Journal of Materials Chemistry B
·
2026
·
IF 6.2
Jiahao Du,Yunyun Sun,Dong Yu,Shengwei Lu,Simin Yu,Mei Wang,Guoqing Zhou,Songxin Xu,Lei Zhang,Yefei Zhu,Longxiang Zhou
Inflammatory bowel disease (IBD) is a refractory gastrointestinal disorder characterized by sustained intestinal inflammation, mucosal barrier dysfunction, and gut dysbiosis. Excess reactive oxygen species (ROS) is a key driver of these pathological processes. Although CeO₂-based nanozymes can scavenge ROS, its clinical application is limited by poor aqueous stability. Here, we developed an oral nanozyme by co-encapsulating ultrasmall CeO₂ nanoparticles and the clinical drug 5-aminosalicylic acid (5-ASA) within liposomes. The resulting formulation (CeLA) exhibited excellent colloidal stability and robust ROS-scavenging activity, and provided marked cytoprotection against oxidative stress in vitro. In a dextran sulfate sodium (DSS)-induced colitis model, CeLA alleviated clinical symptoms, restored intestinal barrier integrity, and suppressed pro-inflammatory cytokine expression. Notably, CeLA also reshaped the dysbiotic gut microbiome by reducing pro-inflammatory bacterial taxa. This multifunctional nanozyme integrates antioxidant, anti-inflammatory, and microbiome-modulating effects, offering a promising therapeutic strategy for IBD.
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JOURNAL OF COLLOID AND INTERFACE SCIENCE
·
2026
·
IF 9.6
Ruofei Li,Hao Zhou,Jing Yao,Tiefeng Xu,Gangqiang Wang,Wangyang Lu
The conversion of 5-hydroxymethylfurfural (HMF) to 2,5-furandicarboxylic acid (FDCA) via aerobic oxidation is a crucial step toward transforming biomass into sustainable bio-based energy materials. In this study, a mesoporous Au-CoO x /m-CeO 2 catalyst was prepared using vacuum-assisted in situ self-assembly to realise this conversion. The well-defined mesostructure, as confirmed by transmission electron microscopy and nitrogen adsorption–desorption analyses, significantly enhanced active site accessibility and facilitated reactant diffusion, thereby accelerating the selective oxidation of HMF to produce FDCA. This catalytic system achieved complete conversion of HMF and an FDCA yield of 99.89 ( ± 0.03)% under ambient pressure at 90 °C. Using Au/m-CeO 2 or Au-CoO x /CeO 2 as catalysts under identical conditions, the FDCA yields were limited to 56.8 ( ± 1.9)% and 78.1 ( ± 0.8)%, respectively. The optimal catalyst also demonstrated outstanding durability, retaining 93.9 ( ± 0.7)% FDCA yield after 18 reuse cycles. This remarkable activity was attributed to the integrated Au-CoO x /m-CeO 2 architecture, wherein a synergistic metal–oxide interaction coupled with the ordered mesoporous CeO 2 framework collectively optimised the reaction–diffusion process, driving efficient HMF oxidation. This study therefore provides a new perspective for designing efficient catalysts for the conversion of HMF to FDCA, which is conducive to the conversion of biomass resources.
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INDUSTRIAL & ENGINEERING CHEMISTRY RESEARCH
·
2026
·Vol. 65
·期 33
·17553-17569
·
IF 3.9
Shi Ketao,Tang Ningjing,Xu Zhen,Zhu Youbing,Gong Ruidi,Jiao Nianming,Wang Hui
Bifunctional dehydrogenation-cracking
metal/zeolite catalysts
are
promising for the production of light olefins from alkanes, but their
activation commonly relies on high-temperature calcination. This conventional
activation can induce metal migration and aggregation, damage the
zeolite framework, reduce micropore accessibility, and alter the acid-site
distribution, thereby compromising the dehydrogenation-cracking synergy.
Herein, ion-exchanged Ag/ZSM-5 catalysts were activated by dielectric
barrier discharge (DBD) plasma as a mild alternative to thermal calcination
for nitrate removal and Ag-site reconstruction. Plasma activation
could effectively remove nitrate precursors while better preserving
the crystallinity, micropore accessibility, and acidity of ZSM-5.
