EUROPEAN POLYMER JOURNAL
·
2024
·
IF 5.8
Sihan Shen,Ran Xie,Yiqun Wang,Lingyu Jia,Zhangran Zhu,Hai Ma,Lifang Wang,Feng Sui,Yu Zhao,Qinghe Zhao,Yanjun Chen
Ferroptosis represents a novel procedure of programmed cell death driven by iron-dependent lipid peroxidation, and may offer a promising strategy for cancer therapy. In this study, we developed poly (2-ethyl-2-oxazoline)-poly (lactic acid)-SS-poly (β-amino ester) (PEOz-PLA-SS-PBAE) loaded with β-elemene. The disulfide bond mediated depletion of glutathione (GSH) and inactivation of glutathione peroxidase 4 (GPX4) will lead to inactivation of the antioxidant system of the tumor cell, and β-elemene has the capacity to generate reactive oxygen species (ROS), and the above changes would induce a disruption of the redox balance within the tumor cell, resulting in ferroptosis of the tumor cell. In conclusion, in this study, water insoluble β-elemene was solubilized by the triblock copolymer to construct a pH/GSH dual-responsive nano-delivery system, and combined with iron death and chemotherapy to exert combinatory inhibition effect on breast cancer cells, which provides a new idea for the potential clinical application of β-elemene
✓ 已验证
产品关联
DOI
高影响因子
NANOTECHNOLOGY
·
2024
·
IF 2.9
Yuhai He,Chen Wang,Qiuhua Wu,Guolin Zhang
In this paper, a new Janus-structured nano drug delivery carrier Fe3O4@TiO2&mSiO2 was designed and synthesized, which consisted of a spherical head and a closely connected rod. The head was a nanocomposite of core/shell structure with magnetic spinel ferric tetraoxide core and anatase titanium dioxide shell (Fe3O4@TiO2), and the rod was ordered mesoporous silica (mSiO2). The nanocarriers showed excellent magnetic targeting capability (saturation magnetization, 25.18 emu g-1). The core/shell heads endowed the carriers with fine microwave responsiveness. The pore volume of mesoporous nanocarriers was 0.101 cm3 g-1, and the specific surface area was 489.0 m2 g-1. Anticancer drug doxorubicin could be loaded in the mesoporous of the carriers to form Fe3O4@TiO2&mSiO2-DOX. The drug loading capacity was 10.4%. Fe3O4@TiO2&mSiO2-DOX exhibited acid-sensitive and microwavesensitive release properties along with good bio-compatibility. Fe3O4@TiO2&mSiO2 Janus nanoparticles are expected to be ideal drug carriers.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
ACS Omega
·
2024
·
IF 3.7
Di Zhang,Wanyu Wei,Tianxiang Xie,Xue Zhou,Xu He,Jie Qiao,Rui Guo,Gang Jin,Ningbo Li
In this study, the mesoporous Fe3O4 nanodrug carriers containing disulfide bonds (CHO-SMNPs) were successfully synthesized and characterized. Doxorubicin (DOX) was loaded onto the CHO-SMNPs as a model drug and gatekeeper through the formation of imine bonds with the aldehyde groups on the surface of the mesoporous materials. This drug carrier demonstrates effective drug release triggered by pH, glutathione (GSH), and near-infrared (NIR) light, along with satisfactory photothermal conversion efficiency under NIR irradiation at 808 nm. Furthermore, CHO-SMNPs exhibit excellent blood compatibility and biodegradability. They also show good biocompatibility and efficient cellular uptake in HeLa and MCF-7 cancer cells. Most importantly, the CHO-SMNPs/DOX has shown significant effectiveness in killing both HeLa and MCF-7 cancer cells. Consequently, CHO-SMNPs/DOX presents substantial potential as a magnetic-targeted, pH/GSH/NIR triple-triggered drug delivery system for synergistic chemo-photothermal therapy in tumor treatment.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
FOOD CHEMISTRY
·
2025
·
IF 9.8
Junting Wang,Jiaxuan Liu,Zhiqiang Li,Qun Li
Barrier films are essential for food packaging, but conventional solutions hinder the circular economy. This study introduces hemicellulose-based antioxidant crosslinked composite films as a sustainable alternative. We develop pH-responsive films (K-B/PVA/OA) using polyvinyl alcohol (PVA), silanized hemicellulose (KHC), blueberry anthocyanin (BA) as a pH indicator, and oxalic acid (OA) as a crosslinker. The films exhibit excellent oxygen and water vapor barrier properties and can be easily fabricated via solution casting with food-safe dispersions. The oxygen permeability ( OP ) decreases from 13.22 ± 0.65 × 10 −14 to 3.24 ± 0.98 × 10 −14 cm 3 ·μm/(m 2 ·d·Pa), and the water vapor permeability coefficient ( Pv ) drops from 15.43 ± 0.85 × 10 −13 to 7.27 ± 0.46 × 10 −13 g·cm/(cm 2 ·s·Pa). Tensile strength and modulus increase from 32.63 MPa and 765.80 MPa to 41.24 MPa and 1281.39 MPa. Esterification between PVA and hemicellulose raises surface energy, increasing the contact angle from 39.4° to 78.34°. Strawberries packaged in these films maintain their structure and exhibit a visible color change after 7 days, offering sustainable, real-time monitoring packaging.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
