PROCESS SAFETY AND ENVIRONMENTAL PROTECTION
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2024
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IF 6.9
Guangyu Zhang,Feng Sun,Jian Zhao,Bing Sun,Wei Xu,Zhe Yang
The rational design of emergency relief systems for butene-1 polymerization processes is significantly complicated by the high viscosity characteristic of these systems. This study systematically investigates the runaway reaction dynamics and relief characteristics associated with butene-1 polymerization. The findings indicate that the pressure relief associated with the polymerization runaway of butene-1 is characteristic of a high-viscosity, two-phase flow vapor system. Based on the results of closed-cell tests, the venting sizing is determined for the pressure release of butene-1 polymerization plant that produces 50,000 tons annually. However, detailed relief simulation studies reveal that the release phase of butene-1 polymerization systems encounters challenges due to polymer precipitation. This precipitation can lead to blockages within the discharge line, consequently reducing the system`s release capacity. Our analysis demonstrates that maintaining pressure buffering during the relief phase facilitates the flash vaporization of butene-1 monomer within the reactor, significantly mitigating polymer discharge. To address the issues arising from polymer precipitation, we strongly recommend the implementation of a dual-valve control mechanism, comprising a rupture disc and a safety valve, alongside a reduction in the discharge pipeline length. The outcome of this research provides a dependable solution for the rational design of emergency relief systems tailored to high-viscosity polymerization systems, specifically addressing the challenges posed by polymer precipitation that can obstruct discharge pipelines.
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INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
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2024
·
IF 7.7
Wang Liu,Ya-Min Qin,Jin-Yang Shi,De-Ling Wu,Chun-Yang Liu,Juan Liang,Song-Zi Xie
This study aimed to evaluate the influence of ultrasonic degradation on the physicochemical and biological characteristics of Polygonatum cyrtonema polysaccharide (PCP, 8.59 kDa). PCP was subjected to ultrasonic treatment for 8, 16, and 24 h and yielded the degraded fractions PCP-8, PCP-16, and PCP-24 (5.06, 4.13, and 3.69 kDa), respectively. Compared with the intact PCP, PCP-8, PCP-16 and PCP-24 had a reduced particle size (decrements of 28.03 %, 46.15 % and 62.54 %, respectively). Although ultrasonic degradation did not alter the primary structure of PCP, its triple helical and superficial structures were disrupted, with degraded fractions demonstrating reduced thermal stability and apparent viscosities compared with those of the intact PCP. Furthermore, the functional properties of the degraded fractions were different. PCP-16 most favourably affected GLP-1 secretion, while PCP-8 and PCP-24 exhibited the strongest antioxidant and enzyme inhibitory activities, respectively. Hence, controlled ultrasound irradiation is an appealing approach for partially degrading PCP and enhancing its bioactivity as a functional agent.
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CERAMICS INTERNATIONAL
·
2024
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IF 5.1
Xinyuan Lyu,Luchao Ren,Le Xin,Xianfu Luo,Hui Peng,Zhichao Dong,Cuncheng Li,Panpan Lyu,Mingwei Zhang
A novel series of (1- x )MgGa 2 O 4 - x BaCu(B 2 O 5 ) ( x = 0.1–0.5) microwave dielectric ceramics were prepared by solid phase method. By adding BaCu(B 2 O 5 ) additives, the sintering temperature of MgGa 2 O 4 ceramics was reduced from 1410 °C to 925 °C. Through an analysis of the trend in packing fraction and FWHM value of T 2g Raman peak, the underlying influence mechanism of various intrinsic factors on the dielectric loss of ceramic were revealed. And the density, as the external factors, exhibits a positive correlation with the dielectric constant and Q × f value. In addition, the high bond strength of Ga-site reduces lattice distortion and consequently enhances the frequency temperature coefficient. The microwave dielectric properties of (1- x )MgGa 2 O 4 - x BaCu(B 2 O 5 ) ( x = 0.3) are found to be superior at a sintering temperature of 925 °C (ε r = 9.42, Q × f = 35,480 GHz, τ f = −22.7 ppm/°C, at 14 GHz). Moreover, the chemical compatibility of ceramics cofiring with Ag electrode makes them a highly promising substrate for microwave communications.
