CARBOHYDRATE POLYMERS
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2021
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IF 9.381
Huijuan Jing,Xin Huang,Xiaojing Du,Ling Mo,Chaoyang Ma,Hongxin Wang
In this work, a novel synthesis strategy of sodium alginate/carboxymethyl chitosan hydrogel beads promoted by hydrogen bond was described. The beads were prepared by dropping the blends of two polymers into the citric acid solution. Besides hydrogen bonding , electrostatic interactions were also involved in the formation of the hydrogel beads. The thermal stability experiments revealed that the more the content of carboxymethyl chitosan , the better the thermal stability of the beads. The beads exhibited excellent pH sensitivity, pH reversibility, and lactoferrin loading capacity. The swelling ratio of the bead and its protein releasing profile was pH-dependent, which could prevent premature protein release in the gastric environment. Also, the circular dichroism results demonstrated that lactoferrin could maintain its structure during the loading and releasing process. The obtained results revealed that the hydrogel beads prepared in this work could be used as a potential protein carrier for oral delivery.
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INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
·
2021
·
IF 6.953
Lingyuan Chen,Jiali Tang,Xinyue Zhang,Shixing Wang,Zhaogang Ren
A novel benzothiazole modified chitosan ( BCS ) with excellent Au(III) adsorption performance and selectivity was prepared as adsorbents. The structure and morphology of the adsorbents were characterized by FTIR, SEM, XRD and XPS. The adsorption property of the adsorbents for Au(III) were investigated under different reaction time, initial concentration of Au(III), temperature, pH and coexisting ions. The maximum adsorption capacity of BCS for Au(III) was 1072.22 mg/g at 298 K and optimal pH = 4, which was better than that of other adsorbents reported in literature. The adsorption kinetics and isotherm models fit the pseudo-second-order and Langmuir equations. This shows that the adsorption process of Au(III) is a monolayer chemical adsorption. The adsorption process can proceed spontaneously and belong to the endothermic reaction according to the thermodynamic results. The excellent adsorption performance is mainly attributed to the ion exchange and chelation of the nitrogen, sulfur and oxygen groups on the adsorbent with gold ions. Significantly, BCS has excellent selectivity toward Au(III) and remarkable recycle performance. With the high adsorption capacity, excellent selectivity and outstanding reusability, the BCS adsorbent could be a promising candidate to adsorb Au(III) from wastewater.
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INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
·
2021
·
IF 6.953
Wanwen Kang,Jiacheng Liang,Ting Liu,Hui Long,Langhuan Huang,Qingshan Shi,Jingxian Zhang,Suiping Deng,Shaozao Tan
We synthesized a temperature-sensitive antibacterial hydrogel, defined as NIPAM-CG/GM hydrogel. First, vinyl carboxymethyl chitosan (CG) was synthesized as a crosslinking carrier and silane dispersed graphene (GM) was synthesized as a reinforcer. Then, the N-isopropylacrylamide (NIPAM) monomer was free-radical polymerized with the vinyl groups of CG and GM to form a NIPAM-CG/GM hydrogel without any crosslinking agent. The influences of different hydrogel compositions on the microstructure, compressive properties, swelling, drug loading, and drug release properties of the hydrogels were discussed, and its temperature sensitivity was also demonstrated. The results showed that the lower critical solution temperature (LCST) and mechanical properties of the hydrogel could be adjusted by controlling the amount of CG and GM. Next, its biocompatibility was characterized, and its antibacterial performance was tested against Escherichia coli and Staphylococcus aureus . The antibacterial mechanism was explained by measuring the difference in the ion concentration outside the membrane and changes in the morphology of live/dead bacteria. NIPAM-CG/GM had a high drug loading and nearly complete drug release at a physiological temperature of 37 °C. Its moderate mechanical properties, excellent biocompatibility, and antibacterial effects give NIPAM-CG/GM great potential applications as a wound dressing.
