AKT1 and TNF-α, were implicated in the therapeutic effects of Folium Isatidis against PCV2. Isovitexin was identified to be the core component that directly binds to AKT1 and TNF-α, thereby inhibiting the PI3K/AKT signaling pathway and regulating TNF-α expression and activity to suppress PCV2 replication and alleviate PCV2-induced lung injury. Conclusions Our study reveals that Isovitexin, the core anti-PCV2 component of Folium Isatidis , exerts its effect by inhibiting the PI3K/AKT pathway and modulating TNF-α, thereby outlining a novel therapeutic strategy for combating PCV2 infection and associated respiratory injuries.
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FOOD CHEMISTRY
·
2026
·
IF 10.4
Shixiao Wei,Shu Wang,Hao Zhang,Xiaowei Chen,Xing Qiao,Shangde Sun,Yanlan Bi,Mingfu Wang,Yueliang Zhao
The accumulation of toxic α,β-unsaturated aldehydes in lipid-rich foods poses significant safety risks. This study elucidated the formation patterns of nine aldehydes in bulk flaxseed oil versus oil-in-water (O/W) emulsions, while evaluating the inhibitory mechanisms of gallates. In simulated systems, acrolein-trapping capacity declined with increasing alkyl chain length due to steric hindrance. Crucially, in simulated lipid models, gallates failed to scavenge acrolein, proving their inhibitory effect in bulk oil relied solely on upstream antioxidant activity, with octyl gallate being most effective. Conversely, emulsions promoted a catastrophic 519-fold aldehyde surge and favored accumulation of toxic hydroxy-alkenals. The superior performance (85.5% inhibition) and rapid depletion of propyl gallate in emulsions suggested a more complex mechanism involving both interfacial antioxidant activity and potential carbonyl scavenging. These findings highlight that simply increasing lipophilicity of polyphenols does not guarantee the enhancement of their inhibitory effect on aldehydes accumulation, necessitating matrix-specific strategies.
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高影响因子
FUEL
·
2026
·
IF 7.8
Kande Liu,Sitan Wang,Ranran Tao,Ziying Ju,Lishan Zheng,Naiwang Liu,Fahai Cao,Xuan Meng,Li Shi
As a vital chemical intermediate, o-cresol is integral to many high-value manufacturing processes. Its synthesis via the methylation of phenol using methanol represents a green and atom-efficient route. Despite exhibiting promising ortho -selectivity, conventional α-Fe 2 O 3 catalyst are often limited by insufficient activity under mild conditions, restricting their practical utility. To address the limited catalytic efficiency of conventional α-Fe 2 O 3 in low-temperature o-cresol synthesis, a nano α-Fe 2 O 3 catalyst was fabricated using a polyethylene glycol (PEG) assisted precipitation method. The catalyst was comprehensively characterized using XRD, N 2 physisorption, TEM, NH 3 -TPD, XPS and EPR. These analyses elucidated the role of PEG in the catalyst synthesis, demonstrating that the PEG-assisted method significantly enhances specific surface area, acidity and oxygen vacancies, thereby collectively improving catalytic performance. Compared to α-Fe 2 O 3 , the novel catalyst achieved a significantly higher phenol conversion of 15.8 % versus 8.5 % under 340 °C and 3 h −1 . Furthermore, the amount of PEG added in the assisted precipitation process was optimized and the mechanism of the phenol methylation reaction over 2.5PEG/α-Fe 2 O 3 was clarified. The results provide a basis for designing efficient catalysts, thereby facilitating their industrial application in o-cresol production.
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FOOD CHEMISTRY
·
2026
·
IF 10.4
Dong Wang,Mengrong Li,Yuanyuan Zheng,Xiangyu Zhang,Lifeng Han,Di Chen
A novel liquid-filled stick microextraction method with integrated in situ derivatization was developed. • Simultaneous derivatization and extraction were integrated into a single streamlined workflow. • The ready-to-use design minimizes manual reagent preparation and operational complexity. • Superior sensitivity was achieved with detection limits ranging from 0.04 to 0.29 ng/mL. • The platform successfully monitored α-dicarbonyl compounds in herbal oral liquids and granules. α-Dicarbonyl compounds (α-DCs) are critical indicators of quality and safety in herbal products, yet their analysis is challenging due to complex matrices and lacking fluorophores. This study developed a liquid-filled stick microextraction with in situ chemical derivatization (LFSME-ISD) method to streamline sample preparation. By pre-loading 50 μL of 2,3-diaminonaphthalene-saturated deep eutectic solvent (DES) into a hollow stick sealed with a polypropylene fabric tip, the ready-to-use device enables simultaneous derivatization and extraction upon activation and immersion. α-DCs are converted into fluorescent, hydrophobic derivatives, which partition into the DES phase. Under optimized conditions (60 min shaking at 60 °C followed by 1 min ultrasonic-assisted desorption), the method coupled with liquid chromatography-fluorescence detection demonstrated excellent linearity (R 2 ≥ 0.9927), low detection limits (0.04–0.29 ng/mL), satisfactory recoveries (91.1–104.0%), and high precisions (RSD ≤ 9.8%). Applied to herbal liquids and granules, LFSME-ISD provides a convenient and ready-to-use screening tool for monitoring quantifiable α-DCs in herbal matrices. Download: Download high-res image (132KB) Download: Download full-size image
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ANALYTICA CHIMICA ACTA
·
2026
·
IF 6.1
Chun-Pu Mao,Jiu-Ting Tan,Kai Wang,Fei-Fei Cai,Hong-Bin Dai
Herein, hepatocellular carcinoma (HCC) and acute kidney injury (AKI) were accomplished using α - l -fucosidase (AFU)-responsive fluorescent probe, HD-AFU , which incorporates the canonical AFU recognition moiety and a structurally optimized hemicyanine-thioxanthene signaling unit. In comparison with recently reported probes, HD-AFU demonstrated robust and reliable performance in monitoring AFU activity across HCC and AKI models. This probe enabled mitochondrial-targeted intracellular imaging to track AFU dynamics during progression and therapeutic intervention. In the orthotopic transplanted tumor mouse model, HD-AFU exhibited consistent capabilities for visualizing HCC status. To validate the accuracy of the probe in detecting AFU in AKI, we established four AKI models, including cisplatin-induced, gentamicin-induced, hyperuricemic nephropathy, and diabetic nephropathy models. The accurate establishment of these four models holds significant importance for subsequent fluorescence imaging studies. Additionally, we employed losartan and metformin to treat hyperuricemic nephropathy and diabetic nephropathy, respectively, and utilized the probe to achieve the screening and validation of therapeutic drugs. Furthermore, in a long-term induced HCC and AKI model validated by serum indices and histopathological assessment, HD-AFU successfully visualized the diagnostic and therapy process. These presented herein offer valuable insights for the development of effective diagnostic strategies.
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