MOLECULES
·
2024
·Vol. 29
·期 21
·5166
·
IF 4.2
Peng Wang,Xu Zhang,Xi Le,Junjun Chen,Guangyan Zhang,Junjian An,Nianjie Feng,Junxian Xie
A thorough understanding of the lignin–carbohydrate complex (LCC) structure has a significant meaning in the high-value utilization of lignocellulose. In this work, the complex (DHPKGC) was obtained by an addition reaction between konjac glucomannan (KGM) and quinone methides generated in the synthesis of dehydrogenation polymers (DHPs) to simulate the formation of LCCs. The effect of pH on the prepared DHPKGC was investigated. The structure of the DHPKGC was characterized by Fourier Transform Infrared (FTIR),13C-Nuclear Magnetic Resonance (13C-NMR), and two-dimensional Heteronuclear Single Quantum Coherence Nuclear Magnetic Resonance (2D HSQC NMR) analyses. The results indicated the pH of 4.0 was conducive to the polymerization reaction between DHPs and oxidized KGM by the TEMPO/NaClO/NaBr system. In addition, the resultant DHPKGC was connected by benzyl ester linkages. Overall, this study aims to gain greater insight into the process of LCC formation in plants.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Materials Today Bio
·
2025
·
IF 10.2
Ziling Li,Huiling Lei,Jiannan Hu,Tong Zhou,Shuaiqi Yuan,Xinyue Ma,Yunfei Zhu,Chao Liu,Decai Wang,Yuzhou Wu,Shuyun Xu
The pneumonia induced by carbapenem resistant Klebsiella pneumoniae (CRKP) has high morbidity and mortality. Among the antibiotics currently available, polymyxin B (PMB) is considered to be the last line of defense. Routine intravenous administration of PMB has many problems, such as severe neurotoxicity and nephrotoxicity. In this study, a novel inhaled PMB-loaded albumin nanoparticles (PEG-pHSA@PMB) capable of penetrating airway mucus and responding to the infection microenvironment is constructed. An acid-responsive functional molecule (PEBA) and NH 2 -PEG-SH are linked to the surface of human serum albumin (HSA) via the conjugation reaction. Subsequently, PMB is loaded through electrostatic interactions to yield PEG-pHSA@PMB. The sulfhydryl groups of PEG-pHSA@PMB interact with mucins to help penetrate mucus after inhaled. In an acidic environment, the protonation of the tertiary amino groups within PEG-pHSA@PMB causes the charge alteration, which leads to the release of PMB. It demonstrated excellent mucus permeability, potent bactericidal activity, and superior bacteriostatic effects compared to sole PMB. Inhalation of PEG-pHSA@PMB significantly reduced the bacterial load in the lungs of mice with CRKP pneumonia, alleviating inflammatory response. Moreover, PEG-pHSA@PMB exhibited good cytocompatibility and biosafety. The novel strategy of the inhalation drug delivery system is promising for the treatment of pneumonia caused by drug-resistant bacteria.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
ACS Applied Nano Materials
·
2024
·
IF 5.3
Yunpeng Zhou,Jing Wang,Jiawei Yang,Long-Hui Duan,Hai-Bo Liu,Junfei Wu,Lina Gao
SBA-15@MOF-525 composites were constructed by in situ self-assembly of a metal–organic framework (MOF-525) with mesoporous SBA-15 silica. MOF-525 crystals were confined inside the mesopores as well as grown on the outside surface of SBA-15, under the impact of the structure-directing role of SBA-15, and the composites exhibited both microporous and mesoporous characteristics. In general, the adsorption of tetracycline (TC) on MOF-525 was affected by pH. The adsorption capacity of MOF-525 decreased rapidly, especially in an alkaline environment, due to the collapse of the MOF-525 skeleton. By contrast, incorporating MOF-525 into SBA-15 improved the stability of MOF-525. The adsorption of TC on SBA-15@MOF-525 was almost unaffected by pH. High and stable adsorption capacity over a wide pH range was maintained under acidic, neutral, and alkaline environments. The composites were used effectively for TC adsorption. The maximum adsorption capacity of TC on SBA-15@MOF-525 was 690 mg/g, which is higher than that of most of the reported adsorbents. The great potential of SBA-15@MOF-525 in practical applications was demonstrated by investigating the adsorption of TC in lake water samples.
