APPLIED SURFACE SCIENCE
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2012
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IF 2.103
Zhongbo Li,Guowen Meng,Ting Liang,Zhuo Zhang,Xiaoguang Zhu
We report a facile low-cost synthetic approach to large-scale Ag nanosheet-assembled films with a high density of uniformly distributed sub-10 nm gaps between the adjacent nanosheets on Si substrates via galvanic cell reactions. The distribution density of Ag nanosheets on substrates could be tailored by tuning the duration of the HF-etching and the concentration of citric acid in the solution. Furthermore, in conjunction with a conventional photolithography, highly uniform patterned Ag nanosheet-assembled structures with different morphologies can be achieved on Si substrates via galvanic-cell-induced growth. By using rhodamine 6G as a standard test molecule, the large-scale Ag nanosheet-assembled films exhibit highly active and homogenous surface-enhanced Raman scattering (SERS) effect and also show promising potentials as reliable SERS substrates for rapid detection of trace polychlorinated biphenyls (PCBs).
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ACS Applied Nano Materials
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2023
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IF 5.9
Yu Yang,Hao Cheng,Ruijue Chen,Qiying Chen,Si Gao,Li Chen,Wenyi Huang,Hongxing Kong,Lijun Li,Jun Feng
In this work, we have fabricated a surface-enhanced Raman scattering (SERS) magnetic immunosensor using a sandwich structure consisting of an SERS tag, a supporting substrate with magnetic properties, and a target. On the one hand, the SERS tag consists of AgNPs, a metal–organic framework called the zeolite imidazolate framework-67 (ZIF-67), and R6G, which acts as a Raman reporter. Due to the self-selective SERS-enhancing properties of ZIF-67 and better adsorption to analytes, SERS tags with this structure can further enhance the sensing capabilities. On the other hand, after surface functionalization with the human carboxylesterase 1 (hCE1) antibody, the nanostructure containing CoFe2O4 as the magnetic core and Ag NPs as the shell was used as the magnetic support substrate. The introduction of the CoFe2O4 magnetic core can not only realize the rapid separation of biological samples to simplify pre-treatment procedures but also stabilize and uniformly distribute the AgNPs and increase the Raman “hot spots”, thereby further enhancing the SERS intensity and improving the reproducibility. Not only that, the SERS signal can be further enhanced by the synergistic effect generated by the plasmonic coupling of the CoFe2O4 magnetic core–Ag satellite nanostructure (CoFe2O4/Ag). hCE1 in HepG-2 cell lysates and culture supernatants was rapidly determined using the constructed SERS magnetic immunosensor, and hCE1 released from acetaminophen-treated HepG-2 cells into the extracellular medium was also monitored in real time. The limit of detection was as low as 3.6 pg/mL, and the linear response covered a range of hCE1 concentrations (1.0 ng/mL–1.0 mg/mL) spanning 3 orders of magnitude. This strategy can be used for the quantitative detection of complex trace proteins or enzymes in biological samples.
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TALANTA
·
2024
·
IF 5.6
Gao-feng Wu,Jian Zhu,Guo-jun Weng,Hao-yu Cai,Jian-jun Li,Jun-wu Zhao
The development of an ultra-sensitive detection method for carbohydrate antigen 19-9 (CA19-9) is very important for the early diagnosis of pancreatic cancer. In this work, we developed a new strategy to achieve a variety of Au–Ag hybrid nanoparticles from janus to core-satellite which is controlled by the volume of AgNO 3 and the concentration of benzimidazolecarboxylic acid (MBIA). With the volume of AgNO 3 increased, Au–Ag hybrid nanoparticles changed from janus to core-satellite and the characteristic absorption peak showed two opposite trends. The size and number of Ag islands were determined by the concentration of MBIA. Au–Ag core-satellites nanoparticles with a large number of small-sized Ag have the highest SERS intensity. Then we used them as SERS nanotags and Au-Polystyrene nanospheres modified by captured anti-CA19-9 antibody as solid substrates to realize the ultra-sensitive detection of CA19-9 with a low limit of detection of 1.25 × 10 −6 IU/mL and a wide linear range of 1.00 × 10 −5 -1.00 × 10 4 IU/mL. This work not only demonstrates that MBIA and AgNO 3 were the key factors in the growth of Au–Ag hybrid nanoparticles from 2D to 3D structure but also supplies an ultra-sensitive detection method for CA19-9 which has a potential practicability in the clinical early diagnoses of pancreatic cancer.
