CHEMICAL ENGINEERING JOURNAL
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2025
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IF 13.2
Man Zhao,Liwu Qiang,Meng Bai,He Xiao,Li Zhang,Junming Zhang,Tianjun Hu,Baoliang Lv,Shengxiang Wang,Jianfeng Jia
Rational design of Ni-based electrocatalysts for methanol electrooxidation reaction (MOR) and in-depth understanding of their catalytic mechanism remain a challenge. Herein, carbon dots/graphene heterostructure is constructed to load Ni(OH) 2 and the role of carbon dots focuses on regulating distribution and electronic property of Ni(OH) 2 . Regulation mechanism of carbon dots on Ni(OH) 2 for optimizing MOR activity are revealed by in-situ Raman, in-situ FTIR, operando electrochemical impedance spectroscopy, X-ray absorption fine structure (XAFS) spectroscopy, and so on. It’s found carbon dots could disperse Ni species and regulate their distribution configuration. Appropriate amount of carbon dots promotes the formation of highly dispersed CDs&Ni(OH) 2 type. Because of strong interaction between Ni(OH) 2 and CDs, coordination environment and local electronic structure of Ni in Ni-CDs/G can be regulated by carbon dots, leading to phase-ratio variation of α-Ni(OH) 2 /β‑Ni(OH) 2 and d-band center shift of Ni(OH) 2 . For the best Ni-4CDs/G electrocatalyst, more formed α-Ni(OH) 2 lead to d-band center downshift from the E F level and optimized its adsorption of methanol. Ni-4CDs/G shows the specific activity of 299.2 mA cm −2 and mass activity of 3756.5 mA mg −1 at peak current. In water splitting test, lower initial overpotential of 140 mV is found in methanol electrolysis than that in water electrolysis. This opens a new door to regulate the metal-based electrocatalysts by CDs and will inspire more people to explore CDs-based materials for electrocatalytic application.
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SCIENCE OF THE TOTAL ENVIRONMENT
·
2024
·
IF 8.2
Yiju Zhang,Huali He,Denghui Meng,Li Zhu,Wei Jia,Shaoying Liu,Jingjing Jiao,Ren Ren,Yu Zhang
Furan represents one of the dietary-sourced persistent organic pollutants and thermal processing contaminants. Given its widespread occurrence in food and various toxicological effects, accurately assessing furan exposure is essential for informing public health risks. Furan is metabolized to a reactive primary product, cis -2-butene-1,4-dial (BDA) upon absorption. Some of the resulting BDA-derived metabolites have been proposed as potential exposure biomarkers of furan. However, the lack of quantification for recognized and feasible furan biomarkers has hampered the development of internal exposure risk assessment of furan. In this study, we employed reliable non-targeted metabolomics techniques to uncover urinary furan metabolites and elucidate their chemical structures. We characterized 8 reported and 11 new furan metabolites derived from the binding of BDA with glutathione (GSH), biogenic amines, and/or amino acids in the urine of male rats subjected to varying doses of furan. Notably, a mono-GSH-BDA adduct named cyclic GSH-BDA emerged as a highly prospective specific biomarker of furan exposure, as determined by an ultrahigh-performance liquid chromatography-tandem mass spectrometry method. Cyclic GSH-BDA demonstrated a robust mass spectrometry ion response intensity and exhibited evident time- and dose response. Additionally, we conducted a comprehensive profiling of the kinetics of potential furan biomarkers over time to capture the metabolic dynamics of furan in vivo. Most urinary furan metabolites reached peak concentrations at either the first (3 h) or second (6 h) sampling time point and were largely eliminated within 36 h following furan treatment. The present study provides novel insights into furan metabolism and sheds light on the biomonitoring of furan exposure.
