JOURNAL OF HEALTH POPULATION AND NUTRITION
·
2024
·Vol. 43
·期 1
·1-9
·
IF 2.4
Huang Zhi,Ma Keyu,Yin Xiaochen,Li Ziming,Chen Ming,Duan Yujie,Li Li,Hu Yuming
Background Childhood overweight and obesity is becoming an emerging face of malnutrition. The aims of this study were to develop fatty acid (FAs) related dietary patterns and explored the associations of FAs related dietary patterns with overweight and obesity among Chinese children. Methods An observational study was conducted on 435 children aged 4 to 7 years old in South Central China. Erythrocyte FAs composition was analyzed by gas chromatography-mass spectrometry. Diet was collected by food frequency questionnaires and dietary patterns were evaluated by reduced rank regression. The logistic regression analysis was used to exploring the association of dietary patterns with overweight and obesity. Results The prevalence of overweight, obesity, and overweight or obesity were 6.52, 4.59, and 11.11% in Chinese children, respectively. Twenty five types of FAs were detected in erythrocyte of children and four FAs related dietary patterns were identified. The dietary pattern positively correlated with n-3 PUFAs, but negatively with SFAs,was characterized by high intake of fish, shrimp, crab and shellfish, leaf-off vegetable, nuts, and tubers, which have a significantly decreased overweight risk (OR = 0.580, 95%CI: 0.375 ∼ 0.895, P = 0.014).The pattern positively strong associated with n-6 PUFAs, but negatively strong with n-3 PUFAs, had high intake of snacks, leaf-off vegetable, fresh beans, and coarse cereals, which have a significantly decreased obesity risk (OR = 0.518, 95%CI: 0.325 ∼ 0.827, P = 0.006). Conclusion Four FAs related dietary patterns were identified. The dietary pattern with high intake of fish, shrimp, crab and shellfish decreased overweight risk by increasing n-3 PUFAs, and decreasing SFAs. The dietary pattern with high intake of plant food, decreased obesity risk by providing an balanced n-6/n-3 PUFAs ratio.
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Advanced Composites and Hybrid Materials
·
2025
·Vol. 8
·期 1
·1-14
·
IF 21.8
Wang Ping,Shi Mengting,Ling Jiacheng,Yang Li,Liu Wenxiu,Zhou Yiyang,Xu Jie,Chen Mei,Li Guilin
The enhancement of the flame retardancy of polydicyclopentadiene (PDCPD) while maintaining its excellent mechanical properties has long been an important and critical technical challenge for many years. In this contribution, we designed and synthesized a new flame-retardant monomer containing double norbornene groups (NB-PDP) which can undergo the frontal ring-opening metathesis polymerization (FROMP) with dicyclopentadiene (DCPD) and 5-dicyclopentadiene-2-carboxylic acid (NB-COOH). Through the formulation optimization, the flame retardancy and mechanical properties of the copolymers could be easily regulated. To investigate the influencing mechanism of the NB-PDP and NB-COOH on the properties of the copolymers, the thermodynamics and kinetics of the FROMP, as well as the micro-structures, mechanical properties, and flame-retardant performance of the PDCPD/NB-PDP/NB-COOH copolymers were systematically studied. The findings suggest that the integration of NB-PDP and NB-COOH resulted in a diverse array of physical and chemical cross-linking networks within the system. Consequently, the tensile strength of the copolymers reached a maximum of 63.1 MPa and the elongation at break achieved up to 28.5%, representing the increases of 43.0% and 154.0% compared to that of PDCPD without any modification, respectively. It is worth mentioning that except the flame-retardant NB-PDP, NB-COOH could also serve as the carbon source to enhance the char formation and further improve the flame-retardant properties, such as the limiting oxygen index (LOI), peak heat release rate (PHRR), total heat release (THR), and total smoke production (TSP). These phenomena indicate that the material exhibits excellent mechanical properties and conspicuous flame retardancy. This work provided an efficient method for the preparation of the intrinsically flame-retardant PDCPD materials and a new strategy for the constructing of the thermosetting materials with excellent comprehensive performance.
