AIP Advances
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2020
·Vol. 10
·期 3
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IF 1.337
Qi Honghua,Zhang Ting,Zhang Deyi,Wang Kunjie,Wang Yi
To study the effects of emulsifier content on the structure and thermal properties of encapsulated phase change materials (PCMs), four kinds of paraffin/chitosan (CS) macroencapsulated PCMs with different emulsifier contents were fabricated via the piercing–solidifying method. The effects of emulsifier content on macro-profile, micromorphology, thermal energy storage properties, and thermal durability of the as-prepared composite, as well as the structure of the optimal capsules, were investigated. The results show that the non-spherical degree, average diameter, and compressive strength decreased first and then increased with increase in emulsifier content, resulting in thermal energy storage capacity’s increase at first and then its decrease. The optimal macro-capsules, fabricated at the critical micelle concentration of the emulsifier, present a regular spherical surface and microencapsulated paraffin wax inside. The paraffin content is as high as 85%, with a phase change latent heat of 112.6 J g −1 for melting and 118.7 J g −1 for solidification. The melting enthalpy and weight loss ratio of the optimal paraffin/chitosan composite after 600 heating/cooling cycles only changed to 0.71% and 1.17%, respectively. These results not only suggest that the piercing–solidifying method can be employed to fabricate macro-capsules with high heat storage performance and excellent thermal stability but also reveal that paraffin/CS can be used in thermal management at low temperature.
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Journal of Cleaner Production
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2020
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IF 7.246
Meng Li,Xingqi Zhu,Hu Yang,Xianchuan Xie,Yuanting Zhu,Guizhou Xu,Xuejiao Hu,Zhengyu Jin,Ye Hu,Zibin Hai,Aimin Li
Starch wastewater treatment required extensive optimization because of its high concentrations of organic compounds and concentrated emissions. An environmental friendly dual flocculant , composed of cationic chitosan and anionic poly-glutamic acid, was investigated. Initial mechanistic studies involving independent injections of chitosan and poly-glutamic acid revealed their primary mechanisms of charge neutralization and bridging respectively. The highest removal rates of turbidity by chitosan and poly-glutamic acid were 90.1% and 91.8%. Dosing pattern studies showed that initial chitosan dosing provided the highest removal rate and widest effective pH range. Mechanistic studies using zeta potential and floc measurements, confirmed that chitosan neutralized negative charges, while long-chained poly-glutamic acid aggregated particulates . The effects of wastewater quality storage time, compound ratio, and total dosage were studied, with optimization at 0 h, 1:1, and 80 mg L −1 , which outperformed traditional flocculants polyaluminium chloride and polyferric sulfate. The removal rates of chemical oxygen demand , total nitrogen, total phosphorus and turbidity were 44.8, 53.4, 28.1, and 98.3%. The sediment was detected containing 95% of organic matters and 5.6% of total nutrients making it an excellent organic fertilizer . This dual system is promising in starch wastewater treatment and resource recovery considering its eco-friendly and effective flocculation performance.
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FOOD HYDROCOLLOIDS
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2020
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IF 7.053
Hafiz Muhammad Ahsan,Ying Pei,Xiaogang Luo,Yixiang Wang,Yan Li,Bin Li,Shilin Liu
In order to increase the stability of the food foam system, microcrystalline cellulose (MCC) and chitosan (CHN) were used as stabilizer based on Pickering effect. The MCC/CHN colloidal particles had the initial morphology of MCC, the addition of CHN had an obvious influence on the surface zeta potential of the MCC, and it indicated that there was a strong interaction between MCC and CHN, which had been proved by using FTIR results. The MCC/CHN colloidal particles had typical shear thinning and elastic gel-like behaviors, and the Pickering emulsions stabilized by using the MCC/CHN colloidal particles also had the similar rheology properties. The pH had an obvious effect on the stability and emulsifying ability of the Pickering emulsions, and when the pH was near to 7.0, the emulsions had gelation behavior and there were inter-droplet interactions in the emulsion systems. For practical application, the solid foams were prepared from the Pickering emulsions at pH 7.0. The obtained foams had porous structure, and the molecular weight of the CHN had an influence on the strength of the foams, the energy absorption of the foams was increased from 17.66 kJ/m 3 to 32.86 KJ/m 3 with the increase of the molecular weight of the chitosan from 200 mPa s to 400 mPa s. The results indicated that MCC/CHN colloidal particles could be used to prepare food-grade solid foams through Pickering emulsions, which had great potential to produce safe, clean, and green products.
