Nature Communications
·
2025
·Vol. 16
·期 1
·1-11
·
IF 15.7
Shi Chenyang,Wang Jianan,Lei Xia,Zhou Qisen,Wang Weitao,Yang Zhichun,Liu Sanwan,Zhang Jiaqi,Zhu He,Chen Rui,Pan Yongyan,Tan Zhengtian,Liu Wenguang,Zhao Zhengjing,Cai Zihe,Qin Xiaojun,Zhao Zhiguo,Li Jingbai,Liu Zonghao,Chen Wei
The employment of self-assembled molecular hybrid could improve buried interface in perovskite solar cells (PSCs). However, the interplay among hybrid self-assembled monolayers (SAMs) during the deposition process has not been well-studied. Herein, we study the interaction between co-adsorbents and commonly used SAM material, [4-(3,6-dimethyl-9 H -carbazol-9-yl)butyl]phosphonic acid (Me-4PACz) for wide-bandgap (WBG) PSCs. It is found that the co-adsorbent, 6-aminohexane-1-sulfonic acid (SA) tends to fill the uncovered sites without interference with Me-4PACz, ensuring the formation of a dense hole selective layer. Moreover, the use of SA/Me-4PACz mixed SAMs could effectively reduce the interfacial non-radiative recombination loss, optimize the energy alignment at the buried interface and regulate the crystallization of WBG perovskite. As a result, the 1.77 eV WBG PSCs deliver a power conversion efficiency (PCE) of 20.67% (20.21% certified) and an impressive open-circuit voltage ( V OC ) of 1.332 V (1.313 V certified). By combining with a 1.26 eV narrow-bandgap (NBG) PSC, we further fabricate 2-terminal all-perovskite tandem solar cells (TSCs) with a PCE of 28.94% (28.78% certified) for 0.087 cm 2 and 23.92% for mini-module with an aperture area of 11.3 cm 2 .
✓ 已验证
产品关联
DOI
PubMed
高影响因子
MICROCHIMICA ACTA
·
2024
·Vol. 191
·期 6
·1-14
·
IF 5.3
Guo Qi,Wang Du,Ma Fei,Fang Mengxue,Zhang Liangxiao,Li Peiwu,Yu Li
Phytosterols (PSs), a class of naturally occurring bioactive lipid compounds, have been found to possess a significant cholesterol-lowering effect. In developing countries, the consumption of rapeseed oil is the primary pathway of PS intake for the general population. However, developing low-cost, real-time, and high-throughput screening techniques for PSs remains a challenge. Here, a Cu-based nanocomposite CuOx@C was synthesized via a simple method of the calcination of HKUST-1 and systematically characterized by scanning electron microscopy, transmission electron microscopy, X-ray diffraction, and X-ray photoelectron spectroscopy. The CuOx@C demonstrated excellent peroxidase-like (POD-like) activity, functioning as a peroxidase mimic to facilitate the catalysis of 3,3′,5,5′-tetramethylbenzidine (TMB) into its oxidized form (oxTMB), thereby initiating a discernible color response. On the basis of this discovery, a CuOx@C-based colorimetric method for detecting total sterols in rapeseed was successfully constructed via cascade reactions. After optimizing the conditions, the high-throughput screening of total sterols in rapeseed could be completed in only 21 min, which significantly facilitated the sensing of PSs. A linear range of 0.6–6 mg/g was achieved for the detection of total sterols in rapeseed samples, thereby satisfying the requirements for detection. In addition, due to the high stability of CuOx@C and the specificity of cholesterol oxidase, the developed method had excellent stability and selectivity toward PSs, indicating that this work has huge prospects for commercial application. This innovative work overcomes the limitation of the instrumental method and provides a portable and reliable tool for total sterols detection. It can also facilitate the development of oilseeds with a high content of PSs. Graphical abstract
✓ 已验证
产品关联
DOI
PubMed
高影响因子
POLYMER BULLETIN
·
2024
·
IF 3.1
Yu Zuolong,Chen Yao,Chen Yongfei,Wei Yunxiao,Fu Changchun,Liu Dan,Niranjan Keshavan,Han Chao
Six types of γ-polyglutamic acid (γ-PGA)/cold water-soluble starch (St) composite film models were constructed using molecular dynamics simulation, and their properties were investigated and compared with the corresponding experimental values. The compatibility between the composite film components was analyzed using the radial distribution function and mean square displacement (MSD). The hydrogen-bond number and bond energy were used to track the film-formation process. The mechanical property data of the films were extracted, and MSD was used to analyze the permeability of the film to carbon dioxide, oxygen, water vapor, and carbon-16 saturated fatty acids. Finally, the simulated values of mechanical properties and permeability were compared with the experimental values. The results demonstrated that γ-PGA is well compatible with St. The intramolecular and intermolecular hydrogen bonds of γ-PGA and St did not change considerably during the film-formation process. The simulated values of the mechanical properties exhibited a similar trend as the experimental values; however, in terms of permeability, a difference was observed between the initial values of the simulated design and actual material parameters, as well as the complexity of the experiment.