✓ 已验证
产品关联
DOI
高影响因子
FOOD HYDROCOLLOIDS
·
2024
·
IF 11
Xuedi Ma,Zheng Zhang,Zhao Li,Zhengzong Wu,Lu Lu,Katsuyoshi Nishinari,Meng Zhao,Bo Cui
The impact of phase separation behavior on the performance of hydrogels has always been the research focus. This study explored the relationship of “pH-microstructure-hydrogel properties” of phase-separated hydrogels composed of type-A gelatin (GE, 5 wt%) and hydroxypropyl starch (HPS, 3 wt%). The results revealed that changes in the microstructure of the hydrogel at different pHs significantly impacted the gel properties. At pH 4.00 and 11.00, phase separation occurred in the GE/HPS gel with a microstructure of HPS-in-GE. In particular, at pH 5.00, 6.00, 7.00, and 9.00, severe phase separation resulted in the separation of substantial aggregates of HPS and GE, resulting in a continuous phase structure. At pH 2.00 and 3.00, phase separation was suppressed, resulting in a homogeneous microstructure. Compared to the phase-separated gels at pH 4.00–11.00, the homogeneous systems at pH 2.00 and 3.00 displayed a synergistic effect with higher gel strength. Analysis of intermolecular forces in the GE/HPS gel indicated that hydrogen bonding was the primary interaction force. Furthermore, the addition of GE/HPS into hawthorn jelly at about pH 3.00 effectively preserved the structural appearance and exhibited higher levels of hardness, thus improving the sensory properties of hawthorn jelly. In summary, phase separation decreased the storage modulus of GE/HPS gel, but the compatibility of GE/HPS macromolecules exhibited synergistic effects at 2.00 and 3.00 and improved the hydrogel mechanical properties. This work provides some new insights for GE/HPS-based gel foods.
✓ 已验证
产品关联
DOI
高影响因子
Nanomaterials
·
2024
·Vol. 14
·期 8
·696
·
IF 4.4
Lingyu Liu,Fengchen Zhou,Yuxiang Zhang,Yanhua Sun,Shixing Zhang,Kun Cai,Ruichong Qiu,Yi Lin,Wenjun Fa,Zihua Wang
A new sol-gel method that employs cation exchange from an aqueous metal ion solution with H+ions of granulated alginic acid was developed for synthesizing high-purity Y2O3nanoparticles. In this study, the cation exchange kinetics of H+~Y3+in aqueous solution were analyzed using on-line pH technology and off-line inductively coupled plasma-atomic emission spectrometry (ICP-AES) analysis. Pseudo 2nd-order models were utilized to evaluate the parameters of the kinetics, suggesting that the concentration of H+~Y3+involved in the cation exchange reaction was 1:1.733. Further, a comprehensive understanding of the Y-ALG calcination process was developed using thermo-gravimetric analysis, along with results obtained from differential scanning calorimetry (TGA/DSC). A detailed analysis of the XRD Rietveld refinement plots revealed that the crystallite sizes of Y2O3nanoparticles were about 4 nm (500 °C) and 15 nm (800 °C), respectively. Differential pulse voltammetry (DPV) was employed to investigate the electrochemical oxidation of catechol. The oxidation peak currents of catechol at Y2O3(500 °C)/GCE and Y2O3(800 °C)/GCE showed two stages linear function of concentration (2.0~20.0 × 10−6mol/L, 20.0~60.0 × 10−6mol/L). The results indicated that the detection limits were equal to 2.4 × 10−7mol/L (Y2O3(500 °C)/GCE) and 7.8 × 10−7mol/L (Y2O3(800 °C)/GCE). The study not only provided a method to synthesize metal oxide, but also proposed a promising on-line pH model to study cation exchange kinetics.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Theranostics
·
2024
·
IF 12.4
Linfeng Fan,Lulu Jin,Tianchi Tang,Yonghe Zheng,Zihang Chen,Haopu Lin,Chao Ding,Tingting Wang,Huaijun Chen,Yinghan Guo,Chaoran Xu,Hang Zhou,Xinyan Wu,Xiongjie Fu,Feng Yan,Zhengwei Mao,Gao Chen
Rationale: Intracerebral hemorrhage (ICH) is a devastating cerebrovascular disease resulting from blood extravasating into the brain parenchyma. Escalation of erythrophagocytosis (a form of efferocytosis), avoiding the consequent release of the detrimental erythrocyte lysates, may be a promising target of ICH management. The ADAM17 inhibitor and liver X receptor (LXR) agonist could promote efficient efferocytosis and injury repair. Nevertheless, the poor bioavailability and restriction of the blood-brain barrier (BBB) hinder their application. Therefore, it is needed that biocompatible and smart nanoplatforms were designed and synthesized to realize effective therapy targeting erythrophagocytosis. Methods: We first assessed the synergistic effect of therapeutic GW280264X (an ADAM17 inhibitor) and desmosterol (an LXR agonist) on erythrophagocytosis