ACS Food Science & Technology
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2026
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IF 3
Jiayi Chen,Dandan Zhang,Lu Liu,Xiaoli Wu,Meihan Guo,Hong Yan Zou,Xi Yang
Herein, a cost-effective, naked-eye-readable platform for on-site biogenic amines (BAs) detection and shrimp freshness monitoring was developed based on a ratiometric fluorescent CDs–RhB hybrid nanosystem that was constructed by integrating carbon dots (CDs) with rhodamine B (RhB). Biogenic amines induced a significant enhancement in the green fluorescence emission of CDs, while the red fluorescence emission of RhB remained unchanged, enabling an instant self-calibration during detection. Loaded on filter paper to form disposable test strips, the nanosystem enabled a visible color transition from orange to green with increasing BAs concentration. Readable via a smartphone RGB app, the paper-based assay showed a linear response of 5.0–250 μM with a limit of detection (LOD) of 3.56 μM using histamine as the model analyte. Validated through on-site shrimp quality evaluation, the paper-based sensor established a reliable “nanoprobe–paper–phone” strategy, facilitating on-site and quantitative freshness assessment in real-world demand scenarios.
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ACS Applied Nano Materials
·
2026
·
IF 5.5
Yi Cao,Xiaotong Wei,Likui Zhu,Yunlong Xie,Xiaobing Hu,Huang He,Wenfeng Qiu
Recently, numerous researchers have overcome the insufficient energy density of metal oxides in energy storage applications by tailoring their dimensions to the quantum dot scale and integrating them with carbon-based matrices. In this work, Hf6Ta2O17 quantum dots (HTO-QDs) were synthesized in situ on the surface of biomass-derived carbon nanospheres (CNS) via a polymer-derived ceramic method, resulting in CNS@HTO-QDs composites. The influence of varying HTO-QDs content on the microstructure and energy storage performance of the composites was systematically investigated using XRD, SEM, TEM, FTIR, and an electrochemical workstation. The results indicate that the uniformly dispersed HTO-QDs on the CNS surface significantly enhance the energy storage performance of the composite. Among them, CNS@HTO-QDs-25, with the highest HTO content, exhibits the maximum specific capacitance (485.3 F g–1). Combined XPS analysis and first-principles calculations reveal that the HTO quantum dots not only contribute additional pseudocapacitance to enhance the electrochemical performance of the composite, but also provide strong interfacial interactions via the formation of M–O–C covalent bonds with the CNS matrix to improve the ion adsorption and transport capabilities of the composite material. Additionally, a symmetric supercapacitor (CNS@HTO-QDs-25||CNS@HTO-QDs-25) prepared in this study exhibits excellent specific capacitance, superior energy density, and good cycling stability, demonstrating an effective approach to the development of composites of transition metal oxides and carbon-based materials.
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ACS Applied Nano Materials
·
2026
·
IF 5.5
Lixia Li,Paihao Yan,Dongxu Zhang,Tao Feng,Quan Yuan,Yanhong Liu,Hailong Liu,Baodong Mao
The electrocatalytic nitrate reduction reaction (NO3RR) has emerged as a promising strategy for ammonia (NH3) synthesis under ambient conditions. However, the sluggish anodic oxygen evolution reaction (OER) not only significantly restricts the overall efficiency of the NO3RR process, but also inevitably wastes electrical energy. In this study, we synthesized a series of CuCo layered double hydroxide (LDH) nanosheets by adjusting the Cu/Co ratio, which demonstrate enhanced electrocatalytic activity for the NO3RR at the cathode and organic pollution degradation at the anode. Specifically, Cu2Co1-LDH nanosheets exhibit an exceptional NH3 yield of 0.32 mmol h–1 cm–2 and a high Faradaic efficiency (FE) of 82.24% at −1.0 V vs reversible hydrogen electrode (RHE). Meanwhile, the optimized Cu4Co1-LDH nanosheets achieve highly efficient 2,4-dichlorophenol (2,4-DCP) oxidation reaction (DOR) at 1.9 V vs RHE, which is 1.5 times higher than that of the Cu1Co1-LDH. Ultimately, the Cu2Co1-LDH cathode and Cu4Co1-LDH anode were coupled to form an asymmetric NO3RR||DOR bifunctional system that maintains a high NH3 yield and 2,4-DCP degradation at a current density of 10 mA cm–2 under a cell voltage of 1.89 V, 230 mV lower than that of the NO3RR||OER arrangement. A series of electrochemical tests reveal that the excellent electrocatalytic performance of the CuCo-LDH nanosheets stems from the bimetallic synergy and layered nanostructure, which effectively inhibit the competing reactions and enhance the charge-transfer efficiency. This study demonstrates an effective design for bifunctional nanocatalysts to address the kinetic sluggishness in the NO3RR and a strategy for asymmetric coupling with the degradation of organic pollutants.