More importantly, it suppressed Ag migration and aggregation, increased
the fraction of highly dispersed Ag + species associated
with exchange sites, and promoted a more favorable Brønsted/Lewis
acid balance. As a result, the plasma-activated Ag/ZSM-5 catalysts
exhibited enhanced catalytic performance in n -hexane
cracking, with higher selectivity to light olefins. At a low Ag loading,
the plasma-activated catalyst delivered a light-olefin selectivity
of 50.7% after 6 h of reaction, higher than those of the calcined
counterpart (46.8%) and parent ZSM-5 (34.7%). Meanwhile, it showed
slower deactivation during the 6 h fixed-bed reaction, together with
lower tendencies toward hydrogen transfer, aromatics formation, and
coke deposition.
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ELECTROCHIMICA ACTA
·
2026
·
IF 5.8
Yinghang Kou,Zilong Liu,Zhenyu Wang,You Fu,Mingjie Jia,Yaxin Li,Yinggang Jia,Hong-bin Sun
A 5-Ph-Tet protective layer is engineered on Zn for dendrite-free aqueous zinc-ion batteries. • Strong Zn-tetrazole coordination lowers the desolvation barrier and guides preferential Zn (002) deposition. • The layer suppresses byproduct formation by modulating the interfacial chemical environment. • It enables 3400 h of cycling in a symmetric cell and 5000 cycles in a Zn@5-Ph-Tet||NVO full cell. Constructing an artificial interfacial protective coating on the zinc surface represents a facile yet effective strategy to suppress dendrite growth and parasitic reactions in aqueous zinc-ion batteries. In this work, a protective coating containing 5-phenyl-1H-tetrazole (5-Ph-Tet) was applied onto the zinc anode surface. Owing to its electrochemical properties and a pKa of approximately 4.3, 5-Ph-Tet can buffer local pH variations at the zinc anode interface during the inevitable hydrogen evolution reaction (HER). Furthermore, the abundant zincophilic nitrogen atoms on 5-Ph-Tet coordinate with Zn 2+ , thereby facilitating uniform Zn deposition. Electrochemical evaluations validated the effectiveness of the 5-Ph-Tet protective layer: the symmetric cell exhibited a cycling life of 3400 h under the testing conditions of 1 mA cm −2 and 1 mAh cm −2 (versus only 105 h for Bare Zn), while the Zn||NVO full cell demonstrated excellent cycling stability at 1 A g −1 , remaining free from short-circuiting even after 5000 cycles. This work offers a new strategy for future investigations into anode protection in aqueous zinc-ion batteries.
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CATALYSIS LETTERS
·
2025
·Vol. 155
·期 7
·1-14
·
IF 2.4
Ren Xiaohong,Bao Zien,Wang Yong,Yu Xiaoqiang,Rong Zeming
To address the low hydrogenolysis efficiency of 4-O-5 bonds in lignin catalytic conversion, Ni-Pt/HZSM-5 bimetallic catalyst with a Ni/Pt molar ratio of 47:1 was developed using diphenyl ether (DPE) as a model compound. The results revealed that electron transfer from Ni to Pt induced a positive charge on the Ni surface, significantly enhancing its adsorption and activation capacity toward electron-rich 4-O-5 bonds. At 100 °C and 5 bar H 2 , the conversion of DPE reached 90.3% with 93.1% selectivity (phenol and benzene) and Ni-Pt/HZSM-5 retained stable over five cycles of use. When Ni-Pt/HZSM-5 was applied to pine sulfate lignin depolymerization at 220 °C and 5 bar H 2 , with yields of 12.9 wt% for phenol and 4-propylphenol and 16.3 wt% for methoxy phenolic compounds. Overall, this study would promote the application and development of high-efficiency bimetallic catalysts for the production of valuable chemicals from biomass. Graphical
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CHEMICAL ENGINEERING JOURNAL
·
2025
·
IF 13.2
Xia Jiang,Ziheng Ding,Wenhua Zhang,Zhicheng Jiang,Bi Shi
Electrocatalytic production of 2,5-furandicarboxylic acid (FDCA) from 5-hydroxymethylfurfural (HMF) is a sustainable and clean pathway for harvesting both value-added chemicals and green hydrogen (H 2 ). Herein, B, N doped porous carbon supporting Co (Co/BN-C) with abundant pyridinic N-B species was constructed via a one-pot method using chitosan as precursors, which was further applied for the paired electrocatalysis of an HMF oxidation reaction (HMFOR) and H 2 evolution reaction (HER). H 3 BO 4 as a templating agent could increase the specific surface area of the catalyst and expose more active sites for the HMFOR. Meanwhile, H 3 BO 4 also acted as a B source to dope heteroatoms in the carbon matrix, creating surface defects and thus improving electrical conductivity. Besides, B, N-doped carbon substrate induced the electron deficiency of Co nanoparticle, resulting in the strong adsorption of HMF on the catalyst surface via the interactions between the aldehyde group/furan ring of HMF and the catalyst. Consequently, the Co/BN-C catalyst exhibited remarkable performance with a high HMF conversion (> 99%) and selectivity to FDCA (> 98%) and remained high activity after 8 cycles.