in vitro . Then a pH-responsive neutrophil membrane-based nanoplatform (NPEOz) served as a carrier to accurately deliver therapeutic GW280264X and desmosterol to the damaged brain was prepared via co-extrusion. Afterwards, their pH-responsive performance was valued in vitro and targeting ability was assessed through fluorescence image in vivo. Finally, the pro-erythrophagocytic and anti-neuroinflammatory ability of the nanomedicine and related mechanisms were investigated. Results: After the synergistical effect of the above two drugs on erythrophagocytosis was confirmed, we successfully developed neutrophil-disguised pH-responsive nanoparticles to efficiently co-deliver them. The nanoparticles could responsively release therapeutic agents under acidic environments, and elicit favorable biocompatibility and ability of targeting injury sites. D&G@NPEOz nanoparticles enhanced erythrophagocytosis through inhibiting shedding of the efferocytotic receptors MERTK/AXL mediated by ADAM17 and accelerating ABCA-1/ABCG-1-mediated cholesterol efflux regulated by LXR respectively. In addition, the nano-formulation was able to modulate the inflammatory microenvironment by transforming efferocytes towards a therapeutic phenotype with reducing the release of proinflammatory cytokines while increasing the secretion of anti-inflammatory factors, and improve neurological function. Conclusions: This biomimetic nanomedicine is envisaged to offer an encouraging strategy to effectively promote hematoma and inflammation resolution, consequently alleviate ICH progression.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
JOURNAL OF COLLOID AND INTERFACE SCIENCE
·
2024
·
IF 9.4
Yanjing Liu,Ruitao Wang,Shuhong Liu,Yunsong Xu,Zhirong Zhang,Ying Song,Zhongping Yao
The Fenton-like activated molecular oxygen technology demonstrates significant potential in the treatment of refractory organic pollutants in wastewater, offering promising development prospects. We prepared a N -doped C -coated copper-based catalyst Cu 0 /NC3-600 through the pyrolysis of Mel-modified Cu-based metal–organic framework (MOF). The results indicate that the degradation of 20 mg/L norfloxacin (NOR) was achieved using 1.0 g/L Cu 0 /NC3-600 across a wide pH range, with a removal rate exceeding 95 % and total organic carbon (TOC) removals approaching 70 % after 60 min at pH 5–11. The nitrogen doping enhances the electronic structure of the carbon material, facilitating the adsorption of molecular oxygen. Additionally, the formed carbon layer effectively prevent copper leaching,contributing to increased stability to a certain extent. Subsequently, we propose the catalytic reaction mechanism for the Cu 0 /NC/air system. Under acidic conditions, Cu 0 /NC3-600 activates molecular oxygen to produce the •O 2 – , which serves as the primary active species for NOR degradation. While in alkaline conditions, the high-valent copper species Cu 3+ is generated in conjunction with •O 2 – , both working simultaneously for NOR degradation. Furthermore, based on the LC-MS results, we deduced four possible degradation pathways. This work offers a novel perspective on expanding the pH range of copper-based catalysts with excellent ability to activate molecular oxygen for environmental water treatment.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
FOOD CHEMISTRY
·
2024
·
IF 8.5
Yumeng Shi,Jiayi Tang,Wenyu Yan,Yan Liu,Yuchun Liu,Huan Chen,Cheng Yang,Chunhuan Liu,Rong Liang
Oleogels have been explored as a new lipid-based delivery system, however, their insolubility and unsuitable shape severely limit their application in food systems. Herein, core-shell oleogel capsules with high monodispersity (coefficient variation (CV) < 5%)) were prepared via gravity-assisted co-flowing microfluidic device and simply air-drying. The oleogel capsules with oleogel core and ultrathin calcium-alginate shell were prepared. Oleogel capsules maintained their original shape at pH = 2.0 but swelled rapidly at pH = 6.8 and 7.4. The swelling ratio of shell can be adjusted by inner fluid flow rate ( Q in ). Notably, the core with beeswax (BW) crystal network, effectively improved the stability performances and also could provide thermal response. Finally, the oleogel capsules demonstrated excellent sustained release and UV protection of lipophilic bioactives. This work sheds light on development of novel oleogel capsules, making them ideal candidates for smart food encapsulation applications.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
危险品化学品经营许可证（带存储）