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ACS Nano
·
2026
·
IF 17.3
Wei Fang,Hongxian Zhao,Yuxin Zhang,Suwen Bai,Yumei Luo,Ruijuan Han,Zhenye Yang,Bangning Cheng,Chungen Qian,Juan Du
The application of more blood proteins into health risk prediction and disease diagnostics has long garnered significant interest. However, comprehensive profiling of proteins in blood samples (plasma or serum), particularly low-abundance proteins, remains technically challenging due to the masking effect imposed by high-abundance proteins and the extraordinarily wide dynamic range of protein abundances. Herein, we developed an efficient strategy that leveraged the protein corona formed on surfactant-modified magnetic nanoparticles for the selective enrichment of low-abundance plasma proteins. Coupled with liquid-chromatography tandem mass spectrometry (LC-MS/MS) analysis, this strategy allowed for the detection of over 3500 plasma proteins in a single run, which was approximately three times and five times more than the number of proteins detected by the antibody-dependent depletion method and the direct digestion method, respectively. The application of our method to an acute myocardial infarction (AMI) cohort and corresponding healthy control group resulted in the identification of 5000 more plasma proteins and the discovery of seven potential AMI diagnostic biomarkers, which showed superior accuracy in diagnosis compared to conventionally used cardiac troponins. The magnetic nanoparticles (MNPs) and surfactants are commercially accessible and cost-effective, and moreover, the modification protocol is simple. These features ensure the ready adoption of our method by other laboratories, even those lacking specialized nanotechnology expertise. Additionally, the magnetic properties of MNPs can further facilitate the smooth integration with automated sample processing systems, thereby expediting large-scale clinical studies.
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ANALYTICAL CHEMISTRY
·
2026
·
IF 7.3
Juan Wang,Yujia Ren,Baojian Huang,Chuanping Li,Shuai Qin,Shaojun Dong,Daoqing Fan
Exploring novel-type nanozymes with programmatically manipulated enzyme-mimicking activity for targets’ accurate identification and multimodal biosensing represents one of the most fascinating yet challenging research frontiers. Herein, taking DNAs as programmable biotemplates, we prepared bimetallic PtAg nanocluster-zyme via simple in situ reduction. Among them, the A20-templated PtAg nanozyme exhibited superior peroxidase-like (POD-like) activity, as confirmed by optical analyses, steady-state kinetics, and electron paramagnetic resonance spectroscopy, with •O2– and •OH identified as the primary reactive oxygen species. Taking Pt-AMP with the Pt–N4 coordination structure as representative, pluralistic DFT calculations were performed. Corresponding results manifested the superior affinity of nanozyme for H2O2 and TMB, the elongated O–O bond length of H2O2 and facilitated electron-transfer ability at the catalytic core. Subsequently, by harnessing the efficient catalytic oxidation of TMB and AR, we fabricated a colorimetric-photothermal-fluorescent trimodal sensing platform for assessing total antioxidant capacity and alkaline phosphatase activity. Superior to previous single/dual-modal biosensors, this work demonstrated significant advantages in sensitivity, reliability, and accuracy, and showed acceptable adaptability in diversified real matrices (human serum, tablets, and beverages). Furthermore, we fabricated target-responsive cascade logic circuits by virtue of the proper incorporation of trimodal signals and Boolean logic, and achieved the smart recognition of targets. This work not only provided a mild, simple, and efficient biotemplated approach for the programmable tuning of noble-metal nanozymes’ catalytic activity but also enlightened novel pathways for the operation of logic-empowered intelligent biosensors.