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FOOD AND CHEMICAL TOXICOLOGY
·
2026
·
IF 3.2
Dongying Qin,Xunlin Chen,Keyan Pan,Zixuan Tang,Zhongzheng Chen,Xiaorong Lin,Yuanyuan Zhang
5-Hydroxymethylfurfural (5-HMF), a common by-product of thermal-processed foods, poses a potential risk of intestinal toxicity upon ingestion. However, its underlying toxic mechanisms remain incompletely understood. In this study, we investigated the effects and potential molecular pathways of 5-HMF using normal human intestinal epithelial cells (HIEC-6). The results showed that 5-HMF inhibited the proliferation of HIEC-6 cells in a concentration-dependent manner and induced apoptosis possibly through both the death receptor and mitochondrial pathways, as evidenced by increased activities of caspase-8 and caspase-9. 5-HMF increased intracellular reactive oxygen species (ROS) levels by 1.42 to 2.12 fold, disrupted antioxidant enzymes activities, and increased malondialdehyde content, indicating oxidative damage. Meanwhile, 5-HMF upregulated the mRNA expression of the pro-inflammatory cytokines TNF-α and IL-6 and downregulated the mRNA and protein expression of key tight junction proteins ZO-1, Occludin and Claudin-1, indicating promotion of inflammation and impairment of epithelial barrier. 5-HMF also altered the mRNA expression of MAPK pathway-associated genes and NF-κB , indicating a possible correlation between this signaling cascade and the toxic effects of 5-HMF. Collectively, these findings provide a theoretical foundation for the risk assessment of dietary 5-HMF exposure and for future mechanistic studies on the role of MAPK signaling in 5-HMF-induced intestinal toxicity.
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Materials Today Chemistry
·
2026
·
IF 7.4
Tengxin Ren,Lei Yang,Zicheng Li,Zhiping Wu,Na Liu,Caixia Zhu,Minghui Tan,Lishu Shao,Hao Chen,Linlin Zhao,Noritatsu Tsubaki
5-Hydroxymethylfurfural (HMF) is an important biomass-based platform molecule, its oxidation product, 2,5-furandicarboxylic acid (FDCA), can be used to produce polyethylene furanoate (PEF) that replace petroleum-based compound polyethylene terephthalate (PET). At present, the development of low-cost and efficient catalytic systems remained a significant challenges. In this work, ZSM-5 and SBA-15 zeolites were used as a composite support with micro-mesopores structure through a simple and efficient mechanical treatment, and then Co–Mn bimetallic sites were loaded on the composites by co-precipitation methods. These catalysts exhibited showed different morphology, distribution of active components, and micro-mesopores structure by adjusting Co/Mn molar ratio, loading amounts and calcination temperature. The effects of pore structure, metal composition and distribution, and electronic structure on the catalytic conversion of HMF were studied. Specially, the valence state and content of Co and Mn active species had a significant impact on the catalytic performance of HMF, and we found that the content of Mn 4+ directly affected the selectivity of FDCA, and with a positive correlation between them into a certain extent. Under optimized conditions, 15Co 2 Mn-ZS-21-400 catalyst achieved 92.2% HMF conversion and 81.7% FDCA yield. Its order micro-mesoporous structures provided rapid reaction kinetics, and the synergistic effect of the bimetallic sites enhanced the catalytic activity. Mechanism study revealed that the Co and Mn species were coordinated through electron transfer during the redox process, thereby enabling the cyclic transformation between Co 3+ and Co 2+ , as well as Mn 4+ and Mn 3+ , and then gradually oxidize HMF into FDCA. In addition, 15Co 2 Mn-ZS-21-400 maintained excellent activity after five cycles, the conversion and yield kept at 89.2% and 79.1%, respectively. This work provided a new strategy for developing highly selective and stable thermal catalysts for HMF to FDCA.
