Journal of Inflammation Research
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2026
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IF 4.6
Jianglong Chen,Yunfei Cui,Rujie Zhou,Yu Zhu,Meijia Chen,Jinhua Su,Jinhui Wang,Guang Li
Objective To explore the therapeutic effect and molecular mechanism of Arundina graminifolia (D.Don) Hochr (BYJ) on renal fibrosis in chronic kidney disease (CKD) mice.Methods Phytochemical profiles of the methanol extract BYJ were analyzed using ultra-performance liquid chromatography-quadrupole time-of-flight tandem mass spectrometry (UPLC-Q-TOF-MS), while network pharmacology and molecular docking were employed to predict the core active components and therapeutic targets. For experimental validation, a CKD mouse model was established via adenine induction. Mice were randomly assigned to normal control, model, and three BYJ treatment groups (low-dose: 2 g/kg·d, middle-dose: 4 g/kg·d, and high-dose: 8 g/kg·d, crude drug equivalent). Assessments included renal function parameters, histopathological changes, inflammatory markers, and oxidative stress indicators. The associated molecular mechanisms were analyzed using immunohistochemistry staining and Western blot.Results In silico analysis identified five core targets—PIK3R1, AKT1, SRC, MTOR, and EGFR—and suggested esculetin as a key active component with strong binding affinity to these targets. Experimentally, BYJ administration significantly reduced in serum creatinine (SCr), blood urea nitrogen (BUN), and the kidney index, and ameliorated glomerular atrophy and tubular dilation. Furthermore, BYJ treatment downregulated pro-inflammatory factors (eg, IL-1β), elevated superoxide dismutase (SOD) activity, and decreased malondialdehyde (MDA) content. The intervention suppressed the epithelial-mesenchymal transition (EMT) process, as evidenced by the upregulation of E-cadherin and downregulation of α-SMA expression. Mechanistic verification indicated that BYJ treatment was associated with attenuated the overactivated of TGF-β/PI3K-AKT/mTOR pathway in renal tissues.Conclusion The methanolic extract of BYJ effectively attenuates CKD progression in mice, which is associated with by modulated the overactivation of the TGF-β/PI3K-AKT/mTOR pathway, inhibited the EMT process, and ameliorated inflammatory response and oxidative stress. These findings provide a preliminary theoretical basis for the development of BYJ as a potential candidate agent for CKD treatment.
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DOI
PubMed
高影响因子
Current Computer-Aided Drug Design
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2026
·Vol. 22
·期 3
·180-194
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IF 1.5
Siluo Wu,Jiayang Wang,Ziheng Luo,Bifeng Li,Liangliang Xu,Liuchao Hu,Rihe Hu
Background Qi-Gui-Jian-Gu decoction (QGJG), as a clinical empirical formula, has clinical benefits in promoting bone formation, but the underlying mechanism for its application in treating fractures has not been investigated. Methods The potential therapeutic target and signaling pathway of QGJG for treating fractures were analyzed by network pharmacology. In vitro, we used bone marrow mesenchymal stem cells (MSCs) to evaluate osteogenic differentiation and mineralization by alizarin red staining, quantitative real-time polymerase chain reaction (qRT-PCR), western blot (WB), and immunofluorescence staining. In vivo, the 8w male SPF C57BL/6J mouse femoral fracture model was constructed, and the therapeutic effects of QGJG were evaluated. Results and Discussion By network pharmacology analysis, we found that glycogen synthase kinase 3 beta (GSK3β) was a potential therapeutic target of QGJG for treating fractures. The canonical Wnt signaling pathway was selected as the potential molecular mechanism. QGJG was confirmed to upregulate the mRNA levels of alkaline phosphatase (ALP) and bone morphogenetic protein 2 (BMP2), thereby promoting osteogenic differentiation and mineralization. Mechanistically, QGJG inhibited GSK3β while increasing p-Ser9-GSK3β to increase β-catenin protein expression and its nuclear translocation, implying the activation of the canonical Wnt signaling pathway. In vivo, QGJG administration promoted fracture healing, as demonstrated by the up-regulation of OPN and Osx, and accelerated the progression of ossification at 2 and 3 weeks after surgery. Conclusion QGJG promotes osteogenic differentiation and fracture healing by activating the canonical Wnt pathway.
