Polymers
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2025
·Vol. 18
·期 1
·126
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IF 4.9
Adila Abdirym,Xue Wu,Bin Liu
This work investigated the stabilization mechanisms and β-carotene encapsulation characteristics of cellulose nanofibrils (CNFs) stabilized Pickering emulsions (PE) prepared by different emulsification processes. For 48 days of storage, ultrasound-prepared Pickering emulsions (US-PE) stabilized by at least 2.0 wt.% CNFs have obvious cream stabilization, and high-pressure homogenization-prepared Pickering emulsions (HPH-PE) stabilized by over 1.6 wt.% CNFs have excellent cream stabilization. The stabilization of HPH-PE, which was superior to that of US-PE, mainly relied on the steric stabilization of CNFs’ space networks. Although the encapsulation efficiency of β-carotene in US-PE was higher than that in HPH-PE when the CNF concentration was over 1.2 wt.%, the retention rate of β-carotene in US-PE was obviously lower than that in HPH-PE. So, the internal space structure of CNF-stabilized HPH-PE was conducive to stabilizing the emulsion and protecting the bioactive molecule.
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Journal of Physical Chemistry Letters
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2025
·
IF 4.6
Ruan Zhang,Shuai Liu,Xianyu Hu,Yong Zhang,Yunlei Zhong,Qing Guo,Xiyuan Feng
In the post-Moore era, next-generation optoelectronics and neuromorphic computing systems require ultrawide bandgap semiconductors with tunable properties. β-Ga2O3 stands as a promising candidate, possessing a bandgap of 4.5–4.9 eV and a high critical electric field of ∼ 8 MV/cm. However, its practical application is hindered by difficulties in synthesizing high-quality 2D forms and optimizing metal–semiconductor contacts. In this study, highly crystalline ultrathin 2D β-Ga2O3 nanoflakes with improved interface quality and enhanced carrier transport dynamics were synthesized using a space-confined CVD approach. The nanoflakes exhibit excellent structural and crystalline quality, as evidenced by the characteristic peaks in Raman spectroscopy and XRD, along with the clear lattice structure observed via TEM. Metal–semiconductor–metal devices with Ti–Ti, Pd–Pd, and Ti–Pd electrode configurations were fabricated and evaluated through current–voltage and time-resolved current–time measurements. The results reveal that the Schottky barrier height at the metal–Ga2O3 interface plays a decisive role in device performance. Notably, the Ti–Ti device exhibited a distinctive two-stage photocurrent decay after light illumination ceased, attributed to defect-mediated trapping and release of photogenerated carriers. By incorporating this unique photoresponse behavior into a deep neural network, promising image recognition accuracy was achieved on the Modified National Institute of Standards and Technology data set. This work not only offers a reliable pathway for synthesizing high-quality 2D β-Ga2O3 but also demonstrates its potential for application in high-performance optoelectronics and neuromorphic computing.
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FIBERS AND POLYMERS
·
2025
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IF 2.3
Meng Xiaoyu,Zhao Huiru,Zhao Ajiao,Shi Xuan,Qiu Hua,Chen Kunlin
Functional textiles featuring odor adsorption, controlled release, and antibacterial properties have attracted considerable interest for applications in personal care and environmental purification. To address the limited stability and durability of native β-cyclodextrin (β-CD) in health-protective textile coatings, a chemically modified β-CD was synthesized using DPT as a functionalizing agent. The successful chemical modification of β-CD was validated through Fourier Transform Infrared (FT-IR) and Proton Nuclear Magnetic Resonance ( 1 H NMR) spectroscopy. These microcapsules were then applied to fabric coatings, endowing the textiles with multifunctional properties, including odor control and ultraviolet (UV) protection. The results demonstrated that increasing the modified β-CD content from 10 to 25% improved the adsorption rate of trans-2-nonenal from 23.97 to 64.48% at room temperature. Under UV irradiation, brominated diphenylthiophene acts as a photosensitizer that generates reactive radicals and enhances molecular activity, effectively degrading trans-2-nonenal via radical attack and photooxidation reactions. Additionally, the treated fabrics also exhibited significantly enhanced UV-shielding performance, achieving an UPF value of 73.5, which remained at 40.29 even after 30 abrasion cycles. These findings indicate the potential of modified β-CD microcapsules in creating durable, multifunctional textiles with superior sensory and protective capabilities. Graphical
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METABOLIC ENGINEERING
·
2025
·
IF 6.8