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CHEMICAL ENGINEERING JOURNAL
·
2026
·
IF 12.5
Fengyi Lu,Zheng Zhang,Xiaoying Tian,Qiongyao Su,Jinyang Li,Liangfang Zhu,Changwei Hu
Valorization of abundant biomass-derived cellulose into initial platform chemicals (IPCs) generally suffers from low process efficiency due to the difficulty in dissolution of recalcitrant cellulose that owns complex inter‐/intra-molecular hydrogen-bond network in structure. Herein, a coupled strategy of formylation-driven cellulose dissolution and regeneration is successfully established to break the trade-off between process efficiency and concentration barrier for reliable production of 5-hydroxymethylfurfural (HMF), an important IPC, from high-loading cellulose. This strategy initiates from the formylation of microcrystalline cellulose (MCC) in an anhydrous deep eutectic solvent (DES) composed of zinc bromide (ZnBr 2 ) and formic acid (FA), which allows the deconstruction of pristine hydrogen-bond network and re-construction to formylated cellulose (FC) with a maximum formyl substitution of 1.67. The subsequent regeneration of FC from water or ethanol causes the transformation of cellulose from type I to type II with smaller polymerization degree and crystallinity, thereby enabling the improvement of solubility and reactivity of regenerated FC (RFC) in water for the subsequent AlCl 3 -catalyzed conversion to HMF. A distinguished space-time yield of 231.1 g·L −1 ·h −1 with a high HMF yield of 63.9 mol% has been achieved from RFC (25.0 wt % in water phase) in a low-boiling biphasic 1,4-dioxane/NaCl-H 2 O solvent, which is so far the highest process efficiency achieved in cellulose-to-HMF conversion. It exemplifies an advance in high-efficient production of IPCs from renewable cellulose feedstock by breaking the concentration barrier for future biomass refinery.
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Biochar
·
2026
·Vol. 8
·期 1
·91
·
IF 15.1
Hu Jinye,Wang Yunpu,Jiang Haiwei,Wu Jiabo,Luo Ting,Wang Qi,Hu Yuhang,Hu Kaisong,Zhou Wenguang,Fan Liangliang
Bio-oil from pyrolysis of microalgal biomass tends to exhibit high oxygen and nitrogen content, which is challenging for the commercial application of algae-based fuels. This study started with wet torrefaction of Chlorella to improve its fuel properties, and then Zeolite Socony Mobile-5 (HZSM-5) was used to synthesize HZSM-5 coated biochar (HZSM-5@biochar) catalyst for catalytic pyrolysis. During the process, up to 96.06% of aromatics with benzene, toluene and xylene (BTX) selectivity of 83.24% and a yield of 94.64 mg g −1 was obtained under specific conditions (wet torrefaction at 200 °C, pyrolysis at 500 °C, catalyst-to-feedstock ratio of 20:1). Meanwhile, the content of oxygenates and nitrogenates was reduced from 82.14% under non-catalytic condition to 3.26%. The catalytic conversion pathway was hypothesized by catalytic experiments with model compounds. The transformation process of oxygen- and nitrogen-containing functional groups was probed by XPS and in situ DRIFTS to help elucidate the deoxygenation and denitrogenation mechanism during the catalytic pyrolysis of Chlorella . Besides, the excellent stability of HZSM-5@biochar was demonstrated by six-cycle experiments. The composite catalyst also showed lower yield of coke (0.33%) with less aromaticity after a single use compared to HZSM-5, whose coke yield was 1.87%. Scanning electron microscopy analysis revealed that compared to HZSM-5@biochar, the used HZSM-5 formed more amorphous components suspected to be coke. Graphical
The alternative text for this image may have been generated using AI.