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ANALYTICAL CHEMISTRY
·
2026
·
IF 7.3
Xinyi Wang,Jiayi Yao,Mingyang Zhao,Haoran Wang,Jingkai Gu,Xiangjun Meng
Polyethylene glycols (PEGs), commonly used in pharmaceutical applications, have recently been associated with potential adverse effects, highlighting the necessity for a thorough understanding of their in vivo metabolism. The inherent molecular weight polydispersity of PEGs, as polymers, poses challenges for systematic metabolic investigations. Here, we propose “polymeromics” as an innovative methodology for elucidating PEG metabolism. This approach allows for detailed molecular weight profiling and facilitates the precise identification of metabolites. In this proof-of-concept study, methoxy polyethylene glycol 2000 (mPEG2000) was employed as a model polymer. Using liquid chromatography coupled with high-resolution mass spectrometry and clustering analysis, we achieved, for the first time, a comprehensive molecular-weight-resolved characterization of the in vivo metabolism of mPEG2000. Our findings identified a range of mPEG2000 metabolites and revealed that midchain scission occurs during in vivo metabolism, with the hydroxyl radical being the primary species responsible for this cleavage. Furthermore, we elucidated the plasma kinetics, tissue distribution, and excretion profiles of mPEG2000 and its metabolites. This study introduces an innovative platform for investigating the in vivo metabolism of PEG, providing new insights into its biological fate and informing the development of safer PEGylated pharmaceuticals.
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ACS Catalysis
·
2026
·
IF 13.6
Shuangfeng Ren,Yihui Li,Ye Chen,Xiaoling Mou,Ziang Zhao,Hejun Zhu,Xiaoyan Liu,Yu Meng,Li Yan,Apoorva Ravi,Amol Amrute,Ronghe Lin,Yunjie Ding
The rational design of selective, earth-abundant Ni-based catalysts for the reverse water–gas shift (RWGS) reaction is often hampered by an incomplete understanding of their operando active states. This study reveals that the CO2 hydrogenation selectivity over Ni–Zn catalysts is governed by a support-dependent, reaction-induced dynamic restructuring, rather than by any static, preformed sites. Through a combination of in situ characterization and theoretical calculations, we demonstrate that the active Ni–Zn intermetallic core encapsulated by ZnO forms dynamically only under the RWGS atmosphere on ZrO2 and TiO2 supports, but not on Al2O3 or during mere H2 reduction. Crucially, we identify in situ-generated CO as the essential inducer of this reconstruction, likely via facilitating ZnO reduction. Furthermore, the product selectivity (CO vs CH4) is dictated by the kinetic competition between CO desorption and its deep hydrogenation, a principle quantitatively linked to the evolved electronic structure of the active surface. This work shifts the paradigm toward designing catalysts that evolve into optimal structures in operando and provides a fundamental kinetic framework for selective CO2 conversion.
