BMC BIOLOGY
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2024
·Vol. 22
·期 1
·1-17
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IF 4.4
Yang Yuxuan,Li Wenqing,Sun Kaineng,Sun Siyu,Zhang Yong,Chen Lin,Ni Yangyue,Hou Min,Xu Zhipeng,Chen Lu,Ji Minjun
Background Inflammatory bowel disease (IBD), a persistent gastrointestinal disease, is featured with impaired gut immunity. Previous studies have demonstrated that tuft cells can regulate the intestinal type 2 immune response by activating downstream ILC2 and Th2 cells and repair gut barrier upon invasion of parasitic helminths, bacteria, protozoans, and enteritis through different chemo-sensing receptors, such as bitter taste receptors. Berberine is a widely used in the treatment of diarrhea in clinic, however the mechanism underlying this effect is not clear. In this study, we aim to explore the relationship between berberine and tuft cells in dextran sulfate sodium (DSS) -induced colitis.Results Our data showed that berberine significantly ameliorated DSS-induced colitis and regulating type 2 innate immune lymphocytes (ILC2) and Th2 immune cells via tuft cells in the gut. Furthermore, the effect of berberine on colitis was partially abolished by U73122, a bitter taste receptor inhibitor, suggesting that bitter taste signalling pathway played an important role in the effect of berberine on relieving colitis.Conclusion sBerberine ameliorates dextran sulfate sodium -induced colitis through tuft cells and bitter taste signalling. Our study reveals the unique pharmacological mechanisms of berberine in the context of colitis, laying the foundation for further clinical applications of this compound.
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NPG Asia Materials
·
2024
·Vol. 16
·期 1
·1-17
·
IF 8.6
Su Shenghui,Xie Jiajun,Gao Jian,Liu Shencai,Dong Xieping,Li Jianwei,Gao Zhong Feng,Chen Keyuan,Liu Weilu
Patients suffering from osteoporotic fractures often require effective fixation and subsequent bone repair. However, the currently available materials are functionally limited and often fail to improve outcomes in this patient population. In this study, we developed orthopedic adhesives doped with romosozumab-loaded mesoporous bioactive glass nanoparticles to aid in osteoporotic fracture fixation and restore dysregulated bone homeostasis. These adhesives were designed to promote osteoblast formation while simultaneously inhibiting osteoclastic bone-resorbing activity, thus working synergistically to promote the healing of osteoporotic fractures. Orthopedic adhesives exhibit injectability, reversible adhesiveness, and malleability, enhancing their adaptability to complex clinical scenarios. Furthermore, the release of romosozumab from mesoporous bioactive glass nanoparticles accelerated osteogenesis and inhibited osteoclastogenesis, delaying the bone resorption process. This dual action contributes to the regulation of bone regeneration and remodeling. Notably, our orthopedic adhesive could restore the disrupted bone homeostasis associated with osteoporotic fractures.
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Nature Communications
·
2025
·Vol. 16
·期 1
·1-26
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IF 15.7
Li Kai,Yu Xuan,Xu Yanteng,Wang Haixia,Liu Zheng,Wu Chong,Luo Xing,Xu Jiancheng,Fang Youqiang,Ju Enguo,Lv Shixian,Chan Hon Fai,Lao Yeh-Hsing,He Weiling,Tao Yu,Li Mingqiang
Non-nucleotide stimulators of interferon gene (STING) agonists hold promise as immunotherapeutic agents for postsurgical adjuvant treatment of tumors. However, their limited effect duration hampers therapeutic effectiveness, necessitating prolonged administration of multiple doses that heightens infection risk and impacts patient compliance. Here, we develop an implantable dual-drug depot in a sandwich-like configuration, with a non-nucleotide STING agonist (MSA-2) in the outer layers of 3D-printed scaffolds and an immunogenic apoptosis inducer (doxorubicin, DOX) in the inner layer of electrospun fibers. We discover that MSA-2 can elicit endoplasmic reticulum stress-mediated and general immunogenic apoptosis of cancer cells. The stimulations with tumor-associated antigens and damage-associated molecular patterns from cancer cells, along with proinflammatory factors secreted by matured dendritic cells and M1-polarized macrophages, can depolymerize intracellular microtubules guiding activated STING trafficking towards lysosomes for degradation. Collectively, the dual-drug depots can initiate a long-lasting cascaded immunotherapy and chemotherapy, suppressing postsurgical tumor recurrence and metastasis.