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Advanced Sensor and Energy Materials
·
2026
·
IF 12.3
Ifeanyichukwu Michael Onyemaobi,Li Sun,Yujiao Xie,Xinyu Miao,Shishuai Zheng,Jie Lin,Aiguo Wu
Advances in nanostructured materials and liquid biopsy technologies are improving the detection and monitoring of carcinomas. As the application of biomedical surface-enhanced Raman spectroscopy (SERS) continues to evolve, the integration of porous organic frameworks (POFs) onto SERS platforms is yielding substantial signal enhancements, enabling the compositional analysis of rare circulating tumor cells (CTCs). The optimization of SERS bioprobes has shown accuracy in distinguishing cancerous cells from healthy ones. However, preparing such platforms with self-cleaning surfaces presents challenges at almost every stage, including limited chemical specificity, substrate reliability, instability, and the intricacies of detecting molecules in hot zones. These challenges often result in inconsistent performance due to inadequate molecular confinement and unfavorable orientation effects, triggered by suboptimal bonding chemistry. In this study, a self-cleaning Au@HOF/I 2 core-shell nanoparticle was successfully prepared. The SERS-active platform was developed via a solvothermal process, wherein a gold (Au) core is enveloped by a thin-layered hydrogen-bonded organic framework (HOF) in conjunction with an iodine-catalyzed reaction. Upon assessment, it achieved a detection limit of up to 5.12×10 –16 mol/L. During cancer diagnosis, at 25 min, the SERS-active bioprobe (Au@HOF/I 2 @4MBN@CS-HA@EpCAM) showcased remarkable sensitivity and specificity. With a 9.01×10 7 enhancement factor (EF) influenced by the local optical field and a limiting detection accuracy of 1 cell/mL, the bioprobe effectively targeted HeLa and MCF-7 cell lines as viable CTC models with capturing efficiencies of ≥94% and ≥98%, respectively. We anticipate that this contaminant-free SERS biosensor will furnish valuable diagnostic guidance and inspire new ideas for the precise identification of other disease-related biomarkers.
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ANALYTICAL CHEMISTRY
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2026
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IF 7.3
Runzi Zhang,Shunbi Xie,Xiaoyu Yang,Wanyi Xiong,Yi He
Currently, surface-enhanced Raman scattering (SERS) biosensors face practical challenges, including SERS substrate waste and unsatisfactory detection results. Accordingly, the highly efficient and regenerable SERS substrate HOF@Au was collaborated with a target-triggered identifying-cleaving-rolling-assembly cycling nanodevice (ICRACN) as a cascade signal amplification system to achieve an ultrasensitive detection of roxithromycin (RXM). In this system, abundant Au nanoparticles (NPs) were reduced in situ on the surface of alkali-resistant HOF-102 to form a uniform and high-enhancement SERS substrate HOF@Au, thereby enhancing the accuracy and stability of the sensor. Furthermore, aptamer-mediated specific recognition, efficient cleavage activity of DNA nanorollers, and a pH-responsive DNA triplex structure were engineered to construct ICRACN. In the presence of the target, it was specifically recognized by the aptamer, leading to the activation of the DNAzyme. Meanwhile, the dynamic nanorollers were triggered to initiate cleavage of a specific site along a defined pathway, enabling highly efficient signal amplification. Concurrently, the triplex structure formed by the two single-stranded DNA atoms on the SERS substrate was opened, allowing the capture of the SERS tag and generating a pronounced SERS signal. The proposed strategy achieved the sensitive detection of RXM with a low limit of detection of 3.97 × 10–14 mol/L. Moreover, modulation of pH induced reversible folding and unfolding of the triplex structure to facilitate regeneration of the SERS substrate, which simplified operational procedures and reduced detection costs. As a result, this work presents a novel, regenerable SERS biosensor and offers valuable insights into the design of multifunctional sensing platforms for analytical applications.