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LANGMUIR
·
2025
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IF 3.9
Lingling Zou,Meihua Zhu,Xinpeng Li,Yin Yang,Qi Zhou,Wenjun Yuan,Na Hu,Xiangshu Chen,Hidetoshi Kita
Construction of hierarchical pore structure in supported titanium silicalites was an effective strategy to enhance catalytic performance and avoid the separation process in industrial applications. Herein, the hierarchical TS-2 zeolites were successfully prepared on the TiO2-modified α-Al2O3 pellets by “bottom-up” method, which had good and stable catalytic performance for the allyl chloride epoxidation. TritonX-100 could construct a mesopore structure, restrain nucleation, and affect titanium coordination of the zeolites, which was beneficial for preparing large size, much hexa-coordination titanium content, and hierarchically supported TS-2 zeolites in this work. Besides, the TiO2-modified layer greatly increased the density and surface reactivity of hydroxyl groups on the α-Al2O3 pellet, which were well-situated to prepare homogeneous and anatase-free hierarchical TS-2 zeolite layers. The hierarchically supported TS-2 zeolites were applied to the epoxidation of allyl chloride with hydrogen peroxide, and allyl chloride conversion and epichlorohydrin selectivity were up to 99.13% and 96.53%, respectively.
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IONICS
·
2024
·
IF 2.4
Wu Fang,Ge Jin-Long,Zhu Yujun,Jiao Yuhong,Wu Zhong,Feng Chao,Zhao Yupei,Li Qiu
The development of high-performance and cost-effective electrocatalysts toward the oxygen evolution reaction (OER) is remarkably desirable but challenging. Herein, we design and fabricate a sea urchin-like S-doped Ni(OH) 2 electrocatalyst on nickel foam using a simple hydrothermal method, followed by treatment with Na 2 S solution. The introduction of S not only modulates the electronic structure of Ni(OH) 2 , but also improves the electronic conductivity, thus enhancing the OER performance of Ni(OH) 2 . Owing to the free-standing feature, modified electronic structure, and sea urchin-like structure, the optimized S-Ni(OH) 2 –30 min delivers excellent OER performance with overpotentials of 306 and 392 mV at 10 and 100 mA cm −2 , respectively, Tafel slope of 89.2 mV dec −1 , and stability for 30 h at 50 mA cm −2 . This work demonstrates the importance of incorporating S in Ni(OH) 2 to optimize the electronic structure for improving OER activity and provides a promising pathway to synthesize Ni(OH) 2 -based electrocatalysts.
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AMB Express
·
2024
·Vol. 14
·期 1
·1-16
·
IF 3.5
Yan Yan,Yuan Haisheng,Yang Fan,Na Heiya,Yu Xiuling,Liu Jingran,Wang Yuzhen
Non-alcoholic fatty liver disease (NAFLD) is becoming a significant global public health threat. Seabuckthorn ( Hippophae rhamnoides L.) has been used in traditional Chinese medicine (TCM). The hypolipidemic effects of Seabuckthorn polysaccharides (SP) against high-fat diets (HFD)-induced NAFLD were systematically explored and compared with that of Bifidobacterium lactis V9 ( B. Lactis V9). Results showed that HFD-induced alanine transaminase (ALT) and aspartate aminotransferase (AST) levels decreased by 2.8-fold and 4.5-fold, respectively, after SP supplementation. Moreover, the alleviating effect on hepatic lipid accumulation is better than that of B. Lactis V9. The ACC and FASN mRNA levels were significantly reduced by 1.8 fold ( P < 0.05) and 2.3 folds ( P < 0.05), respectively, while the CPT1α and PPARα mRNA levels was significantly increased by 2.3 fold ( P < 0.05) and 1.6 fold ( P < 0.05), respectively, after SP administration. SP activated phosphorylated-AMPK and inhibited PPARγ protein expression, improved serum oxidative stress and inflammation ( P < 0.05). SP supplementation leads to increased hepatic expression of nuclear factor erythroid 2-related factor 2 (Nrf-2), heme oxygenase-1 (HO-1) and Superoxide dismutase-2 (SOD-2). Furthermore, SP treatment improved HFD-induced intestinal dysbiosis. Lentisphaerae , Firmicutes , Tenericutes and Peptococcus sp., RC9_gut_group sp., and Parabacteroides sp. of the gut microbiota were significantly associated with hepatic steatosis and indicators related to oxidative stress and inflammation. Therefore, SP can mitigate hepatic lipid accumulation by regulating Nrf-2/HO-1 signaling pathways and gut microbiota. This study offers new evidence supporting the use of SP as a prebiotic treatment for NAFLD.