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Biomass Conversion and Biorefinery
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2025
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IF 4.1
Cao Shuangming,Sun Jianguo,Liu Qian,Gu Yonghua
Crab shells, as the waste from seafood processing, are emerging as a valuable resource for recycling and environmental protection. By combusting the organic components of crab shells, the high-calcium crab shell ash (CSA) is produced. This ash serves as a promising raw material for CO 2 mineralization, contributing to energy conservation and emission reduction. In this study, the systematic mineralization experiment of CSA was conducted using wet carbonation, focusing on the effects of reaction temperature, liquid–solid ratio, particle size, and stirring speed on CO 2 mineralization. The optimal mineralization conditions were achieved at a temperature of 60 °C, a liquid–solid ratio of 10 mL/g, a stirring speed of 700 rpm, and a CSA particle size exceeding 200 mesh, resulting in a carbonation efficiency of 66.10%. Furthermore, we improved the mineralization process by modifying the CSA with Na 2 CO 3 and employing microwave treatment. The carbonation efficiency significantly increased to 71.80% with a Na 2 CO 3 concentration of 1.75 mol/L. Notably, microwave drying further enhanced the carbonation efficiency of CSA to 73.01%. Our findings contribute to a deeper understanding of CSA mineralization and establish a theoretical foundation and research direction for enhancing the carbon sequestration capacity and subsequent application performance of crustacean biomass ash.
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International Journal of Minerals Metallurgy and Materials
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2025
·
IF 7.2
Wang Chao,Wu Zhongxian,Wang Tongbo,Qiao Bo,Huang Hao,Ran Jincheng,Ma Guangxi,Tao Dongping
To investigate the mechanisms of how nanobubbles enhance the flotation separation performance of galena from pyrite, the effects of nanobubbles on the surface properties of galena and pyrite and the interactions between mineral particles and air bubbles were examined in this study. Various analytical techniques, including focused beam reflectance measurement (FBRM), three-phase contact line (TPCL) analysis, atomic force microscopy (AFM), and contact angle measurement, were employed. It has been demonstrated that nanobubbles significantly enhanced the flotation recovery of galena and its flotation selectivity from pyrite, as compared to the conventional flotation process. The preferential formation of nanobubbles on the galena surface, which is more hydrophobic than pyrite surface, further increased the surface hydrophobicity and agglomeration of galena particles. The introduction of nanobubbles into the flotation system also increased in the maximum TPCL length and detachment length between the galena surface and bubbles, contributing to the enhanced flotation efficiency.
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IONICS
·
2025
·
IF 2.6
Yang Yue,Zhang Zheng,Ma Tianhui,Jia Shaoting,Huang Chao
To achieve high density and high Li-ion conductivity in the garnet LLZO (Li 7 La 3 Zr 2 O 12 ), an effective strategy is to dope it with high-valence elements to stabilize the cubic phase and to lower the sintering temperature. As well known, flash sintering (FS) is characterized by short sintering times and low furnace temperature. Herein, the doping modification of Ta-LLZO by flash sintering at 700 °C for the higher conductivity of LLZO was investigated in the present study. The results indicate that the addition of an appropriate amount of Ta 5+ can enhance the ionic conductivity. The relative density of the sintered cubic Li 6.4 La 3 Zr 1.4 Ta 0.6 O 12 is 94.72%, with a corresponding total ion conductivity of 9.8 × 10 –4 S cm −1 , demonstrating good electrical performance. A solid-state lithium metal battery with Li 6.4 La 3 Zr 1.4 Ta 0.6 O 12 electrolyte was assembled, and its electrical performance was tested at 50 °C. The results showed that an initial discharge specific capacity of 126.5 mAh g −1 at a 0.1C rate could be reached.
