JOURNAL OF POWER SOURCES
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2025
·
IF 7.9
You Chen,Chunxiang Lu,Shuxia Yuan,Xiaodan Ren,Shijie Wu,Haozhi Duan,Ran Yuan
Lithium-sulfur batteries (LSBs) are considered a promising class of energy storage devices due to their high theoretical energy density and specific capacity. Key challenges to improving LSB performance include mitigating the shuttle effect of soluble polysulfides (LiPSs) and enhancing the conductivity of the sulfur cathode. In this study, we present a tubular material composed of porous nitrogen-doped carbon (PNC) and nitrogen-doped carbon nanotubes (NCNT) as a sulfur host (PNC/NCNT). The porous structure of PNC/NCNT provides abundant space for sulfur accommodation, while its disordered mesoporous structure and high electronic conductivity help alleviate the shuttle effect of LiPSs through nitrogen-induced defects and active sites. As a result, the PNC/NCNT/S cathode significantly enhances the poor electrical conductivity of sulfur cathodes, offering improved rate performance and robust cycling stability, with a capacity retention of 859.1 mAh g −1 after 500 cycles at 1 C and a minimal capacity fading of 0.031 % per cycle.
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高影响因子
CHEMICAL ENGINEERING JOURNAL
·
2025
·
IF 13.2
Xiaoli Pan,Qing Li,Ying Wang,Yingxi Li,Shuang Liu,Yun Duan,Huacheng Tang,Xiao Zhou,Xiaomin Lai,Fuchen Jiang,Zhen Huang,Xuebo Li,Jun Lu
Diabetic wounds represent one of the most prevalent complications in patients with diabetes mellitus. Elevated reactive oxygen species (ROS), bacterial infections, persistent inflammation, and impaired angiogenesis collectively contribute to delayed diabetic wound healing. In this study, a multifunctional, injectable, photoinitiator-free, photocrosslinkable hydrogel (G/Z@M) based on insect-derived chitosan was developed. The hydrogel system incorporated lipoic acid (LA), which possesses photopolymerization capability and potent antioxidant activity, to modify quaternized chitosan (QMCS). Through self-initiated photo-crosslinking of QMCS-LA, the hydrogel's three-dimensional network was constructed. Simultaneously, the ZIF-8@MPN nanocomposite was constructed by coating ZIF-8 with a metal-polyphenol network (MPN) functional coating formed through the coordination of epigallocatechin gallate (EGCG) with Ga 3+ . This nanocomposite was then loaded onto the QMCS-LA network. Both in vitro and in vivo experiments demonstrated that the G/Z@M hydrogel possesses great biocompatibility, antibacterial, anti-inflammatory, antioxidant, and pro-angiogenic activities, effectively promoting the healing of full-thickness skin defect wounds in MRSA-infected diabetic rats. In conclusion, the G/Z@M hydrogel presents an innovative therapeutic approach for diabetic infected wounds by simultaneously regulating oxidative stress, bacterial infection, persistent inflammation, and impaired angiogenesis.
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高影响因子
FOOD RESEARCH INTERNATIONAL
·
2025
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IF 8
Fangcheng Hu,Xingyuan Liu,Chunping Chen,Yushan Liu,Xiaotong Xu,Lin Han,Caian He,Min Wang
The clinical translation of urolithin A (UA), an ellagitannin-derived metabolite with antioxidant and mitophagy-inducing properties, is hampered by its poor solubility, limited stability, and low oral bioavailability. To address these limitations, we developed a core-shell nanoplatform (UA@ZIF-8@CMG) comprising a ZIF-8 core for efficient encapsulation and a carboxymethyl β-glucan (CMG) shell for enhanced stability and potential targeting. The optimized formulation exhibited a high drug-loading capacity (12.65 %), markedly improved UA stability, and demonstrated pH-responsive release, with minimal leakage (22 %) under simulated gastric conditions followed by sustained release in the intestinal environment. In vitro studies revealed reduced cytotoxicity and a dual cellular uptake mechanism, involving putative Dectin-1-mediated endocytosis in macrophages and nonspecific uptake in intestinal cells. This uptake profile resulted in superior preservation of mitochondrial membrane potential and more effective ROS scavenging compared with free UA. The key innovation of this system lies in the synergistic ZIF-8@CMG architecture, which integrates robust protection, controlled release, and cell-type-specific uptake, thereby distinguishing it from previously reported delivery platforms. Collectively, this work presents a translatable strategy to enhance UA bioavailability and therapeutic performance, underscoring its promise for both nutraceutical and pharmaceutical applications.