Yapeng Zhang,Chenwen Liu,Wenqiang Li,Zhidong Ma,Bo Lv,Lei Qin,Chun Li
β-caryophyllene, a plant-derived sesquiterpene, serves as a food flavoring, anti-inflammatory agent, antioxidant, and high-energy fuel source. Extraction of β-caryophyllene from plants is a costly and inefficient process. Therefore, microbial cell factories have been employed for the production of β-caryophyllene. However, the limited yield is insufficient for its industrial application. In this study, we balanced the utilization of cellular resources for growth and production by systematically regulating the sterol synthesis pathway to maximize the synthesis of β-caryophyllene. In the competitive pathways concerning sterol and fatty acid synthesis, genes expression was suppressed by substituting the original promoters with a glucose-sensing promoter P HXT1 and a sterol synthesis promoter P ERG7 , respectively. This approach effectively increased the production of β-caryophyllene by 6.8 times, reaching 854.7 mg/L. Engineering glucose-sensing pathway altered the strength of P HXT1 , resulting in an increase in β-caryophyllene production to 1.25 g/L. The cell growth and β-caryophyllene production were further boosted through diploid fusion, resulting in 21.4 g/L β-caryophyllene in fed-batch fermentation. This represents the highest reported production of β-caryophyllene to date. This study provides a valuable reference for the production of sesquiterpenes in microbial cell factories.
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JOURNAL OF APPLIED POLYMER SCIENCE
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2025
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IF 2.8
Zhe Zong,Wei Zhao,Siyi Li,Na Liang,Shaoping Sun
A novel polymer Bio-CD-SS-TPE is designed and synthesized by modifying hydroxypropyl-β-cyclodextrin with the aggregation-induced emission (AIE) featured tetraphenylethylene derivative, disulfide bond, and biotin. The polymer can self-assemble into micelles in an aqueous phase and encapsulate paclitaxel (PTX) in the hydrophobic core. As expected, the Bio-CD-SS-TPE micelles exhibit excellent AIE performance and cell imaging capability. With the effect of disulfide bonds, the PTX-loaded micelles quickly release the drug upon the trigger of glutathione. In vivo study indicates the superior tumor inhibition effect and lower systemic toxicity of the PTX-loaded micelles. The Bio-CD-SS-TPE micellar system holds great potential in cancer treatment and bioimaging.
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Materials
·
2025
·Vol. 18
·期 23
·5313
·
IF 3.2
Shasha Hong,Yuan Jiao,Ruyu Li,Peng Lei,Chuan Dong,Shang Guo,Shaomin Shuang
Synergetic therapeutic study using multifunctional nanoplatforms has been developed as an innovative modality for effective cancer treatment to improve the clinical efficiency of anticancer drugs and reduce severe off-target side effects. Herein, an artificial nanoplatform (denoted as PPy-RhB-PDA-CD-LA) was prepared by grafting β-cyclodextrin (β-CD) derivatives and lactobionic acid (LA) on the surface of rhodamine B (RhB)-doped polypyrrole nanoparticles (PPy-RhB NPs) using polydopamine (PDA) as the intermediate linker. Doxorubicin (DOX) was selected and successfully loaded onto the nanoplatforms with a high loading content of 327 mg/g. Furthermore, significant NIR light-triggered release of DOX was observed in a weak acidic tumor microenvironment. The nanoplatform exhibited superior photostability with a high photothermal effect of 51.7% under irradiation by a 808 nm laser and a competent temperature sensitivity (SR is 1.44% °C−1) under a single wavelength excitation. MTT assay against SMMC-7721 cells clearly illustrated that the nanoplatform had low cytotoxicity at a high level (200 μg/mL) after 24 h and high therapeutic efficacy of chemo-phototherapy. Thus, it is highly promising for use in biomedical applications.
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MATERIALS LETTERS
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2025
·
IF 2.7
Yufang Chen,Lanlan Zuo,Hang Yu,Wenjin Song,Jinhui Wang,Xianxian Shi,Peitao Xiao,Di Lu
Electrospun poly (vinylidene fluoride- co -hexafluoropropylene) (PVDF-HFP) fibrous separators with controlled crystalline orientation were successfully developed for lithium metal batteries (LMBs). The electrospun separator exhibits a well-aligned fibrous network and predominant β-phase crystallization, demonstrating significantly enhanced ionic conductivity (0.63 mS cm −1 ) and superior electrolyte wettability compared to conventional NIPS-derived separators. The unique architecture enables homogeneous lithium deposition and extends cycling stability to 700 h in Li||Li cells, while maintaining excellent rate capability with 136.3 mAh g −1 at 2C in L cells. This work provides valuable insights into designing advanced polymer separators through microstructure and crystalline phase control for high-performance energy storage applications.