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APPLIED BIOCHEMISTRY AND BIOTECHNOLOGY
·
2026
·
IF 3.5
Zhou Jianguo,Jiang Yanjun,He Ying,Ma Li,Yue Xiaoyang,Zhou Liya,Liu Guanhua,Zheng Xiaobing
Nucleoside analogues play a crucial role in antiviral and anticancer drug synthesis. Owing to their high catalytic efficiency and substrate specificity, nucleoside 2′-deoxyribosyltransferases (NDTs) emerge as promising biocatalysts for nucleoside analogue synthesis. However, wild-type NDTs suffer from low yields in synthesizing halogen-substituted 2′-deoxypyrimidine nucleosides due to steric hindrance from halogen substituents in the active pocket and competitive product hydrolysis. Herein we identify an NDT from Bacillus haynesii ( Bh NDT) via sequence screening and introduce an E56T/D60A ( Bh NDT-M2) double mutation to disrupt the salt bridges and increase structural flexibility, thereby widening the active pocket and enhancing catalytic activity. The Bh NDT-M2 mutant displays markedly improved activity and efficiency for synthesizing 5-fluoro-2′-deoxyuridine (FdUrd), achieving 62% of yield under 20 mM substrate, which is twice that of the wild-type. In addition, we find that high substrate concentration can bring an unexpected inhibitory effect on hydrolytic side reactions, which further improve the catalytic performance of Bh NDT-M2, achieving a 55% yield of under 150 mM substrate. The Bh NDT-M2 also exhibits high substrate specificity toward a range of 2′-deoxypyrimidine nucleoside analogues. To facilitate practical applications, Bh NDT-M2 is immobilized onto an amino-functionalized resin, and the resulting immobilized enzyme shows excellent reusability, with only 20% loss of activity after eight cycles. Collectively, these properties establish Bh NDT-M2 as a promising biocatalyst and lay the foundation for large-scale nucleoside analogue synthesis. Graphical The alternative text for this image may have been generated using AI.
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Catalysts
·
2026
·Vol. 16
·期 3
·
IF 4.5
Yao He,Jie Zhang,Renhua Huang,Nanxin Li,Yunwu Zheng
CO2-assisted catalytic pyrolysis presents a viable and promising approach to addressing plastic waste pollution and mitigating climate change. However, the effects of the metal–catalyst combination mode and the spatial distance between metal–acid sites on catalytic performance remain unclear. In this study, the reaction behaviors of the configurations, Fe3O4and ZSM-5 in tandem catalysis (Fe3O4&HZ), their physical mixture (Fe3O4-HZ), and Fe-loaded ZSM-5 (Fe/HZ), were compared in polypropylene pyrolysis under a CO2atmosphere. The aromatic contents followed this order: Fe/HZ > Fe3O4-HZ > Fe3O4&HZ > ZSM-5 > Fe3O4. Specifically, Fe/HZ with the highest degree of metal–zeolite proximity achieved an aromatic content of 66.1%, significantly higher than the 34.2% obtained with Fe3O4&HZ, demonstrating that closer metal–acid proximity promoted aromatic formation. Moreover, Fe/HZ significantly reduced coke deposition. Based on characterization results from XRD, SEM, TEM, XPS, and NH3-TPD, the enhanced spatial proximity between metal and acid sites strengthened the functional synergy between iron-based redox sites and zeolitic Brønsted acid sites. This synergy facilitated the reverse water–gas shift reaction of CO2, which consumed hydrogen generated during aromatization and shifted the reaction equilibrium toward enhanced aromatic production. These findings would offer theoretical and strategic insights into the optimization of CO2-assisted catalytic pyrolysis systems for the sustainable upcycling of plastic waste.
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