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Frontiers in Genetics
·
2025
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IF 2.8
Minglu Zhang,Jianbo He,Rao Fu,Guojian Bao,Yijun Lu,Zechuan Zhang,Jiawu Yan,Jialu Ding,Fei Yang,Beicheng Sun
Introduction: Small nucleolar RNA (snoRNA) mediates RNA modifications, including 2′-O-methylation (Nm) and pseudouridine (Ψ), which has been proven to impact tumor progression. However, the role of snoRNA in the epigenetics of tumors remains poorly understood due to the lack of sufficiently effective experimental methods to identify snoRNA targets. Here, we identified SNORD13H, a C/D box snoRNA, as being downregulated in hepatocellular carcinoma (HCC), and its low expression was associated with HCC development.Methods: To elucidate specific roles of SNORD13H in HCC, we used a comprehensive array of methodologies, including flow cytometry, xenograft mouse model, reverse transcription at low dNTP concentration followed by PCR (RTL-P) assay, and surface sensing of translation (SUnSET) assay.Results: In this study, we first demonstrated that reduced SNORD13H serves as a biomarker for HCC, facilitating cellular proliferation. SNORD13H mediates 2′-O-methylations of 18S rRNA and RAS mRNA, thereby enhancing translation efficiency and regulating RAS protein levels in HCC. The diminution of SNORD13H activates the RAS pathway, contributing to the progression of HCC.Discussion: Our study establishes SNORD13H as a dual-function regulator in HCC progression. Furthermore, our findings indicate that SNORD13H is detectable in plasma, highlighting its potential utility in tumor screening.
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Food & Function
·
2025
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IF 5.4
Ting Liu,Qiang Meng,Yijun Zhang,Mengxi Yu,Jianming Ye,Wei Song,Yane Luo,Tianli Yue
The gut microbiota and its associated micro-ecosystem were closely related to the onset and development of ulcerative colitis (UC). We found that Corynebacterium glutamicum (C. glutamicum) helps rebuild gut eubiosis from diabetes dysbiosis, while its effects on UC remain unknown. This study aims to investigate the therapeutic effects and mechanisms of C. glutamicum on UC. In this study, C. glutamicum was encapsulated with thiolated hyaluronic acid (HA-SH) to form a hydrogel termed as CG-HA-SH. The adhesion and distribution of CG-HA-SH in the intestine were evaluated, along with its therapeutic effects on UC mice, including its impact on the gut microbiota. Additionally, changes in short-chain fatty acids (SCFAs) in the intestines of UC mice were analyzed, and RNA sequencing (RNA-Seq) was employed to investigate the mechanisms by which C. glutamicum alleviated inflammation. HA-SH enhanced the resistance of C. glutamicum in gastric and intestinal fluids, providing approximately 12 hours of adhesion at colitis inflammation sites. C. glutamicum reduced the levels of pro-inflammatory factors like IL-1β (by 97.31%) and TNF-α (by 90.10%) while increasing anti-inflammatory IL-10 (by 197.59%) in the colon. It also increased the abundance of E. fissicatena, Muribaculum, and butyrate, enhanced intestinal tight junctions (OCC, by 318.93%) and mucus barrier (MUC2, by 515.93%). The mRNA levels of cIAP1/2 decreased by 4.33 folds, their protein expression levels were reduced by 36.97% correspondingly. The enrichment of TNF pathway was the most significant. Therefore, C. glutamicum exhibited remarkable efficacy in alleviating inflammation and reshaping dysbiotic gut microbiota by downregulating the cIAP1/2-mediated TNF signaling pathway and NF-κB signaling pathway. cIAP1 and cIAP2 might serve as effective therapeutic targets.