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INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
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2025
·
IF 8.5
Li Wen,Jinxia Zheng,Zhijie Ke,Jian Dong
Enzymes catalyze cascade reactions in a crowded cellular environment where as much as half of cell volume is occupied by various macromolecules. Nonspecific interaction between enzymes and crowders and excluded volume of the crowders can superimpose on each other and complicate catalytic activity of the enzymes. This study investigates the interaction between a β-galactosidase (β-Gal) and glycosylated acrylamide polymer (P(Glc-β-EAAm)) and unravels the macromolecular crowding effect of the glycopolymer on enzymatic cascade catalysis consisting of β-Gal, glucose oxidase and hydrogen peroxidase. Binding of the glycopolymer induced conformational alterations in β-Gal and gave rise to static fluorescence quenching and stable complex formation with β-Gal via nonspecific interaction. Fluorescence resonance energy transfer assays further demonstrated a compact association between β-Gal and glycopolymer crowders, with binding affinity correlating with the molecular weight of glycopolymer. The reduction of the apparent kinetic constants of the catalysis with the glycopolymer size showed the role of the multivalent effect in enzyme-substrate interactions. The kinetics also depended on the chain overlapping conditions of the crowders. Therefore, the macromolecular crowding effect on the cascade reaction is jointly associated with the crowder's multivalent effect, chain overlapping conditions of the crowders, in addition to the volume exclusion effect of the crowders.
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ENZYME AND MICROBIAL TECHNOLOGY
·
2026
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IF 3.9
Jianwei Wang,Xin Wang,Wulong Jiang,Lin Xiang,Zhijian Deng,Rong Hu,Lianshun Wang,Yuting Cong,Li Wang,Yuan Wang,Jing Gu,Yanan Lu,Guojun Yang,Hua Wang
A novel GH16 β-1,3-1,4-glucanase, Sl GH16, was identified from Streptomyces lividans and exhibits considerable thermostability and a broad pH tolerance, retaining appreciable activity under industrially relevant high-temperature and extreme pH conditions. Sl GH16 preferentially hydrolyzes barley β-glucan to produce low-molecular-weight oligosaccharides (DP3–DP5), offering some potential for functional feed and oligosaccharide production. Integrative structural analyses, including AlphaFold3 modeling, molecular docking, and molecular dynamics simulations, revealed that two disulfide bonds (Cys161-Cys169, Cys181-Cys186) and the central aromatic residue Phe248 act as important stabilizing elements, preserving substrate-binding integrity and overall protein rigidity. Site-directed mutagenesis confirmed the important roles of these residues in catalytic efficiency and thermal resilience. The combination of moderate stability, precise substrate recognition, and efficient oligosaccharide generation positions Sl GH16 as a promising candidate biocatalyst for high-temperature industrial applications. This study not only elucidates the structural determinants of GH16 enzyme thermostability but also provides a mechanistic reference for rational protein engineering aimed at enhancing enzyme performance under harsh processing conditions.