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Journal of Pharmaceutical Innovation
·
2024
·Vol. 19
·期 4
·1-13
·
IF 2.7
Feng Runliang,Chen Shiyu,Zhao Yingshun,Wang Mingzhu,Li Yuli,Jia Yunjing,Song Zhimei
Purpose To improve azithromycin’s antibacterial activity at different pH through combination therapy. Method Azithromycin- and ibuprofen-loaded micelles were fabricated by the self-assembly of MPEG-PVL copolymer, respectively. Results The drug-loaded micelles had controlled drug release property with water-solubility improvement. Notably, at pH 7.4 or 6.0, the in vitro antibacterial experiments demonstrated that there was no synergistic effect for the two native drugs against S. aureus , but a significant synergy was observed when the two preparations were used in combination. In vitro PI fluorescence staining experiment demonstrated that the introduction of ibuprofen-loaded micelles obviously increased cellular uptake under low concentration of azithromycin-loaded micelles. Through SEM and spectral evaluation experiments, it was found that ibuprofen-loaded micelles could increase the cell permeability by interacting with proteins and phospholipids in the cell membrane, which was conducive to promoting azithromycin-loaded micelles to enter the cells and play a drug effect. Conclusion The azithromycin- and ibuprofen-loaded micelles with synergistically enhanced antibacterial activity are potential candidates for effective bacterial combination therapy. Graphical Abstract
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ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
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2024
·
IF 0
Wang Fei,Jin Yulong,Xue Yun,Yu Shuihang,Liu Na,Ma Qingxiang,Xu Jie,Xue Bing,Wei Xuejiao
It is desirable but challenging to develop highly-efficient catalysts for the direct synthesis of dimethyl carbonate (DMC) from methanol and CO 2 . The vacancy-mediated incorporation of heteroatom into surface reconstruction is an efficient method of defect engineering for enhancing the catalytic properties. In this work, manganese-doped cerium oxide porous nanoribbons (Mn/CeO 2 -BTC) were prepared derived from a Ce-BTC by a sacrificial template approach. It is found that the catalytic activity of Mn/CeO 2 -BTC catalysts can be readily controlled by varying the amount of Mn dopants and the as-synthesized 0.1-Mn/CeO 2 -BTC exhibited an outstanding activity for the synthesis of DMC from CO 2 and methanol, which reached a high DMC yield (6.53 mmol DMC /g cat. ) without any dehydrating agents. Based on characterization results, the enhanced performance may be attributed to the defective structures caused by Mn doping and the porous nanoribbons of the CeO 2 crystals, which provide more surface oxygen vacancies and acidic-basic sites, favoring adsorption and activation of CO 2 and methanol.
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Journal of Inorganic and Organometallic Polymers and Materials
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2024
·
IF 3.9
Liu Pengwei,Wei Manlin,Shen Xiaojuan
Due to the good integration with the current silicon-based electronic devices, silicon-based supercapacitor have been considered as one of the promising energy storage devices. However, their practical application is largely hindered by complex and costly manufacturing processes. In this study, a novel NiSi@MnO x electrode was fabricated with a simple and cost-effective method, where Ni nanoparticles and MnO x nanoparticles were sequentially electrodeposited on the silicon nanowire arrays (SiNWs). Ni particles served as the protective layer on the silicon surface as well as the current collector of the composite, and MnO x functioned as the electrochemical material of the electrode. As the deposition time of MnO x increased, the structure of NiSi@MnO x changed from core–shell to embedded. The electrochemical results demonstrated that when MnO x was embedded in Silicon nanowires, the NiSi@MnO x electrode achieved an excellent area capacitance of 328.6 mF/cm 2 at 1 mA/cm 2 , which also displayed an impressive capacitance retention of 79.05% after 7000 cycles. Additionally, an all-solid-state asymmetric SC (ASC) of NiSi@MnO x //Fe 2 O 3 /N-rGO was fabricated by using NiSi@MnO x as positive electrode, Fe 2 O 3 /N-rGO loaded on NF as negative electrode. The ASC exhibited a remarkable energy density of 0.021 mWh/cm 2 at the power density of 0.7998 mW/cm 2 , surpassing the majority of reported values for silicon-based/MnO x -based supercapacitors. This study provides a simple, time-effective, and low-cost method to prepare high-performance 3D silicon-based electrodes. Graphical Abstract
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Nature Communications
·
2025
·Vol. 16
·期 1
·1-12
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IF 15.7
Wang Jiaqi,Liu Yue,Yang Ganceng,Jiao Yanqing,Dong Youming,Tian Chungui,Yan Haijing,Fu Honggang
Anion exchange membrane seawater electrolysis is vital for future large-scale green hydrogen production, however enduring a huge challenge that lacks high-stable oxygen evolution reaction electrocatalysts. Herein, we report a robust OER electrocatalyst for AEMSE by integrating MXene (Ti 3 C 2 ) with NiFe sulfides ((Ni,Fe)S 2 @Ti 3 C 2 ). The strong interaction between (Ni,Fe)S 2 and Ti 3 C 2 induces electron distribution to trigger lattice oxygen mechanism, improving the intrinsic activity, and particularly prohibits the dissolution of Fe species during OER process via the Ti-O-Fe bonding effectively, achieving notable stability. Furthermore, the good retention of sulfates and the abundant groups of Ti 3 C 2 provide effective Cl - resistance. Accordingly, (Ni,Fe)S 2 @Ti 3 C 2 achieves high OER activity (1.598 V@2 A cm -2 ) and long-term durability (1000 h) in seawater system. Furthermore, AEMSE with industrial current density (0.5 A cm -2 ) and durability (500 h) is achieved by (Ni,Fe)S 2 @Ti 3 C 2 anode and Raney Ni cathode with electrolysis efficiency of 70% and energy consumption of 48.4 kWh kg -1 H 2 .