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BIOCHEMICAL SYSTEMATICS AND ECOLOGY
·
2025
·
IF 2
Li-Juan Hu,Xian-Sheng Ye,Kuan Lin,Jie Gao,De-Sen Yang,Guo-Ping Gan,Xi-Ji Shu,Wei Liu,You-Hua Yang
One previously undescribed 2-arylbenzofuran derivative ( 1 ), three stilbenes ( 2 - 4 ), three acetophenone glycosides ( 5 – 7 ), three phenylpropanoids ( 8 – 10 ), and eight flavonoids ( 11 – 18 ) were isolated from the rhizome of Smilax china L. in this study. NMR spectra elucidated their structures and were compared with previously reported data. Compounds 1 , 5 – 7 , 10 , and 18 were identified for the first time in Smilax china L. The cytotoxicity of the isolated compounds was detected on HeLa cells by the CCK-8 method, and compound 4 was found to possess the highest cytotoxic activity with an IC 50 value of 34.81 ± 1.50 μg/mL. Further studies revealed that the cytotoxic effect of compound 4 on HeLa cells was related to apoptosis and the cell cycle. In addition, the chemotaxonomic significance of the isolated compounds was discussed.
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CURRENT MICROBIOLOGY
·
2025
·Vol. 82
·期 9
·1-18
·
IF 2.6
Xu Wenyi,Guan Yinghua,Tian Liping,Fu Yu,Zhang Yinghui,Liu Yanhong,Hu Yanfei,Zhao Bowen,Wu Chongming
The global prevalence of type 2 diabetes mellitus (T2DM) is currently surging, posing significant health and socioeconomic burdens. Probiotics have emerged as promising interventions due to their safety and potential metabolic benefits. Gut microbiota plays a critical role in the pathophysiology of metabolic diseases in humans, offering valuable insights for therapeutic strategies such as probiotics. Here, aiming to identify novel probiotics from the human gut microbes to combat T2DM, a total of 203 human intestinal bacterial strains were screened in vitro to evaluate their enzymatic inhibition of α-glucosidase and α-amylase, in which Lacticaseibacillus paracasei Glu-07 (= QH-142 = CGMCC 23796) exhibited the highest inhibitory efficacy (81.05% and 72.56% for α-glucosidase and α-amylase, respectively). In HepG2 cells, L. paracasei Glu-07 elevated glucose uptake and consumption by 22.4% and 85.8%. Oral administration of strain Glu-07 in diabetic mice significantly improved hyperglycemia, hyperlipidemia, and restored the structure and composition of gut microbiota toward a healthier profile. Mechanistically, strain Glu-07 activated the AMPK-AKT1-GSK3β/FOXO1 signaling pathways by modulating the expression of key genes, enhanced glycolysis and fatty acid ꞵ-oxidation, and inhibited gluconeogenesis and lipogenesis. It also stimulated GLP-1 secretion, potentially via triggering the GPR41/43-GLP-1 axis, and increased the abundance of beneficial gut microbes, such as Akkermansia muciniphila (~ threefold). The dual regulations synergistically support strain Glu-07 as a promising probiotic candidate for T2DM management.