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高影响因子
JOURNAL OF ELECTRONIC MATERIALS
·
2022
·Vol. 51
·期 8
·4493-4508
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IF 2.047
Chen Yuan Tao,Wang Fang,Zhang Min,Zeng Han
2-Methyl imidazole and Zn(NO 3 ) 2 were proposed as raw materials for the hemoglobin (Hb) accommodation matrix ZIF-8, and the encapsulation of Hb molecules onto ZIF-8 was achieved by hydrogen bond interaction and electrostatic attraction. The electrochemical sensing performance of H 2 O 2 for Hb integration into metal–organic framework (MOF) material was analyzed systematically and evaluated quantitatively to identify the key factor in limiting the sensing efficiency. The influence of mutual interactions between Hb and ZIF-8 on the spectroscopic features and sensing efficiency for complexes with Hb incorporation was estimated by multiple techniques to explore the impact of those interactions on the relevant steps involved in the catalysis. The results from experiments revealed that the hydrogen bond between Hb and ZIF-8 led to non-oriented aggregation of enzyme molecules onto the MOF with reduced active surface area and inhibited catalytic activity. The relatively weak interaction between heme protein and MOF material did not result in serious distortion in the structure or chemical nature of Hb entrapment into ZIF-8. The presence of a mutual interaction between Hb and ZIF-8 did not impose a serious negative effect on heterogeneous electron shuttle (28.2–91.2 s −1 ) for the heme site in Hb entrapment into ZIF-8, which was classified into a typical quasi-reversible and thin-film confining mode with the involvement of four electrons and two H + ions. The results showed that hb-induced electrocatalysis was limited by the step of substrate diffusion (1.3 × 10 −3 s −1 ). The Hb-based electrode demonstrated excellent affinity to dissolved H 2 O 2 (Michaelis constant: 28.0 μM) and desirable sensing performance (low detection limitation: 3.7 μM). Graphical Abstract Illustration of the procedure for preparing the electrode based on MOF material (ZIF-8) with hemoglobin accommodation via physical adsorption and electrostatic attraction, which gives rise to non-oriented distribution of hemoglobin attachment onto the surface and inner cavity of ZIF-8.
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BIOORGANIC CHEMISTRY
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2021
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IF 5.275
Ren-ren Xie,Chun-ling Su,Wei Li,Xiao-Yan Zou,Yu-si Chen,Huang Tang
A series of 8-substituted sampangine derivatives have been designed, synthesized and tested for their ability to inhibit cholinesterase and penetrate the blood–brain barrier. Their chelating ability toward Zn 2+ and other biologically relevant metal ions was also demonstrated by isothermal titration calorimetry. The new derivatives exhibited high acetylcholinesterase inhibitory activity, high blood–brain barrier penetration ability and high chelating selectivity for Zn 2+ . Moreover, compound 10 with the strongest binding affinity to Zn 2+ was selected for further research. Western blotting analysis, transmission electron microscopy, DCFH-DA assay and paralysis experiment indicated that compound 10 suppressed the formation of Zn 2+ -Aβ complexes, alleviated the Zn 2+ induced neurotoxicity and inhibited the production of ROS catalyzed by Zn 2+ in Aβ42 transgenic C. elegans . Furthermore, compound 10 also inhibited the expressions of pro-inflammatory cytokines, such as NO, TNF-α, IL-6 and IL-1β, induced by Zn 2+ + Aβ 1-42 in BV2 microglial cells. In general, this work provided new insights into the design and development of potent metal-chelating agents for Alzheimer’s disease treatment.
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高影响因子
MICROCHEMICAL JOURNAL
·
2024
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IF 4.9
Yanjia Guo,Juan Lu,Jing Wang,Yujia Song,Ruidan Li,Li Tian
PM6 is a polymer donor characterized by a wide bandgap, commonly utilized in high-performance polymer solar cells. In this study, we applied PM6 to the field of electrochemiluminescence for the first time. By sequentially modifying PM6, CS@luminol and ZIF-8 on the electrode, we constructed a simple yet novel electrochemiluminescence (ECL) sensor for the detection of the colorant sunset yellow (SY). As a donor, PM6 enhanced the charge transfer rate within the system and improved its luminescence performance. CS served to stabilize the luminescent reagent due to its viscosity. ZIF-8 acted as an accelerator in the luminol luminescence system, facilitating the absorption of more active oxygen and generating additional reactive species on the electrode surface. The combined action of PM6 and ZIF-8 resulted in a luminol ECL sensor that exhibited a sensitive and stable signal. When exposed to sunset yellow, the ECL signal diminished consistently with increasing concentrations of SY. Under optimal conditions, the ECL attenuation signal demonstrated a linear relationship with the logarithm of SY concentration, with a linear range of 5.0 × 10 − 13 –5.0 × 10 − 8 mol L -1 , and a detection limit of 1.67 × 10 −13 mol L -1 (S/N = 3). The constructed sensor exhibited excellent stability, selectivity, and repeatability, making it suitable for the actual detection of sunset yellow in sports drinks.