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CARBOHYDRATE POLYMERS
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2020
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IF 7.182
Jie Pan,Zheng Zhang,Ziyao Zhan,Yanfei Xiong,Yifeng Wang,Kaiyuan Cao,Yanjun Chen
Herein, for the first time the electrodeposition of carboxylated chitosan is studied and utilized for the synthesis of silver nanoparticles (AgNPs) and generation of AgNPs/carboxylated chitosan nanocomposite films. Particularly, AgNPs are in situ synthesized on electrodes or substrates during the electrodeposition. Carboxylated chitosan not only acts as the green reducing agent and stabilizing agent for preparing AgNPs, but also serves as the main component in the electrodeposited nanocomposite film. The experimental results indicate that a smooth and homogeneous film is formed on the silver plate after electrodeposition, and the electrodeposited film can be detached from the silver plate as an independent film. The TEM observation and spectroscopic analysis results confirm the existence of AgNPs (the average size of 10 nm) in the nanocomposite film. The nanocomposite films with various shapes can be fabricated by the spatial selectivity of electrodeposition. In addition, the nanocomposite film containing AgNPs shows favorable antibacterial properties.
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ACS Biomaterials Science & Engineering
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2020
·
IF 4.152
Yufeng Shou,Jiahui Zhang,Shifeng Yan,Pengfei Xia,Pengliang Xu,Guifei Li,Kunxi Zhang,Jingbo Yin
Chitosan (CS) hydrogels are widely used in wound hemostatic agents due to their superior biocompatibility, biodegradability, and hemostatic effect. However, most of them fail to achieve great hemostatic effect because of poor adhesion to bleeding tissues. Also, the conventional implantation surgery of hemostatic hydrogels to internal bleeding wounds may cause secondary trauma to the human body. In this work, catechol-hydroxybutyl chitosan (HBCS-C) has been designed and prepared by grafting hydroxybutyl groups and catechol groups to the CS backbones. The multifunctional HBCS-C hydrogels are fabricated with the properties of thermosensitivity, injectability, tissue-adhesion, biodegradation, biocompatibility, and wound hemostasis. They exhibit excellent liquid-gel transition at different temperatures, through the changes of hydrophilic–hydrophobic interaction and hydrogen bonds generating from hydroxybutyl groups. By the multiple interactions between catechol groups/amino groups and tissues, the biocompatible hydrogels can strongly adhere on the surface of tissue. To further study, the bleeding rat-liver models are made to evaluate the hemostatic effects. After injecting the hydrogel precursor solution into the rat body, the hydrogels are not only formed in situ within 30 s but are also firmly adhered to the bleeding tissues which shows effective hemostasis. The injectability and tissue-adhesion improvement in this study gives a new insight into hemostatic agents, and the multifunctional hydrogels have a great potential in the biomedical application.
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FERROELECTRICS
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2020
·
IF 0.669
Qi Tang,Ting Yang,Song Wang,Hai-Lin Cong,Xin-Rui Yang,You-Qing Shen,Bing Yu
Magnetic composites have been widely used in the area of wastewater treatment, which own the properties of simple and quick adsorption and separation functions. This article presented a cost-effective and chemically modified adsorbent (Fe3O4@SiO2@Chitosan) based on a novel facile light-assisted technique for methyl orange (MO) removal. The characterization results of FT-IR, TEM, XRD and the hysteresis loop showed that Fe3O4@SiO2@Chitosan was successfully prepared. The adsorption properties of the magnetic Fe3O4@SiO2@Chitosan composite had been discussed in detail. Results show that the magnetic composite was able to remove more than 99.15% of dyes in water under optimized conditions. The Fe3O4@SiO2@Chitosan composite was stable and easily recovered, which demonstrated that the Fe3O4@SiO2@Chitosan can be successfully used as a reusable absorbent for effective removal of methyl orange from wastewater.