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INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
·
2023
·
IF 8.2
Yaqi Zhang,Hongliang Wei,Bingya Hua,Chunwang Hu,Wenjing Zhang
Chitosan based hydrogels with multiple stimulus responses have broad application prospects in many fields. Considering the advantages of semi interpenetrating network (IPN) technology and the special temperature and ion responsiveness of polymers containing zwitterionic groups, a semi-IPN hydrogel was prepared through in situ free radical polymerization of N , N -dimethyl acrylamide and [2-(methacryloyloxy)ethyl]dimethyl-(3-sulfopropyl) ammonium hydroxide with polyethylene glycol dimethacrylate as a crosslinker and carboxymethyl chitosan as filler. The gel mass fraction and swelling ratio were measured, and the preparation conditions were optimized. The result indicated that the hydrogel possessed a unique thermo-/pH−/ ion-sensitive behavior. The swelling ratio increased with the increase of temperature and ion concentration, and showed a decreasing trend with the increase in pH. In addition, the hydrogel was stable when the stimuli changed. Adsorption behavior of the hydrogel to Eosin Y (EY) was systematically investigated. The adsorption process can be described well by the pseudo-second-order kinetic model and Langmuir isotherm model, indicating that it was a chemical adsorption. The experiments indicated that the hydrogel exhibited good antifouling and reusability features. Therefore, the semi-IPN hydrogel with antifouling properties and thermo-/pH−/ion-sensitivity can be easily manufactured is expected to find applications in water treatment fields.
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INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
·
2023
·
IF 8.2
Pei Li,Tao Xu,Xuan Dang,Lu Shao,Linlin Yan,Xiaobin Yang,Lexun Lin,Liping Ren,Rong Song
Periodontitis is a chronic inflammatory disease primarily driven by host inflammation and plaque-induced immune responses. Controlling the host inflammatory response and improving the periodontal inflammatory microenvironment are crucial to promoting periodontal tissue regeneration . In this study, the blended nanofiber membranes previously prepared by our research group were improved, and we developed multifunctional chitosan/polyvinyl alcohol/graphene oxide/astaxanthin coaxial nanofiber membranes. Scanning electron microscopy showed that the prepared nanofibers had a smooth surface and a uniform diameter distribution. The mechanical property test results showed that the coaxial nanofiber membranes exhibited higher tensile strength compared to the blended nanofiber membranes, which increased from 4.50 ± 0.32 and 3.70 ± 0.45 MPa to 7.12 ± 0.22 and 5.62 ± 0.79 MPa respectively. Drug release studies indicated that the “shell-core” structure of coaxial nanofibers significantly reduced the initial burst release of astaxanthin (ASTA), with only 13.49 % and 10.71 % release in the first 24 h, and drug release lasted for over a week. Animal experiments confirmed that the coaxial nanofiber membranes loaded with ASTA promoted periodontal bone defect repair while inhibiting periodontal inflammation. In conclusion, the prepared coaxial nanofiber membranes are a promising sustained-release drug system for treating periodontitis.
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DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY
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2019
·
IF 2.367
Jingwen Luo,Jiang Sun,Xiaoting Luo,Yinghui Wei,Hangsheng Zheng,Chaofeng Mu,Wenjie Yao
Objective: This article aims to design low molecular weight chitosan (LMWC)-based conjugates of Rhein (RH) by means of an amino acid linker (Alanine) for improved solubility and enhanced bioavailability.Significance: Rhein is a potential candidate for the therapy of kidney disease. However, the poor solubility, inadequate bioavailability, and lack of proper formulation restrict its clinical applicability. LMWC-drug conjugates offer the potential to improve the water-solubility of RH, increase its oral absorption, and thereby enhance its bioavailability.Methods: The conjugates were synthesized via a carbodiimide reaction and confirmed using UV-vis, FTIR, and 1H-NMR spectroscopy. The water-solubility and in vitro release properties were evaluated. Free RH and RH-LMWC conjugates were administered at an equivalent oral gavage dose of RH at 35 mg/kg for pharmacokinetic studies in Sprague Dawley rats.Results: The conjugates with RH content of 9.65% were successfully synthesized and featured a satisfactory water-solubility of 9.73 mg/mL, which exhibited a sustained release pattern over 72 h, and the enzymes present may promote the degradation of the conjugate to increase the release of Rhein. Oral administration of RH-LMWC conjugates to rats led to seven-folds and 3.1-folds increase in the T1/2 and AUC0–∞, respectively, as compared to RH suspension.Conclusion: The present work demonstrated that the RH-LMWC conjugates exhibited sustained release properties with outstanding oral bioavailability enhancements compared to administration of RH itself. Potentially, RH-LMWC conjugates may serve as a promising lead for developing a new platform for RH oral delivery.