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RARE METALS
·
2025
·
IF 11
Fan Siyu,Xu Tianxi,Yang Hui,Ge Yan,Wang Genlin,Ohno Teruhisa,Xu Bin
In this study, a novel Ce-based metal–organic framework (Ce–OFDC) was synthesized via the hydrothermal method. To enhance its photocatalytic antimicrobial properties, polymeric carbon nitride (PCN) was incorporated into the Ce-OFDC matrix, forming a Ce-OFDC/PCN composite material. Antibacterial assays demonstrated that Ce-OFDC/PCN had significant inhibitory effects on both Escherichia coli ( E. coli ) and Staphylococcus aureus ( S. aureus ), achieving inhibition rates of 99.5% and 94.3%, respectively. Notably, the antibacterial performance of Ce-OFDC/PCN was superior to that of Ce-OFDC or PCN alone. Furthermore, photocurrent and electrical impedance scanning measurements demonstrated that the Ce-OFDC/PCN composites showed improved photocurrent response and superior efficiency in separating photogenerated electrons and holes. The photocurrent density of Ce-OFDC/PCN reached 120 μA cm −2 , which was 1.5 times higher than that of PCN (80 μA cm −2 ) and 12 times higher than that of Ce-OFDC (10 μA cm −2 ). Electron paramagnetic resonance analysis indicated that reactive oxygen species played a crucial role in the antimicrobial process, with superoxide radicals (·O 2 − ) and hydroxyl radical (·OH) showing the most prominent influence. We conducted reactive oxygen species (ROS) scavenging experiments to further confirm this view. After adding glutathione (GSH) to remove all ROS, the antibacterial efficiency of Ce-OFDC/PCN decreased by about 40%. Adding D-mannitol to remove ·OH reduced the inhibition rate to 54.7%, and adding superoxide dismutase (SOD) to remove ·O 2 − reduced the inhibition rate to 65.4%. The Ce-OFDC/PCN heterostructure increased the separation efficiency of photogenerated electrons and holes, producing increased reactive oxygen species. That, in turn, contributed to the observed superior photocatalytic antibacterial performance. This research significantly advanced the development of metal–organic framework (MOF)-based materials and provided valuable insights into the design of antimicrobial photocatalysts. Graphic abstract
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npj Biofilms and Microbiomes
·
2025
·Vol. 11
·期 1
·1-12
·
IF 9.2
Wu Tong,Guo Sheng-Zhi,Zhang Yi,Zhao Xi-Ze,Ran Cong-Guo,Liu Feng-Lan,Wang Run-Hua,Li De-Feng,Zhu Hai-Zhen,Jiang Cheng-Ying,Shen Xi-Hui,Liu Shuang-Jiang
The capability to understand and construct synthetic microbiomes is crucial in biotechnological innovation and application. Tetrabromobisphenol A (TBBPA) is an emerging pollutant, and the understanding of its biodegradation is very limited. Here, a top-down approach was applied for the enrichment of TBBPA-degrading microbiomes from natural microbiomes. Ten keystone taxa correlated to TBBPA degradation and their co-occurrence interactions were identified by the dissection of the degrading microbiomes. Those keystone taxa were targeted and cultivated, and the genomic information was obtained by genome sequencing of strains and metagenomic binning. The keystone bacterial strains showed efficient degradation of TBBPA, and L -amino acids were important co-metabolic substrates to promote the degradation. Guided by this knowledge, a bottom-up approach was applied to design and construct a simplified synthetic consortium SynCon2, that consisted of four strains. The SynCon2 demonstrated efficient TBBPA degradation activity and soil bioremediation. Our study demonstrates the importance of the application of multiple tools in understanding the functions of microbiomes and provides an integrated top-down and bottom-up strategy for the construction of synthetic microbiomes with various applications.