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Biomaterials Science
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2020
·Vol. 8
·期 16
·4603-4615
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IF 6.183
Tingting Wu,Binglin Li,Wanshun Wang,Lingling Chen,Zhan Li,Ming Wang,Zhengang Zha,Zefeng Lin,Hong Xia,Tao Zhang
The strontium-substituted hydroxyapatite (SrHA) is a commonly used material in bone regeneration for its good osteoconductivity and high alkaline phosphatase (ALP) activity. Scaffolds used in bone defects require a high compressive modulus. However, the SrHA nanoparticle-doped scaffold cannot properly fit the required mechanical properties. Therefore, a lot of effort has been used to fabricate synthetic bone scaffolds with biocompatibility, suitable mechanical properties, antibacterial ability and osteoconductivity. Here, we used a facile hydrothermal method to synthesize graphene oxide (GO)-reinforced SrHA nanoparticles. The incorporation of GO can be used as nucleation and growth active sites of hydroxyapatite. In addition, GO is easy to self-assemble into a layered structure in the dispersion, which can effectively regulate the deposition of hydroxyapatite on the surface of GO. The scaffold was fabricated using a freeze-drying method by incorporating SrHA/GO nanoparticles into chitosan (CS) and quaternized chitosan (QCS) mixed solutions. The compressive modulus of the CS/QCS/SrHA/GO scaffold reached 438.5 kPa, which was 4-fold higher than that of the CS/QCS scaffold. The CS/QCS/SrHA/GO scaffold exhibited significantly higher in vitro mineralization levels and ALP activity. In vivo rat skull repair indicated that the CS/QCS/SrHA/GO scaffold had a significant role in promoting bone regeneration. This study provides a new strategy for modifying hydroxyapatite to satisfy the biomedical demand of bone tissue engineering scaffolds.
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DRUG DELIVERY
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2020
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IF 4.902
Tan Yang,Jianfang Feng,Qian Zhang,Wei Wu,Hailan Mo,Lanzhen Huang,Wei Zhang
A delivery system based on l-carnitine (LC) conjugated chitosan (CS)-stearic acid polymeric micelles has been developed for improving the oral bioavailability of paclitaxel (PTX) through targeting intestinal organic cation/carnitine transporter 2 (OCTN2). Stearic acid grafted chitosan (CS-SA), as micelle skeleton material, was synthesized by 1-ethyl-3-(3-dimethylaminopropyl) carbodiimide (EDC)-mediated coupling reaction. The PTX-loaded micelles were prepared by solvent evaporation-hydration method, and the ligand LC was conjugated onto the micelle surface by anchoring its derivative stearoyl group to the lipophilic core of micelle. The modified polymeric micelles showed regular spherical shapes with small particle size of 157.1 ± 5.2 nm and high drug loading capacity of 15.96 ± 0.20 wt%, and the micelle stability in water was supported by low critical micelle concentration of 14.31 ± 0.21 μg/ml. The drug-loaded micelles presented a slow and incomplete in vitro release, and the pharmacokinetic studies indicated the micelle carriers increased the relative bioavailability of PTX to 165.8% against the commercial formulation. The enhancement effect on intestinal absorption was also confirmed by the intracellular uptake of Caco-2 cells. The proposed micelle carrier system manifested a prospective tool for oral drug delivery.
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Nanotechnology Reviews
·
2019
·Vol. 8
·期 1
·645-660
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IF 2.759
Yu Miao,Jiawei Lu,Junhui Yin,Changchun Zhou,Yaping Guo,Shumin Zhou
Melanoma is the most lethal dermal tumor, and a high recurrence rate and skin defects are two main serious problems. An antimelanoma material,which effectively inhibits tumor recurrence and possesses excellent biocompatibility, is urgently needed to treat melanoma. In this study, we developed a novel antitumor Yb 3+ [Yb(NO 3 ) 3 ]containing chitosan hydrogel (Yb-CS hydrogel) by dissolving Yb(NO 3 ) 3 and chitosan in acetic acid solution and forming composite hydrogels by a freeze-drying process after adding NaOH to the mixed solution. In vitro studies demonstrated that the Yb 3+ produces effect of inducing cell death in Yb-CS hydrogel. Moreover, we found that the Yb-CS hydrogel inhibited a focal adhesion kinase (FAK)-dependent signaling pathway and induced B-16 cell anoikis. However, the Yb-CS hydrogel was less effective on L929 normal mouse dermal cells. In vivo studies showed that the Yb-CS hydrogel inhibited the recurrence of melanoma in a mouse bare xenograft tumor model. We concluded that the Yb-CS hydrogel could potentially be used in the antimelanoma field, especially in the inhibition of melanoma recurrence.