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MICROCHIMICA ACTA
·
2026
·Vol. 193
·期 4
·270
·
IF 5.4
Wang Yuqing,Liu Yutong,Liu Ziqi,Wang Xinyue,Yu Menglu,Gao Guanghui,Zhao Yunli,Hong Jing
A novel MXene nanosheet-supported Fe₃O₄@Ag nanozyme, designed for the dual-mode colorimetric and surface-enhanced Raman scattering (SERS) detection of the pesticide thiram in fruits is presented. The composite ingeniously integrates three key functions: magnetic enrichment, SERS signal amplification, and peroxidase-like nanozyme activity. The resulting nanozyme sensor demonstrates high sensitivity and specificity for thiram detection. The colorimetric method showed a linear range of 0.05 µM to 30 µM with a LOD of 0.016 µM, while the SERS method exhibited a linear range of 10 − 4 M to 10 − 8 M with a LOD of 3.44 × 10 − 9 M. This performance satisfies the demands for agricultural safety monitoring. The present work highlights the significant potential of the developed colorimetric-SERS dual-mode nanozyme platform for on-site pesticide residue determination .
Section
Graphical
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TALANTA
·
2026
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IF 6.7
Yue Liu,Yu Wu,Lihan Feng,Xinyi Zhang,Jihui Lang,Qi Zhang,Naveen Reddy Kadasala,Wenshi Zhao,Yang Liu
Ciprofloxacin (CIP) is widely utilized for the treatment of bacterial infections due to its broad-spectrum antibacterial properties; however, excessive residues inevitably cause environmental pollution. Therefore, the development of sensitive and accurate analytical methods for CIP detection remains important. Herein, a novel self-cleaning surface-enhanced Raman scattering (SERS) sensor was fabricated for the ultrasensitive and specific detection of CIP. ZnFe 2 O 4 -Cu 2 O-Au@Ag (ZCAA) nanocomposites (NCs) were synthesized by decorating ZnFe 2 O 4 -Cu 2 O with various amounts of Au@Ag nanocrystals, thereby integrating dual functions of pollutant detection and photocatalytic degradation. Finite-difference time-domain (FDTD) simulation was adopted to elucidate the correlation between Au@Ag loading density and SERS performance. After modification with molecular imprinted polymers (MIPs), the prepared ZnFe 2 O 4 -Cu 2 O-Au@Ag-MIPs (ZCAA-MIPs) exhibited robust anti-interference capability, enabling specific detection of CIP even in the presence of structurally similar antibiotics such as tetracycline (TC) and oxytetracycline (OTC). A limit of detection (LOD) of 9.3 × 10 −11 M was achieved in aqueous media. Furthermore, the sensor successfully identified trace CIP on the epidermal surfaces of river snail, demonstrating its practical applicability in real-world samples. Time-resolved photoluminescence (TRPL) and X-ray photoelectron spectroscopy (XPS) analyses revealed that the synergistic interaction between the ZnFe 2 O 4 -Cu 2 O heterojunction and Au@Ag nanocrystals accelerated charge carrier migration and optimized interfacial charge transfer. Density functional theory (DFT) calculations further verified the superior degradation capacity of ZCAA substrate. Benefiting from its intrinsic magnetic properties, ZCAA-MIPs sensor was easily recycled under external magnetic field and retained stable SERS performance after five consecutive recycling cycles. This magnetic MIPs-SERS sensor provides a reliable and sustainable platform for monitoring CIP residues in complex water environments.