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Food Bioscience
·
2026
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IF 6.2
Ruya Zhang,Shiyuan Wang,Yongbo Cheng,Chen Yang,Hui Yi,Wenge Yang,Changbin Gong
Citrus essential oil valorizes agro by-products. This biodegradable non-toxic food packaging replaces petroleum plastics. • β-Cyclodextrin metal framework reduces oil loss, overcoming cyclodextrin pore limits and metal framework toxicity. • Polylactic acid and chitosan blend improves film physical performance and antimicrobial properties. To break through the bottlenecks of existing active packaging in terms of antibacterial activity and sustained-release performance, this study fabricated polylactic acid/chitosan nanofibrous films loaded with citrus essential oil encapsulated in β-cyclodextrin metal-organic framework (CEO/β-CD-MOF/PLA/CS) via electrospinning. The properties of the resulting films were systematically investigated. The results indicated that after the introduction of CEO/β-CD-MOF into the nanofibrous films, the thermal stability and hydrophobicity of the film were improved. The film enabled sustained release of CEO for up to 240 h, and the inhibitory effects of the film against Escherichia coli , Staphylococcus aureus and Botrytis cinerea were dose-dependent. Furthermore, the composite film effectively delayed the spoilage of blackberries. Thus, the CEO/β-CD-MOF/PLA/CS nanofibrous film developed in this study demonstrated significant potential for fruit preservation. Download: Download high-res image (448KB) Download: Download full-size image
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PHYTOMEDICINE
·
2026
·
IF 11.3
Zhuorui Li,Ningbo Zhang,Limei Dai,Xiangzhen Meng,Jiaqi Huang,Qingwen Hei,Zhinan Mei,Hui Xiong
Bairesi Pills promote repigmentation in hydroquinone-induced vitiligo mice. • Bairesi Pills reduce hippuric acid levels and restore gut-skin axis homeostasis. • Bairesi Pills and their active constituents including piperine and quercitrin, enhance melanogenesis through modulation of the MAPK14/β-catenin pathway. Background Bairesi Pills is a traditional Uyghur medicinal formula prescribed for vitiligo. However, its bioactive constituents and specific pharmacological mechanisms remain to be fully elucidated. Purpose This study aims to elucidate the underlying mechanisms and identify the active constituents of Bairesi Pills in the treatment of vitiligo. Methods A hydroquinone-induced vitiligo mouse model was established to evaluate the effects of Bairesi in vivo. Serum untargeted metabolomics and gut microbiome analyses were integrated to identify key differential metabolites and explore the association between gut dysbiosis and skin depigmentation. In vitro, melanocyte oxidative injury models were established using H₂O₂ or hippuric acid. Transcriptome sequencing was performed to screen differentially expressed genes and related signaling pathways. MAPK14 overexpression and pharmacological inhibition were further used to verify the effects and mechanisms of Bairesi and its active constituents in alleviating hippuric acid-induced oxidative stress. Results In vivo, Bairesi ameliorated oxidative stress and promoted pigment deposition in vitiligo-like mice, which was associated with enhanced intestinal mucus barrier integrity, reshaped gut microbiota, and reduced hippuric acid accumulation. In vitro, H₂O₂ or hippuric acid induced oxidative injury and MAPK activation in melanocytes, whereas Bairesi, piperine, and quercitrin suppressed MAPK14 activation, alleviated oxidative stress, and restored melanin synthesis, but these protective effects were attenuated by MAPK14 overexpression. Conclusion Bairesi Pills ameliorates vitiligo-like depigmentation by reshaping the gut microbiota–metabolite profile, reducing hippuric acid accumulation, and reversing HA-induced oxidative stress through inhibition of MAPK14 phosphorylation. Download: Download high-res image (219KB) Download: Download full-size image
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SEPARATION SCIENCE AND TECHNOLOGY
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2026
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IF 2.5
Nizar Lefi,Abdellatif Sakly,Mohamed Bouzid,Saleh T. Alanezi,Md. Mahmudur Rahman,Reem Alreshidi,Abdelmottaleb Ben Lamine,Salah Knani
This study investigated the adsorption behavior of shikimic acid (SA) on a newly biosynthesized polymeric nanocomposite adsorbent (FPCD-COOH-BA), which is mild to prepare and cost-effective for wastewater treatment. Using a detailed statistical-physical model, we found that SA is physisorbed via van der Waals forces and hydrogen bonds. A thermodynamic analysis showed that the process was spontaneous and endothermic; the entropy evaluation indicates an increase in the system’s disorder before half saturation and a decrease after half saturation is exceeded. These results provide new insights on SA adsorption at the molecular level and highlight the importance of statistical physics in the interpretation of adsorption phenomena.