研究领域:
药剂学
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药物化学
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生物医学工程
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COLLOIDS AND SURFACES B-BIOINTERFACES
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2018
·
IF 3.997
Miao Zhao,Ying Chen,Rongcheng Han,Dan Luo,Libo Du,Qiang Zheng,Lijun Wang,Yuankai Hong,Yang Liu,Yinlin Sha
We here report a facile synthesis of chitosan shelled quantum dot (QD/fGC) that holds essential properties requisite for biological applications, such as excellent water solubility, super colloidal stability, and low nonspecific adsorption as well as ease of functionalization. In this method, the amphiphilic glycol chitosan fragment (MW 1.0–1.7 kDa) was assembled on the top of CdSeS/ZnS nanocrystal through hydrophobic interaction in aqueous solution, without displacing the native coordinating ligands, which result in a higher quantum yield of about 0.26, 46% of the uncoated CdSeS/ZnS QDs in chloroform (0.57). In addition, the prepared QD/fGC composes an individual semiconductor core and presents an extremely small size of about 6.03 ± 1.50 nm (n = 399) in diameter. By conjugation with bioactive amines via 1-ethyl-3-(3-dimethylaminopropyl) carbodiimide (EDC)-based hydroxyl activation approach, the functionalized QD/fGC presented excellent recognition of specific cells in fluorescent imaging. Our work provides a new general method of chitosan modification of hydrophobic nanoparticles for biomedical applications.
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INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
·
2026
·
IF 8.7
Haoming Gu,Xijun Wang,Shuibo Zheng,Haisong Qi
Chitosan-based films suffer from issues such as poor plasticity and inadequate barrier properties. Herein, high toughness chitosan-based films were fabricated by chemical crosslinking between chitosan with acetoacetylated poly(vinyl alcohol) via the Mannich multicomponent reaction. The structure and properties of the resulting chitosan-based composite films were comprehensively investigated by methods such as FT-IR analysis, acid treatment, tensile testing and so on. The results demonstrated that the constructed network structure significantly enhanced the mechanical performance of the films with a tensile strength of 74.4 MPa and an elongation at break of 102.7%. Especially, the toughness of chitosan-based composite films reach up to 67.6 MJ/m 3 , which is much higher than those reported in the literature. Meanwhile, these films exhibited low oxygen and water vapor permeability coefficients of 8.6 × 10 −6 and 4.5 × 10 −6 mol·mm·m −2 ·d −1 ·kPa −1 , respectively. Application in strawberry preservation demonstrated that the films effectively regulated the micro-environment, extending shelf life by 6 days. This study provides a sustainable and efficient strategy for designing high-performance bio-based packaging films for strawberry preservation.
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ACS Applied Materials & Interfaces
·
2023
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IF 9.5
Hao Guo,Haifeng Shen,Juping Ma,Penghui Wang,Zheng Yao,Wenjie Zhang,Xiaoyan Tan,Bo Chi
Iatrogenic ulcers resulting from endoscopic submucosal dissection surgery remain a significant clinical concern due to the risk of uncontrolled bleeding. Herein, we have developed an injectable shear-thinning hydrogel cross-linked through electrostatic interactions and hydrogen bonding. The hydrogel underwent comprehensive characterization, focusing on rheological behavior, injectability, microstructure, film-forming capability, adhesion, swelling behavior, degradation kinetics, antibacterial efficacy, hemostatic performance, and biocompatibility. The incorporation of poly(vinyl alcohol) notably enhanced the internal structural stability and injection pressure, while the Laponite content influenced self-healing ability, modulus, and viscosity. Additionally, the hydrogel exhibited pH sensitivity, appropriate degradation, and swelling rates and displayed favorable film-forming and adhesion properties. Notably, it demonstrated excellent resistance against Escherichia coli and Staphylococcus aureus, highlighting its potential to create an optimal wound environment. In vivo studies further confirmed the hydrogel’s exceptional hemostatic performance, positioning it as an optimal material for endoscopic submucosal dissection (ESD) surgery. Moreover, cell experiments and hemolysis tests revealed high biocompatibility, supporting their potential to facilitate the healing of iatrogenic ulcers post-ESD surgery. In conclusion, our hydrogels hold great promise as endoscopic treatment materials for ESD-induced ulcers given their outstanding properties.