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SENSORS AND ACTUATORS B-CHEMICAL
·
2025
·
IF 7.7
Huan Li,Keyu Tao,Hongbo Chen,Shuifeng Zhang,Huadong Sheng,Linglin Fu
Trace allergens hidden in food products, particularly those arising from cross-contamination during manufacturing, can elicit severe and potentially life-threatening allergic reactions. This underscores critical demand for rapid and ultrasensitive detection technologies to identify trace-level allergens in food matrices, thereby enabling proactive prevention of food allergy risks. In this study, a surface-enhanced Raman scattering-based lateral flow immunoassay (SERS-LFA) based on the Au MBA @AgNPs-Apt SERS tag was developed for rapid and ultrasensitive screening of the allergenic risks in food. With the competitive detection principle, the SERS-LFA achieved detection of target allergenic proteins with a limit of detection (LOD) of 2.2 ng/mL within 8 min. Notably, by integrating additional test line on the nitrocellulose (NC) membrane, the method was adapted for multi-target detection. Under the optimized conditions, the SERS-LFA could simultaneously detect milk allergenic β-lactoglobulin (β-Lg) and fish allergenic parvalbumin (PV) with LODs of 40 ng/mL and 1.1 ng/mL, respectively. The proposed method demonstrated excellent specificity, reproducibility, and comparable performance to commercial ELISA kits in real-sample analysis, establishing a robust on-site methodology for rapid allergy risk screening in complex food matrices.
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MICROCHEMICAL JOURNAL
·
2026
·
IF 5.2
Xinyu Lan,Tingting Liu,Jianjun Li,Jian Zhu,Junwu Zhao,Guojun Weng
Silver coated gold nanobipyramids (Au NBPs@Ag) have opened up a wide range of applications in sensing based on the etching, due to the fact that a tiny change in shape or composition could directly lead to optical changes. Here, we developed an ultrasensitive surface-enhanced Raman scattering (SERS) method for S 2− sensing by using Au NBPs@Ag as nanoprobes. This strategy was revealed to be related to the redox reaction between S 2− and the silver nanoshell of the Au NBPs@Ag. The silver nanoshell was gradually etched as the S 2− concentration was gradually increased. Meanwhile, the generated Ag 2 S was secondary deposited on the surface of etched Au NBPs@Ag. Thus, the etching of silver shell and secondary deposition of Ag 2 S induced SERS decrease of the nanoprobes, which was not only highly selective toward S 2− but also showed a linear logarithmic dependence on S 2− concentrations from 10 −5 to 10 −8 M, with a limit of detection (LOD) of 4.7 × 10 −8 mol/L. Spike recovery tests in tap water demonstrated recoveries of 104.00%, 98.86%, and 105.32% with relative standard deviations (RSD) between 2.52% and 3.98%, validating high accuracy for S 2− detection. This approach provided a novel SERS strategy for trace sulfide monitoring in drinking water systems.
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SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
·
2026
·
IF 4.6
Yuxuan He,Jiayi Wei,Ming Cai,Junpeng Xia,Boheng Song,Jinxin Cheng,Xuanyu Sha
The performance of surface-enhanced Raman scattering (SERS) hinges on plasmonic hot spots that are both abundant and spatially uniform. Here, we propose a ligand-regulated, interface-confined growth strategy: on a bowl-like mesoporous polydopamine (PDA) scaffold, the ammoniacal silver precursor [Ag(NH 3 ) 2 ] + first forms a surface coordination layer with catechol and amine sites on PDA, lowering the activity of free Ag + and enriching Ag(I) at the interface, thereby shifting nucleation from homogeneous in the bulk to interface-confined. The ensuing constrained growth suppresses coalescence/bridging and excessive coarsening, yielding Ag nanoparticle arrays with controlled size, tunable interparticle gaps, and high spatial uniformity, and producing dense yet discrete coverage across both the inner and outer interfaces of the bowl. The concave curvature and dual-interface connectivity provide continuous coupling pathways and abundant adsorption sites, establishing a three-dimensional continuous hot-spot network. Correlative multi-technique characterization and spectroscopic analyses (SEM, EDS mapping, UV–Vis, XPS) elucidate the structure-optical-performance relationship, revealing a sparse-to-dense optimal regime and a coalescence-induced degradation regime, and identifying a precursor concentration of 50 mM as the optimal window. The resulting substrate exhibits good reproducibility for R6G (RSD ≈ 10.99 %) and affords clear molecular fingerprinting and linear quantification for pesticide analysis, with limits of detection of 55 ng mL −1 for methyl parathion and 0.209 ng mL −1 for thiram. This template-free, mild, and generalizable strategy provides a scalable route to three-dimensional plasmonic SERS substrates, leveraging PDA surface chemistry to prevent Ag aggregation at the source while constructing continuous hot spots networks.