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高影响因子
ENVIRONMENTAL RESEARCH
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2026
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IF 8.2
Qiawen Zhang,Wensheng Qi,Dapeng Liu,Ganwei Zhang,Shusu Shen,Yaoliang Hong
To improve the permeability-selectivity balance in polyamide nanofiltration membranes, a dual-charged composite membrane (PES-CS/SBE-β-CD-PA) was fabricated via interfacial polymerization on a self-assembled CS/SBE-β-CD interlayer designed to regulate the interfacial availability and transport of PEI monomers during polyamide formation, yielding a selective layer with a lower apparent cross-sectional thickness (approximately 173 nm) and more uniform morphology. The negative potential of the interlayer-terminated surface before IP (−9.8 mV), the positive potential of the final PA surface (15.63 mV), and the sequential fabrication process support the designed negative-interlayer/positive-PA configuration. The optimized membrane exhibits a molecular weight cut-off of 445 Da, an average pore size of 0.51 nm, and MgCl 2 and MgSO 4 rejections of 94.00% and 91.34%, respectively, while maintaining a water permeance of 15.20 L m −2 ·h −1 ·bar −1 . The morphology, pore-size, and charge results support a separation mechanism combining steric/hydration effects with charge-dependent Donnan partitioning. In addition, the membrane shows improved antifouling properties and stable separation performance during 72 h continuous filtration under the tested conditions. This work presents an effective interfacial-regulation strategy for constructing nanofiltration membranes with balanced separation and antifouling performance.
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高影响因子
BIOSENSORS & BIOELECTRONICS
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2026
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IF 11.8
Xianghui Li,Wei Wang,Zhehao Weng,Yanling Huang,Huabin Cai,Jiexin Wu,Xiaoli Huang,Jinzhuan Chen,Zhenyu Lin
Postoperative delirium (POD) is a severe postoperative neurocognitive complication associated with neuroinflammation and blood-brain barrier dysfunction. As a clinically relevant circulating biomarker for POD, S100-β detection is of great importance for accurate diagnosis and progression evaluation. Traditional approaches generally rely on converting antigen-antibody recognition events into the changes in labeled signal molecules, while neglecting the intrinsic charge properties of S100-β. Herein, a bioinspired microchannel-based ion current rectification (ICR) sensor was developed for sensitive S100-β detection, where S100-β antibodies were immobilized on the microchannel surface to simulate natural molecular recognition processes. The low isoelectric point of S100-β (∼4.7) renders the protein negatively charged under neutral conditions. Specific antigen and antibody recognition increased the interfacial negative charge density of the microchannel, thereby facilitating cation transport and enhancing the rectification response under an applied electric field. This process mimics the biological processes of channel opening and ion influx in living systems. The detected rectification ratio (RR) values was linearly correlated with the logarithm of S100-β concentration in the range of 0.01 ∼ 5.0 ng/mL with a detection limit of 4.0 pg mL −1 (S/N = 3). The sensor also showed good selectivity, as well as high stability with small RSD of 2.45%. The proposed sensor was successfully applied to the clinical serum analysis, showing good agreement with enzyme-linked immunosorbent assay and high recovery rates of 97.8% - 104.0%. This work provides a promising strategy for POD-related biomarker analysis and broadens the application of bioinspired microchannel-based ICR sensors in clinical diagnostics and bioanalytical sensing.
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INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
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2026
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IF 8.7
Kaihan Li,Can Zhao,Kunshan Wang,Hongyu Liang,Suzhen Zhou,Jinbo Fan
β-Lg can simultaneously load and protect the three flavonoid compounds, namely Isl, Gen, and Bai. • In terms of stability, the β-Lg-multilinked compound shows a better protective effect against the three types of flavonoids. • A spectroscopic approach was adopted to elucidate the binding mechanisms of three flavonoids with β-Lg. • The conformational characteristics of the complexes were investigated through molecular docking and dynamics simulations. This study elucidates the interaction mechanisms of Isoliquiritigenin (Isl), Genistein (Gen) and Baicalein (Bai) with β-lactoglobulin (β-Lg), with a focus on the protein's capacity for the co-encapsulation and stabilization of these flavonoids. The binding mechanisms were characterized using fluorescence spectroscopy, high-performance liquid chromatography, non-radiative energy transfer analysis, molecular simulations. The results demonstrated that the binding affinity ( K a ) followed the order Bai > Gen > Isl. Accordingly, the calculated binding distances for Isl, Gen and Bai were 5.36 nm, 4.49 nm, and 4.20 nm, respectively. β-Lg is capable of co-encapsulating two or three flavonoids simultaneously. The most stable ternary complex (β-Lg-Isl-Gen-Bai) formed when the flavonoids were added in the sequence of Bai, Isl, and then Gen. The β-Lg multi-ligand complex provided superior protection for Isl, Gen, and Bai compared to their respective single-ligand complexes across all tested parameters: stability, antioxidant capacity, and α-amylase inhibition. For Isl, the retention rate improvement under storage stability is the largest, reaching 73.86 ± 1.04%; for Gen, the retention rate improvement under light stability is the largest, reaching 75.22 ± 0.77%; and for Bai, the retention rate improvement under thermal stability is the largest, reaching 71.90 ± 1.02%. β-Lg simultaneously encapsulates and stabilizes three flavonoids Isl, Gen, Bai, serves as a natural and potent protein carrier for these bioactive compounds, and offers theoretical support for their protection against degradation.