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JOURNAL OF NANOBIOTECHNOLOGY
·
2025
·Vol. 23
·期 1
·1-17
·
IF 12.6
Xu Jia,Deng Cheng,Gao Tang,He Mengrong,Fu Wenpei,Zhang Xin,Bai Yin,Qiu Jiani,Wang Rui,Chen Yihan,Jin Qiaofeng,Zhang Li,Lv Qing,Xie Mingxing,Wu Wenqian
Chronic rejection (CR) remains the leading cause of morbidity and mortality in heart transplantation survivors. The primary pathological features of CR encompass cardiac allograft vasculopathy and myocardial fibrosis. Currently, its diagnosis heavily relies on invasive procedures, underscoring the pressing need for non-invasive evaluation methods. This study introduces a novel approach utilizing mannose-modified microbubbles (MBman) targeting CD206 (mannose receptor) positive M2 macrophages for early CR detection. In vitro experiments demonstrate substantial adhesion of MBman to M2 macrophages compared to common microbubbles (MBcon). In a CR rat model, MBman and MBcon are administered at three distinct time points (2 weeks, 4 weeks, and 6 weeks), followed by contrast-enhanced ultrasound images and quantitative analysis using the ultrasound destruction-supplementation method. Starting at 2 weeks and continuing through 6 weeks, MBman demonstrates significantly higher signal intensity than MBcon in allograft rats. However, this difference is not observed in isograft rats at any of the indicated time points. These findings suggest an increase in M2 macrophage infiltration in allografts compared to isografts. Furthermore, the signal intensity of MBman positively correlates with the percentage of CD206 in allograft rats. This study proposes a promising approach, simultaneous noninvasive ultrasound molecular imaging, for the early-stage evaluation of CR.
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npj Clean Water
·
2025
·Vol. 8
·期 1
·1-10
·
IF 11.4
Lu Tianxin,Wu Qinglin,Zhou Yu,Wang Xuanzhi,Shi Weiwei
Interfacial solar evaporation is an innovative technique that has attracted significant attention for its potential applications across a variety of fields. Traditional evaporators either apply the hydrophobic surface or the hydrophilic, exposed to solar irradiation. However, both situations result in the poor heat and mass transfer with the long-term operations, further lower down evaporation performance. Herein, Janus membranes (FePP) were designed with dynamically reversible solar evaporation interfaces; the top surface exhibited superhydrophobic exposed to solar irradiation while superhydrophilic in the dark environment. This property minimizes salt fouling by regulating salt deposition during evaporation cycles, while facilitating easy recovery during the hydrophilic state. The solar evaporation performance has improved with the average rate of 1.48 ± 0.05 kg m −2 h −1 , 2.6 times more than the control group of water interface without FePP under one-sun irradiation. Furthermore, it demonstrated excellent stability and strong salt-resistance ability in the long-term desalination and highly saline water operation. Even outdoor field tests, FePP also showed strong solar evaporation and desalination performance exposed to the changing irradiation under the sun. This work further promotes the practical applications of the solar interfacial evaporators into the wastewater treatment, water desalination and purification, and energy production.
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Stem Cell Research & Therapy
·
2025
·Vol. 16
·期 1
·1-21
·
IF 7.3
Liao Guolong,Long Canling,Guo Rui,Wang Sushan,Han Ruijuan,Yang Jianhua,Liu Jia
Background Interstitial cystitis/bladder pain syndrome (IC/BPS) is a chronic condition characterized by debilitating pelvic pain. Mesenchymal stem cell-derived extracellular vesicles (MSC-EVs) are recognized as pivotal mediators of MSCs’ paracrine activity and represent a novel therapeutic approach for IC/BPS. However, their efficacy is hindered by the inherent variability of primary MSCs (pMSCs) from different donors and their susceptibility to senescence during culture expansion.Methods To overcome these challenges, we developed conditionally immortalized mesenchymal stem cells (iMSCs) using a doxycycline-regulated simian virus 40 Large T expression system in pMSCs. The conditioned proliferation capacity of iMSCs was evaluated using cell counting and immunocytochemistry. The expression of surface markers on iMSCs was assessed by flow cytometry. The osteogenic and adipogenic differentiation capabilities of iMSCs at different population doubling (PD) numbers were analyzed by qPCR, alizarin red staining, and oil red O staining. The EVs secreted by iMSCs were characterized using Western blot, scanning electron microscopy, and particle size analysis. In vitro and in vivo bladder inflammation models were used to evaluate the therapeutic effects of EVs on IC/BPS.Results These iMSCs exhibited precisely controlled proliferation, maintained surface marker expression and differentiation capacities, comparable to pMSCs up to PD 40. The characteristics of iMSC-EVs are equivalent to those of pMSCs. Furthermore, in vitro cellular experiments demonstrate that iMSC-EVs provide protective effects against LPS/ATP-induced damage in SV-HUC-1 cells. Additionally, administration of iMSC-EVs significantly enhanced tissue healing and anti-inflammatory capabilities in an IC/BPS animal model.Conclusion sIn summary, this approach produced a reliable source of functional MSCs and EVs, with iMSC-EVs demonstrating robust immunomodulatory properties and promoting tissue healing in IC/BPS. This method represents a promising alternative to pMSCs for IC/BPS therapy.