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Cell Death Discovery
·
2024
·Vol. 10
·期 1
·1-16
·
IF 6.1
Liu Zhaohong,Xiang Peng,Zeng Shengmei,Weng Ping,Wen Yilin,Zhang Wanping,Hu Hui,Zhao Dezhang,Ma Limei,Yu Chao
Vascular endothelial injury initiates atherosclerosis (AS) progression. N -Acetylneuraminic acid (Neu5Ac) metabolic disorder was found to intensify endothelial mitochondrial damage. And GLS2-associated glutaminolysis disorder contributed to mitochondrial dysfunction. However, mechanisms underlying Neu5Ac-associated mitochondrial dysfunction as well as its association with GLS2 remains unclear. In this study, we constructed GLS2 −/− ApoE −/− mice by using HBLV-GLS2 shRNA injection. And methods like immunofluorescence, western blotting, transmission electron microscopy were applied to detect profiles of endothelial injury and AS progression both in vivo and in vitro. We demonstrated that Neu5Ac accumulation increased GLS2 expression and promoted glutaminolysis disorder, which further induced endothelial mitochondrial dysfunction via a pyroptosis-dependent pathway in vivo and in vitro. Mechanically, Neu5Ac interacted with SIRT3 and led to FOXO3a deacetylation and phosphorylation, further facilitated c-Myc antagonism and ultimately increased GLS2 levels. Inhibition of GLS2 could improve mitochondrial function and mitigate pyroptosis process. In addition, blocking Neu5Ac production using neuraminidases (NEUs) inhibitor could rescue endothelial damage and alleviate AS development in ApoE −/− mice. These findings proposed that Neu5Ac induced GLS2-mediated glutaminolysis disorder and then promoted mitochondrial dysfunction in a pyroptosis-dependent pathway. Targeting GLS2 or inhibiting Neu5Ac production could prevent AS progression.
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Advanced Fiber Materials
·
2024
·
IF 17.2
Wang Rongmei,Zhang Zixing,Qin Jie,Meng Qiufeng,Du Yong,Zhang Fan
Polymer-based thermoelectric (TE) films feature several prominent merits, involving available multi-component compositions, versatile patterning fabrication, and readily integration. Therefore, these materials hold a huge potential as the continuous power supply for wearable devices. Herein, we reported the preparation of a series of vinylene-linked triazole-cored covalent organic frameworks (COFs) by Knoevenagel condensation of 2, 4, 6-trimethyl-1, 3, 5-triazine as the core monomer. The as-prepared COFs tend to generate the nano- or micro-fiber morphologies with tunable lengths and diameters through changing the polyphenylene building blocks. Accordingly, these COF fibers could be readily composited with single-walled carbon nanotubes (SWCNTs) to form the flexible free-standing films upon a simple vacuum filtration method. A film sample containing 30 wt% g-C 18 N 3 -COF exhibited the highest power factor of 68.93 μW/(m K 2 ) at 420 K. The manipulated 4-leg flexible thermoelectric generator (f-TEG) released a maximum output power and power density of 343.5 nW and 0.32 W/m 2 at a temperature difference of 35 K. After bending for 1000 times at a radius of 15 mm, the resistance change rate of the as-fabricated f-TEGs was less than 5%, exhibiting excellent stability and flexibility. This work might not only broaden the potential application scope of COF materials but also provide a new fabrication strategy towards energy harvesting. Graphical Abstract
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