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高影响因子
ACS Food Science & Technology
·
2026
·
IF 3
Kexin Han,Yuying Wang,Xiaohe Ren,Hexin Lv
A green oxidative-gelation strategy was developed to transform water-insoluble paramylon (β-1,3-glucan) from Euglena gracilis into an off-white hydrogel (EPG) without cross-linkers. Alkaline dissolution, acid-neutralization, and mild H2O2 oxidation (8%, v/v, 5 h) disrupted crystallinity and reduced molecular weight while preserving the β-1,3-glycosidic backbone and triple-helix conformation. Systematic optimization based on dry weight recovery, viscosity, and SEM morphology identified 5 h as the optimal oxidation time. EPG exhibited superior antioxidant capacity compared to native paramylon, scavenging 88.1% of DPPH and 98.0% of ABTS radicals at 2.5 mg·mL–1. Oral administration in mice confirmed the safety and efficacy of EPG in enhancing hepatic antioxidant enzyme activity (SOD increased by 165%, MDA decreased by 52.6%). This solvent-free approach provides a scalable route for producing clean-label, high-performance polysaccharide hydrogels suitable for food and biomedical applications.
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高影响因子
PHYTOTHERAPY RESEARCH
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2026
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IF 8.1
Jianmei Zheng,Lu Cheng,Yingmin Wei,Mingshi Ren,Lei Wang,Jingwen Wang,Wuliu Zhou,Hui Huang,Feihua Wu
Metabolic dysfunction-associated steatotic liver disease (MASLD) is a prevalent chronic liver disorder with limited treatment and manifests as hepatic lipid accumulation. The reduction of nuclear receptor corepressor 1 (NCoR1) activates the nuclear receptor PPARα, which plays a crucial role in alleviating lipid accumulation. We found that Scutellarin (Scu) regulated autophagy-mediated NCoR1/PPARα to enhance fatty acid (FA) β-oxidation and peroxisome production, thereby alleviating the lipid accumulation of MASLD. We used palmitic acid (PA)-treated human hepatocellular carcinoma (HepG2) and alpha mouse liver 12 (AML12) cells, as well as high-fat diet-fed C57BL/6J mice to evaluate the protective effect of Scu on MASLD. Scu reduced the levels of total cholesterol, triglycerides, and lipid droplets, whereas it dose-dependently increased the levels of β-hydroxybutyrate. In addition, Scu increased mRNA and protein expression of PPARα and promoted the transcriptional activity of FA β-oxidation-related target genes. In vitro, inhibition of PPARα with small interfering RNA (siRNA) abolished the activation of FA β-oxidation by Scu. Cellular thermal shift assay and drug affinity responsive target stability demonstrated that Scu did not interact directly with PPARα. Moreover, Scu increased the protein expression of 70-kDa peroxisomal membrane protein and the mRNA expression of peroxisome biogenesis-related genes. These effects were reversed by PPARα-siRNA. Scu improved the impaired autophagy while reducing the mRNA and protein expression of NCoR1. Notably, Scu reduced the colocalization of NCoR1 with PPARα and increased its colocalization with the autophagosome GABARAP. 3-MA, an autophagy inhibitor, attenuated Scu-mediated protective effects by FA β-oxidation and peroxisome biogenesis both in vitro and in vivo. In summary, Scu reduces lipid accumulation by improving the impaired autophagy, decreasing NCoR1 expression to activate PPARα, thereby simultaneously enhancing FA β-oxidation and peroxisome biogenesis, ultimately ameliorating hepatic steatosis.