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Acta Biomaterialia
·
2026
·
IF 10.4
Hanrun Zheng,Wei Meng,Jianting Han,Maerziya Muhetaer,Qin Cao,Xiangdong Xue
Early-to-mid detection of Alzheimer's disease (AD) remains challenging because clinically used amyloid positron emission tomography (PET) probes primarily visualize fibrillar β-amyloid (Aβ) deposits and require radioactive isotopes. Magnetic resonance imaging (MRI) offers a radiation-free alternative, but its application in molecular AD diagnosis is limited by insufficient blood–brain barrier (BBB) penetration and poor specificity toward early-to-mid Aβ species. Here, we developed a BBB-crossing liposomal MRI probe, Lipo@D1D2-Gd, by integrating a natural Aβ oligomer-binding receptor domain with a gadolinium chelator. The extracellular D1D2 domains of human leukocyte immunoglobulin-like receptor B2 (LilrB2), a neuronal receptor that recognizes neurotoxic Aβ oligomers, were recombinantly produced and bioorthogonally conjugated with a gadolinium chelator. The resulting D1D2-Gd retained its Aβ-binding capability and MRI contrast activity. To enable brain delivery, D1D2-Gd was encapsulated within maltose-functionalized PEGylated liposomes designed to facilitate BBB transport. After intravenous administration to 4-month-old 5xFAD mice, Lipo@D1D2-Gd crossed the BBB, accumulated in Aβ-rich brain regions, and generated MRI contrast enhancement that differentiated 5xFAD mice from wild-type controls. Systemic safety evaluation showed no obvious hematological, biochemical, or histological toxicity. This study establishes a receptor-derived, BBB-crossing biomaterial platform for radiation-free molecular imaging of early-to-mid AD-associated Aβ pathology. Statement of Significance 1) Promising Targeting Strategy: We repurposed a human-derived natural receptor domain (LilrB2 D1D2) as a targeting module for β-amyloid (Aβ) oligomers, a key pathogenic species in Alzheimer’s disease (AD). 2) Non-invasive MRI Approach: We constructed a liposomal probe designed to deliver the Gd-labeled targeting agent to the brain, enabling the detection of Aβ-associated pathology in 4-month-old 5xFAD mice via non-radioactive MRI , well before overt cognitive decline. 3) Experimental Validation: We demonstrate the probe's association with Aβ oligomers/plaques , effective BBB crossing, differences in MRI signals between AD model and wild-type mice, and an initially favorable biosafety profile, with no observed toxicity under the tested conditions. 4) Clinical Translation Potential: Our work presents a promising pathway toward a safe, accessible, and early-to-mid-stage AD screening tool , with the potential to facilitate population-wide screening and earlier therapeutic intervention. Download: Download high-res image (347KB) Download: Download full-size image
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FOOD CHEMISTRY
·
2025
·
IF 9.8
Ziqi Chen,Junbai Zhong,Songyu Wang,Zhiyuan Huang,Qin Zhang,Qiang Zhao
This study aimed to valorize underutilized agricultural by-products by converting them into functional cellulose nanofibers for stabilizing Pickering emulsions and protecting β-carotene. Cellulose nanofibers were prepared from rice bran, wheat bran, and soybean residue, and their performance was compared to bacterial cellulose nanofibers. The resulting emulsions exhibited excellent stability, with no significant phase separation over 30 days, and enhanced structural robustness. Higher concentrations of cellulose nanofibers accelerated the reduction of interfacial tension and increased viscosity. Notably, the retained lignin and hemicellulose in cellulose nanofibers contributed to their performance. Compared with bacterial cellulose nanofibers, the agricultural by-product cellulose nanofibers reduced interfacial tension more effectively and provided superior UV protection (>90 % β-carotene retention after 4 h) and antioxidant activity (approximately 90 % DPPH scavenging). This work highlights the value of partially purified cellulose nanofibers and presents a sustainable strategy for converting agricultural waste into effective emulsion stabilizers and bioactive protective agents.
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CARBOHYDRATE POLYMERS
·
2025
·
IF 12.5
Bowen Zou,Xiaohan Zheng,Ruilin Sun,Xiaokang Na,Ming Du,Chao Wu
Developing sustainable plant-animal binary protein gels is limited by weakened gel properties arising from the partial replacement of animal proteins with plant proteins. Although β-glucan could effectively promote aggregation and gelation in single-protein systems, its functionality in binary protein systems remains largely unexplored. Herein, oat β-glucan (OG) and yeast β-glucan (YG), differing in structural characteristics, were incorporated to construct a robust interacting whey-pea protein system with strengthened gelling properties. Conformational and interaction analyses revealed that β-glucan induced the formation of larger aggregates by unfolding protein structure, enhancing hydrophobic interactions, and reducing electrostatic repulsion. With relevance to the enhanced cross-linking, β-glucan triggered a phase transition of the binary protein system from liquid to gel state upon heating. The resulting robust gel network markedly restricted the diffusion of non-network proteins and reduced the mobility of the remaining immobilized water. Notably, YG exhibited a greater capacity than OG to enhance gel stiffness and network density, likely due to stronger hydrogen-bonding interactions conferred by its branched structure. Furthermore, YG accelerated gelation by shortening the nucleation period through increasing the concentration of unfolded proteins. This study provides new insights into leveraging β-glucan structure to enhance the gelation and functionality of sustainable plant-animal binary protein systems.
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