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INDUSTRIAL & ENGINEERING CHEMISTRY RESEARCH
·
2026
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IF 3.9
Heyuan Zhang,Tian Tang,Jinfei Chen,Linhan Yu,Liuyang Xu,Yumin Wang,Wenyun Qiao,Yanrong Chen,Xuesen Du
A key issue with conventional cobalt-based catalysts in ammonia decomposition is the aggregation and sintering of active sites under high-temperature conditions, leading to rapid deactivation. Here, we discovered that the performance of the Co/Al2O3 catalyst was significantly enhanced through nitrogen plasma pretreatment. At a reaction temperature of 600 °C, the hydrogen production rate of the catalyst increased by 22% after 25 W plasma treatment compared to the untreated sample, while its apparent activation energy also decreased significantly (from 66.1 ± 1.2 to 48.6 ± 2.9 kJ/mol). Regarding stability, after 40 h of testing at 600 °C, the catalyst maintained 76% ammonia conversion, demonstrating excellent stability. To investigate the underlying cause of this performance enhancement, characterization revealed that pretreatment induced the formation of the CoAl2O4 spinel phase. This phase optimized the electronic structure and spatial distribution of active sites, thereby enhancing intrinsic activity. Characterization results further confirmed that this treatment effectively suppressed sintering of the active components at high temperatures, removed impurities from the pore channels, and strengthened metal–support interactions. This was manifested in an improved cobalt dispersion, increased CoAl2O4 crystallinity, and enhanced surface reducibility. Therefore, this study demonstrates that nitrogen plasma pretreatment is an effective strategy for preparing high-performance ammonia decomposition catalysts through interfacial restructuring.
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INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
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2026
·Vol. 27
·期 4
·1778
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IF 5.6
Thabang Mokoba,Yiyi Lin,Hongyang Chen,Shaojun Yuan
Efficient oil-water separation remains a major challenge in oily wastewater treatment, highlighting the need for advanced materials that combine superwettability, structural durability, and long-term recyclability. Here, we develop a hierarchical ZOMO-PAA@CuC2O4NR@CM membrane via sequential chemical oxidation, oxalic acid etching, and spray-coating of ε-Keggin-type Na-ZnM ZOMO nanoparticles within a polyacrylic acid (PAA) matrix. The resulting architecture couples CuC2O4nanorods with hydrophilic ZOMO-PAA coatings to achieve superhydrophilicity and underwater superoleophobicity. Structural characterization confirmed uniform nanoparticle dispersion, high crystallinity, and robust framework integrity. The membrane exhibits ultrafast water spreading (0°), underwater oil contact angles above 150°, and sliding angles as low as 4°, enabling broad-spectrum oil repellence, antifouling, and self-cleaning. The as-prepared membrane efficiently separates both surfactant-free and surfactant-stabilized emulsions, including aliphatic and aromatic oils stabilized by cationic, anionic, and non-ionic surfactants, with high water fluxes (1695–2675 L·m−2·h−1and ~900 L·m−2·h−1, respectively) and separation efficiencies above 99.1%. The membrane further demonstrates chemical stability under acidic, alkaline, and saline conditions, alongside consistent oil–water separation behavior across multiple cycles. These findings establish ZOMO-PAA@CuC2O4NR@CM as a robust and scalable platform for advanced oily wastewater treatment.
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Catalysts
·
2026
·Vol. 16
·期 2
·
IF 4.5
Li Bai,Junlong Zhao,Yunyu Ning,Jiawen Lv,Rui Bao,Pinwen Zhu,Yanli Chen,Huilian Liu,Qiang Tao
The intrinsic electronic and structural properties of the transition metal rhenium (Re) endow it with substantial application potential in electrocatalysis. However, the high cost of Re requires the development of Re-based materials to reduce cost and optimize the performance at the same time. Herein, a one-step high-pressure and high-temperature (HPHT) synthetic strategy is proposed for fabricating Re-C phase gradient composites, presenting a facile and efficient pathway to develop high-performance hydrogen evolution reaction (HER) electrocatalysts. By studying the structural evolution of Re toward ReC and uncovering its intrinsic mechanism, the regulation of the material’s electrocatalytic activity was successfully realized. Experimental results confirm that HPHT conditions of 5 GPa and 1400 °C effectively induce the formation of multiple crystalline phases of Re-C solid solution and ReC in the Re-C composite. These phases have coherent phase boundaries and form the phase gradient composites. Compared with element Re, the synergistic effect of phase gradient composites broadens the electronic state range by increasing electron transfer from Re to C in ReC (increasing the binding energy) and reduces the binding energy in Re-C solid solution. The broad electronic states range in the phase gradient composites exhibits optimal HER overpotentials of 150 mV (acidic electrolyte) and 166 mV (alkaline electrolyte) at 10 mA cm−2. These findings provide a promising strategy to boost catalysts’ electrocatalytic performance via constructing phase gradient composites.