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PubMed
高影响因子
CERAMICS INTERNATIONAL
·
2026
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IF 6
Zhenghong Ju,Siyong Gu,Tao Li,Chujun Lin,Jidong Ma,Dongxu Qiao,Zhongyou Que,Huifeng Lu,Houan Zhang
Silicon nitride (Si 3 N 4 ) ceramics fabricated via hot-pressing sintering exhibit pronounced anisotropy in their properties, which restricts their practical applications. To clarify underlying mechanism responsible for this anisotropy, this study investigates the effect of β-Si 3 N 4 content on the anisotropy of microstructure, mechanical properties, and thermal conductivity of hot-pressed Si 3 N 4 ceramics. Results indicate that preferential growth of rod-like β-Si 3 N 4 along sintering pressure direction, together with intrinsic property differences between its c -axis and a -axis, induces the anisotropy in both microstructure and material properties of Si 3 N 4 ceramics. Among investigated samples, Si 3 N 4 ceramic consisting primarily of elongated rod-like β-Si 3 N 4 and small amount of residual α-Si 3 N 4 , exhibits highest degree of microstructural texture and most pronounced anisotropy in mechanical properties and thermal conductivity. Fracture toughness and flexural strength of Si 3 N 4 ceramics are higher in direction perpendicular to sintering pressure while thermal conductivity is higher in direction parallel to sintering pressure. Consequently, it is difficult to simultaneously optimize mechanical properties and thermal conductivity in same direction.
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高影响因子
CHEMICAL ENGINEERING JOURNAL
·
2026
·
IF 12.5
Yingnan Ai,Qicheng Chen,Binjian Nie,Dong Wang,Xianglin Wang
A polysaccharide-functionalized hydrogel strategy is proposed for ZISFB cathodes. • A “capture–immobilization” mechanism enables dual regulation of iodine species. • The assembled battery delivers an ultrahigh energy density of 179 Wh L −1 . • Compatible with low-cost microporous membranes, scalable for commercialization. Zinc‑iodine single flow batteries (ZISFBs) possess an exceptionally high theoretical energy density; however, the static cathode configuration imposes severe challenges, including interfacial passivation and pronounced shuttle effects. To address these issues, we propose a novel poly(vinyl alcohol) (PVA)/β-cyclodextrin (β-CD) composite hydrogel with supramolecular functionalization. Benefiting from the host–guest inclusion provided by β-CD and the physical confinement dominated by the three-dimensional hydrophilic PVA network, the hydrogel effectively mitigates I₂-induced passivation on the electrode surface while suppressing the shuttling of polyiodide species (I₃ − /I₅ − ). Building on this, we impregnated the PVA/β-CD hydrogel into the pores of cathodic carbon felt in situ, leveraging the framework's high specific surface area and three-dimensional conductive pathways. This integration markedly shortens the charge-transport length, overcomes the intrinsic ionic-transport limitations of the gel medium, and mitigates polarization. Under highly concentrated 6 M KI electrolyte and deep I − /I₂ conversion conditions, the assembled ZISFBs deliver an ultrahigh discharge energy density of 179 Wh L −1 , an energy efficiency of 82.56%, and stable cycling for over 340 h. Importantly, this material is compatible with lower-cost microporous membranes, reducing the membrane cost by ∼96% compared with Nafion-based systems, demonstrating outstanding potential for commercial scale-up. Zinc–iodine single-flow batteries (ZISFBs) are promising for large-scale energy storage due to their intrinsic safety and high theoretical energy density. However, their practical operation is still hindered by two key issues: (i) severe cathode passivation caused by insulating iodine (I₂) deposition during deep charging, and (ii) pronounced polyiodide (e.g., I₃ − /I₅ − ) shuttling across separators, which triggers self-discharge and low coulombic efficiency—especially when low-cost microporous membranes are used. To address these challenges, we propose an in situ constructed PVA/β-cyclodextrin (β-CD) supramolecular hydrogel (CD–P) impregnated into porous carbon felt. Benefiting from β-CD host–guest inclusion and the three-dimensional hydrogel confinement, CD–P establishes a “capture–immobilization” mechanism that synchronously stabilizes iodine species and suppresses polyiodide crossover, thereby realizing high-performance and highly stable zinc–iodine single flow batteries. As a result, the assembled ZISFBs deliver an ultrahigh discharge energy density of 179 Wh L −1 (approaching the theoretical limit of ∼220 Wh L −1 in 6 M KI), a high energy efficiency of up to 82.56%, and stable operation for over 340 h. Importantly, our strategy enables the replacement of expensive Nafion membranes with inexpensive microporous membranes, substantially reducing membrane costs and improving system-level economic competitiveness. Download: Download high-res image (185KB) Download: Download full-size image
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危险品化学品经营许可证（带存储）