BIOMASS & BIOENERGY
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2026
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IF 7
Xian Shi,Jun Qian,Siyu Zhou,Wanni Liu,Xing Chen,Xinyi Xing,Ying Guan,Siquan Xu
Glucose valorization is a promising approach for achieving high-value utilization of biomass, with its catalytic conversion to 5-hydroxymethylfurfural receiving considerable attention. However, developing an efficient and robust heterogeneous catalyst for the process remains challenging. Herein, we demonstrate a feasible strategy that combines the in-situ growth of a hafnium phosphide (HfP) active phase with the anchoring capability of a three-dimensional alumina support (F 3D -Al 2 O 3 ) to achieve catalyst availability. Various characterization techniques confirmed that the constructed HfP/F 3D -Al 2 O 3 catalyst possesses a well-developed three-dimensional flower-like hierarchical porous structure, which fully exposes the acidic sites and enhances mass transfer, thus outperforming two-dimensional sheet-like and one-dimensional bulk catalysts. Under optimal reaction conditions, the HfP/F 3D -Al 2 O 3 catalyst drove the conversion of glucose into the desired HMF with a yield of 70%. Benefiting from the interaction between the support Al 3+ center (Al V ) and the HfP active phase, the HfP/F 3D -Al 2 O 3 catalyst remained effective even after ten consecutive cycles. Furthermore, the pathway for the conversion of glucose into HMF catalyzed by HfP/F 3D -Al 2 O 3 was also monitored, revealing that it proceeds through the isomerization of glucose via a 1, 2-enediol intermediate followed by dehydration of fructose. Therefore, the glucose conversion pathway presented in this study has the potential to provide valuable insights for bioenergy refining technologies.
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高影响因子
CHINESE JOURNAL OF CHEMICAL ENGINEERING
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2026
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IF 3.5
Wang Xiang,Sien Yan,Weijie Wang,Ningwei Yang,Yan Wang,Tingting Kang,Linhuo Gan
As a high-quality carbon source, this study employed the gradient acid precipitation method to separate and extract bamboo lignin (BL) fractions from alkaline pulping black liquor, aiming to investigate the influence of BL fraction on the yield of lignin-derived carbon supported tin oxide (SnO x /LC) and its catalytic performance in the conversion of glucose to 5-hydroxymethylfurfural (5-HMF), utilizing various testing methods for detailed characterization. The characterization results revealed that SnO x /LC-2 was thermally stable with both Lewis acid and Brønsted acid sites, and the Sn element was uniformlmly dispersed on carbon carrier surface. In addition, with decreasing pH of black liquor, the molecular weight and polydispersity of BL fraction were significantly reduced, and its structural homogeneity was effectively improved. More importantly, the relative content of syringl unit and the content difference between phenolic hydroxyl and carboxylic acid groups in the structure of BL fractions both showed linear negative correlations with 5-HMF yield, which revealed the constitutive relationship between the molecular structural features of lignin and the catalytic performance of SnO x /LC, thus contributing to the high-value utilization of industrial lignin.
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Journal of Analysis and Testing
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2026
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IF 9.4
Su Jin-yuan,Cai Shuai,Wang Xi-xi,Cui Yuan-yuan,Yang Cheng-xiong
In this work, we present the synthesis of a pillar[5]arene-based microporous organic network (MON) and its combination with magnetic microspheres to construct novel MP[5]A-MON composites for efficient magnetic solid-phase extraction (MSPE) of four phthalate esters (PAEs) from complex samples. The designed MP[5]A-MON composites integrate the advantages of Fe 3 O 4 , pillar[5]arene macrocycles, and MON networks, providing multiple interaction sites, including host-guest, π–π stacking, and hydrophobic interactions, along with rapid magnetic separation (< 15 s) for PAE extraction. Under optimized conditions, the established MP[5]A-MON-MSPE-HPLC-UV method demonstrates wide linear ranges (0.5–1000 µg/L), low limits of detection (0.15–0.75 µg/L), high enrichment factors (94.9–97.1), minimal adsorbent consumption (4 mg), and a short extraction time (6 min). This study not only pioneers a new category of MON materials but also highlights the potential of pillar[n]arene-based MONs in the enrichment and separation of environmental contaminants.