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CELLULOSE
·
2023
·Vol. 30
·期 18
·11875-11887
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IF 5.7
Chen Kunlin,Ni Yezhou,Shi Xuan,Jia Zhenhua,Qiu Hua,Portale Giuseppe
The growing interest in green synthesis and multifunctional application of microcapsules is due to their eco-friendly nature, health benefits, safety advantages, controlled release capabilities, and enhanced protection and stability. In this study, chitosan microcapsules were synthesized using a green double emulsion-simple coacervation method. The shell and core materials are derived from plants and are environmentally friendly, while the preparation process does not require volatile organic solvents. Both water-soluble vitamin C (VC) and oil-soluble lemon essential oil (LEO) were loaded as active substances in the chitosan microcapsules. The prepared microcapsules are about 3 μm in size and exhibit good thermal stability. Further modified microcapsules with UV crosslinked monomers could be coated on the fabric to form a functional fabric coating as well as UV crossing linkers. The obtained functional fabric based on chitosan microcapsules has the slow-release property of VC and LEO. The sustained-release VC exhibits a skincare effect and is beneficial to human health. Furthermore, this coated fabric has durable antibacterial properties due to the synergistic effect of LEO and chitosan. This method offers a sustainable solution for creating innovative microcapsules with diverse applications such as medical textiles, home textiles, cosmetics, and more. Graphical abstract
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Scientific Reports
·
2023
·Vol. 13
·期 1
·1-18
·
IF 4.6
Zhang Meng,Liu Yunqing,Yin Zhizhen,Feng Dan,Lv Hui
The magnetic chitosan/sludge biochar composite adsorbent was prepared using chitosan, Fe 3 O 4 , and sludge biochar as raw materials. The composite adsorbent was able to achieve rapid solid–liquid separation under an applied magnetic field. The morphology and microstructure of the composite adsorbent were characterized by FTIR, XRD, SEM, VSM, and BET analysis. The adsorption performance of the composite adsorbent on Cu 2+ was investigated through static adsorption experiments, and the effects of adsorbent dosage, initial concentration of Cu 2+ , initial pH of the solution, and adsorption temperature on the adsorption efficiency of Cu 2+ were discussed. The results showed that chitosan and Fe 3 O 4 were successfully loaded on sludge biochar. When the initial concentration of Cu 2+ was 30 mg/L, the dosage of the magnetic chitosan/sludge biochar composite material was 0.05 g, the adsorption time was 180 min, pH was 5, and the temperature was room temperature, the maximum removal rate of Cu 2+ reached 99.77%, and the maximum adsorption capacity was 55.16 mg/g. The adsorption kinetics and adsorption isotherm data fitted well with the pseudo-second-order kinetic model and Langmuir adsorption isotherm model, indicating that the adsorption process was chemisorption with monolayer coverage.
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INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
·
2023
·
IF 8.2
Dongxing Dong,Xiaoli Lv,Qiushi Jiang,Jingjing Zhang,Zhengyi Gu,Weimin Yu,Zhaolian Han,Ning Wang,Wenli Hou,Zhiqiang Cheng
In this study, a multifunctional nanofiber dressing that can promote antibacterial, analgesic and healing was prepared by electrospinning technology. Hydrophobic polycaprolactone (PCL)/chitosan (CS)/lidocaine hydrochloride (LID) and epidermal growth factor (EGF) were used as scaffold materials and dissolved in trifluoroacetic acid to prepare spinning solution. The morphology of PCEL dressing was observed by scanning electron microscopy. The fiber structure was dense and the average diameter was 297.0 nm. The water absorption capacity test and water contact angle measurement showed that the fiber had good water absorption and hydrophilicity (1302 %, 139.258°). Drug release was 84 % within 60 h. In the results of antibacterial experiment, the dressing showed certain antibacterial properties . The results of cell experiments show that the dressing can promote cell proliferation . In addition, coagulation experiments showed that the dressing could quickly coagulate the blood within 4 min. In addition, PCEL dressing promoted collagen deposition and vascularization through animal models of pressure sores. Therefore, multifunctional dressing can be used as an ideal auxiliary means for the treatment of pressure sores, and it is a promising alternative to chronic wound healing.
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