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Cell Death Discovery
·
2025
·Vol. 11
·期 1
·1-16
·
IF 7
Lu Hui,Fu Wenying,Xia Yiqun,Yan Ying,Shu Chongchong,Chen Yinghua,Xu Chenxin,Zheng Peisen,Shen Xin,Cui Ri,Zou Peng,Ni Daoyong
Adagrasib, a KRASG12C inhibitor, recently received accelerated approval from the US FDA for the treatment of patients diagnosed with KRASG12C-mutated non-small cell lung cancer. Although adagrasib has demonstrated excellent clinical efficacy and good safety, the molecular mechanism underlying the antitumor activity of adagrasib remains elusive. Here, we report that adagrasib treatment markedly inhibited the growth of cells harboring the KRASG12C mutation, whereas the non-KRASG12C cell lines H1299 and PC-9 were also sensitive to adagrasib, indicating that adagrasib exerted off-target effects. Mechanism studies indicated that adagrasib treatment reduced the level of NRF2 via upregulating its ubiquitination, and NRF2 overexpression can reverse the adagrasib-induced cell death in H23 and H1299 cells. Furthermore, adagrasib treatment significantly increased the cellular ROS level and thereby activating autophagy and AKT signaling pathways in H23 and H1299 cells. Importantly, combination of adagrasib with panobinostat demonstrated enhanced antitumor activity in vitro and in vivo. Overall, our data elucidate a novel mechanism of adagrasib, which will be critical for the clinical application of adagrasib.
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IRANIAN POLYMER JOURNAL
·
2025
·
IF 2.8
Zhu Guanglai,Xu Chao,Xu Ziyi,Yu Yitao,Sun Cuicui,Zhuang Haihua,Ma Baichang,Hou Yantao,Li Bing,Wang Zhenhua,Dai Caifeng
Phthalonitrile (PN) resins are high-performance thermosetting polymers recognized for their exceptional thermal stability and flame resistance, making them attractive candidates for aerospace, electronics, and high-temperature structural applications. However, their broader adoption is hindered by two primary challenges: the high melting point of PN precursors and the volatility of conventional curing agents, which complicate processing and raise safety concerns. Despite ongoing research, effective strategies that simultaneously address these issues while enhancing the overall performance of PN resins remain limited. In this study, we introduce a novel self-catalyzing curing agent, 4-(7-amino-1-naphthoxy) phthalonitrile (ANP), which functions both as a precursor and curing agent. The presence of amino and naphthoxy groups promotes efficient curing without the need for external catalysts, thereby expanding the processing window. Additionally, amino and cyano groups act as reactive sites and flexibilizers, enhancing the properties of bisphenol A-based PN (AFPN) resin systems. Thermal analysis revealed that the ANP-modified resin exhibits outstanding thermal and thermo-oxidative stability, with a 5% weight loss temperature ( T 5% ) exceeding 450 °C and a glass transition temperature ( T g ) above 439 °C. Vector network analysis further demonstrated excellent dielectric properties, with a dielectric constant ( D k ) of 3.15 and a dissipation factor ( D f ) of 0.017 at 9.05 GHz. These findings indicate that ANP effectively overcomes key limitations of conventional PN resins. As a multifunctional curing agent, ANP shows significant potential for the development of advanced PN-based composites in aerospace, electronic packaging, and microelectronic applications. Graphical abstract
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FIBERS AND POLYMERS
·
2025
·
IF 2.3
Zhang Lele,Sun Yi,Yang Haiwei,Sun Wanlin,Kuai Long,Wang Zongqian
Polyethylene terephthalate (PET) textile waste, which is resistant to degradation, contributes significantly to environmental pollution. Currently, traditional methods, such as high-temperature and high-pressure treatments, microwave heating, etc. exhibit low initial degradation rates for polyester fibers while also facing challenges such as high energy consumption, complex degradation products, and difficulties in subsequent reuse. Thus, research on efficient recycling and sustainable development of PET waste has become imperative. Here, we report a novel method to degrade PET fibers completely at low temperatures within 1 h. A synergistic hydrolysis system consisting of a deep eutectic solvent (ChCl–EG DES) composed of choline chloride and ethylene glycol, along with sodium hydroxide (NaOH) was used to facilitate the highly efficient and complete degradation of polyester fibers under mild conditions. The degradation process can be conducted at temperature below 100 °C, achieving a degradation rate of up to 100%, with the degradation product being sodium terephthalate, which exhibits a high purity of 99.85% and can be directly reused as a raw material without complex treatments and purification steps. The degradation kinetic of polyester fibers fits first-order reaction, with an activation energy of 108.59 kJ/mol. Overall, this study provides a green, low-cost, and energy-saving strategy with practical application value for efficient degradation and recycling of polyester fibers.