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高影响因子
International Journal of Nanomedicine
·
2024
·
IF 6.6
Xueyun Fu,Xue Tian,Jing Lin,Qian Wang,Lingwen Gu,Ziyi Wang,Menghui Chi,Bing Yu,Zhuhui Feng,Wenyao Liu,Lina Zhang,Cui Li,Guiqiu Zhao
Background: Fungal keratitis is a serious blinding eye disease. Traditional drugs used to treat fungal keratitis commonly have the disadvantages of low bioavailability, poor dispersion, and limited permeability.Purpose: To develop a new method for the treatment of fungal keratitis with improved bioavailability, dispersion, and permeability.Methods: Zeolitic Imidazolate Framework-8 (ZIF-8) was formed by zinc ions and 2-methylimidazole linked by coordination bonds and characterized by Scanning electron microscopy (SEM), X-ray diffraction (XRD), and Zeta potential. The safety of ZIF-8 on HCECs and RAW 264.7 cells was detected by Cell Counting Kit-8 (CCK-8). Safety evaluation of ZIF-8 on mice corneal epithelium was conducted using the Draize corneal toxicity test. The effects of ZIF-8 on fungal growth, biofilm formation, and hyphae structure were detected by Minimal inhibit concentration (MIC), crystal violet staining, Propidium Iodide (PI) testing, and calcofluor white staining. The anti-inflammatory effects of ZIF-8 on RAW 246.7 cells were evaluated by Quantitative Real-Time PCR Experiments (qPCR) and Enzyme-linked immunosorbent assay (ELISA). Clinical score, Colony-Forming Units (CFU), Hematoxylin-eosin (HE) staining, and immunofluorescence were conducted to verify the therapeutic effect of ZIF-8 on C57BL/6 female mice with fungal keratitis.Results: In vitro, ZIF-8 showed outstanding antifungal effects, including inhibiting the growth of Aspergillus fumigatus over 90% at 64 μg/mL, restraining the formation of biofilm, and destroying cell membranes. In vivo, treatment with ZIF-8 reduced corneal fungal load and mitigated neutrophil infiltration in fungal keratitis, which effectively reduced the severity of keratitis in mice and alleviated the infiltration of inflammatory factors in the mouse cornea. In addition, ZIF-8 reduces the inflammatory response by downregulating the expression of pro-inflammatory cytokines TNF-α, IL-6, and IL-1β after Aspergillus fumigatus infection in vivo and in vitro.Conclusion: ZIF-8 has a significant anti-inflammatory and antifungal effect, which provides a new solution for the treatment of fungal keratitis.
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高影响因子
Analytical Methods
·
2024
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IF 2.7
Lian Xia,Can Yuan,Tianqiang He,Jiaxin Cui
Facile and sensitive determination of plant growth regulators (PGRs) in food samples is crucial but still poses a significant challenge. In this study, to enhance the sensitivity of the HPLC-DAD method for PGR detection, a dispersive solid phase extraction (d-SPE) method using zeolitic imidazolate framework-8 (ZIF-8) as the highly effective adsorbent is developed. ZIF-8 nanoparticles are formed through the coordination of Zn2+ with 2-methylimidazole. Due to its high porosity, large surface area, abundant π electronics and nitrogen electronics, ZIF-8 exhibits a strong affinity to PGRs due to the synergistic effects of π–π interaction, van der Waals force, H-bond, and surface effect. Under the optimal d-SPE conditions, the sensitivity of the method is significantly enhanced with outstanding performances, including a wide range of linearity (2.0–200 ng g−1) with high correlation coefficients (R ≥ 0.9989), low limits of detection (LODs, 0.9–8.0 ng g−1 for all PGRs), satisfactory precision (intra-day RSDs ≤ 3.3%, inter-day RSDs ≤ 4.2%), and high accuracy (recovery: 86.6–101.5%). The developed method was successfully applied to quantitatively detect 9 PGRs in fruit samples, yielding satisfactory results. This d-SPE-HPLC-DAD method, characterized by high sensitivity, simplicity, efficiency, ease of practice and cost-effectiveness for PGR detection, shows potential for detecting PGRs in other complex samples and provides a strategy for designing target-affinity adsorbents.