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Chemical Engineering and Processing-Process Intensification
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2026
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IF 4.2
Haodong Chu,Mengdi Li,Weichen Zhao,Qingmao Yang,Chun Shen,Tianwei Tan
Production of 5-chloromethylfurfural (CMF) from fructose conducted in two-liquid phase system has achieved a considerable CMF yield. However, correlation between extraction process and CMF yield has not been reported yet. Herein, we found quantitative relation between interfacial specific area ( a ), extraction efficiency of 5-hydroxymethylfurfural (HMF) (E HMF ),a significant precursor of CMF and selectivity of CMF (S CMF ) in the microreactor. First, we systematically investigated the impact of flow rate ratio of two phases ( F C /F D ), total fluid velocity ( u ) and residence time on S CMF and E HMF . It turned out that both F C /F D and u had a significant impact on S CMF and E HMF . In addition, both u and F C /F D had a significant impact on interfacial specific area ( a ). As u varied, we fitted and observed a linear relation between u & a (R 2 =0.994), a & E HMF (R 2 =0.997) and E HMF & S CMF (R 2 =0.999). It indicated that CMF selectivity could be controlled by HMF extraction under certain conditions. Based on these results, we proposed a strategy for obtaining high CMF productivity from fructose in the microreactor. 93.9% CMF yield (11 g/L fructose concentration) and 89.9% CMF yield (110 g/L fructose concentration) were obtained. To the best of our knowledge, this work first proposes coordination between reaction and extraction in CMF production.
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Surfaces and Interfaces
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2026
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IF 6
Mengxue Sun,Qing Sun,Jiawei Sheng
The development of efficient and stable catalysts for peroxymonosulfate (PMS) activation is essential for the removal of persistent pharmaceutical pollutants such as 5-fluorouracil (5-FU). In this work, a novel, economical, and facile one-step molten salt synthesis strategy is developed to simultaneously etch the MAX phase (Mo 2 TiAlC 2 ) and in-situ anchor multiple cobalt-active species, leading to the direct formation of multi-interfacial Co/Mo-carbide/oxide hybrids. By employing a CaCl 2 /CoCl 2 molten salt system at 800 °C—which acts as both etchant and reaction medium—selective delamination of Al layers is achieved to produce Mo 2 TiC 2 MXene nanosheets, while catalytically active phases (Mo 3 Co 3 C, Co, and Mo 2 C) are generated in situ. Comprehensive characterization confirms the successful construction of abundant heterogeneous interfaces among these phases. The unique multi-interfacial architecture synergistically enhances electron transfer and exposes numerous active sites, thereby enabling highly efficient PMS activation. As a result, the hybrid catalyst exhibits exceptional performance in degrading 5-FU, with high degradation efficiency and rapid reaction kinetics. Radical quenching tests and electron paramagnetic resonance (EPR) analyses reveal that both radical (SO 4 • − , •OH, O 2 • − ) and non-radical ( 1 O 2 ) pathways act synergistically in the degradation process. This study offers a green and efficient “forging” strategy for designing MXene-derived composites with tunable compositions and interfaces. It not only avoids the use of fluorides but also introduces CaCl 2 as a novel molten salt etchant, demonstrating great potential for advanced oxidation processes and other applications.
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MOLECULAR PHARMACEUTICS
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2026
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IF 4.5
Wenqian Bai,Miaomiao Li,Junyao Li,Wenrong Cai,Yong Kong,Haiying Chen
A vitamin K3 (VK3)-loaded metal–organic framework (Cu/ZIF-8/VK3) was synthesized by a one-pot method. After the coencapsulation of Cu/ZIF-8/VK3 and 5-fluorouracil (5-FU) in the hyaluronate acid (HA)/carboxymethyl chitosan (CMCS) hydrogels formed via an amidation reaction, a drug-controlled release system (Cu/ZIF-8/VK3/5-FU/HA/CMCS) was obtained. In the weakly acidic media, the amide bonds in the HA/CMCS hydrogels are prone to be hydrolyzed, resulting in the release of 5-FU and Cu/ZIF-8/VK3; and the Cu/ZIF-8/VK3 is further degraded in the acidic environment, leading to the release of VK3 and Cu2+. The released Cu2+ can be reduced by glutathione (GSH) to Cu+, which can react with intracellular H2O2 to produce cytotoxic hydroxyl radicals (·OH) for chemodynamic therapy (CDT). On the other hand, H2O2 can be replenished through the redox cycling of VK3 in the presence of NAD(P)H: quinone oxidoreductase-1 (NQO1), generating stable ·OH for enhanced CDT. Cytotoxicity assay demonstrates that the developed drug-controlled release system has excellent biocompatibility, which can effectively inhibit the growth of mouse breast tumor cells 4T1 due to the synergistic chemotherapy and enhanced CDT.