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JOURNAL OF CHEMICAL AND ENGINEERING DATA
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2024
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IF 2
Yong Zheng,Jiahuan Luo,Ling Li,Qian Wang,Huichao Lv,Kai Wang,Changwei Lai
In this study, six pure 1-alkyl-2-methylpyrazolium-based ionic liquids (ILs) with methyl sulfate and bis(trifluoromethylsulfonyl)imide anions ([Cnmpz][MeSO4] and [Cnmpz][NTf2], n = 2, 3, and 4) were prepared and characterized. The density, viscosity, and refractive index of these pure ILs were measured from 298.15 to 353.15 K at 101.3 kPa, which fitted well with the corresponding empirical equations. Moreover, the values of the isobaric thermal expansion coefficient were also obtained. The results of experiments and density functional theory calculations indicate that the adjacent positions of two nitrogen atoms in pyrazolium cations lead to the close packing of ions, strong cation–anion interaction, and high molar polarizability per unit volume. The effects of temperature and N-alkyl chain length on the density, viscosity, and refractive index of these ILs are similar to those for imidazolium-based salts. Compared with [Cnmpz][MeSO4], [Cnmpz][NTf2] exhibits a higher density, lower viscosity, and lower refractive index under the same conditions. Moreover, the correlation between density and refractive index was studied, and a new empirical equation was proposed to express this correlation at different temperatures. It is expected that this work will enable deeper insights into the properties, structure, and structure–property relationship of pure pyrazolium-based ILs.
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PETROLEUM SCIENCE AND TECHNOLOGY
·
2025
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IF 1.4
Airong Li,Pan Liu,Yulong Zhao,Yikai Zou
The exploration of shale gas has increasingly emerged in recent years. In this work, the ionic liquid (IL) of 1-butyl-3-methylimidazole ferric tetrachloride was firstly used as a chemical additive to improve the dissolution of shale and enhance shale gas desorption. The analyses of total organic carbon (TOC), Fourier transform infrared spectroscopy, X-ray diffractometer, X-ray photoelectron spectroscopy, and Brunauer–Emmett–Teller measurement were performed. The results revealed that the TOC content was reduced by 66.2% using a concentration of 0.1 mol/L 1-butyl-3-methylimidazole ferric tetrachloride with a solid-liquid ratio of 1:20 at 60 °C and a duration of 48 hr and the dissolution rate of shale was 18.95 wt%. Inorganic minerals within shale were dissolved, and irregular pores were observed, which improve the permeability of shale and the flow of shale gas. Meanwhile, the characterization of residues in the solution presented that the structures of long carbon chain, carbon-sulfur and amines, amides, or heterocyclic within kerogen may be disrupted, which is beneficial for the shale gas desorption. The isothermal adsorption results proved that the adsorption capacity of methane on the kerogen treated was decreased by 53.16%, which inferred that the desorption ability of shale gas can be improved.
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LWT-FOOD SCIENCE AND TECHNOLOGY
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2024
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IF 6
Xiaoling Zheng,Shuang Jiang,Yueyang Ren,Sixian Wang,Yong Xie,Tao Le
Accurate and rapid detection of nitrofurantoin metabolite 1-aminohydantoin (AHD), as one of the tissue-bound toxic metabolites in foods, is crucial. In this study, a fluorescent aptasensor was constructed for the detection of AHD, using anti-AHD aptamers firstly obtained by high-efficiency magnetic crosslinking precipitation (MCP)-SELEX. The AHD-specific aptamers were optimized and identified for their binding affinity and specificity using fluorescence-based assays and molecular dynamics simulations. The truncated aptamer AHD50-1, which exhibited highest affinity ( K d = 86 nM) and an excellent specificity, was applied to the construction of fluorescent aptasensor. Under optimized conditions, the aptasensor showed a low limit of detection (0.2 ng/mL) and a wide dynamic linear range (0.25–150 ng/mL). For the five types of samples (pork, beef, shrimp, fish and honey), the recoveries ranged from 89.4% to 110.04%, with coefficients of variation ranging from 1.43% to 14.46%. These results obtained by the proposed aptasensor corroborate very well with the method of HPLC for detection of AHD, indicating that the developed aptasensor provides an efficient and promising sustainable strategy for monitoring AHD in animal derived food.