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Crystals
·
2026
·Vol. 16
·期 2
·126
·
IF 2.9
Yuhang Liu,Ziqing Wu,Fenghua Chen,Yongming Liu,Rongrong Xue
In the organic biomineralization of guanine (GUA), amorphous GUA is utilized to enhance its solubility, facilitating its transport for the formation of biominerals, and GUA nanocrystals are employed to protect tissues from ultraviolet damage. These principles of GUA biomineralization inspire us to improve the solubility and photostability of trans-resveratrol (RES) using bio-purines, which limits its bioavailability. Bio-purines, such as GUA, hypoxanthine (HYP), and adenine (ADE), were used as co-formers in the amorphous systems of RES. Amorphous RES-2Purines with a 1:2 molar ratio were prepared via the neat ball-milling method and confirmed by powder X-ray diffraction, Raman spectroscopy, and diffuse reflectance spectroscopy. The stability, dissolution profiles, and photostability of RES-2Purines were comprehensively compared. RES-2Purines show high amorphous-to-crystalline transformation temperatures (>100 °C), confirmed by the differential scanning calorimetry-thermogravimetric analysis. Both RES-2HYP and RES-2ADE show an enhanced RES solubility (about 1.6-fold that of raw RES) in water and the simulated gastric fluid (pH 1.2). RES-2Purines can recrystallize quickly after being dispersed in water, which limits the solubility enhancements of RES-2Purines. RES-2Purines have better photostability than raw RES. Bio-purines are promising co-formers for amorphous systems to enhance the solubility and photostability of poorly water-soluble compounds.
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MOLECULES
·
2026
·Vol. 31
·期 3
·514
·
IF 5.1
Xiangjuan Meng,Mingwei Zhao,Zhenfeng Ma,Xinjie Xu,Zhongzheng Xu,Yuxin Xie,Yining Wu,Ziyi Wang,Wenhao Ren,Huan Zhang
CO2flooding is an effective technique for enhancing oil recovery in low-permeability reservoirs. However, it is often hindered by severe CO2channeling. This challenge is particularly pronounced in near-wellbore regions with large pressure differentials and in fractured reservoirs, where high CO2injection rates and rapid breakthrough require channel blocking systems with high mechanical strength and excellent CO2-resistant performance. In this work, a smart responsive polymer was synthesized and subsequently crosslinked with a highly active phenolic resin crosslinking agent to develop a smart responsive polymer gel channel blocking system. The resulting gel exhibits CO2-responsive strength enhancement and excellent CO2-resistant performance. The static and dynamic gelation behaviors, nonlinear rheological properties, CO2-resistant performance, channel blocking, and enhanced oil recovery performance of the smart responsive polymer gel were systematically investigated. The results demonstrate that the polymer gel maintains good structural stability during dynamic transport in the reservoir and does not undergo significant strength degradation under shear conditions. Moreover, the smart responsive polymer gel exhibits excellent CO2-resistant performance within a temperature range of 80–110 °C, salinity up to 10 × 104mg/L, and pressure up to 20 MPa. Moreover, the system shows a significant enhancement in channel blocking and enhanced oil recovery performance, highlighting its promising potential for effective CO2flooding channel blocking in low-permeability reservoirs.
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