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PubMed
高影响因子
Surfaces and Interfaces
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2022
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IF 6.137
Weiquan Li,Die Hu,Ke Yin,Chenglong Yu,Bichun Huang
A series of hierarchical Ru-Ce/H-ZSM-5 were designed and synthesized using the sol-gel method, and they were applied as catalysts for the catalytic combustion of chlorobenzene. The pore diameter of the catalyst was adjusted using an amount of sodium alginate (SA). Among all of the catalysts synthesized, the 0.8 wt.%Ru-10 wt.%Ce/H-ZSM-5 catalyst with a crystallization recipe of 1SiO 2 : 0.02Al 2 O 3 : 0.15TPAOH: 0.04SA: 40H 2 O (named RCZA-0.04) exhibited the optimal catalytic activity, with the 90% conversion of chlorobenzene at 247 °C. In addition, the RCZA-0.04 catalyst maintained superb stability during a long-term reaction at 325 °C. The results of characterizations demonstrated that RCZA-0.04 possessed the largest mesoporous volume, which reduced the diffusion resistance of chlorobenzene and increased the dispersion of the active components, thereby enhancing the catalytic activities. Moreover, the RCZA-0.04 catalyst possessed a low Brønsted/Lewis ratio, which was conducive to the adsorption of chlorobenzene and the cleavage of the C Cl bond.
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FUEL
·
2023
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IF 7.4
Xiao-Yan Zhao,Xue-Yu Ren,Yan-Jun Wang,Jing-Pei Cao,Zi-Meng He,Nai-Yu Yao,Hong-Cun Bai,Hou-Luo Cong
Direct conversion of lignite into light aromatics via catalytic fast pyrolysis is a great challenge because of severe catalyst deactivation and low aromatics yield. The tandem catalysis (1Zn@MCM-41 and ZSM-5) system was employed to promote the conversion of thermally-derived volatiles of lignite into aromatics at 600 °C. The mesoporous Zn-incorporated MCM-41 (xZn@MCM-41) with different doping amount of Zn was prepared with a one-pot hydrothermal procedure. The structure and the dispersion of Zn species of 1Zn@MCM-41 were systematically studied with XRD, SEM, BET, NH 3 -TPD and so on. The presence of 1Zn@MCM-41 significantly expands the lifetime of the microporous ZSM-5. Meanwhile, the yield of aromatics, especially benzene, is also increased to some extent. The content of the long-chain hydrocarbons and the phenolic compounds are decreased significantly after being cracked by the mesoporous 1Zn@MCM-41. More small molecules are able to contact with the active sites located in the micropores of ZSM-5 with the presence of Zn@MCM-41. In addition, the ZSM-5 in the tandem catalysts system presents an excellent stability. Therefore, this meso -microporous tandem catalysis system promotes the preferential cracking of macromolecular compounds, the cracked small molecules generated from which then contact with ZSM-5 to produce aromatics. This work provides a new perspective for the gradient catalyzing lignite-derived volatiles over a tandem catalysis system.
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INDUSTRIAL & ENGINEERING CHEMISTRY RESEARCH
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2022
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IF 4.326
Yuen Bai,Dongyang Liu,Liang Zhao,Jinsen Gao,Chunming Xu,Haitao Pang,Xuhui Gao
The influences of different B (Brønsted) acid site concentrations and the ratio of L (Lewis)/B (Brønsted) on the cracking pathways and product distributions in hexane cracking reactions as a model component of naphtha were investigated. The sodium-modified ZSM-5 catalysts were prepared by the wet impregnation method, and the Si–OH–Al groups of ZSM-5 were broken in the post-treatment process, resulting in a decrease in the number of strong B acid sites (SBAS) and an increase in the number of strong L acid sites (SLAS). The correlations between the n-hexane catalytic cracking reaction pathways and the catalyst acid properties were established. The reduced SBAS inhibits secondary reactions of light olefins such as hydrogen transfer, oligomerization, cyclization, and aromatization, while the increased SLAS and the ratio of SLAS/SBAS promoted the β scission reactions that significantly improved the yields of light olefins. Consequently, the appropriate SBAS and SLAS/SBAS ratios are desirable for the production of ethylene and propylene. The optimal SBAS concentration and SLAS/SBAS ratio ranged from 4.44 to 6.69 μmol/g and 9.18–11.86 for maximum ethylene and propylene yields of 16.14% and 14.63% in hexane catalytic pyrolysis reactions, respectively. Furthermore, the optimally prepared catalysts illustrated superior reactivities and catalytic stabilities in naphtha catalytic pyrolysis reactions under industrial conditions.