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EJNMMI Radiopharmacy and Chemistry
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2024
·Vol. 9
·期 1
·1-17
·
IF 4.4
Chen Lijuan,Li Xiaochen,Ge Yao,Li Huiqiang,Li Ruili,Song Xiaosheng,Liang Jianfei,Zhang Weifeng,Li Xiaona,Wang Xiaoqi,Wang Yunjuan,Wu Yaping,Bai Yan,Wang Meiyun
Background A novel positron emission tomography (PET) imaging tracer, [ 18 F] SynVesT-1, targeting synaptic vesicle glycoprotein 2 (SV2A), has been developed to meet clinical demand. Utilizing the Trasis AllinOne-36 (AIO) module, we’ve automated synthesis to Good Manufacturing Practice (GMP) standards, ensuring sterile, pyrogen-free production. The fully GMP-compliant robust synthesis of [ 18 F] SynVesT-1 boosting reliability and introducing a significant degree of simplicity and its comprehensive validation for routine human use. Results [ 18 F] SynVesT-1 was synthesized by small modifications to the original [ 18 F] SynVesT-1 synthesis protocol to better fit AIO module using an in-house designed cassette and sequence. With a relatively small precursor load of 5 mg, [ 18 F] SynVesT-1 was obtained with consistently high radiochemical yields (RCY) of 20.6 ± 1.2% (the decay-corrected RCY, n = 3) at end of synthesis. Each of the final formulated batches demonstrated radiochemical purity (RCP) and enantiomeric purity surpassing 99%. The entire synthesis process was completed within a timeframe of 80 min (75 ± 3.1 min, n = 3), saves 11 min compared to reported GMP automated synthesis procedures. The in-human PET imaging of total body PET/CT and time-of-flight (TOF) PET/MR showed that [ 18 F] SynVesT-1 is an excellent tracer for SV2A. It is advantageous for decentralized promotion and application in multi-center studies. Conclusion The use of AIO synthesizer maintains high production yields and increases reliability, reduces production time and allows rapid training of production staff. Besides, the as-prepared [ 18 F] SynVesT-1 displays excellent in vivo binding properties in humans and holds great potential for the imaging and quantification of synaptic density in vivo.
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SEPARATION AND PURIFICATION TECHNOLOGY
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2024
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IF 8.1
Xuebi Du,Dawei Shao,Shichao Feng,Yinhua Wan
Two-dimensional (2D) metal–organic framework nanosheets (MONs) materials exhibit significant potential in achieving high CO 2 separation performance. This study presents a demonstration of the rapid synthesis of Ce 6 BTB nanosheets at a low temperature of 80 °C and atmosphere pressure of approximately 1 atm. The resulting Ce 6 BTB nanosheets possess notable characteristics, such as high aspect ratios and 1D diamond shaped channels, which facilitate the fast rapid transport of CO 2 molecules. The Ce 6 BTB was firstly blended into PIM-1 with different loadings to form PIM/Ce 6 BTB mixed matrix membranes (MMMs). The incorporation of well-dispersed Ce 6 BTB fillers enhances the efficiency of CO 2 transport by inter-flake nano-channels and intra-flake pores. Moreover, the increased crystallinity, dense chain spacing, and hydrogen bonding contribute to enhanced sieving ability, resulting in high gas selectivity. Consequently, the MMMs containing 2 wt% Ce 6 BTB demonstrate high CO 2 permeability of 5930 Barrer and CO 2 /N 2 selectivity of 23.2, which is far surpasses 2008 upper bound from Robeson and approaches the refined 2019 upper bound from MeKenow. Furthermore, the PIM/Ce 6 BTB-2 MMMs present relatively good anti-pressure properties and long-term operation stability, which is advantageous in terms of industrial applications.
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JOURNAL OF NANOBIOTECHNOLOGY
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2024
·Vol. 22
·期 1
·1-20
·
IF 10.6
Guo Hong,Li Xia,Mao Dengxuan,Wang Hong,Wei Liangyin,Qu Ding,Qin Xiaoying,Li Xiaoqi,Liu Yuping,Chen Yan
The insufficient abundance and weak activity of tumour-infiltrating lymphocytes (TILs) are two important reasons for the poor efficacy of PD-1 inhibitors in hepatocellular carcinoma (HCC) treatment. The combined administration of tanshinone II A (TSA) and astragaloside IV (As) can up-regulate the abundance and activity of TILs by normalising tumour blood vessels and reducing the levels of immunosuppressive factors respectively. For enhancing the efficacy of PD-1 antibody, a magnetic metal–organic framework (MOF) with a homologous tumour cell membrane (Hm) coating (Hm@TSA/As-MOF) is established to co-deliver TSA&As into the HCC microenvironment. Hm@TSA/As-MOF is a spherical nanoparticle and has a high total drug-loading capacity of 16.13 wt%. The Hm coating and magnetic responsiveness of Hm@TSA/As-MOF provide a homologous-magnetic dual-targeting, which enable Hm@TSA/As-MOF to counteract the interference posed by ascites tumour cells and enhance the precision of targeting solid tumours. Hm coating also enable Hm@TSA/As-MOF to evade immune clearance by macrophages. The release of TSA&As from Hm@TSA/As-MOF can be accelerated by HCC microenvironment, thereby up-regulating the abundance and activity of TILs to synergistic PD-1 antibody against HCC. This study presents a nanoplatform to improve the efficacy of PD-1 inhibitors in HCC, providing a novel approach for anti-tumour immunotherapy in clinical practice.