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CHEMICAL ENGINEERING JOURNAL
·
2019
·
IF 8.355
Yi Ma,Yuanyuan Du,Ying Chen,Chenjie Gu,Tao Jiang,Guodong Wei,Jun Zhou
Aiming to realize a reliable quantification multiphase surface-enhanced Raman scattering (SERS) detection, we designed and synthesized a novel flexible and transparent SERS substrate based on PDMS film modified with forest of Ag/Au nanowires (NWs) through two steps of seed-mediated growth and magnetron sputtering coating. Owing to the flexibility of the polymer matrix, the SERS activity of the Ag/Au NWs/PDMS film was improved by a mechanical stretch strategy, showing a remarkable enhancement factor of 6.74 × 10 6 . Moreover, the versatile hybrid SERS substrate could be utilized to trace pesticides under various conditions. The monitoring of 2-naphthalenethiol with limit of detection (LOD) of 10 −9 M in atmosphere, the detection of methyl parathion (MP) with LOD of 10 −6 mg/mL on the surface of tomato, and the identifying of MP with LOD of 10 −5 mg/mL in soybean oil were all effectively realized. Particularly, the poor linear relationships in the three detections were significantly corrected to guarantee the quantitative analysis by using the intrinsic SERS peak of PDMS as internal standard. The multifunctional Ag/Au NWs/PDMS film developed here is expected to find great potential practical applications in rapid and sensitive on-site monitoring of food and environmental security.
研究领域:
分析化学
·
纳米材料
·
传感器
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食品安全
·
环境监测
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COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
·
2017
·
IF 2.714
Baoyong Liu,Mei Yang,Hongguang Li
In this paper, an effective approach was successfully developed to synthesize gold nanoflowers (GNFs) using a hydrocarbon/fluorocarbon (CH-CF) hybrid surfactant ( 1 ). Upon mixing with aqueous solution of 1 in presense of AgNO 3 , HAuCl 4 could be reduced into GNFs by ascorbic acid (AA). Influences of aging time, concentration of HAuCl 4 , AgNO 3 , AA and 1 as well as temperature were investigated in detail. GNFs could not be obtained at the absence of AgNO 3 and 1 , indicating that both of them play important roles in the formation of these anisotropic gold structures. Influences of AA and temperature are relatively less pronounced, and well-defined GNFs can be synthesized in a wide range of the concentration of AA (1×10 −3 mol·L −1 to 6 × 10 −3 mol·L −1 ) and temperature (25–50 °C). The GNFs have inhomogenous cores, indicating that they are formed by the aggregation of gold crystals of smaller sizes. A two-stage growth pathway was thus proposed to explain the mechanism of the formation of GNFs. With a large surface-to-volume ratio, GNFs show surface-enhanced Raman scattering for solid R6G with enhancement factors up to a magnitude of 10 6 . They can also be used as efficient catalysts for the reduction of 4-nitroaniline by KBH 4 . The strategy demonstrated here is a facile, rapid, and contrallable one-pot method for the synthesis of GNFs in aqueous solution, which will bring out a wide range of applications.
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