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Journal of Coatings Technology and Research
·
2025
·
IF 2.8
Tang Baoling,He Ziyu
The commonly used dispersants for graphene dispersions reduce the conductivity of the composite. In this work, a dispersant with an amphiphilic structure, CA-g-PANI, has been designed and synthesized. The dispersant grafts citric acid (CA) onto polyaniline via an amide reaction, which gives CA-g-PANI the hydrophilic groups (carboxyl groups) and the benzene ring structures that can be π–π conjugated with graphene, and it can improve the dispersion properties of graphene; CA-g-PANI contains the polyaniline structure, which is electrically conductive and enhances the electrical conductivity of graphene dispersions. The molecular structure and properties of the dispersant were systematically characterized through FTIR spectra, UV absorption spectra, and other methods. The graphene-based composites were prepared by screen printing method, and the dispersibility and resistivity of CA-g-PANI were compared with gum arabic and alkali lignin (natural dispersants). Graphene concentration reached up to 30 mg/mL in the presence of CA-g-PANI at the weight ratio of 1:0.03 (CA-g-PANI: graphene). CA-g-PANI also exhibited good performance for stabilizing graphene (stable for 6 days), with an electrical conductivity of up to 917.43 S/m. In the study, it was shown that CA-g-PANI as a graphene dispersant improved the conductivity of graphene dispersions while enhancing the dispersing properties of graphene.
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CURRENT MICROBIOLOGY
·
2025
·Vol. 82
·期 9
·1-14
·
IF 2.6
Xiao Mengzhu,Wu Yujia,Li Wanzhen,Wang Jun,Zhang Weiwei,Gui Lin,Ge Fei
Antibiotics, a milestone invention in modern medicine, have significantly improved human quality of life and serve as a primary weapon against bacterial infections. However, antibiotic abuse has led to the emergence and worsening of bacterial resistance, now a major global public health challenge. Therefore, the efficient use of nanoscale antimicrobial peptides (APs) as therapeutic and diagnostic agents offers a novel strategy to replace conventional antibiotics. In this study, we innovatively combined AP with manganese dioxide (MnO 2 ) and zeolitic imidazolate framework-8 (ZIF-8) to develop a novel composite: ZIF-8-encapsulated and AP-loaded MnO 2 (AP-MnO 2 @ZIF-8). This composite exhibited superior properties, including enhanced biocompatibility, excellent aqueous stability, and increased antibacterial activity. Both in vitro and in vivo AP-MnO 2 @ZIF-8 demonstrated potent efficacy against multidrug-resistant (MDR) Escherichia coli ( E. coli ) and Staphylococcus aureus ( S. aureus ). Its minimum inhibitory concentrations (MICs) were 20 μg/ml for E. coli and 39 μg/ml for S. aureus . Furthermore, colony-forming unit (CFU) assays showed that 150-μg/ml AP-MnO 2 @ZIF-8 reduced bacterial survival below 5%, indicating effective growth inhibition. Crucially, it significantly suppressed bacterial activity in S. aureus -infected mouse wound models. Compared to free AP or MnO 2 alone, AP-MnO 2 @ZIF-8 showed significantly enhanced water solubility, bioavailability, and antibacterial activity. This work provides a foundation for developing AP-based antimicrobial strategies and offers a novel nanomaterial approach to combat the increasingly severe antibiotic resistance crisis. Graphical
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