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ANALYTICAL AND BIOANALYTICAL CHEMISTRY
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2019
·Vol. 412
·期 2
·499-506
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IF 3.286
He Shao-Bin,Chen Feng-Qing,Xiu Ling-Fang,Peng Hua-Ping,Deng Hao-Hua,Liu Ai-Lin,Chen Wei,Hong Guo-Lin
Although a massive research has been devoted on the exploration of noble metal–based nanozyme, less progress has been made in the investigation of palladium (Pd) nanozyme and the interaction between ions and Pd nanozyme. In this study, a new type of Pd nanozyme was prepared by a facile one-pot approach by using carboxylated chitosan as the stabilizer. Owing to the synergistic effect of carboxylated chitosan stabilized Pd nanoparticles (CC-PdNPs) can effectively catalyze the H 2 O 2 -mediated oxidation of 3,3′,5,5′-tetramethylbenzidine sulfate (TMB) accompanied by a blue color change (oxidized TMB), indicating the peroxidase-like activity of CC-PdNPs. Furthermore, the Michaelis-Menten constants and catalytic stability of CC-PdNPs render them suitable for environmental analysis and bio-detection. Here, we found that while introducing the iodine ions (I − ) into the reaction medium, the peroxidase-like activity of CC-PdNPs has been rapidly and effectively inhibited through the formation of Pd-I bond; thus, the active sites of PdNPs can be blocked by I − . Based on this specific inhibition by I − , a facile colorimetric assay has been performed for the detection of I − with an extremely low limit of detection (0.19 nM). Furthermore, the practicality of the proposed sensor also has been demonstrated in tap water, and the satisfactory recoveries were obtained. Our study not only demonstrated a novel Pd–based nanozyme but also provided guidance for I − sensing for environmental analysis, food inspection, and bio-detection.
Graphical abstract
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CARBOHYDRATE POLYMERS
·
2019
·
IF 6.044
Maruthupandy Muthuchamy,Rajivgandhi Govindan,Kadaikunnan Shine,Veeramani Thangasamy,Naiyf S. Alharbi,Muneeswaran Thillaichidambaram,Jamal M. Khaled,Jun-Li Wen,Khalid F. Alanzi
In this study graphene/chitosan nanoparticles (GR/CS NCs) were developed. The homogenous combination of GR and CS was confirmed by FTIR spectroscopy. The combination of CS with GR sheets reduced the XRD intensity of the GR peak in GR/CS NCs, while TEM images revealed the immobile CS coating of GR sheets. Further, the anti-biofilm activity of GR/CS NCs was tested. The tests showed that the formation of biofilm by Pseudomonas aeruginosa and Klebsiella pneumoniae was inhibited at 40□g/mL GR/CS NCs up to 94 and 92 %, respectively. The intracellular and cell surface damage of the bacteria was observed by CLSM and SEM. Also, GR/CS NCs produced a toxic effect of 90 % on Artemia franciscana at 70□g/mL upon 24 h incubation. The recorded properties of the synthesized GR/CS NCs qualify them as potential agents against multi-drug resistant bacteria.
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INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
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2019
·
IF 4.784
Long Li,Jibran Iqbal,Ying Zhu,Fang Wang,Feiyu Zhang,Wanchao Chen,Ting Wu,Yiping Du
Alumina, as a support material, was loaded together with chitosan and hydroxyapatite to form chitosan/Al 2 O 3 -HA composite beads and was used for estradiol and chrysoidin removal from aqueous solution in the present work. The physicochemical properties of the beads were studied with Scanning Electron Microscopy (SEM), Fourier Transform Infrared Spectrometry (FTIR), thermogravimetric analysis (TGA) and Brunauer-Emmett-Teller (BET) surface area analysis. FTIR spectra confirmed that the chitosan was loaded successfully on Al 2 O 3 -HA, and functional groups were immobilized onto the surface of the beads after the synthesis. The adsorption condition including pH, the amount of adsorbent, initial concentration and time were evaluated during the batch experiments. Isotherm data best matched the Langmuir model and the pseudo-second-order model best described the adsorption kinetics . The maximum adsorption capacity was found to be 39.78 mg/g and 23.26 mg/g for estradiol and chrysoidine, respectively. The adsorbed estradiol and chrysoidin were completely eluted from the composite beads with the eluent of 0.1 M H 2 SO 4 /MeOH and the regenerated material was used in several cycles without deterioration in its initial performances. This study suggests that the developed composite beads have high potential for the efficient removal estradiol and chrysoidin from aqueous solution.
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