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JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
·
2025
·
IF 4.9
Jianhong Liu,Yujie Han,Xin He,Xinghua Zhao
Type 2 diabetes (T2DM), a chronic metabolic disorder driven by insulin resistance or deficiency, necessitates novel therapeutic strategies. Piperine (PIP), a bioactive alkaloid from Piper nigrum and Piper longum , exhibits antidiabetic potential but suffers from poor solubility and bioavailability. This study developed two cocrystals, PIP-3,5-DHBA·H 2 O and PIP-2,6-DHBA, to address these limitations. Structural characterization via SCXRD, PXRD, DSC-TGA, FT-IR, and optical microscopy confirmed cocrystal formation. Pharmacokinetic and therapeutic evaluations focused on PIP-3,5-DHBA·H 2 O in STZ-induced diabetic C57BL/6J mice over 10 weeks, assessing metabolic parameters, pancreatic histopathology, and gut microbiota. Results revealed enhanced solubility for both cocrystals, with PIP-3,5-DHBA·H 2 O displaying superior bioavailability (2.8-fold increases in C max and AUC 0–24 ). Treatment significantly reduced fasting glucose, TG, TC, and LDL-C while elevating HDL-C. Gut microbiota analysis demonstrated decreased Firmicutes / Bacteroidetes ratio and enriched beneficial genera ( Coprococcus , Akkermansia ). Mechanistically, the cocrystal improved β-cell function and metabolic regulation. These findings validate cocrystallization as a viable strategy to overcome PIP's physicochemical limitations, offering a dual-functional approach for T2DM management through enhanced bioavailability, metabolic restoration, and microbiome modulation.
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CHEMICAL ENGINEERING SCIENCE
·
2025
·
IF 4.3
Jiqing Rao,Xin Tian,Yuze Sun,Honghai Wang,Rui Wang,Chunli Li,Jiapeng Liu
2-methyltetrahydrofuran (2-MeTHF) and acetonitrile (ACN) are widely used as solvents in the pharmaceutical industry. As 2-MeTHF and ACN form azeotrope that cannot be separated via regular distillation. Therefore, in this study, the molecular mechanism, experiment-based extractant screening, and process design for the separation of the 2-MeTHF-ACN azeotrope were investigated. According to Fourier-transform infrared spectroscopy and density functional theory, the azeotropy was destroyed via the formation of hydrogen bonds between the extractant dimethyl sulfoxide, 2-MeTHF, and ACN. Vapor–liquid phase equilibrium experiments validated the screening results and develop a thermodynamic model of the binary system. Batch distillation experiments obtained 2-MeTHF with a mass purity of 99.6 wt% and ACN with a mass purity of 99.8 wt%. The ED process was designed using Aspen Plus and improved via the integration of the recovered waste heat (ED-HI). A sequential iterative approach was used to minimize the total annual cost (TAC). The ED-HI process resulted in reductions in the TAC, reboiler heat load, and CO 2 emissions of 20.06 %, 25.77 %, and 22.77 %, respectively, compared to those of the ED process. This study provides valuable insight into the effective separation of 2-MeTHF and ACN.
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APPLIED SURFACE SCIENCE
·
2025
·
IF 6.9
Bingchen Li,Zexiong Cui,Yufeng Tao,Jin Xiong,Jinbo Gao,Lihua Liu,Shiwei Song,Pengfei Tian
The slow kinetics of the cathodic hydrogen evolution reaction (HER) present a significant obstacle for alkaline water electrolysis. Consequently, developing non-precious metal HER catalysts with high activity and stability remains a challenge. This study reports a heterostructure catalyst composed of Mo-doped amorphous Ni(OH) 2 nanosheets modified Fe 3 O 4 crystal nanoparticles (Mo-NiOH@Fe 3 O 4 ). This unique structure exhibits a three-dimensional, coral-like structure, which significantly increases the electrochemically active surface area and exposes more active sites to the electrolyte. The incorporation of Mo-doped amorphous Ni(OH) 2 enriches electron density around Fe atoms, modulating their electronic state and optimizing intrinsic activity. As an alkaline hydrogen evolution catalyst, Mo-NiOH@Fe 3 O 4 requires overpotentials of only 23.7 and 140.6 mV to achieve 10 and 100 mA cm −2 , respectively, demonstrating exceptional catalytic activity. Furthermore, it shows negligible performance degradation at 100 mA cm −2 and maintains stability for over 120 h. This work demonstrates that a heterostructure strategy, integrating Mo-doped amorphous Ni(OH) 2 with Fe 3 O 4 , provides a reasonable route for developing low-cost, high-performance HER catalysts.
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