✓ 已验证
产品关联
DOI
高影响因子
Nature Chemistry
·
2024
·
IF 19.2
Ma Baochen,Zhang Haikuo,Li Ruhong,Zhang Shuoqing,Chen Long,Zhou Tao,Wang Jinze,Zhang Ruixin,Ding Shouhong,Xiao Xuezhang,Deng Tao,Chen Lixin,Fan Xiulin
Ideal rechargeable lithium battery electrolytes should promote the Faradaic reaction near the electrode surface while mitigating undesired side reactions. Yet, conventional electrolytes usually show sluggish kinetics and severe degradation due to their high desolvation energy and poor compatibility. Here we propose an electrolyte design strategy that overcomes the limitations associated with Li salt dissociation in non-coordinating solvents to enable fast, stable Li chemistries. The non-coordinating solvents are activated through favourable hydrogen bond interactions, specifically F δ− –H δ+ or H δ+ –O δ− , when blended with fluorinated benzenes or halide alkane compounds. These intermolecular interactions enable a dynamic Li + –solvent coordination process, thereby promoting the fast Li + reaction kinetics and suppressing electrode side reactions. Utilizing this molecular-docking electrolyte design strategy, we have developed 25 electrolytes that demonstrate high Li plating/stripping Coulombic efficiencies and promising capacity retentions in both full cells and pouch cells. This work supports the use of the molecular-docking solvation mechanism for designing electrolytes with fast Li + kinetics for high-voltage Li batteries.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Scientific Reports
·
2025
·Vol. 15
·期 1
·1-17
·
IF 3.9
Xing Yamin,Li Guangyuan,Li Ganggang,Xu Jixuan,Zhang Ting,Li Mengxue,Gao Chunxiao,Fu Miaoran,Zheng Pengyuan,Chu Xiufeng
Metallothioneins (MTs) are a class of cysteine-rich proteins that actively participate in the cellular defense against free radicals. However, owing to the high heterogeneity among different MTs, comprehensive investigations are needed to determine the biological activities and distribution patterns of each MT in different tissues. In the present study, ectopic expression of MT1H significantly inhibited the proliferation of gastric cancer cells. Mechanistically, MT1H was transported into the nucleus and regulated the expression of key genes involved in nutrient transportation and homeostasis, such as SLC6A19, TTC39B, and ADM2, and thereby activating the p53 and autophagy pathways. Additionally, survival analysis of data from the TCGA and other databases revealed that gastric cancer patients with high expression of MT1H had longer survival. Furthermore, MT1H was undetectable in most gastric cell lines, but its expression was increased upon treatment with dexamethasone (Dexa) and the metal ion zinc. Therefore, MT1H emerges as a valuable tumor suppressor, a biomarker for the prognosis, and a promising therapeutic target in gastric cancer patients.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Journal of Analysis and Testing
·
2025
·
IF 7
Liang Yunyan,Zhou Xiaomeng,Liu Wenfeng,Shang Li
Rapid and effective differentiation of cancerous cells is essential for early diagnosis and treatment of tumors. Here, a multichannel sensor array is developed based on four surface-engineered gold-silver nanoclusters (AuAgNCs) to discriminate multiple cancerous and normal cells. Different binding affinities between various cells and AuAgNCs lead to changes in the intrinsic fluorescence of AuAgNCs as well as their peroxide-like activity. Based on the distinct response of dual fluorescence signals of four AuAgNCs, a multichannel sensor array is established, which is capable of accurately identifying both normal and cancerous cells, even cells of different subtypes and homologous cells from various individuals with high sensitivity. Moreover, this fluorescent clusterzyme-based sensor array enables quantitative detection of cancerous cells (e.g., HeLa cells) with good performance, which holds great potential as a promising platform for further cancer diagnosis.