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JOURNAL OF FLUORESCENCE
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2024
·
IF 2.6
Li Ling,Li Zheng-Ling,Wang Wei,Long Xin-Xin,Liu Ping,Wang Guo-Tian,Sun Shi-Qing,Du Rong-Lian
The rapid and accurate detection of programmed death-ligand 1 (PD-L1) expression is of great value in the diagnosis and treatment of tumors. ELISA-based traditional method is the gold standard for protein detection, but there are still some shortcomings, especially the antigen-antibody dependence, greatly increased the detection time and cost. This work constructed a label-free fluorescent probe for rapid and sensitive detection of PD-L1 using a truncated aptamer as recognition molecules and double-stranded DNA specific dyes (SYBR Green I) as signal units. After a series of optimization conditions, this probe has good detection capability for PD-L1 in buffer solution with the detection limit as low as 0.68 ng/mL. Due to the specific recognition ability of aptamer and target, this method also has good selectivity for PD-L1 detection. The recovery of PD-L1 in human serum samples ranges from 86.20 to 96.36%. Compared with other methods, this strategy does not need to be marked, and does not need other complex design and purification process, but simple operation process and strong anti-interference ability. The whole detection process can be completed within 20 min and has good application prospect. This work will provide reference for drug dosage and prognosis evaluation of specific tumor therapy.
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ACS Nano
·
2025
·
IF 16
Susu Zhao,Qian Dang,Aiqing Cao,Marshet Getaye Sendeku,Hai Liu,Jian Peng,Yameng Fan,Hui Li,Fengmei Wang,Yun Kuang,Xiaoming Sun
Ruthenium (Ru)-based catalysts have demonstrated promising utilization potentiality to replace the much expensive iridium (Ir)-based ones for proton exchange membrane water electrolysis (PEMWE) due to their high electrochemical activity and low cost. However, the susceptibility of RuO2-based materials to easily be oxidized to high-valent and soluble Ru species during the oxygen evolution reaction (OER) in acid media hinders the practical application, especially under current density above 500 mA cm–2. Here, a manganese-doped RuO2 catalyst with the hydroxylated metal sites (i.e., H–Mn0.1Ru0.9O2) is synthesized for acidic OER assisted by hydrogen peroxide, where the hydroxylation results in the valence state of the Ru sites below +4. The H–Mn0.1Ru0.9O2 catalyst demonstrates an overpotential of 169 mV at 10 mA cm–2 and promising stability for an OER over 1000 h in an acidic electrolyte. A PEMWE device fabricated with the H–Mn0.1Ru0.9O2 catalyst as the anode shows a current density of 1 A cm–2 at ∼1.65 V, along with a low degradation over continuous tens of hours. Differential electrochemical mass spectrometry (DEMS) results and theoretical calculations confirm that H–Mn0.1Ru0.9O2 performs the OER through the adsorbate evolution mechanism (AEM) pathway, where the synergistic effect of hydroxylation and Mn doping in RuO2 can effectively enhance the stability of Ru sites and lattice oxygen atoms.
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CARBOHYDRATE POLYMERS
·
2024
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IF 10.7
Kaiping Wang,Yuxuan Liu,Zeming Zhang,Ziming Zheng,Wenqi Tang,Wangtianzi Teng,Xu Mu,Jinglin Wang,Yu Zhang
Lentinan (LNT), a natural polysaccharide, has been reported to exhibit immunomodulatory effects in the intestine after oral administration. Herein, we aimed to investigate the lymphatic transport of LNT in Peyer's patches (PPs) by traceable fluorescent labeling and to explore whether/how LNT contacts related immune cells. Near-infrared imaging confirmed the absorption of LNT in the small intestinal segment and its accumulation within PPs after oral administration. Subsequently, tissue imaging confirmed that M cells are the main cells responsible for transporting LNT to PPs, and an M cell model was established to explore the involvement of Dectin-1 in the absorption process. Systematic in vitro and in vivo studies revealed that the Dectin-1 further mediates the uptake of LNT by mononuclear phagocytes in PPs. Moreover, LNT can promote the proliferation and differentiation of mononuclear phagocytes, thereby activating immune responses. In summary, this study elucidates the pharmacokinetic mechanisms by which LNT exerts oral immunomodulatory effects, providing a theoretical basis for the development and application of other polysaccharides.
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