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JOURNAL OF MEMBRANE SCIENCE
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2022
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IF 10.53
Yong Liu,Chao Wu,Zhongming Zhou,Wei Liu,Hongyu Guo,Baoquan Zhang
The development of high-performance mixed matrix membranes (MMMs) with satisfactory structure stability has attracted much attention for the past few years. The rational design and synthesis of fillers to well coordinate themselves in the polymeric matrix is still challenging. The core-shell structured fillers were synthesized via the heteroepitaxial growth of ZIF-8 on ZIF-L(Co) surface (ZIF-L(Co)@ZIF-8), which were then embedded into Pebax to fabricate MMMs for enhanced CO 2 /CH 4 separation. The synthesized fillers and MMMs were characterized via SEM with EDS mapping, TEM, XRD , FIIR and nanoindentation measurements. The effects of ZIF-L(Co)@ZIF-8 loading and filler components on gas separation performance were studied with the evaluation of membrane stability. The experimental results indicated that the filled ZIF-L(Co)@ZIF-8 could be evenly distributed within the bulky Pebax. The synergistic effect of the core-shell structured fillers in adsorption and molecular sieving endowed the synthesized MMMs with superior gas separation performances. The optimal separation performance is achieved for the MMM containing 3 wt% of ZIF-L(Co)@ZIF-8 with a CO 2 permeability of 145.7 Barrer and a CO 2 /CH 4 selectivity of 40.9, corresponding to 79.1% and 110.1% increases over pure Pebax membrane.
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JOURNAL OF ENVIRONMENTAL MANAGEMENT
·
2026
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IF 9.2
Yidan Liu,Lejing Zhou,Li Zhao,Dianrui Yang,Xiaobo Gong,Yong Liu
A novel nitrogen-doped porous carbon catalyst (NCW) was synthesized via in-situ growth of ZIF-8 on balsa sawdust followed by controlled carbonization. The integration of ZIF-8 significantly increased specific surface area, defect density, and electrochemical activity, while nitrogen incorporation—especially pyridinic and graphitic species—enhanced 2e − oxygen reduction reaction (ORR) selectivity, achieving an exceptional H 2 O 2 selectivity of 94%. When immobilized on a graphite cathode and paired with a boron-doped diamond (BDD) anode, the NCW-based electro-Fenton (EF) system enabled robust in-situ H 2 O 2 generation and efficient tetracycline (TC) degradation. Under optimized conditions, the system achieved a maximum H 2 O 2 accumulation of 0.73 mmol L −1 , completed TC removal within 120 min, and a total organic carbon (TOC) mineralization efficiency of 84.6% after 4 h. Quenching experiments and electron paramagnetic resonance (EPR) spectroscopy identified homogeneous and heterogeneous hydroxyl radicals (·OH) and superoxide radicals ( ‐ O 2 · ‐ ) as the key reactive species. The NCW/BDD/EF system demonstrated excellent versatility across various organic pollutants and maintains robust reusability over multiple cycles. This work presents a sustainable strategy for developing wood-derived electro-Fenton catalysts for efficient antibiotic wastewater treatment.
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高影响因子
Clinical and Translational Medicine
·
2026
·Vol. 16
·期 2
·e70619
·
IF 7.9
Yifan Ren,Yuxuan Lu,Qing Cui,Hao Shang,Meng Fan,Yun Sun,Xiali Shi,Rongqian Wu,Hongwei Lu
During AP, MFG‐E8 expression in pancreatic acinar cells is downregulated, resulting in disruption of the ABCE1/MFG‐E8 complex. This impairment leads to defective mitophagy flux, accumulation of lipid peroxides, endoplasmic reticulum stress and ferroptosis, ultimately contributing to pancreatic damage .
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BIOELECTROCHEMISTRY
·
2026
·
IF 4.9
Zijie Pi,Yuanyuan Zhang,Rongqin Yang,Lin Liu,Yu Huang,Yingchi Wu,Tao Gou,Honghao Kang,Tao Zhang,Xiaoling Yang,Xiaoling Liao
A high-performance nanozyme electrochemical sensor was engineered for the sensitive detection of hydrogen peroxide (H 2 O 2 ). The sensor is based on a synergistic ternary nanocomposite of ZIF-8, reduced graphene oxide (RGO), and platinum nanoparticles (Pt NPs). In this design, the Pt NPs serve as the catalytic centers with intrinsic peroxidase-like activity, effectively mimicking natural enzymes to catalyze the electrochemical reduction of H 2 O 2 . This nanocomposite was immobilized on a glassy carbon electrode (GCE) via a combined drop-casting and electrodeposition strategy. Morphological and structural analyses using scanning electron microscopy (SEM), energy-dispersive X-ray spectroscopy (EDS), and X-ray photoelectron spectroscopy (XPS) confirmed the successful fabrication of a uniform nanocomposite architecture. Systematic optimization revealed that the sensor exhibited excellent detection performance for H 2 O 2 , with a sensitivity of 22.3 μA mM −1 cm −2 ( n = 4), a detection limit as low as 59 nM (S/N = 3), a limit of quantification of 0.197 μM, and a linear range of 62 nM–13.07 mM, exhibiting good selectivity and reproducibility. Importantly, the sensor was successfully applied for the real-time, in-situ monitoring of H 2 O 2 released from zebrafish embryos under cadmium ion (Cd 2+ ) induced oxidative stress. This work offers a promising tool for the early assessment of heavy metal-induced oxidative damage.
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高影响因子
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