✓ 已验证
产品关联
DOI
高影响因子
Nature Communications
·
2024
·Vol. 15
·期 1
·1-9
·
IF 14.7
Qi Cheng,Ma Xudong,Zeng Qi,Huang Zhangwei,Zhang Shanshan,Deng Xiaokang,Kong Tiantian,Liu Zhou
Hierarchical compartmentalization, a hallmark of both primitive and modern cells, enables the concentration and isolation of biomolecules, and facilitates spatial organization of biochemical reactions. Coacervate-based compartments can sequester and recruit a large variety of molecules, making it an attractive protocell model. In this work, we report the spontaneous formation of core-shell cell-sized coacervate-based compartments driven by spontaneous evaporation of a sessile droplet on a thin-oil-coated substrate. Our analysis reveals that such far-from-equilibrium architectures arise from multiple, coupled segregative and associative liquid-liquid phase separation, and are stabilized by stagnation points within the evaporating droplet. The formation of stagnation points results from convective capillary flows induced by the maximum evaporation rate at the liquid-liquid-air contact line. This work provides valuable insights into the spontaneous formation and maintenance of hierarchical compartments under non-equilibrium conditions, offering a glimpse into the real-life scenario.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Nature Communications
·
2024
·Vol. 15
·期 1
·1-13
·
IF 14.7
Xia Mengmeng,Wang Qiyue,Liu Yamin,Fang Chunyan,Zhang Bo,Yang Shengfei,Zhou Fu,Lin Peihua,Gu Mingzheng,Huang Canyu,Zhang Xiaojun,Li Fangyuan,Liu Hongying,Wang Guangfeng,Ling Daishun
Targeted assembly of nanoparticles in biological systems holds great promise for disease-specific imaging and therapy. However, the current manipulation of nanoparticle dynamics is primarily limited to organic pericyclic reactions, which necessitate the introduction of synthetic functional groups as bioorthogonal handles on the nanoparticles, leading to complex and laborious design processes. Here, we report the synthesis of tyrosine (Tyr)-modified peptides-capped iodine (I) doped CuS nanoparticles (CuS-I@P1 NPs) as self-catalytic building blocks that undergo self-propelled assembly inside tumour cells via Tyr-Tyr condensation reactions catalyzed by the nanoparticles themselves. Upon cellular internalization, the CuS-I@P1 NPs undergo furin-guided condensation reactions, leading to the formation of CuS-I nanoparticle assemblies through dityrosine bond. The tumour-specific furin-instructed intracellular assembly of CuS-I NPs exhibits activatable dual-modal imaging capability and enhanced photothermal effect, enabling highly efficient imaging and therapy of tumours. The robust nanoparticle self-catalysis-regulated in situ assembly, facilitated by natural handles, offers the advantages of convenient fabrication, high reaction specificity, and biocompatibility, representing a generalizable strategy for target-specific activatable biomedical imaging and therapy.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Nature Communications
·
2025
·Vol. 16
·期 1
·1-12
·
IF 15.7
Wang Xue,Zhong Yuan,Li Tingting,Wang Kunyu,Dong Weinan,Lu Min,Zhang Yu,Wu Zhennan,Tang Aiwei,Bai Xue
Photoluminescence is one of the most intriguing properties of metal nanoclusters derived from their molecular-like electronic structure, however, achieving high photoluminescence quantum yield (PLQY) of metal core-dictated fluorescence remains a formidable challenge. Here, we report efficient suppression of the total structural vibrations and rotations, and management of the pathways and rates of the electron transfer dynamics to boost a near-unity absolute PLQY, by decorating progressive addition of cations. Specifically, with the sequential addition of Zn 2+ , Ag + , and Tb 3+ into the 3-mercaptopropionic acids capped Au nanoclusters (NCs), the low-frequency vibration of the metal core progressively decreases from 144.0, 55.2 to 40.0 cm −1 , and the coupling strength of electrons-high-frequency vibration related to surface motifs gradually diminishes from 40.2, 30.5 to 14.4 meV. Moreover, introducing cation additives significantly reduces electron transfer time from 40, 27 to 12 ps in the pathway from staple motifs to the metal core. This benefits from the shrinkage of the total structure that speeds up the shell-core electron transition, and in particular, the Tb 3+ provides a hopping platform for the excited electrons as their intrinsic ladder-like energy level structure. As a result, it allows a remarkable enhancement in PLQY, from 51.2%, 83.4%, up to 99.5%.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