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BIOCHEMICAL ENGINEERING JOURNAL
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2023
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IF 3.9
Siyuan Chang,Bingfeng Li,Tianyi Chen,Leilei Zhang,Yaru Li,Xuejun He,Sen Zhang,Xin Pan
The catalytic transformation of biomass-derived 5-hydroxymethylfurfural (HMF) into value-added chemicals and biofuels has received considerable interest. Previously, we demonstrated that Pseudomonas aeruginosa PC-1 could be used for selective 900 mM HMF oxidation into 5-hydroxymethyl-2-furancarboxylic acid (HMFCA) with over 90% yield. Here, we aimed to mine the potential aldehyde dehydrogenases (ALDHs) for HMF biocatalysis and improved the catalytic activity and tolerance through protein engineering. ALDHs were heterologously expressed in E. coli BL21 (DE3) and subsequently the most efficient HMF oxidation conditions of E. coli /pET -PaALDH70140 were identified. Based on the structural analysis of PaALDH70140 with the HMF and NAD + complexes, the engineering hotspots in the active site architecture were identified and subjected to saturation mutagenesis . The mutant L172R displayed 175% higher HMF catalytic efficiency than PaALDH70140, and the mutant also showed improved HMF-tolerance. Kinetic parameters suggested that L172R had higher HMF affinity and catalytic efficiency, indicating a higher HMF conversion efficiency than the wild-type. Molecular docking revealed that the mutation introduced new hydrogen bonds between the enzyme and HMF, which fixed the spatial position of HMF and shortened the reaction time of the catalysis, thus enhancing the catalytic efficiency of HMF. In the fed-batch process, E. coli /pET -PaALDH70140 - L172R exhibited a 166% increase in the yield of HMFCA within 22 h, proving its potential for HMF bioconversion applications.
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JOURNAL OF CATALYSIS
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2022
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IF 8.047
Jiang Li,Heyang Liu,Zhidong An,Yue Kong,Lei Huang,Delong Duan,Ran Long,Piaoping Yang,Yuan-Ye Jiang,Jiaxing Liu,Junjie Zhang,Tong Wan,Jiayi Fu,Runze Pan,Xintian Wang,Dionisios G. Vlachos
Heteroatoms-doped carbon materials have recently emerged as effective catalysts for various chemical and electrochemical reactions. The free of metals especially noble metals reduces cost and eliminates issues like sintering or leaching of metals at elevated temperatures in solvents. In this work, selective hydrodeoxygenation (HDO) of 5-hydroxymethylfurfural (HMF) to 2,5-dimethylfuran (DMF) is for the first time achieved over simple nitrogen-doped carbon (N-C) catalysts. At optimal reaction conditions, a 91% yield of DMF is obtained with excellent catalyst stability. Extensive characterization, including extended X-ray absorption fine-structure (EXAFS) and soft X-ray absorption spectroscopy (sXAS), model reactions, basic data science analysis, and DFT calculations suggest that ppm of Fe in particular FeN 3 sites formed in pyrolysis, rather than non-metallic elements, drive key steps such as H 2 activation and deoxygenation of –OH during HMF HDO.
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Frontiers in Pharmacology
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2022
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IF 5.988
Zhang Wensen,Cui Na,Su Fazhi,Wang Yangyang,Yang Bingyou,Sun Yanping,Guan Wei,Kuang Haixue,Wang Qiuhong
Radix Rehmanniae (RR, from Radix Rehmanniae (Gaertn.) DC.) is a natural medicine used in traditional Chinese medicine (TCM) since ancient times for the treatment of blood disorders. RR is steamed to get Rehmanniae Radix Praeparata (RP), which has a tonic effect on blood; the content of 5-hydromethylfurfural (5-HMF) increases more than four times after steaming. Studies have shown that 5-HMF has positive pharmacological effects on cardiovascular and hematological disorders. This study aimed to explore and verify the impact of 5-HMF on rats with chemotherapy-induced blood deficiency syndrome (BDS). Rats were given cyclophosphamide (CP) and acetophenhydrazine (APH) to induce BDS, the coefficients of some organs (liver, spleen, and kidney) were measured, and a routine blood test examined the coefficients of several peripheral blood cells. Metabolomics and network pharmacology were combined to find important biomarkers, targets, and pathways. Western blot was used to detect the expression of CYP17A1 and HSD3B1 proteins in the spleen. All these findings suggested that the 5-HMF significantly increased the number of peripheral blood cells and reversed splenomegaly in rats. In addition, 5-HMF upregulated CYP17A1 and HSD3B1 protein expression in splenic tissues. Also, 5-HMF ameliorated chemotherapy-induced BDS in rats, and its therapeutic mechanism might depend on steroid hormone biosynthesis and other pathways. It acts on blood deficiency via multiple targets and pathways, which is unique to Chinese medicine.
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PubMed
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