JOURNAL OF SOL-GEL SCIENCE AND TECHNOLOGY
·
2025
·
IF 3.2
Liu Hongli,Peng Ziyang,Yuan Wenjin,Zhang Baojie,Chu Peng,Liu Yuhao,Xie Weiqiang,Tao Bingxin,Song Yao,Zu Wenjing,Yu Kun,Bian Chenghao
Mullite fiber aerogels are suitable for high-temperature insulation and other extreme environment applications due to their low density, excellent thermal stability, and low thermal conductivity. However, the elevated thermal conductivity at high temperatures and the limited mechanical strength confined its wider application. In this paper, mullite fibers/silicon carbide (SiC) composite aerogels were prepared by freeze-drying method with polycarbosilane (PCS) as a precursor. The SiC formed during the pyrolysis of PCS served as a high-temperature binder, which can form a tough three-dimensional network structure with mullite fibers. Benefit from the good infrared shielding property and high strength of SiC phase, the high-temperature insulation and mechanical properties of the aerogels were greatly improved. The lowest thermal conductivity of the mullite fibers/SiC aerogel can be 0.037 W·m −1 ·K −1 at room temperature and 0.067 W·m −1 ·K −1 at 1000 °C. Meanwhile the compressive strength can reach 0.31 MPa (10% strain). These favorable properties make it a very promising material in high temperature insulation applications. Graphical
✓ 已验证
产品关联
DOI
高影响因子
JOURNAL OF NANOPARTICLE RESEARCH
·
2025
·Vol. 27
·期 2
·1-9
·
IF 2.6
Li Guo-Wei,Yan Hang-Yu,Zhang Feng-Yuan,Liu Run-Min,Luoshan Meng-Dai,Zhou Li,Wang Qu-Quan
Highly uniform gold nanorods (GNRs) with tunable surface plasmon resonances (SPRs) across the visible and near-infrared (NIR) spectral regions exhibit attractive photothermal conversion properties along with their chemical stability, good dispersibility, and biocompatibility. In this study, we investigate the optimization of photothermal conversion utilizing GNRs as an agent under the laser excitation at 808 nm, within the NIR-I window. The aspect ratio of GNRs is tuned by the AgNO 3 amount in the reaction solution, and the characteristic longitudinal SPR is of 810 nm at the aspect ratio of 4.43, matching well with the laser wavelength. When the extinction intensity (located around 808 nm) of 810-nm GNR solution is adjusted to 1.0, the photothermal conversion efficiency is achieved to an optimal value of 36.1%, which is approximately 1.7 times that of the sample with the extinction intensity of 0.3. These findings offer insights for the design of effective photothermal conversion agents.
✓ 已验证
产品关联
DOI
高影响因子
Nature Communications
·
2024
·Vol. 15
·期 1
·1-16
·
IF 14.7
Ye Qian-Ni,Zhu Long,Liang Jie,Zhao Dong-Kun,Tian Tai-Yu,Fan Ya-Nan,Ye Si-Yi,Liu Hua,Huang Xiao-Yi,Cao Zhi-Ting,Shen Song,Wang Jun
The functions of natural killer (NK) and T cells in innate and adaptive immunity, as well as their functions in tumor eradication, are complementary and intertwined. Here we show that utilization of multi-specific antibodies or nano-antibodies capable of simultaneously targeting both NK and T cells could be a valuable approach in cancer immunotherapy. Here, we introduce a tri-specific Nano-Antibody (Tri-NAb), generated by immobilizing three types of monoclonal antibodies (mAbs), using an optimized albumin/polyester composite nanoparticle conjugated with anti-Fc antibody. This Tri-NAb, targeting PDL1, 4-1BB, and NKG2A (or TIGIT) simultaneously, effectively binds to NK and CD8 + T cells, triggering their activation and proliferation, while facilitating their interaction with tumor cells, thereby inducing efficient tumor killing. Importantly, the antitumor efficacy of Tri-NAb is validated in multiple models, including patient-derived tumor organoids and humanized mice, highlighting the translational potential of NK and T cell co-targeting.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
危险品化学品经营许可证（带存储）